UniProtKB - Q6EE31 (TCPQ_CHICK)
Protein
T-complex protein 1 subunit theta
Gene
CCT8
Organism
Gallus gallus (Chicken)
Status
Functioni
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.By similarity
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- unfolded protein binding Source: GO_Central
GO - Biological processi
- protein folding Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit thetaShort name: TCP-1-theta Alternative name(s): CCT-theta |
Gene namesi | Name:CCT8By similarity |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- centrosome By similarity
- cilium basal body By similarity
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- chaperonin-containing T-complex Source: GO_Central
Other locations
- cell projection Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000223485 | 2 – 548 | T-complex protein 1 subunit thetaAdd BLAST | 547 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 505 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q6EE31 |
PRIDEi | Q6EE31 |
Interactioni
Subunit structurei
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
By similarityGO - Molecular functioni
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 679712, 1 interactor |
STRINGi | 9031.ENSGALP00000025461 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG0362, Eukaryota |
InParanoidi | Q6EE31 |
PhylomeDBi | Q6EE31 |
Family and domain databases
CDDi | cd03341, TCP1_theta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012721, Chap_CCT_theta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02346, chap_CCT_theta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6EE31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALHVPKAPG FAQMLKEGAK HYSGLEEAVY RNIQACKELA QTTRTAYGPN
60 70 80 90 100
GMNKMVINHL EKLFVTNDAA TILRELEVQH PAAKMLVMAS HMQEQEVGDG
110 120 130 140 150
TNFVLVFAGV LLELAEDLLR MGLSVSEVIE GYEKACKKAL EILPDLVCCS
160 170 180 190 200
AKNLRDVDEV ASLLHTSVMS KQYGNESFLS KLIAQACVSI LPDSGHFNVD
210 220 230 240 250
NIRVCKIVGA GVSASSVLHG MVFNKETEGD VTSVKDAKXA VYSCPFDGMI
260 270 280 290 300
TETKGTVLIK NAEELMNFSK GEENLMDLQV KAIADSGANV VVTGGKVADM
310 320 330 340 350
ALHYANKYNL MIVRLNSKWD LRRLCKTVGA TALPRLTPPT LEEMGHCNSV
360 370 380 390 400
YLSEVGDTQV VVFKHEKEDG AISTILIRGS TDNLMDDIER AVDDGVNTFK
410 420 430 440 450
VLTRDKRLVP GGGATEIELA KQITSYGETC PGLDQYAIKK FAEAFEAIPR
460 470 480 490 500
ALAENSGVKA NEVISKLYAV HQEGNKNVGF DIEAEAAAVK DMLEAGILDT
510 520 530 540
YLGKYWGIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK DWDEDQND
Mass spectrometryi
Molecular mass is 60153±4 Da. Determined by MALDI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY393846 mRNA Translation: AAS49611.1 |
RefSeqi | NP_001004389.2, NM_001004389.2 |
Genome annotation databases
GeneIDi | 418486 |
KEGGi | gga:418486 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY393846 mRNA Translation: AAS49611.1 |
RefSeqi | NP_001004389.2, NM_001004389.2 |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 679712, 1 interactor |
STRINGi | 9031.ENSGALP00000025461 |
Proteomic databases
PaxDbi | Q6EE31 |
PRIDEi | Q6EE31 |
Genome annotation databases
GeneIDi | 418486 |
KEGGi | gga:418486 |
Organism-specific databases
CTDi | 10694 |
Phylogenomic databases
eggNOGi | KOG0362, Eukaryota |
InParanoidi | Q6EE31 |
PhylomeDBi | Q6EE31 |
Miscellaneous databases
PROi | PR:Q6EE31 |
Family and domain databases
CDDi | cd03341, TCP1_theta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012721, Chap_CCT_theta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02346, chap_CCT_theta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPQ_CHICK | |
Accessioni | Q6EE31Primary (citable) accession number: Q6EE31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 101 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families