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UniProtKB - Q6FS46 (Q6FS46_CANGA)
Protein
Non-specific serine/threonine protein kinase
Gene
CAGL0H03553g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 17 | ADP; via carbonyl oxygenCombined sources | 1 | |
Binding sitei | 38 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 83 – 85 | ADPCombined sources | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- identical protein binding Source: EnsemblFungi
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein tyrosine kinase activity Source: EnsemblFungi
GO - Biological processi
- autophagy of peroxisome Source: EnsemblFungi
- DNA repair Source: EnsemblFungi
- monopolar spindle attachment to meiosis I kinetochore Source: EnsemblFungi
- peptidyl-tyrosine autophosphorylation Source: EnsemblFungi
- positive regulation of clathrin-dependent endocytosis Source: EnsemblFungi
- regulation of autophagosome assembly Source: EnsemblFungi
- regulation of ER to Golgi vesicle-mediated transport Source: EnsemblFungi
- regulation of protein localization by the Cvt pathway Source: EnsemblFungi
- regulation of vesicle fusion with Golgi apparatus Source: EnsemblFungi
- ribosomal large subunit biogenesis Source: EnsemblFungi
- ribosomal small subunit biogenesis Source: EnsemblFungi
- tRNA wobble uridine modification Source: EnsemblFungi
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Ordered Locus Names:CAGL0H03553gImported |
Organismi | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported |
Taxonomic identifieri | 284593 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › Nakaseomyces/Candida clade › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0130244, CAGL0H03553g |
VEuPathDBi | FungiDB:CAGL0H03553g |
Subcellular locationi
Cytoskeleton
- spindle pole body Source: EnsemblFungi
Golgi apparatus
- Golgi apparatus Source: EnsemblFungi
Nucleus
- nucleus Source: EnsemblFungi
Peroxisome
- peroxisome Source: EnsemblFungi
Plasma Membrane
- plasma membrane Source: EnsemblFungi
Other locations
- cellular bud neck Source: EnsemblFungi
- cellular bud tip Source: EnsemblFungi
- monopolin complex Source: EnsemblFungi
- phagophore assembly site Source: EnsemblFungi
- preribosome, small subunit precursor Source: EnsemblFungi
Interactioni
GO - Molecular functioni
- identical protein binding Source: EnsemblFungi
Protein-protein interaction databases
STRINGi | 5478.XP_446948.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 278 | Protein kinaseInterPro annotationAdd BLAST | 270 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 315 – 340 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 427 – 495 | DisorderedSequence analysisAdd BLAST | 69 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 392 – 419 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 315 – 338 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 441 – 495 | Polar residuesSequence analysisAdd BLAST | 55 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1164, Eukaryota |
HOGENOMi | CLU_019279_2_7_1 |
InParanoidi | Q6FS46 |
OMAi | ESRVYKY |
Family and domain databases
InterProi | View protein in InterPro IPR030509, CK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR11909:SF409, PTHR11909:SF409, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6FS46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLRVGRKFR IGRKIGSGSF GDIYHGTNLI SGEEVAIKLE SIRSRHPQLD
60 70 80 90 100
YESRVYKYLS GGVGIPFIRW FGREGEYNAM VIDLLGPSLE DLFNYCHRKF
110 120 130 140 150
SFKTVIMLAL QMICRVQYIH GRSFIHRDIK PDNFLMGVGR RGSTVHVIDF
160 170 180 190 200
GLSKKYRDFN THRHIPYREN KSLTGTARYA SVNTHLGIEQ SRRDDLESLG
210 220 230 240 250
YMLIYFCKGS LPWQGLKATT KKQKYDRILE KKLCISVETL CAGLPLEFSE
260 270 280 290 300
YMNYCRNLKF DERPDYLYLA RLFKDLSIKL EYHNDHLFDW TMLRYTKAMV
310 320 330 340 350
EKQKDVLMLD TSSTANANKE SGNNNNESNT TSNTKDSKND SFNKVKLLAM
360 370 380 390 400
KKFASHFHYC KNDDKHYPTP EEIKQQTVQN NNAAASLPPE LLSAIDKGME
410 420 430 440 450
NLKQQQNQQQ QQSQQVQMQP LASAELNQDQ LPPQGPEPLL QRQRKETQGQ
460 470 480 490
FVPTQEPVNR ATHYPPNVQT NNMPQVQQQN ISPQNPKPSG DNIWL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR380954 Genomic DNA Translation: CAG59881.1 |
RefSeqi | XP_446948.1, XM_446948.1 |
Genome annotation databases
EnsemblFungii | CAG59881; CAG59881; CAGL0H03553g |
GeneIDi | 2888610 |
KEGGi | cgr:CAGL0H03553g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR380954 Genomic DNA Translation: CAG59881.1 |
RefSeqi | XP_446948.1, XM_446948.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4XH0 | X-ray | 1.99 | A | 1-403 | [»] | |
4XHG | X-ray | 2.15 | A | 1-403 | [»] | |
4XHH | X-ray | 2.91 | A | 1-403 | [»] | |
SMRi | Q6FS46 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 5478.XP_446948.1 |
Genome annotation databases
EnsemblFungii | CAG59881; CAG59881; CAGL0H03553g |
GeneIDi | 2888610 |
KEGGi | cgr:CAGL0H03553g |
Organism-specific databases
CGDi | CAL0130244, CAGL0H03553g |
VEuPathDBi | FungiDB:CAGL0H03553g |
Phylogenomic databases
eggNOGi | KOG1164, Eukaryota |
HOGENOMi | CLU_019279_2_7_1 |
InParanoidi | Q6FS46 |
OMAi | ESRVYKY |
Family and domain databases
InterProi | View protein in InterPro IPR030509, CK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR11909:SF409, PTHR11909:SF409, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6FS46_CANGA | |
Accessioni | Q6FS46Primary (citable) accession number: Q6FS46 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | January 19, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |