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Protein

Mitochondrial glycine transporter

Gene

CAGL0H10538g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
Ordered Locus Names:CAGL0H10538g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome H

Organism-specific databases

CGDiCAL0131438 CAGL0H10538g
EuPathDBiFungiDB:CAGL0H10538g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 33Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei56 – 82Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei111 – 136Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei164 – 187Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei215 – 241Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei270 – 288Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789321 – 297Mitochondrial glycine transporterAdd BLAST297

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447256.1

Structurei

3D structure databases

ProteinModelPortaliQ6FR88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 81Solcar 1UniRule annotationAdd BLAST77
Repeati105 – 189Solcar 2UniRule annotationAdd BLAST85
Repeati211 – 295Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
HOGENOMiHOG000006978
InParanoidiQ6FR88
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6FR88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTGHLIG GFAGGLSSAV ALQPLDLLKT RFQQTKGGTL WQTVKSLDTP
60 70 80 90 100
WQLWRGTLPS AIRTSVGSAL YLSSLNLMRT ALAKRKQFDT ADSVVTGKSS
110 120 130 140 150
NLPQLSMYEN LVTGAFARGT VGYITMPITI IKVRYESTLY NYKSIAEAAK
160 170 180 190 200
SIAAQEGIRG FFRGFGPTCL RDAPYSGLYV LLYEKLKHTL PTILPKSLLQ
210 220 230 240 250
LDSEGRYTAY TSTAINSTSA ILSASMATTV TAPFDTIKTR MQLEPTKFKT
260 270 280 290
FWSTLTTIVT QEHPIKIFSG LSMRLTRKAL SAGIAWGIYE ELIKHFM
Length:297
Mass (Da):32,592
Last modified:July 19, 2004 - v1
Checksum:iC3E7DB744251EC4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA Translation: CAG60189.1
RefSeqiXP_447256.1, XM_447256.1

Genome annotation databases

EnsemblFungiiCAG60189; CAG60189; CAGL0H10538g
GeneIDi2888866
KEGGicgr:CAGL0H10538g

Similar proteinsi

Entry informationi

Entry nameiS2538_CANGA
AccessioniPrimary (citable) accession number: Q6FR88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 19, 2004
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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