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Entry version 120 (07 Oct 2020)
Sequence version 1 (19 Jul 2004)
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Protein

Protein kinase domain-containing protein

Gene

CAGL0K02167g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CAGL0K02167gImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284593 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002428 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome K

Organism-specific databases

Candida Genome Database

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CGDi
CAL0134845, CAGL0K02167g

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:CAGL0K02167g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5478.XP_448319.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 456Protein kinaseInterPro annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni91 – 115DisorderedSequence analysisAdd BLAST25
Regioni605 – 641DisorderedSequence analysisAdd BLAST37
Regioni676 – 849DisorderedSequence analysisAdd BLAST174
Regioni875 – 929DisorderedSequence analysisAdd BLAST55
Regioni950 – 1037DisorderedSequence analysisAdd BLAST88
Regioni1133 – 1162DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi621 – 640PolyampholyteSequence analysisAdd BLAST20
Compositional biasi676 – 768PolarSequence analysisAdd BLAST93
Compositional biasi793 – 808PolyampholyteSequence analysisAdd BLAST16
Compositional biasi810 – 849PolarSequence analysisAdd BLAST40
Compositional biasi875 – 922PolarSequence analysisAdd BLAST48
Compositional biasi956 – 984PolarSequence analysisAdd BLAST29
Compositional biasi1000 – 1037PolarSequence analysisAdd BLAST38
Compositional biasi1147 – 1162PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0585, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003784_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6FN75

KEGG Orthology (KO)

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KOi
K21157

Identification of Orthologs from Complete Genome Data

More...
OMAi
AIMKKCH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6FN75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVITTDSKYI EEVDIPENLQ LEIDLSDPLL KGNSNSNTNV CTQSTLNTTT
60 70 80 90 100
STVSPVRKRF ESLPEGLSAS SSSLDSLNLL LEKQMTKQLN HPQHQEHLGS
110 120 130 140 150
GKYSPLGGNG GKLGRRTKVK ETNRISLTYD PVSKRKVLNT YEIIKELGHG
160 170 180 190 200
QHGKVKLGRD LVTKRLVAIK IVDRHEKKER KFFSFKKPGK TENDKIKREI
210 220 230 240 250
AIMKKCHHKH VVKLIEVLDD LKSRKIYLVL EYCSRGEVKW CPPDCLETEA
260 270 280 290 300
KGPSPLSFQF TREILRGVVL GLEYLHYQGI IHRDIKPANL LLSETGIVKI
310 320 330 340 350
SDFGVSLAAS SSNVDGSDET IDELELAKTA GTPAFFAPEI CLGEDAFEKY
360 370 380 390 400
QLDREELFKG SCISFKIDIW ALGVTLYCLV FGMLPFVSSF ELELFEKIVN
410 420 430 440 450
DPVKFPKYSD MLKNNQVLQM TEEAEYEAAK DLLTRLLEKN PIKRINIEEI
460 470 480 490 500
KRHPFVCWDF DHLDGESEQE LSLKLEEKMN FQCAQRDYLT QISVTMHELN
510 520 530 540 550
NAVCGVGKEI KESDLQSITY RENASSDNSI NLEKFNLIRD RDNSLIVSEG
560 570 580 590 600
SILKNMKDLR RLSSKKSGAD ESLKKETNLE QSQLLLQNLK LVSSEDCEYD
610 620 630 640 650
QDADFEESHG TSYSDNDESA SETLSQKEQF EKEMEEFEKR QQNNNVVNLP
660 670 680 690 700
INSSFASLDS FYIDNFAMTK MGMDNEVTNP EQRNSSASTF TKWNTGSTHS
710 720 730 740 750
VSPISHNSAH FTNNGNPSGN TTNISRNPSS HMLPYSLGMS STRNDRIPRN
760 770 780 790 800
HSISPHYSSN SSRKSRLQLS EAFPAKLKMT SKSKSQTNYH EGYENTEVDR
810 820 830 840 850
EKAGKRASSH PRTQSRMQRA NSTTKNSNHA IAAKNEAANR STDSNRSDSP
860 870 880 890 900
LISLQDMVKA SGSNQDTYNV KKGNFFDNFN GDDDSSSRSS VSSESSESYS
910 920 930 940 950
DVPISEDSYS SASVSRRNTD TESLPYEFGI DSGRASTVSL RDVPQNLGNV
960 970 980 990 1000
RPFLDLHPLT NSSSKGSQQR RDSMNSSGSD SDSDGPGSVL VLRAGNKGHM
1010 1020 1030 1040 1050
RRQNSYQNDR PFNDSASTIT PGATSPKRFY AKGSTLQPTN DRAKGYCKSN
1060 1070 1080 1090 1100
LNPGVMAANA GTLVMSDSRA KPVIGTSDVF GTISNSTLTD VARHPLSRDL
1110 1120 1130 1140 1150
LKDALSSGEN SGRRGSIPLG ILGIGSNSSP MNATVGGTLN KRASWSKDRT
1160
SLSDDELHSK NH
Length:1,162
Mass (Da):129,256
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i770004E6C180FED2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CR380957 Genomic DNA Translation: CAG61280.1

NCBI Reference Sequences

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RefSeqi
XP_448319.1, XM_448319.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG61280; CAG61280; CAGL0K02167g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2890296

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgr:CAGL0K02167g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA Translation: CAG61280.1
RefSeqiXP_448319.1, XM_448319.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5478.XP_448319.1

Genome annotation databases

EnsemblFungiiCAG61280; CAG61280; CAGL0K02167g
GeneIDi2890296
KEGGicgr:CAGL0K02167g

Organism-specific databases

CGDiCAL0134845, CAGL0K02167g
EuPathDBiFungiDB:CAGL0K02167g

Phylogenomic databases

eggNOGiKOG0585, Eukaryota
HOGENOMiCLU_003784_0_0_1
InParanoidiQ6FN75
KOiK21157
OMAiAIMKKCH

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6FN75_CANGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6FN75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 7, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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