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UniProtKB - Q6F0E1 (KTHY_MESFL)
Protein
Thymidylate kinase
Gene
tmk
Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Functioni
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
UniRule annotationCatalytic activityi
- EC:2.7.4.9UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 7 – 14 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- thymidylate kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- dTDP biosynthetic process Source: InterPro
- dTTP biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Nucleotide biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)Alternative name(s): dTMP kinaseUniRule annotation |
Gene namesi | Name:tmkUniRule annotation Ordered Locus Names:Mfl676 |
Organismi | Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum) |
Taxonomic identifieri | 265311 [NCBI] |
Taxonomic lineagei | Bacteria › Tenericutes › Mollicutes › Entomoplasmatales › Entomoplasmataceae › Mesoplasma › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155299 | 1 – 211 | Thymidylate kinaseAdd BLAST | 211 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidylate kinase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0125, Bacteria |
HOGENOMi | CLU_049131_0_2_14 |
OMAi | LEGIDGC |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00165, Thymidylate_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR039430, Thymidylate_kin-like_dom IPR018095, Thymidylate_kin_CS IPR018094, Thymidylate_kinase |
Pfami | View protein in Pfam PF02223, Thymidylate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00041, DTMP_kinase, 1 hit |
PROSITEi | View protein in PROSITE PS01331, THYMIDYLATE_KINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6F0E1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFITIEGMDG SGKTTALQRV KQYLEDLNYK VVMTREPGGL PLSEKIRELI
60 70 80 90 100
LNKDGVGMEP WTEALLFIAA RKEHLEKVIK PYLKKGYIVI SDRFMDSTTA
110 120 130 140 150
YQGGARGLGV DYLNELQKNI LEGFLPDLTL YFELSFEDAE KRLSARPEEK
160 170 180 190 200
NRLDEEGRKF KEAVKLAFEE LVVKEPNRIT VIDASKSPEE VFEETKKVIL
210
EKIELWKKEK R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017263 Genomic DNA Translation: AAT76032.1 |
RefSeqi | WP_011183572.1, NC_006055.1 YP_053916.1, NC_006055.1 |
Genome annotation databases
EnsemblBacteriai | AAT76032; AAT76032; Mfl676 |
GeneIDi | 2898171 |
KEGGi | mfl:Mfl676 |
PATRICi | fig|265311.5.peg.678 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017263 Genomic DNA Translation: AAT76032.1 |
RefSeqi | WP_011183572.1, NC_006055.1 YP_053916.1, NC_006055.1 |
3D structure databases
SMRi | Q6F0E1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 265311.Mfl676 |
Genome annotation databases
EnsemblBacteriai | AAT76032; AAT76032; Mfl676 |
GeneIDi | 2898171 |
KEGGi | mfl:Mfl676 |
PATRICi | fig|265311.5.peg.678 |
Phylogenomic databases
eggNOGi | COG0125, Bacteria |
HOGENOMi | CLU_049131_0_2_14 |
OMAi | LEGIDGC |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00165, Thymidylate_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR039430, Thymidylate_kin-like_dom IPR018095, Thymidylate_kin_CS IPR018094, Thymidylate_kinase |
Pfami | View protein in Pfam PF02223, Thymidylate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00041, DTMP_kinase, 1 hit |
PROSITEi | View protein in PROSITE PS01331, THYMIDYLATE_KINASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KTHY_MESFL | |
Accessioni | Q6F0E1Primary (citable) accession number: Q6F0E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 23, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families