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UniProtKB - Q6F1F6 (Q6F1F6_MESFL)

Entry version 114 (19 Jan 2022)
Sequence version 1 (16 Aug 2004)
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Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationARBA annotation EC:5.6.2.2

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei129Transition state stabilizerUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei130O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, Isomerase, TopoisomeraseUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase 4 subunit AUniRule annotation (EC:5.6.2.2UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit AUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:parCUniRule annotation
Ordered Locus Names:Mfl310Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri265311 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Tenericutes › Mollicutes › Entomoplasmatales › Entomoplasmataceae › Mesoplasma ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006647 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membraneUniRule annotationARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer composed of ParC and ParE.

UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei50Interaction with DNAUniRule annotation1
Sitei86Interaction with DNAUniRule annotation1
Sitei88Interaction with DNAUniRule annotation1
Sitei99Interaction with DNAUniRule annotation1
Sitei105Interaction with DNAUniRule annotation1

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		265311.Mfl310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 467TOP4cInterPro annotationAdd BLAST449

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili439 – 459Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0188, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002977_9_0_14

Identification of Orthologs from Complete Genome Data

More...OMAi		RILYSMW

Family and domain databases

Conserved Domains Database

More...CDDi		cd00187, TOP4c, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.268.10, 1 hit
2.120.10.90, 1 hit
3.90.199.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00937, ParC_type2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006691, GyrA/parC_rep
IPR035516, Gyrase/topoIV_suA_C
IPR013760, Topo_IIA-like_dom_sf
IPR013758, Topo_IIA_A/C_ab
IPR013757, Topo_IIA_A_a_sf
IPR002205, Topo_IIA_dom_A
IPR005741, TopoIV_A_Gpos

The PANTHER Classification System

More...PANTHERi		PTHR43493:SF9, PTHR43493:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03989, DNA_gyraseA_C, 3 hits
PF00521, DNA_topoisoIV, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00434, TOP4c, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101904, SSF101904, 1 hit
SSF56719, SSF56719, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01061, parC_Gpos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6F1F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKIDNSNI ESEKGIISYA LEDLMGERFG RYAKYIIQER ALPDARDGLK 
        60         70         80         90        100
PVQRRILYAM NELNLTYDKP YKKSARVVGE VIGKYHPHGD TSIYDAMVRM 
       110        120        130        140        150
SQWWKLGMPL IDMQGNNGSI DGDNAAAMRY TETRLAKISD LMLDDLNKNT 
       160        170        180        190        200
VKFAPNFDDS EKEPTVLPSY FPNILVNGST GIAAGYATNM PPHNLGEIID 
       210        220        230        240        250
ATIKLIRTPN TRIDTILEIV KGPDFPTGGT VQGRNGIKDA FTTGKGKVIV 
       260        270        280        290        300
NSKWHEEDNN IIIDEIPYEV VKQDLVKKIG DVIDANPGLG ILEVRDETDR 
       310        320        330        340        350
NGLRIAIDLS DKANLDTVRK FLFKSTPLSI SYNYNNVAIV DLQPKQLGII 
       360        370        380        390        400
ELIHAYIAHY KEVFTFRTQF DLNKAEKRLE IILGLIKAMS ILDQVISVIR 
       410        420        430        440        450
SSTNRSDAIE NLISKFVFSQ PQAAAIVDMR LYRLTSTDVV KLQNEKEELD 
       460        470        480        490        500
VNIAKLKAIL NSEEVMDNEI INRLREVKKQ FPTPRRSIVE DSIENLDVEQ 
       510        520        530        540        550
KEVLVEHEYN LWISKDGYLK AIESKLISKN DPAVFGRKPN DMWIAAGEVS 
       560        570        580        590        600
NLQHLILVTN KGTYYSIPLY KLPMSKWRDM GVHVNTIATM DPSEHIVSAF 
       610        620        630        640        650
VVKDFAEALQ QILITSKNGN IKRIPVKDLE TKIFTRAFRI MKLDAVDEIV 
       660        670        680        690        700
SASLITSKTR TCGIITRNGY GVRYHIEDIP VQGTNSKGVK AANLKEDYIV 
       710        720        730        740        750
AGLGLTSEDT IMYLTEKDGV KKFRNEDLPI YIRPKRGIRV LPERKRGTEY 
       760        770        780        790        800
ITFAFNFNAN EENIIKAIDT QDMYQEVNVN KYRHIELTSV TGDFDIKDVA 
       810        820        830        840        850
FASLSEINKV KPNDMPPGAL NADDDAEGYV SKEEIRARQE ANKGKVSAKV 
       860        870        880        890        900
VVSKNIKEES EKRIQSLTGG LSDLLGDISS VLGTPSKSKP KKEVKDEFQL 

DLSDLLEE
Length:908
Mass (Da):102,220
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F57BD247FF687B9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE017263 Genomic DNA Translation: AAT75667.1

NCBI Reference Sequences

More...RefSeqi		WP_011183207.1, NC_006055.1
YP_053551.1, NC_006055.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAT75667; AAT75667; Mfl310

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2897946

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mfl:Mfl310

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|265311.5.peg.310

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017263 Genomic DNA Translation: AAT75667.1
RefSeqiWP_011183207.1, NC_006055.1
YP_053551.1, NC_006055.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi265311.Mfl310

Genome annotation databases

EnsemblBacteriaiAAT75667; AAT75667; Mfl310
GeneIDi2897946
KEGGimfl:Mfl310
PATRICifig|265311.5.peg.310

Phylogenomic databases

eggNOGiCOG0188, Bacteria
HOGENOMiCLU_002977_9_0_14
OMAiRILYSMW

Family and domain databases

CDDicd00187, TOP4c, 1 hit
Gene3Di1.10.268.10, 1 hit
2.120.10.90, 1 hit
3.90.199.10, 1 hit
HAMAPiMF_00937, ParC_type2, 1 hit
InterProiView protein in InterPro
IPR006691, GyrA/parC_rep
IPR035516, Gyrase/topoIV_suA_C
IPR013760, Topo_IIA-like_dom_sf
IPR013758, Topo_IIA_A/C_ab
IPR013757, Topo_IIA_A_a_sf
IPR002205, Topo_IIA_dom_A
IPR005741, TopoIV_A_Gpos
PANTHERiPTHR43493:SF9, PTHR43493:SF9, 1 hit
PfamiView protein in Pfam
PF03989, DNA_gyraseA_C, 3 hits
PF00521, DNA_topoisoIV, 1 hit
SMARTiView protein in SMART
SM00434, TOP4c, 1 hit
SUPFAMiSSF101904, SSF101904, 1 hit
SSF56719, SSF56719, 1 hit
TIGRFAMsiTIGR01061, parC_Gpos, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6F1F6_MESFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6F1F6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: January 19, 2022
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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