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Entry version 131 (18 Sep 2019)
Sequence version 1 (19 Jul 2004)
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Protein

Pleiotropic ABC efflux transporter of multiple drugs CDR1

Gene

CDR1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pleiotropic ABC efflux transporter that transports and confers resistance to structurally and functionally unrelated compounds including rhodamine 6G, Nile red, caspofungin, cycloheximide, or azoles such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, and isavuconazole (PubMed:10543759, PubMed:12244114, PubMed:15105111, PubMed:15105136, PubMed:15388433, PubMed:15498768, PubMed:16803598, PubMed:17581937, PubMed:18591262, PubMed:20038613, PubMed:20450660, PubMed:21134356, PubMed:21408004, PubMed:22788839, PubMed:26482310, PubMed:27486188, PubMed:29371812, PubMed:29784839). Chlorbromuron, itraconazole, yohimbine, ketoconazole, miconazole, clotrimazole, DE-11, tamoxifen, quinidine, verapamil can compete for rhodamine 6G's binding site(s) while compounds such as propanil, chloramphenicol, benomyl, voriconazole, tritylimidazole, ketoconazole, miconazole, tamoxifen, gefitinib shared binding site(s) with fluconazole. Nile red mediated efflux appears to be relatively more specific since only five compounds such as ZW3-12, rhodamine 123, miconazole, clotrimazole, and itraconazole can inhibit its accumulation (PubMed:21134356). Does not use as substrates 4-nitroquinoline 1-oxide (4-NQO) and disulfiram (PubMed:21134356). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314).19 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by clorgyline (PubMed:22203607). Inhibited by RC21v3, a 4-methoxy-2,3,6-trimethylbenzenesulphonyl derivative of the D-octapeptide D-FFKWQRRR, via the interaction with the ectodomain (PubMed:22788839). FK506, enniatin, milbemycin alpha-11, and milbemycin beta-9 also inhibit CDR1 activity (PubMed:22788839). Inhibited by milbemycin A3/A4 oxim derivatives (PubMed:23208712, PubMed:24838041).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi893 – 900ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleiotropic ABC efflux transporter of multiple drugs CDR11 Publication
Alternative name(s):
Pleiotropic drug resistance protein CDR11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDR11 Publication
Ordered Locus Names:CAGL0M01760g
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284593 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002428 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome M

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0136775 CDR1

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CAGL0M01760g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Transmembranei763 – 783HelicalSequence analysisAdd BLAST21
Transmembranei1193 – 1213HelicalSequence analysisAdd BLAST21
Transmembranei1228 – 1248HelicalSequence analysisAdd BLAST21
Transmembranei1278 – 1298HelicalSequence analysisAdd BLAST21
Transmembranei1314 – 1334HelicalSequence analysisAdd BLAST21
Transmembranei1342 – 1362HelicalSequence analysisAdd BLAST21
Transmembranei1466 – 1486HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to susceptibility to the antifungal azole derivatives in azole-resistant clinical isolates (PubMed:10543759, PubMed:16803598). Suppresses the development of high-frequency azole resistance (HFAR) in a medium containing fluconazole (PubMed:11257032).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi188C → A: Leads to loss of resistance to cycloheximide, DE-11, fluconazole, voriconazole, and ketoconazole. 1 Publication1
Mutagenesisi307S → A: Fails to efflux the substrate rhodamine 6G, and increases fluconazole susceptibility; when associated with A-484. 1 Publication1
Mutagenesisi484S → A: Fails to efflux the substrate rhodamine 6G, and increases fluconazole susceptibility; when associated with A-307. 1 Publication1
Mutagenesisi660S → A: Leads to loss of resistance to cycloheximide, DE-11, fluconazole, voriconazole, and ketoconazole. 1 Publication1
Mutagenesisi773Missing : Leads to loss of resistance to cycloheximide, DE-11, fluconazole, voriconazole, and ketoconazole. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004450801 – 1499Pleiotropic ABC efflux transporter of multiple drugs CDR1Add BLAST1499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi96N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi99N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei307Phosphoserine1 Publication1
Glycosylationi323N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Modified residuei484Phosphoserine1 Publication1
Glycosylationi537N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi813N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1159N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1301N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1412N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-307 and Ser-484. Ser-307 and Ser-484 are dephosphorylated on glucose depletion and independently rephosphorylated during glucose exposure or under stress.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6FK23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Azole exposure induced expression 4- to 12-fold via regulation by the transcription factor PDR1 that stimulates gene expression via binding to elements called pleiotropic drug response elements (PDREs) (PubMed:12458010, PubMed:10543759, PubMed:16803598, PubMed:21193550, PubMed:21408004, PubMed:23979762, PubMed:24645630, PubMed:19148266, PubMed:21131438, PubMed:29464833). Expression is highly up-regulated in azole-resistant isolates (PubMed:10543759, PubMed:16735426, PubMed:16891541, PubMed:17158937, PubMed:17581937, PubMed:18591262, PubMed:18782778, PubMed:19380598, PubMed:19196495, PubMed:20038613, PubMed:20450660, PubMed:21134356, PubMed:25818698, PubMed:27486188, PubMed:28894714, PubMed:29371812, PubMed:29784839). Loss of mitochondrial functions leads to increased expression (PubMed:21321146). Expression is temporary increased during the intermediate phase of biofilm development (PubMed:18651314). Expression is down-regulated by the transcription factor STB5 (PubMed:23229483). Expression is negatively regulated by the transcription factor JJJ1 via inactivation of the PDR1 transcriptional pathway (PubMed:29507891). Expression is also decreased by amphotericin B in voriconazole-resistant strains (PubMed:21282443).31 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5478.XP_449421.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6FK23

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 399ABC transporter 1PROSITE-ProRule annotationAdd BLAST254
Domaini857 – 1099ABC transporter 2PROSITE-ProRule annotationAdd BLAST243

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065 Eukaryota
COG0842 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000162078

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6FK23

KEGG Orthology (KO)

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KOi
K08711

Identification of Orthologs from Complete Genome Data

More...
OMAi
PAVWRDS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR005285 Drug-R_PDR/CDR
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 2 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00956 3a01205, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6FK23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLASDKKDA DVASTTTTAQ DDDNLSTYHG FDHHVQDQVR QLARTLTQQS
60 70 80 90 100
SLHQKKEHTL PEEGINPIFT NTEADDYNPR LDPTSDEFSS AEWVQNMSNI
110 120 130 140 150
SNSDPDYYKP YSLGCYWKDL VATGESADIE YQANFLNGPY KGLKTVYNTV
160 170 180 190 200
VPSTASSKDK NFKILKSMEG AVNPGELLVV LGRPGSGCTT LLKSISSNTH
210 220 230 240 250
GFNIAKESTI SYSGMTPNDI RKHFRGEVVY NAEADIHLPH LTVYQTLLTV
260 270 280 290 300
ARLKTPQNRL KGIDRETYAR HLTEVAMATF GLSHTRNTKV GNDLVRGVSG
310 320 330 340 350
GERKRVSIAE VSICGSKFQC WDNATRGLDS ATALEFIRAL KVQASISNAA
360 370 380 390 400
ATVAIYQCSQ DAYDLFDKVC VLYDGYQIYF GPAGKAKEYF QKMGYVSPER
410 420 430 440 450
QTTADFLTAV TSPSERIINQ DYINRGIFVP QTPKEMWEYW RASEDHADLI
460 470 480 490 500
KEIDSKLSDN YDANLAEIKD AHVARQSKRA RPSSPYTVSY GMQIKYLLIR
510 520 530 540 550
NFWRIKQSSG VTLFMVIGNS SMAFILGSMF YKVMKHNTTS TFYFRGAAMF
560 570 580 590 600
FAVLFNAFSS LLEIFSLFEA RPITEKHRTY SLYHPSADAF ASILSEVPAK
610 620 630 640 650
LITAVCFNII YYFLVNFRRN GGVFFFYFLI NIVAVFAMSH LFRCVGSVSK
660 670 680 690 700
TLSAAMVPAS MLLLGLSMYS GFAIPRTKIL GWSKWIWYIN PLAYLFESLM
710 720 730 740 750
INEFHDRKFP CSQYIPSGSV YNNVPADSRI CSSVGAIRGN DYVLGDDFLR
760 770 780 790 800
ESYSYLHKHK WRGFGIGLAY VIFFLVLYLI LCEYNEGAKQ KGEILVFPQN
810 820 830 840 850
IVRRMKKERK LKNVSSDNDV EIGDVSDISD KKILADSSDE SEESGANIGL
860 870 880 890 900
SQSEAIFHWR NLCYDVQIKK ETRRILNNVD GWVKPGTLTA LMGASGAGKT
910 920 930 940 950
TLLDCLAERV TMGVITGEVS VDGKQRDDSF ARSIGYCQQQ DLHLKTSTVR
960 970 980 990 1000
ESLRFSAYLR QPADVSIEEK NQYVEDVIKI LEMEQYADAV VGVPGEGLNV
1010 1020 1030 1040 1050
EQRKRLTIGV ELAAKPKLLV FLDEPTSGLD SQTAWSICQL MKKLANHGQA
1060 1070 1080 1090 1100
ILCTIHQPSA ILMQEFDRLL FLQRGGKTVY FGDLGDGCKT MIDYFESHGS
1110 1120 1130 1140 1150
HKCPPDANPA EWMLEVVGAA PGSHANQDYH EVWRNSDEYQ KVQEELEWMS
1160 1170 1180 1190 1200
NELPKKNTNN SETVHKEFAT GVLYQCKLVS LRLFQQYWRS PDYLWSKFFL
1210 1220 1230 1240 1250
TIFNNIFIGF TFFKADRSLQ GLQNQMLAVF MFTVIFNPLL QQYLPSFVQQ
1260 1270 1280 1290 1300
RDLYEARERP SRTFSWKAFI VSQILVEIPW NILAGTVAFV IYYYAIGFYS
1310 1320 1330 1340 1350
NASVAHQLHE RGALFWLFSC AFYVYIGSLA LFCISFNQVA EAAANMASLM
1360 1370 1380 1390 1400
FTLSLSFCGV LVTPNGMPRF WIFMYRVSPL TYLIDGMLST GVANVAIKCS
1410 1420 1430 1440 1450
NYELLRFSPA ANLTCGEYLG PYLQTVKTGY IVDPSATDTC ELCPYSHTND
1460 1470 1480 1490
FLSSVSSKYS RRWRNWGIFI CYIAFNYIAG IFLYWLARVP KKSGKLAKK
Length:1,499
Mass (Da):169,312
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F395297D29AAE84
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR380959 Genomic DNA Translation: CAG62397.1

NCBI Reference Sequences

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RefSeqi
XP_449421.1, XM_449421.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG62397; CAG62397; CAGL0M01760g

Database of genes from NCBI RefSeq genomes

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GeneIDi
2891191

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cgr:CAGL0M01760g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380959 Genomic DNA Translation: CAG62397.1
RefSeqiXP_449421.1, XM_449421.1

3D structure databases

SMRiQ6FK23
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5478.XP_449421.1

PTM databases

iPTMnetiQ6FK23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG62397; CAG62397; CAGL0M01760g
GeneIDi2891191
KEGGicgr:CAGL0M01760g

Organism-specific databases

CGDiCAL0136775 CDR1
EuPathDBiFungiDB:CAGL0M01760g

Phylogenomic databases

eggNOGiKOG0065 Eukaryota
COG0842 LUCA
HOGENOMiHOG000162078
InParanoidiQ6FK23
KOiK08711
OMAiPAVWRDS

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR005285 Drug-R_PDR/CDR
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00956 3a01205, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDR1_CANGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6FK23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 12, 2018
Last sequence update: July 19, 2004
Last modified: September 18, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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