UniProtKB - Q6FI18 (Q6FI18_HUMAN)

>tr|Q6FI18|Q6FI18_HUMAN CYR61 protein OS=Homo sapiens OX=9606 GN=CYR61 PE=1 SV=1
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL
NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ
CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG
KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS
KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP
HANEAAFPFYRLFNDIHKFRD

Entry version 142 (02 Dec 2020)
Sequence version 1 (10 May 2005)
Previous versions | rss

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Protein

Submitted name:

CYR61 protein

Gene

CYR61

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	25	UDPCombined sources		1

GO - Molecular functionⁱ

extracellular matrix binding Source: Ensembl
insulin-like growth factor binding Source: InterPro
integrin binding Source: Ensembl
nucleotide binding Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process involved in heart morphogenesis Source: Ensembl
atrial septum morphogenesis Source: Ensembl
atrioventricular valve morphogenesis Source: Ensembl
chondroblast differentiation Source: Ensembl
chorio-allantoic fusion Source: Ensembl
extracellular matrix organization Source: Ensembl
intussusceptive angiogenesis Source: Ensembl
labyrinthine layer blood vessel development Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
osteoblast differentiation Source: Ensembl
positive regulation of cartilage development Source: Ensembl
positive regulation of cell differentiation Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of cell-substrate adhesion Source: Ensembl
positive regulation of ceramide biosynthetic process Source: Ensembl
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
positive regulation of phospholipase activity Source: Ensembl
reactive oxygen species metabolic process Source: Ensembl
signal transduction Source: InterPro
ventricular septum development Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Nucleotide-bindingCombined sources

Ligand

Nucleotide-bindingCombined sources

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CYR61 proteinImported Submitted name: Cysteine-rich, angiogenic inducer, 61, isoform CRA_aImported
Gene namesⁱ	Name:CYR61Imported ORF Names:hCG_23652Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142871.15

EuPathDBⁱ

HostDB:ENSG00000142871.15

Keywords - Cellular componentⁱ

SecretedARBA annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA27126

PharmGKBⁱ

PA27126

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_5014310457	25 – 381	Sequence analysisAdd BLAST		357

Keywords - PTMⁱ

Disulfide bondARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6FI18

MaxQBⁱ

Q6FI18

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142871, Expressed in thyroid gland and 242 other tissues

Bgeeⁱ

ENSG00000142871, Expressed in thyroid gland and 242 other tissues

Interactionⁱ

GO - Molecular functionⁱ

insulin-like growth factor binding Source: InterPro
integrin binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	Q6FI18
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	22 – 94	IGFBP N-terminalInterPro annotationAdd BLAST	73
Domainⁱ	98 – 164	VWFCInterPro annotationAdd BLAST	67
Domainⁱ	286 – 360	CTCKInterPro annotationAdd BLAST	75

Sequence similaritiesⁱ

Belongs to the CCN family.ARBA annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

HOGENOMⁱ	CLU_063247_1_0_1
OMAⁱ	SQKCIVQ
Database of Orthologous Groups More...OrthoDBⁱ	999958at2759

Family and domain databases

Gene3Dⁱ	2.20.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR006207, Cys_knot_C IPR006208, Glyco_hormone_CN IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR012395, IGFBP_CNN IPR017891, Insulin_GF-bd_Cys-rich_CS IPR043973, TSP1_CCN IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR001007, VWF_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00007, Cys_knot, 1 hit PF00219, IGFBP, 1 hit PF19035, TSP1_CCN, 1 hit PF00093, VWC, 1 hit
PIRSFⁱ	PIRSF036495, IGFBP_rP_CNN, 1 hit
SMARTⁱ	View protein in SMART SM00041, CT, 1 hit SM00121, IB, 1 hit SM00209, TSP1, 1 hit SM00214, VWC, 1 hit
SUPFAMⁱ	SSF57184, SSF57184, 1 hit SSF82895, SSF82895, 1 hit
PROSITEⁱ	View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS50092, TSP1, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6FI18-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC 
        60         70         80         90        100
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 
       110        120        130        140        150
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 
       160        170        180        190        200
VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA 
       210        220        230        240        250
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR 
       260        270        280        290        300
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 
       310        320        330        340        350
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI 
       360        370        380 
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D

Length:381

Mass (Da):42,027

Last modified:May 10, 2005 - v1

Checksum:ⁱFC0BD39C078CA0B1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK314571 mRNA Translation: BAG37152.1 CR536519 mRNA Translation: CAG38757.1 CH471097 Genomic DNA Translation: EAW73196.1 CH471097 Genomic DNA Translation: EAW73198.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001545.2, NM_001554.4

Genome annotation databases

GeneIDⁱ	3491
KEGGⁱ	hsa:3491
UCSC genome browser More...UCSCⁱ	uc001dle.4, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6FI18	CCN family member 1	)	HUMAN		381	UniRef100_O00622

Protein	Similar proteins		Species	Score	Length	Source
Q6FI18	CCN family member 1		MOUSE		379	UniRef90_P18406
CCN family member 1		PANTR		381
CCN family member 1	)	HUMAN		381
CCN family member 1		RAT		379
Uncharacterized protein		OTOGA		383
+113

Protein	Similar proteins		Species	Score	Length	Source
Q6FI18	CCN family member 1		MOUSE		379	UniRef50_P18406
CCN family member 1	)	HUMAN		381
CCN family member 1		PANTR		381
CCN family member 1		RAT		379
Uncharacterized protein		OTOGA		383
+162

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK314571 mRNA Translation: BAG37152.1 CR536519 mRNA Translation: CAG38757.1 CH471097 Genomic DNA Translation: EAW73196.1 CH471097 Genomic DNA Translation: EAW73198.1
RefSeqⁱ	NP_001545.2, NM_001554.4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4D0Z	X-ray	2.20	X/Y	24-29	[»]
	4D11	X-ray	2.85	L/O/P/X/Z	24-29	[»]
SMRⁱ	Q6FI18
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Proteomic databases

MaxQBⁱ	Q6FI18

MaxQBⁱ

Q6FI18

Protocols and materials databases

Antibodypediaⁱ	19796, 588 antibodies
The DNASU plasmid repository More...DNASUⁱ	3491

Genome annotation databases

GeneIDⁱ	3491
KEGGⁱ	hsa:3491
UCSCⁱ	uc001dle.4, human

Organism-specific databases

CTDⁱ	3491
EuPathDBⁱ	HostDB:ENSG00000142871.15
PharmGKBⁱ	PA27126

Phylogenomic databases

HOGENOMⁱ	CLU_063247_1_0_1
OMAⁱ	SQKCIVQ
OrthoDBⁱ	999958at2759

Miscellaneous databases

BioGRID-ORCSⁱ	3491, 5 hits in 845 CRISPR screens
ChiTaRSⁱ	CYR61, human
GenomeRNAiⁱ	3491

Gene expression databases

Bgeeⁱ	ENSG00000142871, Expressed in thyroid gland and 242 other tissues

Bgeeⁱ

ENSG00000142871, Expressed in thyroid gland and 242 other tissues

Family and domain databases

Gene3Dⁱ	2.20.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR006207, Cys_knot_C IPR006208, Glyco_hormone_CN IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR012395, IGFBP_CNN IPR017891, Insulin_GF-bd_Cys-rich_CS IPR043973, TSP1_CCN IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR001007, VWF_dom
Pfamⁱ	View protein in Pfam PF00007, Cys_knot, 1 hit PF00219, IGFBP, 1 hit PF19035, TSP1_CCN, 1 hit PF00093, VWC, 1 hit
PIRSFⁱ	PIRSF036495, IGFBP_rP_CNN, 1 hit
SMARTⁱ	View protein in SMART SM00041, CT, 1 hit SM00121, IB, 1 hit SM00209, TSP1, 1 hit SM00214, VWC, 1 hit
SUPFAMⁱ	SSF57184, SSF57184, 1 hit SSF82895, SSF82895, 1 hit
PROSITEⁱ	View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS50092, TSP1, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6FI18_HUMAN
Accessionⁱ	Q6FI18Primary (citable) accession number: Q6FI18 Secondary accession number(s): D3DT19
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	December 2, 2020
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6FI18 (Q6FI18_HUMAN)

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CYR61 protein

CYR61

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ