UniProtKB - Q6F3F9 (AGRG6_MOUSE)
Adhesion G-protein coupled receptor G6
Adgrg6
Functioni
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein-signaling pathways (PubMed:24227709, PubMed:21613327).
Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis (PubMed:27501152).
By similarity3 PublicationsPlays an important role in heart developmention (PubMed:24082093).
Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF (PubMed:25695270).
2 PublicationsGO - Molecular functioni
- collagen binding Source: UniProtKB
- extracellular matrix binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB
- laminin binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- cAMP-mediated signaling Source: UniProtKB
- cell surface receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- heart trabecula formation Source: UniProtKB
- mitochondrion organization Source: UniProtKB
- myelination Source: UniProtKB
- myelination in peripheral nervous system Source: UniProtKB
- Schwann cell differentiation Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G-protein coupled receptor G6Alternative name(s): Developmentally regulated G-protein-coupled receptor1 Publication G-protein coupled receptor 126 Cleaved into the following 2 chains: |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916151, Adgrg6 |
VEuPathDBi | HostDB:ENSMUSG00000039116 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 832 | ExtracellularSequence analysisAdd BLAST | 802 | |
Transmembranei | 833 – 853 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 854 – 873 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 874 – 894 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 895 – 899 | ExtracellularSequence analysis | 5 | |
Transmembranei | 900 – 920 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 921 – 940 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 941 – 961 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 962 – 994 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 995 – 1015 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1016 – 1039 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 1040 – 1060 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1061 – 1062 | ExtracellularSequence analysis | 2 | |
Transmembranei | 1063 – 1083 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1084 – 1165 | CytoplasmicSequence analysisAdd BLAST | 82 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000303888 | 31 – 1165 | Adhesion G-protein coupled receptor G6Add BLAST | 1135 | |
ChainiPRO_0000438598 | 31 – 440 | ADGRG6 N-terminal fragment1 PublicationAdd BLAST | 410 | |
ChainiPRO_0000438599 | 441 – 1165 | ADGRG6 C-terminal fragment1 PublicationAdd BLAST | 725 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 67 | PROSITE-ProRule annotation | ||
Disulfide bondi | 94 ↔ 111 | PROSITE-ProRule annotation | ||
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 186 ↔ 254 | PROSITE-ProRule annotation | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 353 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 370 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 424 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 458 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 462 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 478 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 536 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 549 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 563 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 570 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 665 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 674 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 720 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 746 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 781 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 788 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1135 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1138 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 440 – 441 | Cleavage; by furin like-convertase1 Publication | 2 | |
Sitei | 810 – 811 | Cleavage1 Publication | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3685 |
MaxQBi | Q6F3F9 |
PaxDbi | Q6F3F9 |
PeptideAtlasi | Q6F3F9 |
PRIDEi | Q6F3F9 |
ProteomicsDBi | 282039 |
PTM databases
GlyGeni | Q6F3F9, 23 sites |
iPTMneti | Q6F3F9 |
PhosphoSitePlusi | Q6F3F9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000039116, Expressed in utricle of membranous labyrinth and 224 other tissues |
Genevisiblei | Q6F3F9, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- laminin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000043055 |
Miscellaneous databases
RNActi | Q6F3F9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 149 | CUBPROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 154 – 356 | Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST | 203 | |
Domaini | 770 – 822 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 822 | Inhibits receptor signaling in absence of type IV collagenBy similarityAdd BLAST | 782 | |
Regioni | 41 – 355 | Mediates interaction with type IV collagenBy similarityAdd BLAST | 315 | |
Regioni | 446 – 807 | Mediates interaction with laminin-21 PublicationAdd BLAST | 362 | |
Regioni | 1126 – 1165 | DisorderedSequence analysisAdd BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 812 – 820 | STACHELBy similarity | 9 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3714, Eukaryota KOG4193, Eukaryota |
GeneTreei | ENSGT00940000155621 |
HOGENOMi | CLU_002753_3_3_1 |
InParanoidi | Q6F3F9 |
OMAi | SNLSCDV |
OrthoDBi | 148879at2759 |
PhylomeDBi | Q6F3F9 |
TreeFami | TF321769 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit 2.60.220.50, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000859, CUB_dom IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001759, Pentraxin-related IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00431, CUB, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00303, GPS, 1 hit SM00159, PTX, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit SSF49854, SSF49854, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51828, PTX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MMFDTLGKRC CPWRLKPSAL LFLFVLCVTC VPLSVCGCGS CRLVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNTQSCSWT LRAPAGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSVNEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQTLDAYQVS VAKSISIPEL KAFTLCFEAS KVGNEGGDWT
210 220 230 240 250
AFSYSDESLT QLLSLEKASN GYFLSISGSR CLLNNALPVK DKEDIFTENL
260 270 280 290 300
EQLCLVWNNS WGSIGINFKK NYETVPCDST ISAVVPGDGT LLLGSDRDEV
310 320 330 340 350
ASLRGSIYNF RLWNFTMDLK ALSNLSCSVS GNVIDWHNDF WSISTQALKA
360 370 380 390 400
EGNLSCGSYL IQLPAAELTN CSELGTLCQD GIMYRISVVI HNDFNHPEVK
410 420 430 440 450
VQTKVAEWLN STFQNWNYTV YVVNISFHQK VGEDRMKVKR DIMDDDKRLV
460 470 480 490 500
LWALLVYNAT NNVSLNEEKI KQKLMTNNAS LEDGLRLCEV DVNQLGMCSA
510 520 530 540 550
LEDPDGFSWP ATLPSVYKQP CPNKPGFFMT RACLSNGTST FWGPVDTSNC
560 570 580 590 600
SRQSNEVANE ILNQTGDGQN LTSANINSIV EKVKRIVNKE ENIDITLGST
610 620 630 640 650
LMNIFSNILS SSDSDLLESS TEALKTIDEL AFKIDLNSTP HVNIETQNLA
660 670 680 690 700
LGVSSLIPGT NAPSNFSIGL PSNNESYFQM DFGNGQTDPL ASVILPPNLL
710 720 730 740 750
ENLSPEDSVL VRRAQFTFFN KTGLFQDVGS QRKVLVSYVM ACSIGNITIQ
760 770 780 790 800
NLKDPVQIKI KHTRTQEVHH PICAFWDMNK NKSFGGWNTS GCVAHSDLDA
810 820 830 840 850
GETICLCSHF THFGVLMDLP RSASQIDGRN TKVLTFITYI GCGISAIFSA
860 870 880 890 900
ATLLTYVAFE KLRRDYPSKI LMNLSSALLF LNLIFLLDGW VTSFGVAGLC
910 920 930 940 950
TAVAALLHFF LLATFTWMGL EAIHMYIALV KVFNTYIHRY ILKFCIIGWG
960 970 980 990 1000
LPALVVSIIL VSRRQNEVYG KESYGKDQDD EFCWIQDPVV FYVSCAGYFG
1010 1020 1030 1040 1050
VMFFLNVAMF IVVMVQICGR NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT
1060 1070 1080 1090 1100
WGFAFFAWGP LNIPFMYLFS IFNSLQGLFI FIFHCAMKEN VQKQWRRHLC
1110 1120 1130 1140 1150
CGRFRLADNS DWSKTATNII KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS
1160
STTYFKRNSH SDNFS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A571BEJ4 | A0A571BEJ4_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg6 | 1,220 | Annotation score: | ||
A0A140LIH4 | A0A140LIH4_MOUSE | Adhesion G-protein-coupled receptor... | Adgrg6 | 1,193 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB183545 mRNA Translation: BAD27570.1 BC046534 mRNA Translation: AAH46534.1 |
CCDSi | CCDS35848.1 |
RefSeqi | NP_001002268.1, NM_001002268.3 |
Genome annotation databases
Ensembli | ENSMUST00000041168; ENSMUSP00000043055; ENSMUSG00000039116 |
GeneIDi | 215798 |
KEGGi | mmu:215798 |
UCSCi | uc007elk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB183545 mRNA Translation: BAD27570.1 BC046534 mRNA Translation: AAH46534.1 |
CCDSi | CCDS35848.1 |
RefSeqi | NP_001002268.1, NM_001002268.3 |
3D structure databases
AlphaFoldDBi | Q6F3F9 |
SMRi | Q6F3F9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000043055 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q6F3F9, 23 sites |
iPTMneti | Q6F3F9 |
PhosphoSitePlusi | Q6F3F9 |
Proteomic databases
CPTACi | non-CPTAC-3685 |
MaxQBi | Q6F3F9 |
PaxDbi | Q6F3F9 |
PeptideAtlasi | Q6F3F9 |
PRIDEi | Q6F3F9 |
ProteomicsDBi | 282039 |
Protocols and materials databases
Antibodypediai | 1571, 213 antibodies from 28 providers |
Genome annotation databases
Ensembli | ENSMUST00000041168; ENSMUSP00000043055; ENSMUSG00000039116 |
GeneIDi | 215798 |
KEGGi | mmu:215798 |
UCSCi | uc007elk.1, mouse |
Organism-specific databases
CTDi | 57211 |
MGIi | MGI:1916151, Adgrg6 |
VEuPathDBi | HostDB:ENSMUSG00000039116 |
Phylogenomic databases
eggNOGi | KOG3714, Eukaryota KOG4193, Eukaryota |
GeneTreei | ENSGT00940000155621 |
HOGENOMi | CLU_002753_3_3_1 |
InParanoidi | Q6F3F9 |
OMAi | SNLSCDV |
OrthoDBi | 148879at2759 |
PhylomeDBi | Q6F3F9 |
TreeFami | TF321769 |
Enzyme and pathway databases
Reactomei | R-MMU-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
Miscellaneous databases
BioGRID-ORCSi | 215798, 3 hits in 70 CRISPR screens |
ChiTaRSi | Adgrg6, mouse |
PROi | PR:Q6F3F9 |
RNActi | Q6F3F9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039116, Expressed in utricle of membranous labyrinth and 224 other tissues |
Genevisiblei | Q6F3F9, MM |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit 2.60.220.50, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000859, CUB_dom IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001759, Pentraxin-related IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00431, CUB, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00303, GPS, 1 hit SM00159, PTX, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit SSF49854, SSF49854, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51828, PTX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRG6_MOUSE | |
Accessioni | Q6F3F9Primary (citable) accession number: Q6F3F9 Secondary accession number(s): Q811E4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | August 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families