Capping protein, Arp2/3 and myosin-I linker protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• phospholipid binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
• protein-containing complex binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26466680

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• actin filament network formation Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
  • 26466680
• establishment or maintenance of cell polarity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19846667
• establishment or maintenance of monopolar cell polarity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
  • 26466680
• maintenance of cell polarity Source: InterPro
• negative regulation of barbed-end actin filament capping Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26466680
• positive regulation of cell migration Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
  • 26466680
  • 19846667
• positive regulation of extracellular matrix disassembly Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
  • 26466680
• positive regulation of lamellipodium assembly Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26466680
• positive regulation of lamellipodium organization Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
• positive regulation of ruffle assembly Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
  • 26466680
• wound healing, spreading of cells Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 26578515
  • 26466680

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAQTPDGISC ELRGEITRFL WPKEVELLLK TWLPGEGAVQ NHVLALLRWR 
        60         70         80         90        100
AYLLHTTCLP LRVDCTFSYL EVQAMALQET PPQVTFELES LRELVLEFPG 
       110        120        130        140        150
VAALEQLAQH VAAAIKKVFP RSTLGKLFRR PTPASMLARL ERSSPSESTD 
       160        170        180        190        200
PCSPCGGFLE TYEALCDYNG FPFREEIQWD VDTIYHRQGC RHFSLGDFSH 
       210        220        230        240        250
LGSRDLALSV AALSYNLWFR CLSCVDMKLS LEVSEQILHM MSQSSHLEEL 
       260        270        280        290        300
VLETCSLRGD FVRRLAQALA GHSSSGLREL SLAGNLLDDR GMTALSRHLE 
       310        320        330        340        350
RCPGALRRLS LAQTGLTPRG MRALGRALAT NAAFDSTLTH LDLSGNPGAL 
       360        370        380        390        400
GASEDSGGLY SFLSRPNVLS FLNLAGTDTA LDTVRGCSVG GWMTGRADWR 
       410        420        430        440        450
AGRGGLGPPA GVANSLPPQL FAAVSRGCCT SLTHLDASRN VFSRTKSRAA 
       460        470        480        490        500
PAALQLFLSR ARTLRHLGLA GCKLPPDALR ALLDGLALNT HLRDLHLDLS 
       510        520        530        540        550
ACELRSAGAQ VIQDLVCDAG AVSSLDLADN GFGSDMVTLV LAIGRSRSLR 
       560        570        580        590        600
HVALGRNFNV RCKETLDDVL HRIVQLMQDD DCPLQSLSVA ESRLKLGASV 
       610        620        630        640        650
LLRALATNPN LTALDISGNA MGDAGAKLLA KALRVNSRLR SVVWDRNHTS 
       660        670        680        690        700
ALGLLDVAQA LEQNHSLKAM PLPLNDVAQA QRSRPELTAR AVHQIQACLL 
       710        720        730        740        750
RNNRADPASS DHTTRLQPLG LVSDPSEQEV NELCQSVQEH VELLGCGAGP 
       760        770        780        790        800
QGEAAVRQAE DAIQNANFSL SILPILYEAG SSPSHHWQLG QKLEGLLRQV 
       810        820        830        840        850
GEVCRQDIQD FTQATLDTAR SLCPQMLQGS SWREQLEGVL AGSRGLPELL 
       860        870        880        890        900
PEQLLQDAFT RLRDMRLSIT GTLAESIVAQ ALAGLSAARD QLVESLAQQA 
       910        920        930        940        950
TVTMPPALPA PDGGEPSLLE PGELEGLFFP EEKEEEKEKD DSPPQKWPEL 
       960        970        980        990       1000
SHGLHLVPFI HSAAEEAEPE PELAAPGEDA EPQAGPSARG SPSPAAPGPP 
      1010       1020       1030       1040       1050
AGPLPRMDLP LAGQPLRHPT RARPRPRRQH HHRPPPGGPQ VPPALPQEGN 
      1060       1070       1080       1090       1100
GLSARVDEGV EEFFSKRLIQ QDRLWAPEED PATEGGATPV PRTLRKKLGT 
      1110       1120       1130       1140       1150
LFAFKKPRST RGPRTDLETS PGAAPRTRKT TFGDLLRPPT RPSRGEELGG 
      1160       1170       1180       1190       1200
AEGDTSSPDP AGRSRPRYTR DSKAYSMILL PAEEEATLGA RPDKRRPLER 
      1210       1220       1230       1240       1250
GETELAPSFE QRVQVMLQRI GVSRGSGGAE GKRKQSKDGE IKKAGSDGDI 
      1260       1270       1280       1290       1300
MDSSTEAPPI SIKSRTHSVS ADPSCRPGPG SQGPESATWK TLGQQLNAEL 
      1310       1320       1330       1340       1350
RSRGWGQQDG PGPPSPGQSP SPCRTSPSPD SLGLPEDPCL GPRNEDGQLR 
      1360       1370       1380       1390       1400
PRPLSAGRRA VSVHEDQLQA PAERPLRLQR SPVLKRRPKL EAPPSPSLGS 
      1410       1420       1430 
GLGTEPLPPQ PTEPSSPERS PPSPATDQRG GGPNP                 

        10         20         30         40         50
MAQTPDGISC ELRGEITRFL WPKEVELLLK TWLPGEGAVQ NHVLALLRWR 
        60         70         80         90        100
AYLLHTTCLP LRVDCTFSYL EVQAMALQET PPQVTFELES LRELVLEFPG 
       110        120        130        140        150
VAALEQLAQH VAAAIKKVFP RSTLGKLFRR PTPASMLARL ERSSPSESTD 
       160        170        180        190        200
PCSPCGGFLE TYEALCDYNG FPFREEIQWD VDTIYHRQGC RHFSLGDFSH 
       210        220        230        240        250
LGSRDLALSV AALSYNLWFR CLSCVDMKLS LEVSEQILHM MSQSSHLEEL 
       260        270        280        290        300
VLETCSLRGD FVRRLAQALA GHSSSGLREL SLAGNLLDDR GMTALSRHLE 
       310        320        330        340        350
RCPGALRRLS LAQTGLTPRG MRALGRALAT NAAFDSTLTH LDLSGNPGAL 
       360        370        380        390        400
GASEDSGGLY SFLSRPNVLS FLNLAGTDTA LDTLFAAVSR GCCTSLTHLD 
       410        420        430        440        450
ASRNVFSRTK SRAAPAALQL FLSRARTLRH LGLAGCKLPP DALRALLDGL 
       460        470        480        490        500
ALNTHLRDLH LDLSACELRS AGAQVIQDLV CDAGAVSSLD LADNGFGSDM 
       510        520        530        540        550
VTLVLAIGRS RSLRHVALGR NFNVRCKETL DDVLHRIVQL MQDDDCPLQS 
       560        570        580        590        600
LSVAESRLKL GASVLLRALA TNPNLTALDI SGNAMGDAGA KLLAKALRVN 
       610        620        630        640        650
SRLRSVVWDR NHTSALGLLD VAQALEQNHS LKAMPLPLND VAQAQRSRPE 
       660        670        680        690        700
LTARAVHQIQ ACLLRNNRAD PASSDHTTRL QPLGLVSDPS EQEVNELCQS 
       710        720        730        740        750
VQEHVELLGC GAGPQGEAAV RQAEDAIQNA NFSLSILPIL YEAGSSPSHH 
       760        770        780        790        800
WQLGQKLEGL LRQVGEVCRQ DIQDFTQATL DTARSLCPQM LQGSSWREQL 
       810        820        830        840        850
EGVLAGSRGL PELLPEQLLQ DAFTRLRDMR LSITGTLAES IVAQALAGLS 
       860        870        880        890        900
AARDQLVESL AQQATVTMPP ALPAPDGGEP SLLEPGELEG LFFPEEKEEE 
       910        920        930        940        950
KEKDDSPPQK WPELSHGLHL VPFIHSAAEE AEPEPELAAP GEDAEPQAGP 
       960        970        980        990       1000
SARGSPSPAA PGPPAGPLPR MDLPLAGQPL RHPTRARPRP RRQHHHRPPP 
      1010       1020       1030       1040       1050
GGPQVPPALP QEGNGLSARV DEGVEEFFSK RLIQQDRLWA PEEDPATEGG 
      1060       1070       1080       1090       1100
ATPVPRTLRK KLGTLFAFKK PRSTRGPRTD LETSPGAAPR TRKTTFGDLL 
      1110       1120       1130       1140       1150
RPPTRPSRGE ELGGAEGDTS SPDPAGRSRP RYTRDSKAYS MILLPAEEEA 
      1160       1170       1180       1190       1200
TLGARPDKRR PLERGETELA PSFEQRVQVM LQRIGVSRGS GGAEGKRKQS 
      1210       1220       1230       1240       1250
KDGEIKKAGS DGDIMDSSTE APPISIKSRT HSVSADPSCR PGPGSQGPES 
      1260       1270       1280       1290       1300
ATWKTLGQQL NAELRSRGWG QQDGPGPPSP GQSPSPCRTS PSPDSLGLPE 
      1310       1320       1330       1340       1350
DPCLGPRNEE RPLRLQRSPV LKRRPKLEAP PSPSLGSGLG TEPLPPQPTE 
      1360       1370 
PSSPERSPPS PATDQRGGGP NP                               

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 16
   Human chromosome 16: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families