TOLLIP

Functionⁱ

GO - Molecular functionⁱ

interleukin-1, Type I receptor binding Source: Ensembl
SUMO binding Source: Ensembl
ubiquitin conjugating enzyme binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of protein sumoylation Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: TOLLIP proteinImported Submitted name: Toll interacting protein, isoform CRA_aImported Submitted name: cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNAImported
Gene namesⁱ	Name:TOLLIPImported ORF Names:hCG_40380Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000078902.15

EuPathDBⁱ

HostDB:ENSG00000078902.15

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134876213

PharmGKBⁱ

PA134876213

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q6FIE9

PRIDEⁱ

Q6FIE9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000078902
ExpressionAtlasⁱ	Q6FIE9 baseline and differential

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CPSF6	Q16630	3	EBI-10249783,EBI-358410
DAB1	O75553	3	EBI-10249783,EBI-7875264
DAZAP2	Q15038	3	EBI-10249783,EBI-724310
PRR20C	P86479	3	EBI-10249783,EBI-10172814
RBPMS	Q93062	3	EBI-10249783,EBI-740322
SIAH1	Q8IUQ4	3	EBI-10249783,EBI-747107
TOM1	O60784	3	EBI-10249783,EBI-74634

Show more details

GO - Molecular functionⁱ

interleukin-1, Type I receptor binding Source: Ensembl
SUMO binding Source: Ensembl
ubiquitin conjugating enzyme binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q6FIE9, 7 interactors

IntActⁱ

Q6FIE9, 7 interactors

Structureⁱ

3D structure databases

SMRⁱ	Q6FIE9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	229 – 272	CUEInterPro annotationAdd BLAST		44

Phylogenomic databases

eggNOGⁱ	ENOG410IE45 Eukaryota ENOG410XQPY LUCA
HOVERGENⁱ	HBG054213
KEGG Orthology (KO) More...KOⁱ	K05402
OMAⁱ	HVTIPES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JE1

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04016 C2_Tollip, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR003892 CUE IPR037301 Tollip_C2 IPR009060 UBA-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF02845 CUE, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00546 CUE, 1 hit
SUPFAMⁱ	SSF46934 SSF46934, 1 hit
PROSITEⁱ	View protein in PROSITE PS51140 CUE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6FIE9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG 
        60         70         80         90        100
TVGRLNITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW 
       110        120        130        140        150
NKVIHCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLRQGKVEDK 
       160        170        180        190        200
WYSLSGRQGD DKEGMINLVM SYALLPAAMV MPPQPVVLMP TVYQQGVGYV 
       210        220        230        240        250
PITGMPAVCS PGMVPVALPP AAVNAQPRCS EEDLKAIQDM FPNMDQEVIR 
       260        270 
SVLEAQRGNK DAAINSLLQM GEEP

Length:274

Mass (Da):30,282

Last modified:May 10, 2005 - v1

Checksum:ⁱ386E0F284D3837DA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY730683 mRNA Translation: AAX22229.1 AK315592 mRNA Translation: BAG37964.1 CR533477 mRNA Translation: CAG38508.1 CH471158 Genomic DNA Translation: EAX02433.1 CH471158 Genomic DNA Translation: EAX02434.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061882.2, NM_019009.3
UniGeneⁱ	Hs.368527

Genome annotation databases

GeneIDⁱ	54472
KEGGⁱ	hsa:54472

Protein	Similar proteins		Species	Score	Length
Q6FIE9	Toll-interacting protein	)	HUMAN		274
TOLLIP isoform 6		PONAB		274
Toll interacting protein		CERAT		274
Toll interacting protein		RHIRO		274
Toll interacting protein		PAPAN		274
+2

Protein	Similar proteins		Species	Score	Length
Q6FIE9	Toll-interacting protein	)	HUMAN		274
TOLLIP isoform 6		PONAB		274
Toll interacting protein		CERAT		274
Toll interacting protein		RHIRO		274
Toll interacting protein		PAPAN		274
+25

Protein	Similar proteins		Species	Score	Length
Q6FIE9	Toll-interacting protein	)	HUMAN		274
TOLLIP isoform 6		PONAB		274
Toll interacting protein		CERAT		274
Toll interacting protein		RHIRO		274
Toll interacting protein		PAPAN		274
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY730683 mRNA Translation: AAX22229.1 AK315592 mRNA Translation: BAG37964.1 CR533477 mRNA Translation: CAG38508.1 CH471158 Genomic DNA Translation: EAX02433.1 CH471158 Genomic DNA Translation: EAX02434.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061882.2, NM_019009.3
UniGeneⁱ	Hs.368527

3D structure databases

SMRⁱ	Q6FIE9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q6FIE9, 7 interactors

IntActⁱ

Q6FIE9, 7 interactors

Proteomic databases

PRIDEⁱ	Q6FIE9

PRIDEⁱ

Q6FIE9

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54472
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	54472
KEGGⁱ	hsa:54472

Organism-specific databases

CTDⁱ	54472
EuPathDBⁱ	HostDB:ENSG00000078902.15
PharmGKBⁱ	PA134876213

Phylogenomic databases

eggNOGⁱ	ENOG410IE45 Eukaryota ENOG410XQPY LUCA
HOVERGENⁱ	HBG054213
KEGG Orthology (KO) More...KOⁱ	K05402
OMAⁱ	HVTIPES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JE1

Miscellaneous databases

ChiTaRSⁱ	TOLLIP human
GenomeRNAiⁱ	54472

Gene expression databases

Bgeeⁱ	ENSG00000078902
ExpressionAtlasⁱ	Q6FIE9 baseline and differential

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04016 C2_Tollip, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR003892 CUE IPR037301 Tollip_C2 IPR009060 UBA-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF02845 CUE, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00546 CUE, 1 hit
SUPFAMⁱ	SSF46934 SSF46934, 1 hit
PROSITEⁱ	View protein in PROSITE PS51140 CUE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6FIE9_HUMAN
Accessionⁱ	Q6FIE9Primary (citable) accession number: Q6FIE9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	June 20, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q6FIE9 (Q6FIE9_HUMAN)

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TOLLIP protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ