UniProtKB - Q6EEV6 (SUMO4_HUMAN)
Protein
Small ubiquitin-related modifier 4
Gene
SUMO4
Organism
Homo sapiens (Human)
Status
Functioni
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.3 Publications
Keywordsi
Biological process | Ubl conjugation pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Small ubiquitin-related modifier 4Short name: SUMO-4 Alternative name(s): Small ubiquitin-like protein 4 |
Gene namesi | Name:SUMO4 Synonyms:SMT3H4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21181 SUMO4 |
MIMi | 608829 gene |
neXtProti | NX_Q6EEV6 |
Pathology & Biotechi
Involvement in diseasei
Diabetes mellitus, insulin-dependent, 5 (IDDM5)3 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIMKeywords - Diseasei
Diabetes mellitusOrganism-specific databases
DisGeNETi | 387082 |
MalaCardsi | SUMO4 |
MIMi | 600320 phenotype |
PharmGKBi | PA134979206 |
Miscellaneous databases
Pharosi | Q6EEV6 |
Polymorphism and mutation databases
BioMutai | SUMO4 |
DMDMi | 81175019 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000042710 | 1 – 93 | Small ubiquitin-related modifier 4Add BLAST | 93 | |
PropeptideiPRO_0000042711 | 94 – 95 | By similarity | 2 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 93 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Post-translational modificationi
In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.
Keywords - PTMi
Isopeptide bondProteomic databases
EPDi | Q6EEV6 |
jPOSTi | Q6EEV6 |
MassIVEi | Q6EEV6 |
MaxQBi | Q6EEV6 |
PaxDbi | Q6EEV6 |
PeptideAtlasi | Q6EEV6 |
PRIDEi | Q6EEV6 |
ProteomicsDBi | 66280 |
TopDownProteomicsi | Q6EEV6 |
PTM databases
iPTMneti | Q6EEV6 |
PhosphoSitePlusi | Q6EEV6 |
Expressioni
Tissue specificityi
Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.2 Publications
Gene expression databases
Bgeei | ENSG00000177688 Expressed in 236 organ(s), highest expression level in oocyte |
Genevisiblei | Q6EEV6 HS |
Organism-specific databases
HPAi | HPA042123 HPA048064 |
Interactioni
Subunit structurei
Interacts with SAE2. Covalently attached to a number of proteins (Probable).
CuratedProtein-protein interaction databases
BioGridi | 132223, 9 interactors |
ComplexPortali | CPX-3051 sumoylated E2 ligase complex (SUMO4) CPX-3076 activated SUMO4-E1 ligase complex |
IntActi | Q6EEV6, 1 interactor |
STRINGi | 9606.ENSP00000318635 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 95 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 79 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1769 Eukaryota COG5227 LUCA |
HOGENOMi | HOG000207495 |
InParanoidi | Q6EEV6 |
KOi | K12160 |
OrthoDBi | 1583700at2759 |
PhylomeDBi | Q6EEV6 |
TreeFami | TF315116 |
Family and domain databases
InterProi | View protein in InterPro IPR022617 Rad60/SUMO-like_dom IPR000626 Ubiquitin-like_dom IPR029071 Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF11976 Rad60-SLD, 1 hit |
SMARTi | View protein in SMART SM00213 UBQ, 1 hit |
SUPFAMi | SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6EEV6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP
60 70 80 90
RGLSMKQIRF RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023740 | 55 | M → V May be associated with susceptibility to type 1 diabetes; greater NFKB1 transcriptional activity and IL12B expression. 6 PublicationsCorresponds to variant dbSNP:rs237025Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY340238 mRNA Translation: AAR04484.1 AB205057 Genomic DNA Translation: BAH05006.1 AL031133 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47808.1 BC130305 mRNA Translation: AAI30306.1 |
CCDSi | CCDS34549.1 |
RefSeqi | NP_001002255.1, NM_001002255.1 |
Genome annotation databases
Ensembli | ENST00000326669; ENSP00000318635; ENSG00000177688 |
GeneIDi | 387082 |
KEGGi | hsa:387082 |
UCSCi | uc003qml.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia SUMO protein entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY340238 mRNA Translation: AAR04484.1 AB205057 Genomic DNA Translation: BAH05006.1 AL031133 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47808.1 BC130305 mRNA Translation: AAI30306.1 |
CCDSi | CCDS34549.1 |
RefSeqi | NP_001002255.1, NM_001002255.1 |
3D structure databases
SMRi | Q6EEV6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 132223, 9 interactors |
ComplexPortali | CPX-3051 sumoylated E2 ligase complex (SUMO4) CPX-3076 activated SUMO4-E1 ligase complex |
IntActi | Q6EEV6, 1 interactor |
STRINGi | 9606.ENSP00000318635 |
PTM databases
iPTMneti | Q6EEV6 |
PhosphoSitePlusi | Q6EEV6 |
Polymorphism and mutation databases
BioMutai | SUMO4 |
DMDMi | 81175019 |
Proteomic databases
EPDi | Q6EEV6 |
jPOSTi | Q6EEV6 |
MassIVEi | Q6EEV6 |
MaxQBi | Q6EEV6 |
PaxDbi | Q6EEV6 |
PeptideAtlasi | Q6EEV6 |
PRIDEi | Q6EEV6 |
ProteomicsDBi | 66280 |
TopDownProteomicsi | Q6EEV6 |
Protocols and materials databases
DNASUi | 387082 |
Genome annotation databases
Ensembli | ENST00000326669; ENSP00000318635; ENSG00000177688 |
GeneIDi | 387082 |
KEGGi | hsa:387082 |
UCSCi | uc003qml.4 human |
Organism-specific databases
CTDi | 387082 |
DisGeNETi | 387082 |
GeneCardsi | SUMO4 |
HGNCi | HGNC:21181 SUMO4 |
HPAi | HPA042123 HPA048064 |
MalaCardsi | SUMO4 |
MIMi | 600320 phenotype 608829 gene |
neXtProti | NX_Q6EEV6 |
PharmGKBi | PA134979206 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1769 Eukaryota COG5227 LUCA |
HOGENOMi | HOG000207495 |
InParanoidi | Q6EEV6 |
KOi | K12160 |
OrthoDBi | 1583700at2759 |
PhylomeDBi | Q6EEV6 |
TreeFami | TF315116 |
Miscellaneous databases
GeneWikii | SUMO4 |
GenomeRNAii | 387082 |
Pharosi | Q6EEV6 |
PROi | PR:Q6EEV6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177688 Expressed in 236 organ(s), highest expression level in oocyte |
Genevisiblei | Q6EEV6 HS |
Family and domain databases
InterProi | View protein in InterPro IPR022617 Rad60/SUMO-like_dom IPR000626 Ubiquitin-like_dom IPR029071 Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF11976 Rad60-SLD, 1 hit |
SMARTi | View protein in SMART SM00213 UBQ, 1 hit |
SUPFAMi | SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SUMO4_HUMAN | |
Accessioni | Q6EEV6Primary (citable) accession number: Q6EEV6 Secondary accession number(s): A1L3W5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | November 13, 2019 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot