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Protein

Zinc finger protein 470

Gene

ZNF470

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 250C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 391C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri397 – 419C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 470
Alternative name(s):
Chondrogenesis zinc finger protein 1
Short name:
CZF-1
Gene namesi
Name:ZNF470
Synonyms:CZF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197016.11
HGNCiHGNC:22220 ZNF470
neXtProtiNX_Q6ECI4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197016
PharmGKBiPA145007252

Polymorphism and mutation databases

BioMutaiZNF470
DMDMi313104257

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804131 – 717Zinc finger protein 470Add BLAST717

Proteomic databases

MaxQBiQ6ECI4
PaxDbiQ6ECI4
PeptideAtlasiQ6ECI4
PRIDEiQ6ECI4
ProteomicsDBi66276
66277 [Q6ECI4-2]

PTM databases

iPTMnetiQ6ECI4
PhosphoSitePlusiQ6ECI4

Expressioni

Tissue specificityi

Highly expressed in testis. Very low expression in thymus. No expression in other tissues tested. Expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells.1 Publication

Gene expression databases

BgeeiENSG00000197016
CleanExiHS_ZNF470
ExpressionAtlasiQ6ECI4 baseline and differential
GenevisibleiQ6ECI4 HS

Organism-specific databases

HPAiHPA029000

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333223

Structurei

3D structure databases

ProteinModelPortaliQ6ECI4
SMRiQ6ECI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 219Nuclear localization signalSequence analysis4
Motifi385 – 388Nuclear localization signalSequence analysis4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 250C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 391C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri397 – 419C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148943
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ECI4
KOiK09228
OMAiHKQDCGE
OrthoDBiEOG091G02KC
PhylomeDBiQ6ECI4
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ECI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSQEEVEVA GIKLCKAMSL GSVTFTDVAI DFSQDEWEWL NLAQRSLYKK
60 70 80 90 100
VMLENYRNLV SVGLCISKPD VISLLEQEKD PWVIKGGMNR GLCPDLECVW
110 120 130 140 150
VTKSLSLNQD IYEEKLPPAI IMERLKSYDL ECSTLGKNWK CEDLFERELV
160 170 180 190 200
NQKTHFRQET ITHIDTLIEK RDHSNKSGTV FHLNTLSYIK QIFPMEERIF
210 220 230 240 250
NFHTDKKSLK THSVVKKHKQ DRGEKKLLKC NDCEKIFSKI STLTLHQRIH
260 270 280 290 300
TGEKPYECIE CGKAFSQSAH LAQHQRIHTG EKPFECTECG KAFSQNAHLV
310 320 330 340 350
QHQRVHTGEK PYQCKQCNKA FSQLAHLAQH QRVHTGEKPY ECIECGKAFS
360 370 380 390 400
DCSSLAHHRR IHTGKRPYEC IDCGKAFRQN ASLIRHRRYY HTGEKPFDCI
410 420 430 440 450
DCGKAFTDHI GLIQHKRTHT GERPYKCNVC GKAFSHGSSL TVHQRIHTGE
460 470 480 490 500
KPYECNICEK AFSHRGSLTL HQRVHTGEKP YECKECGKAF RQSTHLAHHQ
510 520 530 540 550
RIHTGEKPYE CKECSKTFSQ NAHLAQHQKI HTGEKPYECK ECGKAFSQIA
560 570 580 590 600
HLVQHQRVHT GEKPYECIEC GKAFSDGSYL VQHQRLHSGK RPYECLECGK
610 620 630 640 650
AFRQRASLIC HQRCHTGEKP YECNVCGKAF SHRKSLTLHQ RIHTGEKPYE
660 670 680 690 700
CKECSKAFSQ VAHLTLHKRI HTGERPYECK ECGKAFRQSV HLAHHQRIHT
710
GESSVILSSA LPYHQVL
Length:717
Mass (Da):82,650
Last modified:November 30, 2010 - v3
Checksum:i3CE8F2E9FC5603A3
GO
Isoform 2 (identifier: Q6ECI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-63: G → GKSIFLLLPPHDSVVFYAIIRISHSFPQHRQFLYVFLHAG
     95-251: Missing.

Note: No experimental confirmation available.
Show »
Length:599
Mass (Da):68,573
Checksum:iDEA044259E409522
GO

Sequence cautioni

The sequence BAC85218 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti542C → R in AAS64219 (PubMed:15302581).Curated1
Sequence conflicti584Q → P in AAS64219 (PubMed:15302581).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03114323V → L1 PublicationCorresponds to variant dbSNP:rs10421285Ensembl.1
Natural variantiVAR_031144254K → R. Corresponds to variant dbSNP:rs3752179Ensembl.1
Natural variantiVAR_031145418T → I2 PublicationsCorresponds to variant dbSNP:rs4801177Ensembl.1
Natural variantiVAR_061950642I → T. Corresponds to variant dbSNP:rs35077804Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02366063G → GKSIFLLLPPHDSVVFYAII RISHSFPQHRQFLYVFLHAG in isoform 2. Curated1
Alternative sequenceiVSP_02366195 – 251Missing in isoform 2. CuratedAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484591 mRNA Translation: AAS64219.1
AC007228 Genomic DNA Translation: AAD23607.1
BC136762 mRNA Translation: AAI36763.1
AK129686 mRNA Translation: BAC85218.1 Different initiation.
CCDSiCCDS33122.1 [Q6ECI4-1]
RefSeqiNP_001001668.3, NM_001001668.3 [Q6ECI4-1]
UniGeneiHs.204449

Genome annotation databases

EnsembliENST00000330619; ENSP00000333223; ENSG00000197016 [Q6ECI4-1]
ENST00000391709; ENSP00000375590; ENSG00000197016 [Q6ECI4-1]
GeneIDi388566
KEGGihsa:388566
UCSCiuc002qnl.5 human [Q6ECI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN470_HUMAN
AccessioniPrimary (citable) accession number: Q6ECI4
Secondary accession number(s): A8MTW0
, B9EGU1, Q6ZPA1, Q9Y2N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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