SUMO4

Functionⁱ

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.3 Publications

GO - Molecular functionⁱ

protein tag
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein sumoylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Small ubiquitin-related modifier 4 Short name: SUMO-4 Alternative name(s): Small ubiquitin-like protein 4
Gene namesⁱ	Name:SUMO4 Synonyms:SMT3H4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177688.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21181 SUMO4
MIMⁱ	608829 gene
neXtProtⁱ	NX_Q6EEV6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diabetes mellitus, insulin-dependent, 5 (IDDM5)3 Publications

Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Disease descriptionA form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Keywords - Diseaseⁱ

Diabetes mellitus

Organism-specific databases

DisGeNET More...DisGeNETⁱ	387082
MalaCards human disease database More...MalaCardsⁱ	SUMO4
MIMⁱ	600320 phenotype
PharmGKBⁱ	PA134979206

Polymorphism and mutation databases

BioMutaⁱ	SUMO4
DMDMⁱ	81175019

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000042710	1 – 93	Small ubiquitin-related modifier 4Add BLAST		93
PropeptideⁱPRO_0000042711	94 – 95	By similarity		2

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	93	Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Post-translational modificationⁱ

In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.

Keywords - PTMⁱ

Isopeptide bond

Proteomic databases

EPDⁱ	Q6EEV6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6EEV6
PaxDbⁱ	Q6EEV6
PeptideAtlas More...PeptideAtlasⁱ	Q6EEV6
PRIDEⁱ	Q6EEV6
ProteomicsDBⁱ	66280
TopDownProteomicsⁱ	Q6EEV6

PTM databases

iPTMnetⁱ	Q6EEV6
PhosphoSitePlusⁱ	Q6EEV6

Expressionⁱ

Tissue specificityⁱ

Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000177688 Expressed in 236 organ(s), highest expression level in oocyte
CleanExⁱ	HS_SUMO4
Genevisibleⁱ	Q6EEV6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042123 HPA048064

HPAⁱ

HPA042123
HPA048064

Interactionⁱ

Subunit structureⁱ

Interacts with SAE2. Covalently attached to a number of proteins (Probable).Curated

Protein-protein interaction databases

BioGridⁱ	132223, 9 interactors
ComplexPortalⁱ	CPX-3051 sumoylated E2 ligase complex (SUMO4) CPX-3076 activated SUMO4-E1 ligase complex
STRINGⁱ	9606.ENSP00000318635

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6EEV6
SMRⁱ	Q6EEV6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 95	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST		79

Sequence similaritiesⁱ

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1769 Eukaryota COG5227 LUCA
HOGENOMⁱ	HOG000207495
HOVERGENⁱ	HBG053025
InParanoidⁱ	Q6EEV6
KEGG Orthology (KO) More...KOⁱ	K12160
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10ZQ
PhylomeDBⁱ	Q6EEV6
TreeFamⁱ	TF315116

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01763 Sumo, 1 hit
InterProⁱ	View protein in InterPro IPR022617 Rad60/SUMO-like_dom IPR033950 Sumo IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11976 Rad60-SLD, 1 hit
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6EEV6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP 
        60         70         80         90 
RGLSMKQIRF RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY

Length:95

Mass (Da):10,685

Last modified:November 8, 2005 - v2

Checksum:ⁱ9012CAEE734ED223

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023740	55	M → V May be associated with susceptibility to type 1 diabetes; greater NFKB1 transcriptional activity and IL12B expression. 6 PublicationsCorresponds to variant dbSNP:rs237025Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY340238 mRNA Translation: AAR04484.1 AB205057 Genomic DNA Translation: BAH05006.1 AL031133 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47808.1 BC130305 mRNA Translation: AAI30306.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34549.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001002255.1, NM_001002255.1
UniGeneⁱ	Hs.657168

Genome annotation databases

Ensemblⁱ	ENST00000326669; ENSP00000318635; ENSG00000177688
GeneIDⁱ	387082
KEGGⁱ	hsa:387082
UCSC genome browser More...UCSCⁱ	uc003qml.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q6EEV6	Small ubiquitin-related modifier		PANTR		95	UniRef90_Q6EEV6
UPI0000072D67		HUMAN		95
UPI0002743F7F		PANPA		95

Protein	Similar proteins		Species	Score	Length	Source
Q6EEV6	Small ubiquitin-related modifier		PANTR		95	UniRef50_Q6EEV6
Small ubiquitin-related modifier		PHYCD		94
Small ubiquitin-related modifier		Azumapecten farreri		100
Small ubiquitin-related modifier		MIZYE		100
Uncharacterized protein (Fragment)		GAMAF		76
+51

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

SUMO protein entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY340238 mRNA Translation: AAR04484.1 AB205057 Genomic DNA Translation: BAH05006.1 AL031133 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47808.1 BC130305 mRNA Translation: AAI30306.1
CCDSⁱ	CCDS34549.1
RefSeqⁱ	NP_001002255.1, NM_001002255.1
UniGeneⁱ	Hs.657168

3D structure databases

ProteinModelPortalⁱ	Q6EEV6
SMRⁱ	Q6EEV6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	132223, 9 interactors
ComplexPortalⁱ	CPX-3051 sumoylated E2 ligase complex (SUMO4) CPX-3076 activated SUMO4-E1 ligase complex
STRINGⁱ	9606.ENSP00000318635

PTM databases

iPTMnetⁱ	Q6EEV6
PhosphoSitePlusⁱ	Q6EEV6

Polymorphism and mutation databases

BioMutaⁱ	SUMO4
DMDMⁱ	81175019

Proteomic databases

EPDⁱ	Q6EEV6
MaxQBⁱ	Q6EEV6
PaxDbⁱ	Q6EEV6
PeptideAtlasⁱ	Q6EEV6
PRIDEⁱ	Q6EEV6
ProteomicsDBⁱ	66280
TopDownProteomicsⁱ	Q6EEV6

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	387082
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326669; ENSP00000318635; ENSG00000177688
GeneIDⁱ	387082
KEGGⁱ	hsa:387082
UCSCⁱ	uc003qml.4 human

Organism-specific databases

CTDⁱ	387082
DisGeNETⁱ	387082
EuPathDBⁱ	HostDB:ENSG00000177688.6
GeneCardsⁱ	SUMO4
HGNCⁱ	HGNC:21181 SUMO4
HPAⁱ	HPA042123 HPA048064
MalaCardsⁱ	SUMO4
MIMⁱ	600320 phenotype 608829 gene
neXtProtⁱ	NX_Q6EEV6
PharmGKBⁱ	PA134979206
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1769 Eukaryota COG5227 LUCA
HOGENOMⁱ	HOG000207495
HOVERGENⁱ	HBG053025
InParanoidⁱ	Q6EEV6
KOⁱ	K12160
OrthoDBⁱ	EOG091G10ZQ
PhylomeDBⁱ	Q6EEV6
TreeFamⁱ	TF315116

Miscellaneous databases

GeneWikiⁱ	SUMO4
GenomeRNAiⁱ	387082
Protein Ontology More...PROⁱ	PR:Q6EEV6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177688 Expressed in 236 organ(s), highest expression level in oocyte
CleanExⁱ	HS_SUMO4
Genevisibleⁱ	Q6EEV6 HS

Family and domain databases

CDDⁱ	cd01763 Sumo, 1 hit
InterProⁱ	View protein in InterPro IPR022617 Rad60/SUMO-like_dom IPR033950 Sumo IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
Pfamⁱ	View protein in Pfam PF11976 Rad60-SLD, 1 hit
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SUMO4_HUMAN
Accessionⁱ	Q6EEV6Primary (citable) accession number: Q6EEV6 Secondary accession number(s): A1L3W5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	November 8, 2005
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q6EEV6 (SUMO4_HUMAN)

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Small ubiquitin-related modifier 4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ