UniProtKB - Q6FGU7 (Q6FGU7_HUMAN)
Protein
Submitted name:
RAB7, member RAS oncogene family-like 1
Gene
RAB7L1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GDP binding Source: Ensembl
- GTPase activity Source: InterPro
- GTP binding Source: Ensembl
GO - Biological processi
- regulation of retrograde transport, endosome to Golgi Source: Ensembl
- vesicle-mediated transport Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: RAB7, member RAS oncogene family-like 1ImportedSubmitted name: RAB7, member RAS oncogene family-like 1, isoform CRA_aImportedSubmitted name: RAB7L1 proteinImported |
Gene namesi | Name:RAB7L1Imported ORF Names:hCG_19156Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000117280.12 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
Golgi apparatus
- trans-Golgi network Source: InterPro
Other locations
Expressioni
Gene expression databases
Bgeei | ENSG00000117280, Expressed in nephron tubule and 235 other tissues |
Interactioni
Binary interactionsi
Hide detailsQ6FGU7
With | #Exp. | IntAct |
---|---|---|
BEND7 - isoform 2 [Q8N7W2-2] | 3 | EBI-10249635,EBI-10181188 |
C11orf49 [Q9H6J7] | 3 | EBI-10249635,EBI-721300 |
LDOC1 [O95751] | 3 | EBI-10249635,EBI-740738 |
TRIM27 [P14373] | 3 | EBI-10249635,EBI-719493 |
Protein-protein interaction databases
IntActi | Q6FGU7, 4 interactors |
Chemistry databases
BindingDBi | Q6FGU7 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_041217_10_6_1 |
OMAi | ENNFIGW |
OrthoDBi | 1240760at2759 |
Family and domain databases
CDDi | cd04107, Rab32_Rab38, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030697, Rab29/Rab38/Rab32 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q6FGU7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ
60 70 80 90 100
WSDYEIVRLQ LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ
110 120 130 140 150
RWKQDLDSKL TLPNGEPVPC LLLANKCDLS PWAVSRDQID RFSKENGFTG
160 170 180 190 200
WTETSVKENK NINEAMRVLI EKMMRNSTED IMSLSTQGDY INLQTKSSSW
SCC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 203 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019540 mRNA Translation: AAV38347.1 CR542010 mRNA Translation: CAG46807.1 CH471067 Genomic DNA Translation: EAW91580.1 CH471067 Genomic DNA Translation: EAW91581.1 |
RefSeqi | NP_001129134.1, NM_001135662.1 NP_003920.1, NM_003929.2 XP_005245626.1, XM_005245569.1 XP_005245627.1, XM_005245570.1 XP_005245628.1, XM_005245571.1 |
Genome annotation databases
GeneIDi | 8934 |
KEGGi | hsa:8934 |
UCSCi | uc001hde.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019540 mRNA Translation: AAV38347.1 CR542010 mRNA Translation: CAG46807.1 CH471067 Genomic DNA Translation: EAW91580.1 CH471067 Genomic DNA Translation: EAW91581.1 |
RefSeqi | NP_001129134.1, NM_001135662.1 NP_003920.1, NM_003929.2 XP_005245626.1, XM_005245569.1 XP_005245627.1, XM_005245570.1 XP_005245628.1, XM_005245571.1 |
3D structure databases
SMRi | Q6FGU7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6FGU7, 4 interactors |
Chemistry databases
BindingDBi | Q6FGU7 |
Proteomic databases
MaxQBi | Q6FGU7 |
Protocols and materials databases
Antibodypediai | 20685, 153 antibodies |
DNASUi | 8934 |
Genome annotation databases
GeneIDi | 8934 |
KEGGi | hsa:8934 |
UCSCi | uc001hde.5, human |
Organism-specific databases
CTDi | 8934 |
EuPathDBi | HostDB:ENSG00000117280.12 |
PharmGKBi | PA34151 |
Phylogenomic databases
HOGENOMi | CLU_041217_10_6_1 |
OMAi | ENNFIGW |
OrthoDBi | 1240760at2759 |
Miscellaneous databases
BioGRID-ORCSi | 8934, 5 hits in 842 CRISPR screens |
ChiTaRSi | RAB29, human |
GenomeRNAii | 8934 |
Gene expression databases
Bgeei | ENSG00000117280, Expressed in nephron tubule and 235 other tissues |
Family and domain databases
CDDi | cd04107, Rab32_Rab38, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030697, Rab29/Rab38/Rab32 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6FGU7_HUMAN | |
Accessioni | Q6FGU7Primary (citable) accession number: Q6FGU7 Secondary accession number(s): A0A024R999 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |