UniProtKB - Q6FI13 (H2A2A_HUMAN)
Functioni
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
GO - Molecular functioni
- DNA binding Source: GO_Central
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- chromatin silencing Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6FI13 |
Reactomei | R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329, Cleavage of the damaged pyrimidine R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-1221632, Meiotic synapsis R-HSA-171306, Packaging Of Telomere Ends R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2299718, Condensation of Prophase Chromosomes R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214847, HATs acetylate histones R-HSA-3214858, RMTs methylate histone arginines R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5334118, DNA methylation R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-5689901, Metalloprotease DUBs R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-73728, RNA Polymerase I Promoter Opening R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519, Estrogen-dependent gene expression R-HSA-912446, Meiotic recombination R-HSA-9609690, HCMV Early Events R-HSA-9610379, HCMV Late Events R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9670095, Inhibition of DNA recombination at telomere R-HSA-977225, Amyloid fiber formation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H2A type 2-AAlternative name(s): H2A-clustered histone 18Imported H2A-clustered histone 19Imported Histone H2A.2 Histone H2A/o |
Gene namesi | AND Name:H2AC19 Synonyms:HIST2H2AA4Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4736, H2AC18 HGNC:29668, H2AC19 |
MIMi | 142720, gene |
neXtProti | NX_Q6FI13 |
VEuPathDBi | HostDB:ENSG00000203812.2 HostDB:ENSG00000272196.2 |
Subcellular locationi
Nucleus
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome core, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | S → A: Blocks the inhibition of transcription by RPS6KA5/MSK1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 723790 8337 |
OpenTargetsi | ENSG00000272196 |
PharmGKBi | PA29113 |
Miscellaneous databases
Pharosi | Q6FI13, Tbio |
Genetic variation databases
BioMutai | HIST2H2AA4 |
DMDMi | 74757558 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000055232 | 2 – 130 | Histone H2A type 2-AAdd BLAST | 129 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine2 Publications | 1 | |
Modified residuei | 2 | Phosphoserine; by RPS6KA51 Publication | 1 | |
Modified residuei | 4 | Citrulline; alternate1 Publication | 1 | |
Modified residuei | 4 | Symmetric dimethylarginine; by PRMT5; alternateBy similarity | 1 | |
Modified residuei | 6 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 10 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 10 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 10 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6-succinyllysine; alternate1 Publication | 1 | |
Modified residuei | 14 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Cross-linki | 14 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications | ||
Cross-linki | 16 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications | ||
Modified residuei | 37 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 37 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 37 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 75 | N6-(2-hydroxyisobutyryl)lysine1 Publication | 1 | |
Modified residuei | 76 | N6-(2-hydroxyisobutyryl)lysine1 Publication | 1 | |
Modified residuei | 96 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 96 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 96 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 96 | N6-succinyllysine; alternate1 Publication | 1 | |
Modified residuei | 100 | N6-glutaryllysine1 Publication | 1 | |
Modified residuei | 105 | N5-methylglutamine1 Publication | 1 | |
Modified residuei | 119 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 119 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 119 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 119 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 120 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 120 | N6-glutaryllysine; alternate1 Publication | 1 | |
Cross-linki | 120 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate5 Publications | ||
Modified residuei | 121 | Phosphothreonine; by DCAF12 Publications | 1 | |
Modified residuei | 126 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 126 | N6-glutaryllysine; alternate1 Publication | 1 |
Post-translational modificationi
Deiminated on Arg-4 in granulocytes upon calcium entry.1 Publication
Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.13 Publications
Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.5 Publications
Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).1 Publication
Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.By similarity
Keywords - PTMi
Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6FI13 |
jPOSTi | Q6FI13 |
MassIVEi | Q6FI13 |
MaxQBi | Q6FI13 |
PaxDbi | Q6FI13 |
PeptideAtlasi | Q6FI13 |
PRIDEi | Q6FI13 |
ProteomicsDBi | 66294 |
TopDownProteomicsi | Q6FI13 |
PTM databases
iPTMneti | Q6FI13 |
PhosphoSitePlusi | Q6FI13 |
SwissPalmi | Q6FI13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000203812, Expressed in stomach and 112 other tissues |
Genevisiblei | Q6FI13, HS |
Organism-specific databases
HPAi | ENSG00000203812, Tissue enhanced (bone) ENSG00000272196, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Binary interactionsi
Hide detailsQ6FI13
With | #Exp. | IntAct |
---|---|---|
H2BC15 [U3KQK0] | 3 | EBI-353620,EBI-12142839 |
SMARCB1 [Q12824] | 5 | EBI-353620,EBI-358419 |
LANA1 [Q9QR71] from Human herpesvirus 8 type P (isolate GK18). | 3 | EBI-353620,EBI-15602554 |
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 113933, 48 interactors 593221, 22 interactors |
CORUMi | Q6FI13 |
DIPi | DIP-33167N |
IntActi | Q6FI13, 29 interactors |
MINTi | Q6FI13 |
STRINGi | 9606.ENSP00000475814 |
Miscellaneous databases
RNActi | Q6FI13, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q6FI13 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the histone H2A family.Curated
Phylogenomic databases
eggNOGi | KOG1756, Eukaryota |
GeneTreei | ENSGT00940000156302 |
HOGENOMi | CLU_062828_3_1_1 |
InParanoidi | Q6FI13 |
OMAi | KTDSHKP |
OrthoDBi | 1504122at2759 |
PhylomeDBi | Q6FI13 |
TreeFami | TF300137 |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6FI13-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV
60 70 80 90 100
YMAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK
110 120 130
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
Mass spectrometryi
Molecular mass is 13997.9 Da. Determined by ESI. Monoisotopic with N-acetylserine.1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19779 mRNA Translation: AAC24465.1 AY131971 Genomic DNA Translation: AAN59957.1 AK312163 mRNA Translation: BAG35097.1 CR536525 mRNA Translation: CAG38762.1 CR541872 mRNA Translation: CAG46670.1 AL591493 Genomic DNA Translation: CAI12562.1 AL591493 Genomic DNA Translation: CAI12565.1 CH878687 Genomic DNA Translation: EAW50859.1 BC096705 mRNA Translation: AAH96705.1 BC096739 mRNA Translation: AAH96739.1 BC098171 mRNA Translation: AAH98171.1 |
CCDSi | CCDS30849.1 CCDS934.1 |
PIRi | S06742 |
RefSeqi | NP_001035807.1, NM_001040874.1 NP_003507.1, NM_003516.2 |
Genome annotation databases
Ensembli | ENST00000369159; ENSP00000358155; ENSG00000203812 ENST00000607355; ENSP00000475814; ENSG00000272196 |
GeneIDi | 723790 8337 |
KEGGi | hsa:723790 hsa:8337 |
UCSCi | uc001esw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19779 mRNA Translation: AAC24465.1 AY131971 Genomic DNA Translation: AAN59957.1 AK312163 mRNA Translation: BAG35097.1 CR536525 mRNA Translation: CAG38762.1 CR541872 mRNA Translation: CAG46670.1 AL591493 Genomic DNA Translation: CAI12562.1 AL591493 Genomic DNA Translation: CAI12565.1 CH878687 Genomic DNA Translation: EAW50859.1 BC096705 mRNA Translation: AAH96705.1 BC096739 mRNA Translation: AAH96739.1 BC098171 mRNA Translation: AAH98171.1 |
CCDSi | CCDS30849.1 CCDS934.1 |
PIRi | S06742 |
RefSeqi | NP_001035807.1, NM_001040874.1 NP_003507.1, NM_003516.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SE6 | electron microscopy | 3.50 | C/G | 1-130 | [»] | |
6SEE | electron microscopy | 4.20 | C/G | 1-130 | [»] | |
6SEF | electron microscopy | 3.70 | C/G | 1-130 | [»] | |
6SEG | electron microscopy | 3.10 | C/G | 1-130 | [»] | |
6Y5D | electron microscopy | 4.10 | C/G/O/S | 1-130 | [»] | |
SMRi | Q6FI13 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113933, 48 interactors 593221, 22 interactors |
CORUMi | Q6FI13 |
DIPi | DIP-33167N |
IntActi | Q6FI13, 29 interactors |
MINTi | Q6FI13 |
STRINGi | 9606.ENSP00000475814 |
PTM databases
iPTMneti | Q6FI13 |
PhosphoSitePlusi | Q6FI13 |
SwissPalmi | Q6FI13 |
Genetic variation databases
BioMutai | HIST2H2AA4 |
DMDMi | 74757558 |
Proteomic databases
EPDi | Q6FI13 |
jPOSTi | Q6FI13 |
MassIVEi | Q6FI13 |
MaxQBi | Q6FI13 |
PaxDbi | Q6FI13 |
PeptideAtlasi | Q6FI13 |
PRIDEi | Q6FI13 |
ProteomicsDBi | 66294 |
TopDownProteomicsi | Q6FI13 |
Protocols and materials databases
Antibodypediai | 73310, 84 antibodies 75563, 66 antibodies |
DNASUi | 723790 8337 |
Genome annotation databases
Ensembli | ENST00000369159; ENSP00000358155; ENSG00000203812 ENST00000607355; ENSP00000475814; ENSG00000272196 |
GeneIDi | 723790 8337 |
KEGGi | hsa:723790 hsa:8337 |
UCSCi | uc001esw.4, human |
Organism-specific databases
CTDi | 723790 8337 |
DisGeNETi | 723790 8337 |
GeneCardsi | H2AC18 H2AC19 |
HGNCi | HGNC:4736, H2AC18 HGNC:29668, H2AC19 |
HPAi | ENSG00000203812, Tissue enhanced (bone) ENSG00000272196, Group enriched (blood, lymphoid tissue) |
MIMi | 142720, gene |
neXtProti | NX_Q6FI13 |
OpenTargetsi | ENSG00000272196 |
PharmGKBi | PA29113 |
VEuPathDBi | HostDB:ENSG00000203812.2 HostDB:ENSG00000272196.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1756, Eukaryota |
GeneTreei | ENSGT00940000156302 |
HOGENOMi | CLU_062828_3_1_1 |
InParanoidi | Q6FI13 |
OMAi | KTDSHKP |
OrthoDBi | 1504122at2759 |
PhylomeDBi | Q6FI13 |
TreeFami | TF300137 |
Enzyme and pathway databases
PathwayCommonsi | Q6FI13 |
Reactomei | R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329, Cleavage of the damaged pyrimidine R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-1221632, Meiotic synapsis R-HSA-171306, Packaging Of Telomere Ends R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2299718, Condensation of Prophase Chromosomes R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214847, HATs acetylate histones R-HSA-3214858, RMTs methylate histone arginines R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5334118, DNA methylation R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-5689901, Metalloprotease DUBs R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-73728, RNA Polymerase I Promoter Opening R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519, Estrogen-dependent gene expression R-HSA-912446, Meiotic recombination R-HSA-9609690, HCMV Early Events R-HSA-9610379, HCMV Late Events R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9670095, Inhibition of DNA recombination at telomere R-HSA-977225, Amyloid fiber formation |
Miscellaneous databases
BioGRID-ORCSi | 723790, 71 hits in 533 CRISPR screens 8337, 195 hits in 888 CRISPR screens |
ChiTaRSi | HIST2H2AA3, human HIST2H2AA4, human |
GeneWikii | HIST2H2AA3 |
Pharosi | Q6FI13, Tbio |
PROi | PR:Q6FI13 |
RNActi | Q6FI13, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000203812, Expressed in stomach and 112 other tissues |
Genevisiblei | Q6FI13, HS |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H2A2A_HUMAN | |
Accessioni | Q6FI13Primary (citable) accession number: Q6FI13 Secondary accession number(s): B2R5F0, P20670 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 173 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families