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Protein

Ceramide very long chain fatty acid hydroxylase

Gene

SCS7

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.UniRule annotation

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
Name:SCS7Imported
Ordered Locus Names:CAGL0F03399gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome F

Organism-specific databases

CGDiCAL0131212 SCS7
EuPathDBiFungiDB:CAGL0F03399g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Transmembranei254 – 270HelicalSequence analysisAdd BLAST17
Transmembranei277 – 295HelicalSequence analysisAdd BLAST19
Transmembranei301 – 325HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446117.1

Structurei

3D structure databases

ProteinModelPortaliQ6FUH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68Cytochrome b5 heme-bindingInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the sterol desaturase family. SCS7 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
KOG0539 Eukaryota
COG3000 LUCA
COG5274 LUCA
HOGENOMiHOG000023981
InParanoidiQ6FUH7
KOiK19703
OMAiHHFRIQT
OrthoDBiEOG092C3MYJ

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR006694 Fatty_acid_hydroxylase
IPR014430 Scs7
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF04116 FA_hydroxylase, 1 hit
PIRSFiPIRSF005149 IPC-B_HD, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FUH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAADSSKT LELFPQSVLA KHNSKDDCWV STHERKIYDV SKYLKDHPEE
60 70 80 90 100
ADAVHKALDG KHGTDISQME LTTLKFVTDD YLVGYLATSD EEKKLLTNKS
110 120 130 140 150
HKVEVKLNAD NTFDSTTFVK DLPTEDKLSI TTDYERDYKK HKFLDLNKPL
160 170 180 190 200
LKQILFGNFT KDFYLDQIHR PRHYGKGSAP LFGNFLEAFT KTAWWVVPTV
210 220 230 240 250
WGPVVLYFIT TALMNMNNPL ALFLFGLGIF VWTLIEYCLH RFLFHFDEWL
260 270 280 290 300
PEHSMFFMIH FLLHGCHHYL PMDAYRLVVP PALFVVLCAP IYKLVFAALP
310 320 330 340 350
YYWACAGFAG GMLGYICYDL CHYFLHHSKM PPFMRKLKKY HLEHHYKNYQ
360 370 380
LGFGVTSWFW DKVFGTYLGP DAPLSKMKYE
Length:380
Mass (Da):44,314
Last modified:July 19, 2004 - v1
Checksum:iF362590098AFF0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA Translation: CAG59041.1
RefSeqiXP_446117.1, XM_446117.1

Genome annotation databases

EnsemblFungiiCAG59041; CAG59041; CAGL0F03399g
GeneIDi2887589
KEGGicgr:CAGL0F03399g

Similar proteinsi

Entry informationi

Entry nameiQ6FUH7_CANGA
AccessioniPrimary (citable) accession number: Q6FUH7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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