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Protein

Small ubiquitin-related modifier 4

Gene

SUMO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.3 Publications

GO - Molecular functioni

  • protein tag Source: GO_Central

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 4
Short name:
SUMO-4
Alternative name(s):
Small ubiquitin-like protein 4
Gene namesi
Name:SUMO4
Synonyms:SMT3H4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000177688.6
HGNCiHGNC:21181 SUMO4
MIMi608829 gene
neXtProtiNX_Q6EEV6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, insulin-dependent, 5 (IDDM5)3 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:600320

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi387082
MalaCardsiSUMO4
MIMi600320 phenotype
PharmGKBiPA134979206

Polymorphism and mutation databases

BioMutaiSUMO4
DMDMi81175019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000427101 – 93Small ubiquitin-related modifier 4Add BLAST93
PropeptideiPRO_000004271194 – 95By similarity2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki93Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Post-translational modificationi

In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.

Keywords - PTMi

Isopeptide bond

Proteomic databases

EPDiQ6EEV6
MaxQBiQ6EEV6
PaxDbiQ6EEV6
PeptideAtlasiQ6EEV6
PRIDEiQ6EEV6
ProteomicsDBi66280
TopDownProteomicsiQ6EEV6

PTM databases

iPTMnetiQ6EEV6
PhosphoSitePlusiQ6EEV6

Expressioni

Tissue specificityi

Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.2 Publications

Gene expression databases

BgeeiENSG00000177688 Expressed in 236 organ(s), highest expression level in oocyte
CleanExiHS_SUMO4
GenevisibleiQ6EEV6 HS

Organism-specific databases

HPAiHPA042123
HPA048064

Interactioni

Subunit structurei

Interacts with SAE2. Covalently attached to a number of proteins (Probable).Curated

Protein-protein interaction databases

BioGridi132223, 9 interactors
ComplexPortaliCPX-3051 sumoylated E2 ligase complex (SUMO4)
CPX-3076 activated SUMO4-E1 ligase complex
STRINGi9606.ENSP00000318635

Structurei

3D structure databases

ProteinModelPortaliQ6EEV6
SMRiQ6EEV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 95Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
HOGENOMiHOG000207495
HOVERGENiHBG053025
InParanoidiQ6EEV6
KOiK12160
OrthoDBiEOG091G10ZQ
PhylomeDBiQ6EEV6
TreeFamiTF315116

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6EEV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP
60 70 80 90
RGLSMKQIRF RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY
Length:95
Mass (Da):10,685
Last modified:November 8, 2005 - v2
Checksum:i9012CAEE734ED223
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02374055M → V May be associated with susceptibility to type 1 diabetes; greater NFKB1 transcriptional activity and IL12B expression. 6 PublicationsCorresponds to variant dbSNP:rs237025Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY340238 mRNA Translation: AAR04484.1
AB205057 Genomic DNA Translation: BAH05006.1
AL031133 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47808.1
BC130305 mRNA Translation: AAI30306.1
CCDSiCCDS34549.1
RefSeqiNP_001002255.1, NM_001002255.1
UniGeneiHs.657168

Genome annotation databases

EnsembliENST00000326669; ENSP00000318635; ENSG00000177688
GeneIDi387082
KEGGihsa:387082
UCSCiuc003qml.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

SUMO protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY340238 mRNA Translation: AAR04484.1
AB205057 Genomic DNA Translation: BAH05006.1
AL031133 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47808.1
BC130305 mRNA Translation: AAI30306.1
CCDSiCCDS34549.1
RefSeqiNP_001002255.1, NM_001002255.1
UniGeneiHs.657168

3D structure databases

ProteinModelPortaliQ6EEV6
SMRiQ6EEV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132223, 9 interactors
ComplexPortaliCPX-3051 sumoylated E2 ligase complex (SUMO4)
CPX-3076 activated SUMO4-E1 ligase complex
STRINGi9606.ENSP00000318635

PTM databases

iPTMnetiQ6EEV6
PhosphoSitePlusiQ6EEV6

Polymorphism and mutation databases

BioMutaiSUMO4
DMDMi81175019

Proteomic databases

EPDiQ6EEV6
MaxQBiQ6EEV6
PaxDbiQ6EEV6
PeptideAtlasiQ6EEV6
PRIDEiQ6EEV6
ProteomicsDBi66280
TopDownProteomicsiQ6EEV6

Protocols and materials databases

DNASUi387082
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326669; ENSP00000318635; ENSG00000177688
GeneIDi387082
KEGGihsa:387082
UCSCiuc003qml.4 human

Organism-specific databases

CTDi387082
DisGeNETi387082
EuPathDBiHostDB:ENSG00000177688.6
GeneCardsiSUMO4
HGNCiHGNC:21181 SUMO4
HPAiHPA042123
HPA048064
MalaCardsiSUMO4
MIMi600320 phenotype
608829 gene
neXtProtiNX_Q6EEV6
PharmGKBiPA134979206
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
HOGENOMiHOG000207495
HOVERGENiHBG053025
InParanoidiQ6EEV6
KOiK12160
OrthoDBiEOG091G10ZQ
PhylomeDBiQ6EEV6
TreeFamiTF315116

Miscellaneous databases

GeneWikiiSUMO4
GenomeRNAii387082
PROiPR:Q6EEV6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177688 Expressed in 236 organ(s), highest expression level in oocyte
CleanExiHS_SUMO4
GenevisibleiQ6EEV6 HS

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO4_HUMAN
AccessioniPrimary (citable) accession number: Q6EEV6
Secondary accession number(s): A1L3W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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