UniProtKB - Q6F5E8 (CARL2_HUMAN)

BLAST

>sp|Q6F5E8|CARL2_HUMAN Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2
MAQTPDGISCELRGEITRFLWPKEVELLLKTWLPGEGAVQNHVLALLRWRAYLLHTTCLP
LRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEFPGVAALEQLAQHVAAAIKKVFP
RSTLGKLFRRPTPASMLARLERSSPSESTDPCSPCGGFLETYEALCDYNGFPFREEIQWD
VDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHM
MSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLE
RCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLY
SFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQL
FAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALR
ALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLV
LAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASV
LLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQA
LEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLG
LVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAG
SSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQATLDTARSLCPQMLQGSSWREQLEGVL
AGSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQA
TVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFI
HSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPT
RARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEED
PATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPT
RPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLER
GETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPI
SIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSP
SPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQR
SPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP

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History
Entry version 109 (07 Nov 2018)
Sequence version 2 (18 Mar 2008)
Previous versions | rss
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Protein

Capping protein, Arp2/3 and myosin-I linker protein 2

Gene

CARMIL2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680).3 Publications

GO - Molecular functionⁱ

phospholipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 26578515
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament network formation
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
- 26578515
establishment or maintenance of cell polarity
Source: UniProtKB
Inferred from direct assayⁱ
- 19846667
establishment or maintenance of monopolar cell polarity
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
- 26578515
maintenance of cell polarity Source: InterPro
negative regulation of barbed-end actin filament capping
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
positive regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of extracellular matrix disassembly
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
- 26578515
positive regulation of lamellipodium assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
positive regulation of lamellipodium organization
Source: UniProtKB
Inferred from direct assayⁱ
- 26578515
positive regulation of ruffle assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
- 26578515
wound healing, spreading of cells
Source: UniProtKB
Inferred from direct assayⁱ
- 26466680
- 26578515

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Capping protein, Arp2/3 and myosin-I linker protein 21 Publication Alternative name(s): Capping protein regulator and myosin 1 linker 2Imported F-actin-uncapping protein RLTPRCurated Leucine-rich repeat-containing protein 16C RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein1 Publication
Gene namesⁱ	Name:CARMIL2Imported Synonyms:LRRC16C, RLTPR1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159753.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27089 CARMIL2
MIMⁱ	610859 gene
neXtProtⁱ	NX_Q6F5E8

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1021	R → A: Loss of ability to bind heterodimeric capping protein (CP), unable to inhibit the actin-capping activity of CP and to rescue the loss of lamellipodial ruffling, macropinocytosis, cell polarity, and invadopodia-mediated matrix degradation; when associated with A-1023. 1 Publication	1
Mutagenesisⁱ	1023	R → A: Loss of ability to bind heterodimeric capping protein (CP), unable to inhibit the actin-capping activity of CP and to rescue the loss of lamellipodial ruffling, macropinocytosis, cell polarity, and invadopodia-mediated matrix degradation; when associated with A-1021. 1 Publication	1
Mutagenesisⁱ	1096 – 1106	KKLGTLFAFKK → EEEEEEEEEEE: Loss of accumulation at the cell membrane. Does not alter colocalization at vimentin filaments. Alters monopolar cell polarity, increasing the number of leading edges lacking lamellipodia and ruffles. Inhibits cell migration during wound healing. 1 PublicationAdd BLAST	11
Mutagenesisⁱ	1096 – 1106	KKLGTLFAFKK → GGGGGGGGGGG: Loss of accumulation at the cell membrane. Does not alter colocalization at vimentin filaments. Alters monopolar cell polarity, increasing the number of leading edges lacking lamellipodia and ruffles. Inhibits cell migration during wound healing. 1 PublicationAdd BLAST	11
Mutagenesisⁱ	1096 – 1106	Missing : Loss of accumulation at the cell membrane. Does not alter colocalization at vimentin filaments. Alters monopolar cell polarity, increasing the number of leading edges lacking lamellipodia and ruffles. Inhibits cell migration during wound healing. 1 PublicationAdd BLAST	11

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000159753
PharmGKBⁱ	PA162401371

Polymorphism and mutation databases

BioMutaⁱ	RLTPR
DMDMⁱ	172045901

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000325817	1 – 1435	Capping protein, Arp2/3 and myosin-I linker protein 2Add BLAST		1435

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	991	PhosphoserineCombined sources	1
Modified residueⁱ	993	PhosphoserineCombined sources	1
Modified residueⁱ	1120	PhosphoserineBy similarity	1
Modified residueⁱ	1246	PhosphoserineCombined sources	1
Modified residueⁱ	1303	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1315	PhosphoserineBy similarity	1
Modified residueⁱ	1420	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q6F5E8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6F5E8
PaxDbⁱ	Q6F5E8
PeptideAtlas More...PeptideAtlasⁱ	Q6F5E8
PRIDEⁱ	Q6F5E8
ProteomicsDBⁱ	66290

PTM databases

iPTMnetⁱ	Q6F5E8
PhosphoSitePlusⁱ	Q6F5E8

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts.1 Publication

Developmental stageⁱ

Expressed in fetal skin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000159753 Expressed in 142 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_RLTPR
ExpressionAtlasⁱ	Q6F5E8 baseline and differential
Genevisibleⁱ	Q6F5E8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041402

HPAⁱ

HPA041402

Interactionⁱ

Subunit structureⁱ

Isoform 2: Interacts (via C-terminus) with heterodimeric capping protein (CP); the interaction inhibits CP activity and hence promotes actin polymerization at the barbed end of actin filaments (PubMed:26466680).1 Publication

Protein-protein interaction databases

BioGridⁱ	126970, 5 interactors
IntActⁱ	Q6F5E8, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q6F5E8
STRINGⁱ	9606.ENSP00000334958

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6F5E8
SMRⁱ	Q6F5E8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	64 – 88	LRR 1Add BLAST	25
Repeatⁱ	89 – 111	LRR 2Add BLAST	23
Repeatⁱ	249 – 272	LRR 3Add BLAST	24
Repeatⁱ	274 – 297	LRR 4Add BLAST	24
Repeatⁱ	303 – 326	LRR 5Add BLAST	24
Repeatⁱ	335 – 362	LRR 6Add BLAST	28
Repeatⁱ	393 – 423	LRR 7Add BLAST	31
Repeatⁱ	429 – 452	LRR 8Add BLAST	24
Repeatⁱ	461 – 481	LRR 9Add BLAST	21
Repeatⁱ	492 – 514	LRR 10Add BLAST	23
Repeatⁱ	519 – 543	LRR 11Add BLAST	25
Repeatⁱ	546 – 572	LRR 12Add BLAST	27
Repeatⁱ	581 – 604	LRR 13Add BLAST	24
Repeatⁱ	608 – 631	LRR 14Add BLAST	24
Repeatⁱ	636 – 660	LRR 15Add BLAST	25
Repeatⁱ	664 – 687	LRR 16Add BLAST	24

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	573 – 667	Tropomodulin-likeAdd BLAST		95
Regionⁱ	1087 – 1114	Necessary for localization at the cell membrane1 PublicationAdd BLAST		28

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	905 – 1046	Pro-richAdd BLAST		142
Compositional biasⁱ	1311 – 1435	Pro-richAdd BLAST		125

Domainⁱ

The N-terminal leucine-rich repeat (LRR) domain is necessary for localization to vimentin filaments (PubMed:26466680). The C-terminus is necessary for localization to the cell membrane (PubMed:26578515).2 Publications

Sequence similaritiesⁱ

Belongs to the CARMIL family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4242 Eukaryota ENOG410YEE1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014487
HOGENOMⁱ	HOG000230565
HOVERGENⁱ	HBG108095
InParanoidⁱ	Q6F5E8
KEGG Orthology (KO) More...KOⁱ	K20493
OMAⁱ	PMAQTPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01FI
PhylomeDBⁱ	Q6F5E8
TreeFamⁱ	TF316381

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR029763 CARMIL2 IPR031943 CARMIL_C IPR001611 Leu-rich_rpt IPR011993 PH-like_dom_sf
PANTHERⁱ	PTHR24112:SF32 PTHR24112:SF32, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16000 CARMIL_C, 1 hit PF13516 LRR_6, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6F5E8-1) [UniParc]FASTA Add to basket

Also known as: CARMIL2a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQTPDGISC ELRGEITRFL WPKEVELLLK TWLPGEGAVQ NHVLALLRWR 
        60         70         80         90        100
AYLLHTTCLP LRVDCTFSYL EVQAMALQET PPQVTFELES LRELVLEFPG 
       110        120        130        140        150
VAALEQLAQH VAAAIKKVFP RSTLGKLFRR PTPASMLARL ERSSPSESTD 
       160        170        180        190        200
PCSPCGGFLE TYEALCDYNG FPFREEIQWD VDTIYHRQGC RHFSLGDFSH 
       210        220        230        240        250
LGSRDLALSV AALSYNLWFR CLSCVDMKLS LEVSEQILHM MSQSSHLEEL 
       260        270        280        290        300
VLETCSLRGD FVRRLAQALA GHSSSGLREL SLAGNLLDDR GMTALSRHLE 
       310        320        330        340        350
RCPGALRRLS LAQTGLTPRG MRALGRALAT NAAFDSTLTH LDLSGNPGAL 
       360        370        380        390        400
GASEDSGGLY SFLSRPNVLS FLNLAGTDTA LDTVRGCSVG GWMTGRADWR 
       410        420        430        440        450
AGRGGLGPPA GVANSLPPQL FAAVSRGCCT SLTHLDASRN VFSRTKSRAA 
       460        470        480        490        500
PAALQLFLSR ARTLRHLGLA GCKLPPDALR ALLDGLALNT HLRDLHLDLS 
       510        520        530        540        550
ACELRSAGAQ VIQDLVCDAG AVSSLDLADN GFGSDMVTLV LAIGRSRSLR 
       560        570        580        590        600
HVALGRNFNV RCKETLDDVL HRIVQLMQDD DCPLQSLSVA ESRLKLGASV 
       610        620        630        640        650
LLRALATNPN LTALDISGNA MGDAGAKLLA KALRVNSRLR SVVWDRNHTS 
       660        670        680        690        700
ALGLLDVAQA LEQNHSLKAM PLPLNDVAQA QRSRPELTAR AVHQIQACLL 
       710        720        730        740        750
RNNRADPASS DHTTRLQPLG LVSDPSEQEV NELCQSVQEH VELLGCGAGP 
       760        770        780        790        800
QGEAAVRQAE DAIQNANFSL SILPILYEAG SSPSHHWQLG QKLEGLLRQV 
       810        820        830        840        850
GEVCRQDIQD FTQATLDTAR SLCPQMLQGS SWREQLEGVL AGSRGLPELL 
       860        870        880        890        900
PEQLLQDAFT RLRDMRLSIT GTLAESIVAQ ALAGLSAARD QLVESLAQQA 
       910        920        930        940        950
TVTMPPALPA PDGGEPSLLE PGELEGLFFP EEKEEEKEKD DSPPQKWPEL 
       960        970        980        990       1000
SHGLHLVPFI HSAAEEAEPE PELAAPGEDA EPQAGPSARG SPSPAAPGPP 
      1010       1020       1030       1040       1050
AGPLPRMDLP LAGQPLRHPT RARPRPRRQH HHRPPPGGPQ VPPALPQEGN 
      1060       1070       1080       1090       1100
GLSARVDEGV EEFFSKRLIQ QDRLWAPEED PATEGGATPV PRTLRKKLGT 
      1110       1120       1130       1140       1150
LFAFKKPRST RGPRTDLETS PGAAPRTRKT TFGDLLRPPT RPSRGEELGG 
      1160       1170       1180       1190       1200
AEGDTSSPDP AGRSRPRYTR DSKAYSMILL PAEEEATLGA RPDKRRPLER 
      1210       1220       1230       1240       1250
GETELAPSFE QRVQVMLQRI GVSRGSGGAE GKRKQSKDGE IKKAGSDGDI 
      1260       1270       1280       1290       1300
MDSSTEAPPI SIKSRTHSVS ADPSCRPGPG SQGPESATWK TLGQQLNAEL 
      1310       1320       1330       1340       1350
RSRGWGQQDG PGPPSPGQSP SPCRTSPSPD SLGLPEDPCL GPRNEDGQLR 
      1360       1370       1380       1390       1400
PRPLSAGRRA VSVHEDQLQA PAERPLRLQR SPVLKRRPKL EAPPSPSLGS 
      1410       1420       1430 
GLGTEPLPPQ PTEPSSPERS PPSPATDQRG GGPNP

Length:1,435

Mass (Da):154,689

Last modified:March 18, 2008 - v2

Checksum:ⁱB0D452CE375436A5

Isoform 2 (identifier: Q6F5E8-2) [UniParc]FASTA Add to basket

Also known as: CARMIL2b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
384-419: Missing.
1346-1372: Missing.

« Hide

        10         20         30         40         50
MAQTPDGISC ELRGEITRFL WPKEVELLLK TWLPGEGAVQ NHVLALLRWR 
        60         70         80         90        100
AYLLHTTCLP LRVDCTFSYL EVQAMALQET PPQVTFELES LRELVLEFPG 
       110        120        130        140        150
VAALEQLAQH VAAAIKKVFP RSTLGKLFRR PTPASMLARL ERSSPSESTD 
       160        170        180        190        200
PCSPCGGFLE TYEALCDYNG FPFREEIQWD VDTIYHRQGC RHFSLGDFSH 
       210        220        230        240        250
LGSRDLALSV AALSYNLWFR CLSCVDMKLS LEVSEQILHM MSQSSHLEEL 
       260        270        280        290        300
VLETCSLRGD FVRRLAQALA GHSSSGLREL SLAGNLLDDR GMTALSRHLE 
       310        320        330        340        350
RCPGALRRLS LAQTGLTPRG MRALGRALAT NAAFDSTLTH LDLSGNPGAL 
       360        370        380        390        400
GASEDSGGLY SFLSRPNVLS FLNLAGTDTA LDTLFAAVSR GCCTSLTHLD 
       410        420        430        440        450
ASRNVFSRTK SRAAPAALQL FLSRARTLRH LGLAGCKLPP DALRALLDGL 
       460        470        480        490        500
ALNTHLRDLH LDLSACELRS AGAQVIQDLV CDAGAVSSLD LADNGFGSDM 
       510        520        530        540        550
VTLVLAIGRS RSLRHVALGR NFNVRCKETL DDVLHRIVQL MQDDDCPLQS 
       560        570        580        590        600
LSVAESRLKL GASVLLRALA TNPNLTALDI SGNAMGDAGA KLLAKALRVN 
       610        620        630        640        650
SRLRSVVWDR NHTSALGLLD VAQALEQNHS LKAMPLPLND VAQAQRSRPE 
       660        670        680        690        700
LTARAVHQIQ ACLLRNNRAD PASSDHTTRL QPLGLVSDPS EQEVNELCQS 
       710        720        730        740        750
VQEHVELLGC GAGPQGEAAV RQAEDAIQNA NFSLSILPIL YEAGSSPSHH 
       760        770        780        790        800
WQLGQKLEGL LRQVGEVCRQ DIQDFTQATL DTARSLCPQM LQGSSWREQL 
       810        820        830        840        850
EGVLAGSRGL PELLPEQLLQ DAFTRLRDMR LSITGTLAES IVAQALAGLS 
       860        870        880        890        900
AARDQLVESL AQQATVTMPP ALPAPDGGEP SLLEPGELEG LFFPEEKEEE 
       910        920        930        940        950
KEKDDSPPQK WPELSHGLHL VPFIHSAAEE AEPEPELAAP GEDAEPQAGP 
       960        970        980        990       1000
SARGSPSPAA PGPPAGPLPR MDLPLAGQPL RHPTRARPRP RRQHHHRPPP 
      1010       1020       1030       1040       1050
GGPQVPPALP QEGNGLSARV DEGVEEFFSK RLIQQDRLWA PEEDPATEGG 
      1060       1070       1080       1090       1100
ATPVPRTLRK KLGTLFAFKK PRSTRGPRTD LETSPGAAPR TRKTTFGDLL 
      1110       1120       1130       1140       1150
RPPTRPSRGE ELGGAEGDTS SPDPAGRSRP RYTRDSKAYS MILLPAEEEA 
      1160       1170       1180       1190       1200
TLGARPDKRR PLERGETELA PSFEQRVQVM LQRIGVSRGS GGAEGKRKQS 
      1210       1220       1230       1240       1250
KDGEIKKAGS DGDIMDSSTE APPISIKSRT HSVSADPSCR PGPGSQGPES 
      1260       1270       1280       1290       1300
ATWKTLGQQL NAELRSRGWG QQDGPGPPSP GQSPSPCRTS PSPDSLGLPE 
      1310       1320       1330       1340       1350
DPCLGPRNEE RPLRLQRSPV LKRRPKLEAP PSPSLGSGLG TEPLPPQPTE 
      1360       1370 
PSSPERSPPS PATDQRGGGP NP

Show »

Length:1,372

Mass (Da):148,208

Checksum:ⁱ00F54C84A1D25869

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

R4GMZ7	R4GMZ7_HUMAN	Capping protein, Arp2/3 and myosin-... Capping protein, Arp2/3 and myosin-I linker protein 2	CARMIL2	124	Annotation score:
R4GNC4	R4GNC4_HUMAN	Capping protein, Arp2/3 and myosin-... Capping protein, Arp2/3 and myosin-I linker protein 2	CARMIL2	55	Annotation score:

Sequence cautionⁱ

The sequence BAD26751 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047857	384 – 419	Missing in isoform 2. 1 PublicationAdd BLAST		36
Alternative sequenceⁱVSP_047858	1346 – 1372	Missing in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB113647 mRNA Translation: BAD26751.1 Different initiation. FJ026014 mRNA Translation: ACI49710.1 AC009095 Genomic DNA No translation available. AC010530 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45513.1 [Q6F5E8-1] CCDS81998.1 [Q6F5E8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001013860.1, NM_001013838.1 [Q6F5E8-1] NP_001303955.1, NM_001317026.1 [Q6F5E8-2]
UniGeneⁱ	Hs.611432

Genome annotation databases

Ensemblⁱ	ENST00000334583; ENSP00000334958; ENSG00000159753 [Q6F5E8-1] ENST00000545661; ENSP00000441481; ENSG00000159753 [Q6F5E8-2]
GeneIDⁱ	146206
KEGGⁱ	hsa:146206
UCSC genome browser More...UCSCⁱ	uc002etn.4 human [Q6F5E8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6F5E8	Capping protein regulator and myosin 1 linker 2		HORSE		1467	UniRef90_Q6F5E8
LOW QUALITY PROTEIN: capping protein, Arp2/3 and myosin-I linker protein 2		DELLE		1447
Uncharacterized protein		PAPAN		1436
Uncharacterized protein		MACNE		1436
Capping protein regulator and myosin 1 linker 2		PANTR		1435
+11
Q6F5E8-2	Uncharacterized protein		Cebus capucinus imitator		1374	UniRef90_Q6F5E8-2
Uncharacterized protein		PAPAN		1373
Uncharacterized protein		MACNE		1373
CARMIL2 isoform 4		PONAB		1372
Capping protein regulator and myosin 1 linker 2		PANTR		1372
+7

Protein	Similar proteins		Species	Score	Length	Source
Q6F5E8	Capping protein regulator and myosin 1 linker 2		HORSE		1467	UniRef50_Q6F5E8
LOW QUALITY PROTEIN: capping protein, Arp2/3 and myosin-I linker protein 2		DELLE		1447
Uncharacterized protein		PAPAN		1436
Uncharacterized protein		MACNE		1436
Capping protein regulator and myosin 1 linker 2		PANTR		1435
+238

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB113647 mRNA Translation: BAD26751.1 Different initiation. FJ026014 mRNA Translation: ACI49710.1 AC009095 Genomic DNA No translation available. AC010530 Genomic DNA No translation available.
CCDSⁱ	CCDS45513.1 [Q6F5E8-1] CCDS81998.1 [Q6F5E8-2]
RefSeqⁱ	NP_001013860.1, NM_001013838.1 [Q6F5E8-1] NP_001303955.1, NM_001317026.1 [Q6F5E8-2]
UniGeneⁱ	Hs.611432

3D structure databases

ProteinModelPortalⁱ	Q6F5E8
SMRⁱ	Q6F5E8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126970, 5 interactors
IntActⁱ	Q6F5E8, 3 interactors
MINTⁱ	Q6F5E8
STRINGⁱ	9606.ENSP00000334958

PTM databases

iPTMnetⁱ	Q6F5E8
PhosphoSitePlusⁱ	Q6F5E8

Polymorphism and mutation databases

BioMutaⁱ	RLTPR
DMDMⁱ	172045901

Proteomic databases

EPDⁱ	Q6F5E8
MaxQBⁱ	Q6F5E8
PaxDbⁱ	Q6F5E8
PeptideAtlasⁱ	Q6F5E8
PRIDEⁱ	Q6F5E8
ProteomicsDBⁱ	66290

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	146206
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334583; ENSP00000334958; ENSG00000159753 [Q6F5E8-1] ENST00000545661; ENSP00000441481; ENSG00000159753 [Q6F5E8-2]
GeneIDⁱ	146206
KEGGⁱ	hsa:146206
UCSCⁱ	uc002etn.4 human [Q6F5E8-1]

Organism-specific databases

CTDⁱ	146206
EuPathDBⁱ	HostDB:ENSG00000159753.13
GeneCardsⁱ	CARMIL2
HGNCⁱ	HGNC:27089 CARMIL2
HPAⁱ	HPA041402
MIMⁱ	610859 gene
neXtProtⁱ	NX_Q6F5E8
OpenTargetsⁱ	ENSG00000159753
PharmGKBⁱ	PA162401371
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4242 Eukaryota ENOG410YEE1 LUCA
GeneTreeⁱ	ENSGT00390000014487
HOGENOMⁱ	HOG000230565
HOVERGENⁱ	HBG108095
InParanoidⁱ	Q6F5E8
KOⁱ	K20493
OMAⁱ	PMAQTPD
OrthoDBⁱ	EOG091G01FI
PhylomeDBⁱ	Q6F5E8
TreeFamⁱ	TF316381

Miscellaneous databases

GenomeRNAiⁱ	146206
Protein Ontology More...PROⁱ	PR:Q6F5E8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159753 Expressed in 142 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_RLTPR
ExpressionAtlasⁱ	Q6F5E8 baseline and differential
Genevisibleⁱ	Q6F5E8 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR029763 CARMIL2 IPR031943 CARMIL_C IPR001611 Leu-rich_rpt IPR011993 PH-like_dom_sf
PANTHERⁱ	PTHR24112:SF32 PTHR24112:SF32, 1 hit
Pfamⁱ	View protein in Pfam PF16000 CARMIL_C, 1 hit PF13516 LRR_6, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CARL2_HUMAN
Accessionⁱ	Q6F5E8Primary (citable) accession number: Q6F5E8 Secondary accession number(s): B8X2Z3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	March 18, 2008
	Last modified:	November 7, 2018
	This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q6F5E8 (CARL2_HUMAN)

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Capping protein, Arp2/3 and myosin-I linker protein 2

CARMIL2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Keywords - PTMi

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PTM databases

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Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

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Genome annotation databases

Keywords - Coding sequence diversityi

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Proteomic databases

Protocols and materials databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ