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Protein

Glucose-repressible alcohol dehydrogenase transcriptional effector

Gene

CCR4

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity).By similarity

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi589MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
Biological processTranscription, Transcription regulation
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-repressible alcohol dehydrogenase transcriptional effector (EC:3.1.13.4)
Alternative name(s):
Carbon catabolite repressor protein 4
Cytoplasmic deadenylase
Gene namesi
Name:CCR4
Ordered Locus Names:CAGL0H06149g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome H

Organism-specific databases

CGDiCAL0131866 CAGL0H06149g
EuPathDBiFungiDB:CAGL0H06149g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002906081 – 873Glucose-repressible alcohol dehydrogenase transcriptional effectorAdd BLAST873

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447062.1

Structurei

3D structure databases

ProteinModelPortaliQ6FRT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati391 – 412LRR 1Add BLAST22
Repeati414 – 435LRR 2Add BLAST22
Repeati437 – 459LRR 3Add BLAST23
Repeati460 – 480LRR 4Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 33Gln-richAdd BLAST20
Compositional biasi58 – 201Asn-richAdd BLAST144

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0620 Eukaryota
COG4886 LUCA
COG5239 LUCA
HOGENOMiHOG000294222
InParanoidiQ6FRT2
KOiK12603
OMAiFPNDKFP
OrthoDBiEOG092C0WZC

Family and domain databases

Gene3Di3.60.10.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6FRT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDISMMGYP GMGQQQPQPQ QAQQPQQQPI SMQPHTMMNM MNTNLPPPGM
60 70 80 90 100
MMGGAGSNTG NENMINHGLM SGNPVSGIPN NNSHQLLDQL INKNPNNMGI
110 120 130 140 150
PQQQQDSLAA QMQLPMGGMP MGNGSAHNGN VGMNNNNTGG NNNIPMGNAN
160 170 180 190 200
VLRNNNIIGN LGGSSLAGGN MNSGMPGIST FGNTPGQLAA PPIQPNANAN
210 220 230 240 250
NPMYHPHLED PSLMNNPIWK LQLQLATVSA QSVGQPNIYA RQNAMKKYLA
260 270 280 290 300
TQVPPQNQTQ QQAQAQSQIA ETSKSLVDCT KQALMDIMAP DDSKLKGMSA
310 320 330 340 350
PNTASTTTNS TISTPTTSKI DMNNSREQPS TPSLLLQHKK LSQYSIDEDD
360 370 380 390 400
EVENRMVAPK DTKYNDQIWH AIDLSNLQIF NISPNLMKYD FLTRLYLNGN
410 420 430 440 450
GLESIPSSIR NLKNLRVLDL SHNKLKELPK EIGNCYQLKY LYFFDNQITT
460 470 480 490 500
LPWELGNLCN IQFLGCEGNP LDKELLKILT EKSFTGLIFY LRDNRPEVPY
510 520 530 540 550
PHDRKFIEIN ADGEPEKEYD TVQEAERNLS SDMQKKSFTM LSYNTLCQHY
560 570 580 590 600
ATPKMYRYTP SWALSWDYRR EKLKEQILNF NTDIICLQEV EAKTFEDFWQ
610 620 630 640 650
PLLEKHGYTG LFHAKTRAKT MQSKDSKKVD GCCAFYKTSK FKMLFKECVD
660 670 680 690 700
FSGLWMKHKK FQRTEDYLNR AMNKDNVAIV MKLQHIQSGE IMWLVTTHLH
710 720 730 740 750
WDPKFNDVKT FQVGVLLDHM ETLLKEQNPK QDVKKYPLVI CGDLNSYLSS
760 770 780 790 800
SVYELFSTGR VQHHHDGKDR DFGYFSEDNF SHNLALKSSY NCIGELAFTN
810 820 830 840 850
FTPSFTDVID YIWFSSQALR VRGLLGEVDS EYVSNFIGFP NDKFPSDHIP
860 870
LLGRYEFLKS NNTQNSNSGS RKV
Length:873
Mass (Da):98,578
Last modified:July 19, 2004 - v1
Checksum:i796DB965C95E673D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA Translation: CAG59995.1
RefSeqiXP_447062.1, XM_447062.1

Genome annotation databases

EnsemblFungiiCAG59995; CAG59995; CAGL0H06149g
GeneIDi2888713
KEGGicgr:CAGL0H06149g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA Translation: CAG59995.1
RefSeqiXP_447062.1, XM_447062.1

3D structure databases

ProteinModelPortaliQ6FRT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_447062.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59995; CAG59995; CAGL0H06149g
GeneIDi2888713
KEGGicgr:CAGL0H06149g

Organism-specific databases

CGDiCAL0131866 CAGL0H06149g
EuPathDBiFungiDB:CAGL0H06149g

Phylogenomic databases

eggNOGiKOG0620 Eukaryota
COG4886 LUCA
COG5239 LUCA
HOGENOMiHOG000294222
InParanoidiQ6FRT2
KOiK12603
OMAiFPNDKFP
OrthoDBiEOG092C0WZC

Family and domain databases

Gene3Di3.60.10.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCCR4_CANGA
AccessioniPrimary (citable) accession number: Q6FRT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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