UniProtKB - Q6EFA1 (Q6EFA1_DANRE)
Protein
Submitted name:
Sulfatase 1
Gene
sulf1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Cofactori
Ca2+ARBA annotation
GO - Molecular functioni
- glycosaminoglycan binding Source: GO_Central
- N-acetylglucosamine-6-sulfatase activity Source: GO_Central
GO - Biological processi
- blood circulation Source: ZFIN
- epithelial structure maintenance Source: ZFIN
- glomerular basement membrane development Source: GO_Central
- heparan sulfate proteoglycan metabolic process Source: GO_Central
- negative regulation of fibroblast growth factor receptor signaling pathway Source: GO_Central
- neuromast deposition Source: ZFIN
- positive regulation of vascular endothelial growth factor production Source: GO_Central
- positive regulation of Wnt signaling pathway Source: GO_Central
- regulation of developmental pigmentation Source: ZFIN
- regulation of myotome development Source: ZFIN
- smoothened signaling pathway involved in ventral spinal cord patterning Source: ZFIN
- somitogenesis Source: ZFIN
- vasculature development Source: ZFIN
- vasculogenesis Source: ZFIN
Keywordsi
Molecular function | HydrolaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Sulfatase 1ImportedSubmitted name: Sulfatase FP1cImported |
Gene namesi | Name:sulf1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-9242, sulf1 |
Subcellular locationi
Golgi apparatus
- Golgi stack ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum ARBA annotation
Other locations
- Cell surface ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi stack Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, Golgi apparatusARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015098259 | 22 – 1099 | Sequence analysisAdd BLAST | 1078 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | 3-oxoalanine (Cys)UniRule annotation | 1 |
Post-translational modificationi
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.UniRule annotation
Expressioni
Gene expression databases
Bgeei | ENSDARG00000038428, Expressed in paraxial mesoderm and 71 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 372 | SulfataseInterPro annotationAdd BLAST | 331 | |
Domaini | 534 – 678 | DUF3740InterPro annotationAdd BLAST | 145 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 559 – 600 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 839 – 862 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1049 – 1099 | DisorderedSequence analysisAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 642 – 669 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 559 – 582 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 584 – 598 | AcidicSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the sulfatase family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3731, Eukaryota |
GeneTreei | ENSGT00940000157544 |
OrthoDBi | 1273622at2759 |
TreeFami | TF313545 |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR024609, Extracellular_sulfatase_C IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
Pfami | View protein in Pfam PF12548, DUF3740, 1 hit PF00884, Sulfatase, 1 hit |
SUPFAMi | SSF53649, SSF53649, 2 hits |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6EFA1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMQLVSLAWM MVLAAPLVCF GFTTRGQGLR GRVQGDRRNI RPNIILIMTD
60 70 80 90 100
DQDVELGSLQ VMNKTRKIME DGGTSFTNAF VTTPMCCPSR SSMLTGKYVH
110 120 130 140 150
NHNTYTNNEN CSSPSWQAQH EPRSFAVYLN NTGYRTAFFG KYLNEYNGSY
160 170 180 190 200
IPPGWREWVG LIKNSRFYNY TVCRNGNKEK HGADYAKDYF TDLITNDSIN
210 220 230 240 250
YFRTSKRMFP HRPVMMVISH AAPHGPEDSA PQYSELFPNA SQHITPSYNY
260 270 280 290 300
APNMDKHWIM QYTGPMKPIH MEFTNYLHRK RLQTLMSVDD SVEKVYNALV
310 320 330 340 350
DTGELDNTYI IYTADHGYHI GQFGLVKGKS MPYDFDIRVP FFVRGPNVEP
360 370 380 390 400
GARNNHVVLN IDLAPTILDI AGLDTPPDMD GKSILKLLEQ EKTGNRFKPN
410 420 430 440 450
RKPKVWRDTF LVERGKILRK KEDSASSLNT QHSNSLPKYK KVKEVCQQAE
460 470 480 490 500
FQTPCEQPGQ KWHCVEEVSG KWRLQKCKGS LKEGSKKRTR SLRSRSYDNR
510 520 530 540 550
EKDCHCGERP YKAAKAARRA HRQFGQSSNP RYRPRFVHTR PARSLSVEFE
560 570 580 590 600
GEIYDVDLQA DDKTPLEPRP ISKRHYEPEP GFDSDFGLES DDGSEEMQSD
610 620 630 640 650
DTNAVGYPNS LKVTHKCFIL INDTVRCERE IYQSSRAWKD HKNFVDHEIE
660 670 680 690 700
QLQDKMKKLR EVRGHLKRRR PDECDCSKKS YFSKEREQKN KPERLKNRND
710 720 730 740 750
HLHPFKEAMQ EVDSKAQLYN EIRRRKKERK VRKRQKKGDD CSLPGLTCFT
760 770 780 790 800
HNNDHWQTAP FWNLGGFCAC TSSNNNTYWC LRTVNETHNT LFCEFATGFL
810 820 830 840 850
EYFDLNSDPY QLTNAVYTVE KDILSQLHSQ LMEMRSCQGH KQCNPRPRSS
860 870 880 890 900
DAEHSQPGTS TKVKLPNFTE DVDWQGLADL YSMNESLYEH RHNYSPVLDD
910 920 930 940 950
WMNFWKDVDS MFALLRNLKT LNQTDKLDPL VELGSGVLEE ASGAGSLILE
960 970 980 990 1000
NLATAGPSVD LTPRTFQESH LKSLNELPEG RPTKVSPLPR GDTWVHQLEN
1010 1020 1030 1040 1050
ELGDDGLTFS GNGVTELETR HDFVLRSSKM LDLHQQEEEE DIFQAQGYLP
1060 1070 1080 1090
VSPQPEPAEE TPPAQSDRPQ ERWNFSIKSF THKPRDIQDS EGSASGLSH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6EFA0 | Q6EFA0_DANRE | Extracellular sulfatase | sulf1 | 874 | Annotation score: | ||
Q6EF99 | Q6EF99_DANRE | Extracellular sulfatase | sulf1 | 892 | Annotation score: | ||
F6P5J8 | F6P5J8_DANRE | Sulfatase 1 | sulf1 | 866 | Annotation score: | ||
F1R7B9 | F1R7B9_DANRE | Sulfatase 1 | sulf1 | 118 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382282 Genomic DNA No translation available. CR384092 Genomic DNA No translation available. CR385071 Genomic DNA No translation available. AY332604 mRNA Translation: AAR04055.1 |
RefSeqi | NP_001003846.1, NM_001003846.1 |
Genome annotation databases
Ensembli | ENSDART00000056081; ENSDARP00000056080; ENSDARG00000038428 ENSDART00000180782; ENSDARP00000153732; ENSDARG00000038428 |
GeneIDi | 337298 |
KEGGi | dre:337298 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382282 Genomic DNA No translation available. CR384092 Genomic DNA No translation available. CR385071 Genomic DNA No translation available. AY332604 mRNA Translation: AAR04055.1 |
RefSeqi | NP_001003846.1, NM_001003846.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000056080 |
Genome annotation databases
Ensembli | ENSDART00000056081; ENSDARP00000056080; ENSDARG00000038428 ENSDART00000180782; ENSDARP00000153732; ENSDARG00000038428 |
GeneIDi | 337298 |
KEGGi | dre:337298 |
Organism-specific databases
CTDi | 23213 |
ZFINi | ZDB-GENE-030131-9242, sulf1 |
Phylogenomic databases
eggNOGi | KOG3731, Eukaryota |
GeneTreei | ENSGT00940000157544 |
OrthoDBi | 1273622at2759 |
TreeFami | TF313545 |
Gene expression databases
Bgeei | ENSDARG00000038428, Expressed in paraxial mesoderm and 71 other tissues |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR024609, Extracellular_sulfatase_C IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
Pfami | View protein in Pfam PF12548, DUF3740, 1 hit PF00884, Sulfatase, 1 hit |
SUPFAMi | SSF53649, SSF53649, 2 hits |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6EFA1_DANRE | |
Accessioni | Q6EFA1Primary (citable) accession number: Q6EFA1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |