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Protein

Heat shock protein 70 homolog LHS1

Gene

LHS1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chaperone required for protein translocation and folding in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

GO - Molecular functioni

Keywordsi

Molecular functionChaperone, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 70 homolog LHS1 (EC:3.6.1.3)
Gene namesi
Name:LHS1
Ordered Locus Names:CAGL0F06369g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome F

Organism-specific databases

CGDiCAL0130854 CAGL0F06369g
EuPathDBiFungiDB:CAGL0F06369g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000001355516 – 889Heat shock protein 70 homolog LHS1Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446244.1

Structurei

3D structure databases

ProteinModelPortaliQ6FU50
SMRiQ6FU50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi886 – 889Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
HOGENOMiHOG000111144
InParanoidiQ6FU50
KOiK09486
OMAiNADESCA
OrthoDBiEOG092C0K07

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FU50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSILFLFA IAVQAAFLGI DYGQQSIKAM VVSPKAMMEI VLTPEAKRKD
60 70 80 90 100
TSGICIRNVN GVLERHYGNS IGSLVTRFPQ NTAMHLRSLL GKSMNDKDTI
110 120 130 140 150
ESYLRENPGA NLTSTTRNTI AITIDGVEYP VEQLVAMNLQ EIIDRANQHI
160 170 180 190 200
KETDTTGIDF VEQVGIAIPE QFNQAQRQAL LDALALTSVK DEAVLVSDGL
210 220 230 240 250
SVAIDYALKR PDLEINVPQY YIVFDVGTSA AKATLFSLTQ PEDLSSPIKI
260 270 280 290 300
EIGAFDSEAT VGGSKFIAAI ADIVEDKFLE KNTKITRKSL VENPRARAKI
310 320 330 340 350
IQAAEKAKLV LSANNEAIIS IESLVDDIDF RTTIARSEFQ DIFEDNKHTV
360 370 380 390 400
VKAIKGAIGN QLWDDNISLE DISGVILSGG SSRVPMVQEE IAKLVGEEKI
410 420 430 440 450
LKNVNADETV INGATLKGLK YFGSFKTKPL DITERSLFDY SVEMSGESSS
460 470 480 490 500
KTVFEKGTKF PNESSILYKA PKKFGKELKF DLFESDTRIL SNIVDTTVSS
510 520 530 540 550
KNWTSACKKG QLYLNVTFDL DSNRVFKIKD ITVLCDSDGN AKEEEFEFID
560 570 580 590 600
VINDVTKATD VMPLSNAEIR QLSNAITSWN RKDRERKRVQ ESLNVLEAEL
610 620 630 640 650
YDCRSFIEEF EEKLGEEEFE TLKSFTAFVK EKLEYLEDNS ADMSKKDIEK
660 670 680 690 700
LVRETRSQRD TLSRFYNSLD AALGSKDFQK LVDTASKSIK KYKEIESKNL
710 720 730 740 750
ADLENKAEKF NVIGLNVTEK YNSILSKMSF SSIRRSSEEN IKTLAGLIDE
760 770 780 790 800
VNESIKSKAI DDESLENLIK TKLAFEELIN TLDLENRQWT YQHQLVMKEL
810 820 830 840 850
KKMYNKKMKA IKKQEKQNEN EENGDDEGDD EDETKTKKYL KEATSSGDSS
860 870 880
TIKEEDSTGS NEAGNKGDEE DEEEEEDDSS AGNVFDDEL
Length:889
Mass (Da):99,634
Last modified:July 19, 2004 - v1
Checksum:i58CD2D752B2DD11F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA Translation: CAG59168.1
RefSeqiXP_446244.1, XM_446244.1

Genome annotation databases

EnsemblFungiiCAG59168; CAG59168; CAGL0F06369g
GeneIDi2887859
KEGGicgr:CAGL0F06369g

Similar proteinsi

Entry informationi

Entry nameiLHS1_CANGA
AccessioniPrimary (citable) accession number: Q6FU50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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