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Entry version 106 (31 Jul 2019)
Sequence version 1 (19 Jul 2004)
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Protein

Helicase SWR1

Gene

SWR1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi653 – 700ATPPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase SWR1 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SWR1
Ordered Locus Names:CAGL0M01188g
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284593 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002428 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome M

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0137511 CAGL0M01188g

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CAGL0M01188g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743651 – 1450Helicase SWR1Add BLAST1450

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6FK48

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWR1 chromatin-remodeling complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5478.XP_449396.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6FK48

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini344 – 417HSAPROSITE-ProRule annotationAdd BLAST74
Domaini640 – 805Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1179 – 1332Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi756 – 759DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0388 Eukaryota
KOG0391 Eukaryota
COG0553 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186095

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6FK48

KEGG Orthology (KO)

More...
KOi
K11681

Identification of Orthologs from Complete Genome Data

More...
OMAi
NKPDAFH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6FK48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKNNKLNGK DNRQSKIEKL SELKLRHDQL TNELYHLHEY ISLVEYDPFY
60 70 80 90 100
IPNSENYERL LEEKDVTWGS IFQEKKQLHN ESSGKKVRRS VRHLRDSGSS
110 120 130 140 150
TINELDTMSE NDINLLKEVD ILAKQKLQDL KLQFSNSHIK KKGNTKRAKI
160 170 180 190 200
VKQVPNHQDK SESPQISERD VKTVVKDLKP NHRGSEIKPE IMESSDVKNE
210 220 230 240 250
IENCDFNEKQ LKLYKDDDIA SESDFYFTTS SEDELPNKRR GTIKRRKRIN
260 270 280 290 300
LYVNPPKAVI TNPDNIANSH YPTLHEYLDS FKILEDDMTN EEYNTFIKEQ
310 320 330 340 350
QRFAKMIKKG IETGALKYDP VTETVQPSAR KVPNMFSHAK VDPIQYMYKE
360 370 380 390 400
QNLHIHQEHL INQGLFSSKL VQNRKKQRIA GAKKIAQMIE QHFKHIAGAE
410 420 430 440 450
DRRLKENEKQ RKAIARNIIQ SVKKRWNLAE KAYRILKKDE EEQLKRIQGK
460 470 480 490 500
EHLSKMLEKS SKLLGAQLKQ HPNEDDIENS TSDDFSSTGD SDNLSSSSDE
510 520 530 540 550
ESDDEINDLS EDQKNNINEL KTSSTSAFSS PEISSPSKNP DLGLNSLLTN
560 570 580 590 600
DFENESNSSD TNEEFIMGDS DTSHSDDENL TDDSEDSNDG EHDTTSDNEK
610 620 630 640 650
SDLFPADTTN DPLAVQDVPT PSLLRGTLRT YQKQGLNWLA SLYNNNTNGI
660 670 680 690 700
LADEMGLGKT IQTISLLSYL ACEKHNWGPH LIVVPTSVLL NWEMEFKRFA
710 720 730 740 750
PGFKVLTYYG NPQQRKEKRK GWNKPDAFHV CIVSYQLIVQ DQHSFKRKKW
760 770 780 790 800
QYMVLDEAHN IKNFRSTRWQ ALLNFNTQRR ILLTGTPLQN NIAELWSLLY
810 820 830 840 850
FLMPQTVIDG QKVSGFADLD AFQQWFGRPV DKLIETGGTY EQDNETKRTV
860 870 880 890 900
EKLHQVLRPY LLRRLKADVE KQIPGKYEHI VYCKLSKRQR FLYDDFMSRA
910 920 930 940 950
QTKATLASGN FMSIVNCLMQ LRKVCNHPDL FEVRPIKTSF LFGESVIARY
960 970 980 990 1000
SERANSITRR IHFHDKDTLV DLQNINLQFT NNDLEKTSYH TNTINKLACI
1010 1020 1030 1040 1050
NEFVEEVQKL RKQNAEEERQ KSRHLKINTQ NISNFYEEFM QQKLDEQENK
1060 1070 1080 1090 1100
INFIGYLNSQ RCSRKTVYGM NLIRLLEMPH VSNNCIDDPN YDDLIKPLQT
1110 1120 1130 1140 1150
RLLDGRTTIE KFAVLTPGAV TSNIGELTLG MDEFVTPNSK SGIIPYEELV
1160 1170 1180 1190 1200
QLDNPFHQVQ TKLTIAFPDK SLLQYDCGKL QKLAILLQQL KDGGHRALIF
1210 1220 1230 1240 1250
TQMTKVLDIL EQFLNYHGYL YMRLDGATKI EDRQILTERF NSDPKITVFI
1260 1270 1280 1290 1300
LSSRSGGLGI NLTGADTVIF YDSDWNPAMD KQCQDRCHRI GQTRDVHIYR
1310 1320 1330 1340 1350
FVSEHTIESN ILKKANQKRQ LDDVIIQKGE FTTDYFSKLS VKDLFGSDVV
1360 1370 1380 1390 1400
GDLPVIDTKP LLGSDSEAIK DPKKLEKLLA QAEDEDDVKA ANSALREVNV
1410 1420 1430 1440 1450
DDEDFDESST NKTGGNILNG DDIDEDVDEY EGTNHVEEYM LRFIANGFYF
Length:1,450
Mass (Da):167,290
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i120C95082280BBED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR380959 Genomic DNA Translation: CAG62372.1

NCBI Reference Sequences

More...
RefSeqi
XP_449396.1, XM_449396.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG62372; CAG62372; CAGL0M01188g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2891166

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgr:CAGL0M01188g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380959 Genomic DNA Translation: CAG62372.1
RefSeqiXP_449396.1, XM_449396.1

3D structure databases

SMRiQ6FK48
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5478.XP_449396.1

Proteomic databases

PRIDEiQ6FK48

Genome annotation databases

EnsemblFungiiCAG62372; CAG62372; CAGL0M01188g
GeneIDi2891166
KEGGicgr:CAGL0M01188g

Organism-specific databases

CGDiCAL0137511 CAGL0M01188g
EuPathDBiFungiDB:CAGL0M01188g

Phylogenomic databases

eggNOGiKOG0388 Eukaryota
KOG0391 Eukaryota
COG0553 LUCA
HOGENOMiHOG000186095
InParanoidiQ6FK48
KOiK11681
OMAiNKPDAFH

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWR1_CANGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6FK48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2004
Last modified: July 31, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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