UniProtKB - Q6FG93 (Q6FG93_HUMAN)
Protein
Submitted name:
HCG34604, isoform CRA_c
Gene
VAMP5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- Golgi to plasma membrane protein transport Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: HCG34604, isoform CRA_cImportedSubmitted name: VAMP5 proteinImportedSubmitted name: cDNA FLJ76424, highly similar to Homo sapiens HSPC191 mRNAImported |
Gene namesi | Name:VAMP5Imported ORF Names:hCG_34604Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000168899.4 |
Subcellular locationi
Endosome
- late endosome Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: Ensembl
Other locations
- cytoplasmic vesicle membrane Source: Ensembl
- integral component of organelle membrane Source: Ensembl
- intercalated disc Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 71 – 93 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000168899, Expressed in left adrenal gland and 216 other tissues |
ExpressionAtlasi | Q6FG93, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 65 | V-SNARE coiled-coil homologyInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 96 – 116 | DisorderedSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_064620_4_2_1 |
OMAi | WENKKMK |
OrthoDBi | 1607213at2759 |
Family and domain databases
CDDi | cd15872, R-SNARE_VAMP5, 1 hit |
InterProi | View protein in InterPro IPR001388, Synaptobrevin IPR042855, V_SNARE_CC IPR042166, Vamp5 IPR042581, VAMP5_R-SNARE |
PANTHERi | PTHR47462, PTHR47462, 1 hit |
Pfami | View protein in Pfam PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
PROSITEi | View protein in PROSITE PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6FG93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST
60 70 80 90 100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS
110
SAPRTQDAGI ASGPGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016753 Genomic DNA Translation: AAY24342.1 AK292660 mRNA Translation: BAF85349.1 CR542215 mRNA Translation: CAG47011.1 CH471053 Genomic DNA Translation: EAW99508.1 |
RefSeqi | NP_006625.1, NM_006634.2 |
Genome annotation databases
GeneIDi | 10791 |
KEGGi | hsa:10791 |
UCSCi | uc002spu.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016753 Genomic DNA Translation: AAY24342.1 AK292660 mRNA Translation: BAF85349.1 CR542215 mRNA Translation: CAG47011.1 CH471053 Genomic DNA Translation: EAW99508.1 |
RefSeqi | NP_006625.1, NM_006634.2 |
3D structure databases
SMRi | Q6FG93 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q6FG93 |
Protocols and materials databases
Antibodypediai | 31895, 165 antibodies |
DNASUi | 10791 |
Genome annotation databases
GeneIDi | 10791 |
KEGGi | hsa:10791 |
UCSCi | uc002spu.2, human |
Organism-specific databases
CTDi | 10791 |
PharmGKBi | PA37270 |
VEuPathDBi | HostDB:ENSG00000168899.4 |
Phylogenomic databases
HOGENOMi | CLU_064620_4_2_1 |
OMAi | WENKKMK |
OrthoDBi | 1607213at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10791, 4 hits in 995 CRISPR screens |
ChiTaRSi | VAMP5, human |
GenomeRNAii | 10791 |
Gene expression databases
Bgeei | ENSG00000168899, Expressed in left adrenal gland and 216 other tissues |
ExpressionAtlasi | Q6FG93, baseline and differential |
Family and domain databases
CDDi | cd15872, R-SNARE_VAMP5, 1 hit |
InterProi | View protein in InterPro IPR001388, Synaptobrevin IPR042855, V_SNARE_CC IPR042166, Vamp5 IPR042581, VAMP5_R-SNARE |
PANTHERi | PTHR47462, PTHR47462, 1 hit |
Pfami | View protein in Pfam PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
PROSITEi | View protein in PROSITE PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6FG93_HUMAN | |
Accessioni | Q6FG93Primary (citable) accession number: Q6FG93 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |