UniProtKB - Q6FH11 (Q6FH11_HUMAN)
Protein
Heme oxygenase
Gene
HMOX1
Organism
Homo sapiens (Human)
Status
Functioni
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.UniRule annotation
Catalytic activityi
- heme b + 3 O2 + 3 reduced [NADPH—hemoprotein reductase] = biliverdin IXα + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH—hemoprotein reductase]UniRule annotationARBA annotationEC:1.14.14.18UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 18 | HemeUniRule annotation | 1 | |
Metal bindingi | 25 | Iron (heme axial ligand)UniRule annotation | 1 | |
Binding sitei | 134 | HemeUniRule annotation | 1 | |
Binding sitei | 183 | HemeUniRule annotation | 1 |
GO - Molecular functioni
- enzyme binding Source: Ensembl
- heme binding Source: Ensembl
- heme oxygenase (decyclizing) activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
- phospholipase D activity Source: Ensembl
GO - Biological processi
- angiogenesis Source: Ensembl
- cellular response to arsenic-containing substance Source: Ensembl
- cellular response to cadmium ion Source: Ensembl
- cellular response to cisplatin Source: Ensembl
- cellular response to nutrient Source: Ensembl
- heme catabolic process Source: Ensembl
- heme oxidation Source: UniProtKB-UniRule
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- liver regeneration Source: Ensembl
- negative regulation of DNA binding Source: Ensembl
- negative regulation of DNA-binding transcription factor activity Source: Ensembl
- negative regulation of epithelial cell apoptotic process Source: Ensembl
- negative regulation of macroautophagy Source: Ensembl
- negative regulation of mast cell cytokine production Source: Ensembl
- negative regulation of mast cell degranulation Source: Ensembl
- negative regulation of muscle cell apoptotic process Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of macroautophagy Source: Ensembl
- regulation of blood pressure Source: Ensembl
- regulation of transcription from RNA polymerase II promoter in response to iron Source: Ensembl
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: Ensembl
- response to drug Source: Ensembl
- response to estrogen Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to hypoxia Source: Ensembl
- small GTPase mediated signal transduction Source: Ensembl
Keywordsi
Molecular function | CyclinImported, OxidoreductaseARBA annotation |
Ligand | HemeUniRule annotationARBA annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HMOX1Imported ORF Names:hCG_40033Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100292.16 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Nucleus
- nucleolus Source: Ensembl
Plasma Membrane
- caveola Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000100292, Expressed in layer of synovial tissue and 191 other tissues |
ExpressionAtlasi | Q6FH11, baseline and differential |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
Chemistry databases
BindingDBi | Q6FH11 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 260 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 227 – 248 | PolarSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_057050_0_0_1 |
OMAi | KKSHTMA |
OrthoDBi | 1424194at2759 |
Family and domain databases
Gene3Di | 1.20.910.10, 1 hit |
InterProi | View protein in InterPro IPR002051, Haem_Oase IPR016053, Haem_Oase-like IPR016084, Haem_Oase-like_multi-hlx IPR018207, Haem_oxygenase_CS |
PANTHERi | PTHR10720, PTHR10720, 1 hit |
Pfami | View protein in Pfam PF01126, Heme_oxygenase, 1 hit |
PIRSFi | PIRSF000343, Haem_Oase, 1 hit |
PRINTSi | PR00088, HAEMOXYGNASE |
SUPFAMi | SSF48613, SSF48613, 1 hit |
PROSITEi | View protein in PROSITE PS00593, HEME_OXYGENASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6FH11-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV
60 70 80 90 100
MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR
110 120 130 140 150
WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI
160 170 180 190 200
AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI
210 220 230 240 250
EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV
260 270 280
ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019785 mRNA Translation: AAV38588.1 CR541945 mRNA Translation: CAG46743.1 CR541968 mRNA Translation: CAG46766.1 CH471095 Genomic DNA Translation: EAW60059.1 |
RefSeqi | NP_002124.1, NM_002133.2 |
Genome annotation databases
GeneIDi | 3162 |
KEGGi | hsa:3162 |
UCSCi | uc003ant.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019785 mRNA Translation: AAV38588.1 CR541945 mRNA Translation: CAG46743.1 CR541968 mRNA Translation: CAG46766.1 CH471095 Genomic DNA Translation: EAW60059.1 |
RefSeqi | NP_002124.1, NM_002133.2 |
3D structure databases
SMRi | Q6FH11 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q6FH11 |
Proteomic databases
MaxQBi | Q6FH11 |
Protocols and materials databases
Antibodypediai | 266, 1070 antibodies |
DNASUi | 3162 |
Genome annotation databases
GeneIDi | 3162 |
KEGGi | hsa:3162 |
UCSCi | uc003ant.3, human |
Organism-specific databases
CTDi | 3162 |
EuPathDBi | HostDB:ENSG00000100292.16 |
PharmGKBi | PA29341 |
Phylogenomic databases
HOGENOMi | CLU_057050_0_0_1 |
OMAi | KKSHTMA |
OrthoDBi | 1424194at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3162, 7 hits in 854 CRISPR screens |
ChiTaRSi | HMOX1, human |
GenomeRNAii | 3162 |
Gene expression databases
Bgeei | ENSG00000100292, Expressed in layer of synovial tissue and 191 other tissues |
ExpressionAtlasi | Q6FH11, baseline and differential |
Family and domain databases
Gene3Di | 1.20.910.10, 1 hit |
InterProi | View protein in InterPro IPR002051, Haem_Oase IPR016053, Haem_Oase-like IPR016084, Haem_Oase-like_multi-hlx IPR018207, Haem_oxygenase_CS |
PANTHERi | PTHR10720, PTHR10720, 1 hit |
Pfami | View protein in Pfam PF01126, Heme_oxygenase, 1 hit |
PIRSFi | PIRSF000343, Haem_Oase, 1 hit |
PRINTSi | PR00088, HAEMOXYGNASE |
SUPFAMi | SSF48613, SSF48613, 1 hit |
PROSITEi | View protein in PROSITE PS00593, HEME_OXYGENASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6FH11_HUMAN | |
Accessioni | Q6FH11Primary (citable) accession number: Q6FH11 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |