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UniProtKB - Q6F0U3 (OBG_MESFL)
Protein
GTPase Obg
Gene
obg
Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Functioni
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
UniRule annotationCofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 173 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 193 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 166 – 173 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 191 – 195 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 213 – 216 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 284 – 287 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 313 – 315 | GTPUniRule annotation | 3 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: InterPro
GO - Biological processi
- ribosome biogenesis Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)Alternative name(s): GTP-binding protein ObgUniRule annotation |
Gene namesi | Name:obgUniRule annotation Ordered Locus Names:Mfl522 |
Organismi | Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum) |
Taxonomic identifieri | 265311 [NCBI] |
Taxonomic lineagei | Bacteria › Tenericutes › Mollicutes › Entomoplasmatales › Entomoplasmataceae › Mesoplasma › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000386034 | 1 – 432 | GTPase ObgAdd BLAST | 432 |
Interactioni
Subunit structurei
Monomer.
UniRule annotationProtein-protein interaction databases
STRINGi | 265311.Mfl522 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 159 | ObgPROSITE-ProRule annotationAdd BLAST | 159 | |
Domaini | 160 – 332 | OBG-type GUniRule annotationAdd BLAST | 173 | |
Domaini | 354 – 432 | OCTPROSITE-ProRule annotationAdd BLAST | 79 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0536, Bacteria |
HOGENOMi | CLU_011747_2_0_14 |
OMAi | WVRQTDF |
Family and domain databases
CDDi | cd01898, Obg, 1 hit |
Gene3Di | 2.70.210.12, 1 hit 3.30.300.350, 1 hit 3.40.50.300, 1 hit |
HAMAPi | MF_01454, GTPase_Obg, 1 hit |
InterProi | View protein in InterPro IPR031167, G_OBG IPR006073, GTP-bd IPR014100, GTP-bd_Obg/CgtA IPR036346, GTP-bd_prot_GTP1/OBG_C_sf IPR006074, GTP1-OBG_CS IPR006169, GTP1_OBG_dom IPR036726, GTP1_OBG_dom_sf IPR045086, OBG_GTPase IPR015349, OCT_dom IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom |
PANTHERi | PTHR11702, PTHR11702, 1 hit |
Pfami | View protein in Pfam PF09269, DUF1967, 1 hit PF01018, GTP1_OBG, 1 hit PF01926, MMR_HSR1, 1 hit |
PIRSFi | PIRSF002401, GTP_bd_Obg/CgtA, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF102741, SSF102741, 1 hit SSF52540, SSF52540, 1 hit SSF82051, SSF82051, 1 hit |
TIGRFAMsi | TIGR02729, Obg_CgtA, 1 hit TIGR03595, Obg_CgtA_exten, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51710, G_OBG, 1 hit PS00905, GTP1_OBG, 1 hit PS51883, OBG, 1 hit PS51881, OCT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6F0U3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFIDTAKFT IKAGNGGNGA VSFHTALFVP NGGPNGGDGG NGGSVIFEAD
60 70 80 90 100
GGKHSLLDLK LQKQLSAQDG FKGDIKNMHG AQGKDLIVRV PVGTLIIENK
110 120 130 140 150
TGTILADMDE DKKQVLVAKG GKGGKGNARF ANSRNKAPTI FEAGEIGQFY
160 170 180 190 200
EVKAELKVLA DVGFVGLPNA GKSTLLRAIS NSKPEVADYA FTTLNPQLGV
210 220 230 240 250
SRAKDGSTFV VADLPGLIEG ASLGKGLGHQ FLKHIERCRV ICHVLDMSGN
260 270 280 290 300
YGQEDVIKNY ELIRSELVKY NYKLDERPEI IVANKMDTDE AQLNMMEEDI
310 320 330 340 350
KKYFKDKKVV FVSGLLKDNV DELLLKIAKE LETAKYVPLW EMEQDIYEGI
360 370 380 390 400
KVYRLEEDEE DIQIINKGNG RWEVAGDTIY KIYQKFPITT DDNLLLFNEK
410 420 430
LKKSGVYDML RERGVGAGDI VKVFEYELEW MD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017263 Genomic DNA Translation: AAT75880.1 |
RefSeqi | WP_011183420.1, NC_006055.1 YP_053764.1, NC_006055.1 |
Genome annotation databases
EnsemblBacteriai | AAT75880; AAT75880; Mfl522 |
GeneIDi | 2897989 |
KEGGi | mfl:Mfl522 |
PATRICi | fig|265311.5.peg.526 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017263 Genomic DNA Translation: AAT75880.1 |
RefSeqi | WP_011183420.1, NC_006055.1 YP_053764.1, NC_006055.1 |
3D structure databases
SMRi | Q6F0U3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 265311.Mfl522 |
Genome annotation databases
EnsemblBacteriai | AAT75880; AAT75880; Mfl522 |
GeneIDi | 2897989 |
KEGGi | mfl:Mfl522 |
PATRICi | fig|265311.5.peg.526 |
Phylogenomic databases
eggNOGi | COG0536, Bacteria |
HOGENOMi | CLU_011747_2_0_14 |
OMAi | WVRQTDF |
Family and domain databases
CDDi | cd01898, Obg, 1 hit |
Gene3Di | 2.70.210.12, 1 hit 3.30.300.350, 1 hit 3.40.50.300, 1 hit |
HAMAPi | MF_01454, GTPase_Obg, 1 hit |
InterProi | View protein in InterPro IPR031167, G_OBG IPR006073, GTP-bd IPR014100, GTP-bd_Obg/CgtA IPR036346, GTP-bd_prot_GTP1/OBG_C_sf IPR006074, GTP1-OBG_CS IPR006169, GTP1_OBG_dom IPR036726, GTP1_OBG_dom_sf IPR045086, OBG_GTPase IPR015349, OCT_dom IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom |
PANTHERi | PTHR11702, PTHR11702, 1 hit |
Pfami | View protein in Pfam PF09269, DUF1967, 1 hit PF01018, GTP1_OBG, 1 hit PF01926, MMR_HSR1, 1 hit |
PIRSFi | PIRSF002401, GTP_bd_Obg/CgtA, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF102741, SSF102741, 1 hit SSF52540, SSF52540, 1 hit SSF82051, SSF82051, 1 hit |
TIGRFAMsi | TIGR02729, Obg_CgtA, 1 hit TIGR03595, Obg_CgtA_exten, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51710, G_OBG, 1 hit PS00905, GTP1_OBG, 1 hit PS51883, OBG, 1 hit PS51881, OCT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OBG_MESFL | |
Accessioni | Q6F0U3Primary (citable) accession number: Q6F0U3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 13, 2009 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 23, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families