UniProtKB - Q6FHJ7 (SFRP4_HUMAN)
Protein
Secreted frizzled-related protein 4
Gene
SFRP4
Organism
Homo sapiens (Human)
Status
Functioni
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).By similarity1 Publication
GO - Molecular functioni
- Wnt-protein binding Source: MGI
GO - Biological processi
- bone morphogenesis Source: UniProtKB
- canonical Wnt signaling pathway Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
- negative regulation of non-canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of sodium-dependent phosphate transport Source: BHF-UCL
- negative regulation of Wnt signaling pathway Source: ParkinsonsUK-UCL
- phosphate ion homeostasis Source: BHF-UCL
- positive regulation of apoptotic process Source: BHF-UCL
- positive regulation of canonical Wnt signaling pathway Source: MGI
- positive regulation of epidermal cell differentiation Source: BHF-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of keratinocyte apoptotic process Source: BHF-UCL
- positive regulation of receptor internalization Source: BHF-UCL
- regulation of BMP signaling pathway Source: UniProtKB
- response to hormone Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q6FHJ7 |
Names & Taxonomyi
Protein namesi | Recommended name: Secreted frizzled-related protein 4Short name: sFRP-4 Alternative name(s): Frizzled protein, human endometrium Short name: FrpHE |
Gene namesi | Name:SFRP4 Synonyms:FRPHE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106483.11 |
HGNCi | HGNC:10778, SFRP4 |
MIMi | 606570, gene |
neXtProti | NX_Q6FHJ7 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Cytoplasmic in ovarian tumor cells.
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Nucleus
- nucleus Source: BHF-UCL
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Pyle disease (PYL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
Related information in OMIMOrganism-specific databases
DisGeNETi | 6424 |
MalaCardsi | SFRP4 |
MIMi | 265900, phenotype |
OpenTargetsi | ENSG00000106483 |
Orphaneti | 3005, Pyle disease |
PharmGKBi | PA35694 |
Miscellaneous databases
Pharosi | Q6FHJ7, Tbio |
Chemistry databases
DrugBanki | DB00606, Cyclothiazide DB00790, Perindopril |
Polymorphism and mutation databases
BioMutai | SFRP4 |
DMDMi | 61216780 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000032550 | 19 – 346 | Secreted frizzled-related protein 4Add BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 85 | By similarity | ||
Disulfide bondi | 32 ↔ 78 | By similarity | ||
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 69 ↔ 108 | By similarity | ||
Disulfide bondi | 97 ↔ 136 | By similarity | ||
Disulfide bondi | 101 ↔ 125 | By similarity | ||
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q6FHJ7 |
jPOSTi | Q6FHJ7 |
MassIVEi | Q6FHJ7 |
PaxDbi | Q6FHJ7 |
PeptideAtlasi | Q6FHJ7 |
PRIDEi | Q6FHJ7 |
ProteomicsDBi | 66293 |
PTM databases
GlyConnecti | 1726, 9 N-Linked glycans (1 site) |
GlyGeni | Q6FHJ7, 5 sites |
iPTMneti | Q6FHJ7 |
PhosphoSitePlusi | Q6FHJ7 |
Expressioni
Tissue specificityi
Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).2 Publications
Inductioni
Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and endometrial and breast carcinomas.
Gene expression databases
Bgeei | ENSG00000106483, Expressed in connective tissue and 195 other tissues |
ExpressionAtlasi | Q6FHJ7, baseline and differential |
Genevisiblei | Q6FHJ7, HS |
Organism-specific databases
HPAi | ENSG00000106483, Tissue enhanced (cervix, uterine, endometrium, retina) |
Interactioni
Binary interactionsi
Hide detailsQ6FHJ7
With | #Exp. | IntAct |
---|---|---|
AQP6 [Q13520] | 3 | EBI-2854879,EBI-13059134 |
HSD17B11 [Q8NBQ5] | 3 | EBI-2854879,EBI-1052304 |
GO - Molecular functioni
- Wnt-protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 112322, 21 interactors |
IntActi | Q6FHJ7, 33 interactors |
MINTi | Q6FHJ7 |
STRINGi | 9606.ENSP00000410715 |
Miscellaneous databases
RNActi | Q6FHJ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 139 | FZPROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 178 – 307 | NTRPROSITE-ProRule annotationAdd BLAST | 130 |
Domaini
The FZ domain is involved in binding with Wnt ligands.By similarity
Sequence similaritiesi
Belongs to the secreted frizzled-related protein (sFRP) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000160766 |
HOGENOMi | CLU_058446_0_0_1 |
InParanoidi | Q6FHJ7 |
OMAi | YAPICAL |
OrthoDBi | 1339129at2759 |
PhylomeDBi | Q6FHJ7 |
Family and domain databases
Gene3Di | 1.10.2000.10, 1 hit 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR026560, SFRP4 IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF7, PTHR11309:SF7, 1 hit |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00063, FRI, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50189, NTR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6FHJ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLSILVALC LWLHLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST
60 70 80 90 100
QENAILAIEQ YEELVDVNCS AVLRFFLCAM YAPICTLEFL HDPIKPCKSV
110 120 130 140 150
CQRARDDCEP LMKMYNHSWP ESLACDELPV YDRGVCISPE AIVTDLPEDV
160 170 180 190 200
KWIDITPDMM VQERPLDVDC KRLSPDRCKC KKVKPTLATY LSKNYSYVIH
210 220 230 240 250
AKIKAVQRSG CNEVTTVVDV KEIFKSSSPI PRTQVPLITN SSCQCPHILP
260 270 280 290 300
HQDVLIMCYE WRSRMMLLEN CLVEKWRDQL SKRSIQWEER LQEQRRTVQD
310 320 330 340
KKKTAGRTSR SNPPKPKGKP PAPKPASPKK NIKTRSAQKR TNPKRV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JMJ2 | C9JMJ2_HUMAN | Secreted frizzled-related protein 4 | SFRP4 | 137 | Annotation score: |
Sequence cautioni
The sequence BAG63683 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | V → M in CAG46532 (Ref. 5) Curated | 1 | |
Sequence conflicti | 77 | L → F in AAC04617 (PubMed:10211996).Curated | 1 | |
Sequence conflicti | 141 | A → V in CAG46555 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051964 | 320 | P → T4 PublicationsCorresponds to variant dbSNP:rs1802073Ensembl. | 1 | |
Natural variantiVAR_051965 | 340 | R → K2 PublicationsCorresponds to variant dbSNP:rs1802074Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026692 mRNA Translation: AAC04617.1 DQ420628 mRNA Translation: ABD83351.1 AK302357 mRNA Translation: BAG63683.1 Different initiation. CR541731 mRNA Translation: CAG46532.1 CR541755 mRNA Translation: CAG46555.1 BT019679 mRNA Translation: AAV38485.1 CH236951 Genomic DNA Translation: EAL23981.1 BC047684 mRNA Translation: AAH47684.1 BC058911 mRNA Translation: AAH58911.1 |
CCDSi | CCDS5453.1 |
RefSeqi | NP_003005.2, NM_003014.3 |
Genome annotation databases
Ensembli | ENST00000436072; ENSP00000410715; ENSG00000106483 |
GeneIDi | 6424 |
KEGGi | hsa:6424 |
UCSCi | uc003tfo.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026692 mRNA Translation: AAC04617.1 DQ420628 mRNA Translation: ABD83351.1 AK302357 mRNA Translation: BAG63683.1 Different initiation. CR541731 mRNA Translation: CAG46532.1 CR541755 mRNA Translation: CAG46555.1 BT019679 mRNA Translation: AAV38485.1 CH236951 Genomic DNA Translation: EAL23981.1 BC047684 mRNA Translation: AAH47684.1 BC058911 mRNA Translation: AAH58911.1 |
CCDSi | CCDS5453.1 |
RefSeqi | NP_003005.2, NM_003014.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112322, 21 interactors |
IntActi | Q6FHJ7, 33 interactors |
MINTi | Q6FHJ7 |
STRINGi | 9606.ENSP00000410715 |
Chemistry databases
DrugBanki | DB00606, Cyclothiazide DB00790, Perindopril |
PTM databases
GlyConnecti | 1726, 9 N-Linked glycans (1 site) |
GlyGeni | Q6FHJ7, 5 sites |
iPTMneti | Q6FHJ7 |
PhosphoSitePlusi | Q6FHJ7 |
Polymorphism and mutation databases
BioMutai | SFRP4 |
DMDMi | 61216780 |
Proteomic databases
EPDi | Q6FHJ7 |
jPOSTi | Q6FHJ7 |
MassIVEi | Q6FHJ7 |
PaxDbi | Q6FHJ7 |
PeptideAtlasi | Q6FHJ7 |
PRIDEi | Q6FHJ7 |
ProteomicsDBi | 66293 |
Protocols and materials databases
Antibodypediai | 1568, 366 antibodies |
DNASUi | 6424 |
Genome annotation databases
Ensembli | ENST00000436072; ENSP00000410715; ENSG00000106483 |
GeneIDi | 6424 |
KEGGi | hsa:6424 |
UCSCi | uc003tfo.5, human |
Organism-specific databases
CTDi | 6424 |
DisGeNETi | 6424 |
EuPathDBi | HostDB:ENSG00000106483.11 |
GeneCardsi | SFRP4 |
HGNCi | HGNC:10778, SFRP4 |
HPAi | ENSG00000106483, Tissue enhanced (cervix, uterine, endometrium, retina) |
MalaCardsi | SFRP4 |
MIMi | 265900, phenotype 606570, gene |
neXtProti | NX_Q6FHJ7 |
OpenTargetsi | ENSG00000106483 |
Orphaneti | 3005, Pyle disease |
PharmGKBi | PA35694 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000160766 |
HOGENOMi | CLU_058446_0_0_1 |
InParanoidi | Q6FHJ7 |
OMAi | YAPICAL |
OrthoDBi | 1339129at2759 |
PhylomeDBi | Q6FHJ7 |
Enzyme and pathway databases
PathwayCommonsi | Q6FHJ7 |
Miscellaneous databases
BioGRID-ORCSi | 6424, 2 hits in 850 CRISPR screens |
ChiTaRSi | SFRP4, human |
GeneWikii | SFRP4 |
GenomeRNAii | 6424 |
Pharosi | Q6FHJ7, Tbio |
PROi | PR:Q6FHJ7 |
RNActi | Q6FHJ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106483, Expressed in connective tissue and 195 other tissues |
ExpressionAtlasi | Q6FHJ7, baseline and differential |
Genevisiblei | Q6FHJ7, HS |
Family and domain databases
Gene3Di | 1.10.2000.10, 1 hit 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR026560, SFRP4 IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF7, PTHR11309:SF7, 1 hit |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00063, FRI, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFRP4_HUMAN | |
Accessioni | Q6FHJ7Primary (citable) accession number: Q6FHJ7 Secondary accession number(s): B4DYC1 Q6PD64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations