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UniProtKB - Q6FLP9 (DCW1_CANGA)
Protein
Mannan endo-1,6-alpha-mannosidase DCW1
Gene
DCW1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Functioni
Required for normal synthesis of the cell wall.
By similarityCatalytic activityi
- Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. EC:3.2.1.101
GO - Molecular functioni
- mannan endo-1,6-alpha-mannosidase activity Source: UniProtKB-EC
GO - Biological processi
- budding cell bud growth Source: EnsemblFungi
- carbohydrate catabolic process Source: InterPro
- cell wall organization Source: UniProtKB-KW
- fungal-type cell wall biogenesis Source: EnsemblFungi
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Cell wall biogenesis/degradation |
Protein family/group databases
CAZyi | GH76, Glycoside Hydrolase Family 76 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannan endo-1,6-alpha-mannosidase DCW1 (EC:3.2.1.101)Alternative name(s): Defective cell wall 1 Endo-alpha-1->6-D-mannanase DCW1 |
Gene namesi | Name:DCW1 Ordered Locus Names:CAGL0L01727g |
Organismi | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
Taxonomic identifieri | 284593 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › Nakaseomyces/Candida clade › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0136136, CAGL0L01727g |
VEuPathDBi | FungiDB:CAGL0L01727g |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Cell wall
- cell wall By similarity
Extracellular region or secreted
- extracellular region Source: CGD
Plasma Membrane
- anchored component of plasma membrane Source: EnsemblFungi
Keywords - Cellular componenti
Cell membrane, Cell wall, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000012123 | 19 – 422 | Mannan endo-1,6-alpha-mannosidase DCW1Add BLAST | 404 | |
PropeptideiPRO_0000012124 | 423 – 446 | Removed in mature formSequence analysisAdd BLAST | 24 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 237 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 278 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 334 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 391 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 397 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 422 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, LipoproteinFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 389 – 408 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 389 – 405 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 76 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QSWP, Eukaryota |
HOGENOMi | CLU_025694_1_2_1 |
InParanoidi | Q6FLP9 |
OMAi | TACGFKW |
Family and domain databases
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR005198, Glyco_hydro_76 IPR014480, Mannan-1_6-alpha_mannosidase |
PANTHERi | PTHR12145, PTHR12145, 1 hit |
Pfami | View protein in Pfam PF03663, Glyco_hydro_76, 1 hit |
PIRSFi | PIRSF016302, Man_a_manosd, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6FLP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLVTLLSGL VSLVSVFGLE LDLDDYASLQ NATALVAYGL MDYYTGDQYG
60 70 80 90 100
KTVGMFSDPY YWWQAGGAWG CMLDYWYFMQ NDTYNDKIMA ALLHQTGDNN
110 120 130 140 150
DYVPLNQSTT EGNDDQAFWG IAVMQAAERK FPNPPDDKPQ WLYLTQAVFN
160 170 180 190 200
TMALRWDSET CGGGLRWQIF VWNSGYDYKN TVSNGALFHI AARLARYTGN
210 220 230 240 250
QSYVDWAERV YDWMEDVHLI DNGTYRYVYD GVSINDNCTT VTKYQWTYNQ
260 270 280 290 300
GLMLSGSAYL FNMTGSDLWH ERTHAFLNAS RVFFNNSILY EAACQGPNTC
310 320 330 340 350
NTDQRSFKAY FARFLGSTAE LVPETRQQIM TWLNTSALAA AKSCSGGTDG
360 370 380 390 400
HTCGLNWFRD DWDGMYGLGE QMAALEVMVN TQALKRAPPY NATNGGNSTG
410 420 430 440
DGAAGTKPHP TNLAPLHITG GSRAGAGIIT AIIGISIIAC ALWLVY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR380958 Genomic DNA Translation: CAG61815.1 |
RefSeqi | XP_448845.1, XM_448845.1 |
Genome annotation databases
EnsemblFungii | CAG61815; CAG61815; CAGL0L01727g |
GeneIDi | 2890890 |
KEGGi | cgr:CAGL0L01727g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR380958 Genomic DNA Translation: CAG61815.1 |
RefSeqi | XP_448845.1, XM_448845.1 |
3D structure databases
SMRi | Q6FLP9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5478.XP_448845.1 |
Protein family/group databases
CAZyi | GH76, Glycoside Hydrolase Family 76 |
Genome annotation databases
EnsemblFungii | CAG61815; CAG61815; CAGL0L01727g |
GeneIDi | 2890890 |
KEGGi | cgr:CAGL0L01727g |
Organism-specific databases
CGDi | CAL0136136, CAGL0L01727g |
VEuPathDBi | FungiDB:CAGL0L01727g |
Phylogenomic databases
eggNOGi | ENOG502QSWP, Eukaryota |
HOGENOMi | CLU_025694_1_2_1 |
InParanoidi | Q6FLP9 |
OMAi | TACGFKW |
Family and domain databases
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR005198, Glyco_hydro_76 IPR014480, Mannan-1_6-alpha_mannosidase |
PANTHERi | PTHR12145, PTHR12145, 1 hit |
Pfami | View protein in Pfam PF03663, Glyco_hydro_76, 1 hit |
PIRSFi | PIRSF016302, Man_a_manosd, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCW1_CANGA | |
Accessioni | Q6FLP9Primary (citable) accession number: Q6FLP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families