UniProtKB - Q6FIE9 (Q6FIE9_HUMAN)
Protein
Submitted name:
TOLLIP protein
Gene
TOLLIP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- interleukin-1, type I receptor binding Source: Ensembl
- SUMO binding Source: Ensembl
- ubiquitin binding Source: InterPro
- ubiquitin conjugating enzyme binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- autophagy Source: UniProtKB-KW
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- interleukin-1-mediated signaling pathway Source: Ensembl
- positive regulation of protein sumoylation Source: Ensembl
Keywordsi
Biological process | AutophagyARBA annotation, Immunity, Inflammatory responseARBA annotation, Innate immunityARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: TOLLIP proteinImportedSubmitted name: Toll interacting proteinImportedSubmitted name: Toll interacting protein, isoform CRA_aImportedSubmitted name: cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNAImported |
Gene namesi | Name:TOLLIPImported ORF Names:hCG_40380Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000078902.15 |
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
Other locations
- perinuclear region of cytoplasm Source: Ensembl
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000078902, Expressed in anterior cingulate cortex and 222 other tissues |
ExpressionAtlasi | Q6FIE9, baseline and differential |
Interactioni
Binary interactionsi
Hide detailsQ6FIE9
GO - Molecular functioni
- interleukin-1, type I receptor binding Source: Ensembl
- SUMO binding Source: Ensembl
- ubiquitin binding Source: InterPro
- ubiquitin conjugating enzyme binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q6FIE9, 7 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 229 – 272 | CUEInterPro annotationAdd BLAST | 44 |
Sequence similaritiesi
Belongs to the tollip family.ARBA annotation
Phylogenomic databases
OMAi | YNQGMVP |
OrthoDBi | 1219350at2759 |
Family and domain databases
CDDi | cd04016, C2_Tollip, 1 hit cd14363, CUE_TOLIP, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR003892, CUE IPR041799, TOLIP_CUE IPR037301, Tollip_C2 IPR009060, UBA-like_sf |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF02845, CUE, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00546, CUE, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit |
PROSITEi | View protein in PROSITE PS51140, CUE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6FIE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG
60 70 80 90 100
TVGRLNITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIHCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLRQGKVEDK
160 170 180 190 200
WYSLSGRQGD DKEGMINLVM SYALLPAAMV MPPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PITGMPAVCS PGMVPVALPP AAVNAQPRCS EEDLKAIQDM FPNMDQEVIR
260 270
SVLEAQRGNK DAAINSLLQM GEEP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY730683 mRNA Translation: AAX22229.1 AK315592 mRNA Translation: BAG37964.1 CR533477 mRNA Translation: CAG38508.1 CH471158 Genomic DNA Translation: EAX02433.1 CH471158 Genomic DNA Translation: EAX02434.1 |
RefSeqi | NP_061882.2, NM_019009.3 |
Genome annotation databases
GeneIDi | 54472 |
KEGGi | hsa:54472 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY730683 mRNA Translation: AAX22229.1 AK315592 mRNA Translation: BAG37964.1 CR533477 mRNA Translation: CAG38508.1 CH471158 Genomic DNA Translation: EAX02433.1 CH471158 Genomic DNA Translation: EAX02434.1 |
RefSeqi | NP_061882.2, NM_019009.3 |
3D structure databases
SMRi | Q6FIE9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6FIE9, 7 interactors |
Protocols and materials databases
Antibodypediai | 10168, 553 antibodies |
DNASUi | 54472 |
Genome annotation databases
GeneIDi | 54472 |
KEGGi | hsa:54472 |
Organism-specific databases
CTDi | 54472 |
PharmGKBi | PA134876213 |
VEuPathDBi | HostDB:ENSG00000078902.15 |
Phylogenomic databases
OMAi | YNQGMVP |
OrthoDBi | 1219350at2759 |
Miscellaneous databases
BioGRID-ORCSi | 54472, 9 hits in 879 CRISPR screens |
ChiTaRSi | TOLLIP, human |
GenomeRNAii | 54472 |
Gene expression databases
Bgeei | ENSG00000078902, Expressed in anterior cingulate cortex and 222 other tissues |
ExpressionAtlasi | Q6FIE9, baseline and differential |
Family and domain databases
CDDi | cd04016, C2_Tollip, 1 hit cd14363, CUE_TOLIP, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR003892, CUE IPR041799, TOLIP_CUE IPR037301, Tollip_C2 IPR009060, UBA-like_sf |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF02845, CUE, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00546, CUE, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit |
PROSITEi | View protein in PROSITE PS51140, CUE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6FIE9_HUMAN | |
Accessioni | Q6FIE9Primary (citable) accession number: Q6FIE9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |