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Protein

DNA polymerase

Gene

CAGL0G06666g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Ordered Locus Names:CAGL0G06666gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome G

Organism-specific databases

CGDiCAL0129530 CAGL0G06666g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446650.1

Structurei

3D structure databases

ProteinModelPortaliQ6FSZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 74DNA_pol_alpha_NInterPro annotationAdd BLAST64
Domaini364 – 705DNA_pol_B_exo1InterPro annotationAdd BLAST342
Domaini764 – 1215DNA_pol_BInterPro annotationAdd BLAST452
Domaini1256 – 1449zf-DNA_PolInterPro annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1096 – 1116Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG0970 Eukaryota
COG0417 LUCA
HOGENOMiHOG000163524
InParanoidiQ6FSZ4
KOiK02320
OrthoDBiEOG092C038B

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FSZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASNDKLAK LKKLQALRKG KNANDEDDED NYDKIYDEID EKEYRNRKRQ
60 70 80 90 100
ELLRDDFVVD DDGLGYVDRG VEEEFNSEED YSSNDELDNS TSKGNKKQQP
110 120 130 140 150
KKQIGDMLKA HHSKVVLSGK QLDSKKKQIK LDDFDDILNE FDNEEDEKPI
160 170 180 190 200
LTHRKNASLL SSSPTVKTAM KRSLNDFDSS DNENRRIKNK RVDMNSSPLK
210 220 230 240 250
NQIKNSIPSE SLGGGDTAVN SLETSPTRHV QDSSLLNAVK SEFEQDSSTN
260 270 280 290 300
IDSDDSDEDN VIVTKRKMRT ATAVRKVNLD SKSALSSSPY VTTPGTPITE
310 320 330 340 350
NKKSIGSSVA SYSMSGPLNF ATQKFTKDQI IDPQTGTFKM YWFDFTEVNN
360 370 380 390 400
TLVLFGKIKL LTGEHVSAMI QIDGMCRELY FLPREGRKPE EIHEEIIPLL
410 420 430 440 450
MDKYGLPNIR AKPEHMKYAF ELPGIPHESD YLKVLLPFNT PKSSRDTIPP
460 470 480 490 500
DLSSETFHHV FGGNTNIFES FVVQNKIMGP CWLEIKGGDF SALQNASHTS
510 520 530 540 550
IEVLINRPQD IKPIDIKEMP ELHCTSISIQ TVMNPKQNKQ EIVSITLGTY
560 570 580 590 600
KNLKLDSPIP ENLDPTDIVT LVRPPHGSSF PPGLATLAKQ KLGGQVRLFN
610 620 630 640 650
NEKTLLACFC AMMKVMDPDV LIGHRLEGVY LDVLVHRLHE FNIPTFSTIG
660 670 680 690 700
RRVRKVWPDK FGKVNSGLTH LFIREMVAGR LICDIGNEMG QSLTPKCQNW
710 720 730 740 750
DLAEMYQVTC QVDHKPLEIN YQNTQYQDDV NLLTMALQEN VTNCKIAAEV
760 770 780 790 800
SFRIQILSLT KQLTNLAGNA WSQTLGGTRA GRNEYILLHE FARNGYIVPD
810 820 830 840 850
KETQKMRNQR LRAQDGSDEP EGSSKKSKYQ GGLVFDPEKG LHTNYVLVMD
860 870 880 890 900
FNSLYPSIIQ EFNICFTTVD RDVENIDELP EVPSADKAQG VLPRLLANLV
910 920 930 940 950
ERRREVKKIM KTETDPHKRL QCDIRQQALK LTANSMYGCL GYVNSRFYAR
960 970 980 990 1000
PLAMLVTNKG REILMNTRQL AESMNLIVVY GDTDSVMIDT NCDNYHDAIK
1010 1020 1030 1040 1050
IGNNFKTLVN ERYRLLEIDI DNVFKKLLLH AKKKYAALNV SINKEGKEET
1060 1070 1080 1090 1100
VLEVKGLDMK RREFCPLSRD ISIHVLNTIL SDKDPETALQ EVYYYLEDMR
1110 1120 1130 1140 1150
EKIEKDEIRV DKYKINTKLS KDPSAYPGGK NMPAVQVALR MRKTGRMVKA
1160 1170 1180 1190 1200
GTVITYVITK PAEVENGEAS GAQSVAERAY ALNEVMMKGS NLRPDPEFYL
1210 1220 1230 1240 1250
EKQIYAPVER LLERIDSFDS VRLISALGLD SKKYLRRGGI DGHGSNSNEL
1260 1270 1280 1290 1300
EPLETTISDM ERFKDSSNLI LNCPNCKKEF PYGGIVASNY YQHCYNGLQC
1310 1320 1330 1340 1350
KSCDYLFSPL QMTCQLERAI RSHISLYYAG WLQCDDPTCG NVTRQLSVFG
1360 1370 1380 1390 1400
KRCLNDGCTG VMHYRYTDKQ LYNQLLFFDS LFDCDKNKKR ELKPLYLEGD
1410 1420 1430 1440 1450
QDYPSEKLSD TSINALTEQN RDLLELNHSI VQKYLSDCGR RYVDMATIFE

FMMN
Length:1,454
Mass (Da):165,326
Last modified:July 19, 2004 - v1
Checksum:iD666FC89A736A876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA Translation: CAG59577.1
RefSeqiXP_446650.1, XM_446650.1

Genome annotation databases

EnsemblFungiiCAG59577; CAG59577; CAGL0G06666g
GeneIDi2888004
KEGGicgr:CAGL0G06666g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA Translation: CAG59577.1
RefSeqiXP_446650.1, XM_446650.1

3D structure databases

ProteinModelPortaliQ6FSZ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_446650.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59577; CAG59577; CAGL0G06666g
GeneIDi2888004
KEGGicgr:CAGL0G06666g

Organism-specific databases

CGDiCAL0129530 CAGL0G06666g

Phylogenomic databases

eggNOGiKOG0970 Eukaryota
COG0417 LUCA
HOGENOMiHOG000163524
InParanoidiQ6FSZ4
KOiK02320
OrthoDBiEOG092C038B

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FSZ4_CANGA
AccessioniPrimary (citable) accession number: Q6FSZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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