UniProtKB - Q6FH49 (Q6FH49_HUMAN)
Protein
Submitted name:
NNMT protein
Gene
NNMT
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 20 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 25 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 69 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 85 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 90 | S-adenosyl-L-methionineUniRule annotation | 1 |
GO - Molecular functioni
- nicotinamide N-methyltransferase activity Source: Ensembl
GO - Biological processi
- animal organ regeneration Source: Ensembl
- methylation Source: UniProtKB-KW
- response to drug Source: Ensembl
- response to organonitrogen compound Source: Ensembl
Keywordsi
Molecular function | MethyltransferaseImportedARBA annotation, Transferase |
Ligand | S-adenosyl-L-methionineUniRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: NNMT proteinImportedSubmitted name: Nicotinamide N-methyltransferaseImportedSubmitted name: Nicotinamide N-methyltransferase, isoform CRA_aImported |
Gene namesi | Name:NNMTImported ORF Names:hCG_39357Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166741.7 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000166741, Expressed in right lobe of liver and 210 other tissues |
ExpressionAtlasi | Q6FH49, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 64 | S-adenosyl-L-methionine bindingUniRule annotation | 2 | |
Regioni | 142 – 143 | S-adenosyl-L-methionine bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_082526_1_1_1 |
OMAi | YNFGSRH |
OrthoDBi | 1054662at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR025820, NNMT/PNMT/TEMT_CS IPR000940, NNMT_TEMT_trans IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR10867, PTHR10867, 1 hit |
Pfami | View protein in Pfam PF01234, NNMT_PNMT_TEMT, 1 hit |
PIRSFi | PIRSF000384, PNMTase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS01100, NNMT_PNMT_TEMT, 1 hit PS51681, SAM_MT_NNMT_PNMT_TEMT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6FH49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC
60 70 80 90 100
LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK
110 120 130 140 150
EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG
160 170 180 190 200
AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK
210 220 230 240 250
SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE
260
GLFSLVARKL SRPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF445002 Genomic DNA Translation: ACA06031.1 CR541907 mRNA Translation: CAG46705.1 CH471065 Genomic DNA Translation: EAW67243.1 CH471065 Genomic DNA Translation: EAW67244.1 |
RefSeqi | NP_006160.1, NM_006169.2 |
Genome annotation databases
GeneIDi | 4837 |
KEGGi | hsa:4837 |
UCSCi | uc001por.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF445002 Genomic DNA Translation: ACA06031.1 CR541907 mRNA Translation: CAG46705.1 CH471065 Genomic DNA Translation: EAW67243.1 CH471065 Genomic DNA Translation: EAW67244.1 |
RefSeqi | NP_006160.1, NM_006169.2 |
3D structure databases
SMRi | Q6FH49 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q6FH49 |
Proteomic databases
MaxQBi | Q6FH49 |
PRIDEi | Q6FH49 |
Protocols and materials databases
Antibodypediai | 18379, 462 antibodies |
DNASUi | 4837 |
Genome annotation databases
GeneIDi | 4837 |
KEGGi | hsa:4837 |
UCSCi | uc001por.2, human |
Organism-specific databases
CTDi | 4837 |
EuPathDBi | HostDB:ENSG00000166741.7 |
PharmGKBi | PA251 |
Phylogenomic databases
HOGENOMi | CLU_082526_1_1_1 |
OMAi | YNFGSRH |
OrthoDBi | 1054662at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4837, 4 hits in 839 CRISPR screens |
ChiTaRSi | NNMT, human |
GenomeRNAii | 4837 |
Gene expression databases
Bgeei | ENSG00000166741, Expressed in right lobe of liver and 210 other tissues |
ExpressionAtlasi | Q6FH49, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR025820, NNMT/PNMT/TEMT_CS IPR000940, NNMT_TEMT_trans IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR10867, PTHR10867, 1 hit |
Pfami | View protein in Pfam PF01234, NNMT_PNMT_TEMT, 1 hit |
PIRSFi | PIRSF000384, PNMTase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS01100, NNMT_PNMT_TEMT, 1 hit PS51681, SAM_MT_NNMT_PNMT_TEMT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6FH49_HUMAN | |
Accessioni | Q6FH49Primary (citable) accession number: Q6FH49 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |