UniProtKB - Q6ECI4 (ZN470_HUMAN)
Protein
Zinc finger protein 470
Gene
ZNF470
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 228 – 250 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 256 – 278 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 284 – 306 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 312 – 334 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 340 – 362 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 368 – 391 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 397 – 419 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 649 – 671 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 677 – 699 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 470Alternative name(s): Chondrogenesis zinc finger protein 1 Short name: CZF-1 |
Gene namesi | Name:ZNF470 Synonyms:CZF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22220 ZNF470 |
neXtProti | NX_Q6ECI4 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000197016 |
PharmGKBi | PA145007252 |
Miscellaneous databases
Pharosi | Q6ECI4 |
Polymorphism and mutation databases
BioMutai | ZNF470 |
DMDMi | 313104257 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280413 | 1 – 717 | Zinc finger protein 470Add BLAST | 717 |
Proteomic databases
jPOSTi | Q6ECI4 |
MassIVEi | Q6ECI4 |
MaxQBi | Q6ECI4 |
PaxDbi | Q6ECI4 |
PeptideAtlasi | Q6ECI4 |
PRIDEi | Q6ECI4 |
ProteomicsDBi | 66276 [Q6ECI4-1] 66277 [Q6ECI4-2] |
PTM databases
iPTMneti | Q6ECI4 |
PhosphoSitePlusi | Q6ECI4 |
Expressioni
Tissue specificityi
Highly expressed in testis. Very low expression in thymus. No expression in other tissues tested. Expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells.1 Publication
Gene expression databases
Bgeei | ENSG00000197016 Expressed in 115 organ(s), highest expression level in C1 segment of cervical spinal cord |
ExpressionAtlasi | Q6ECI4 baseline and differential |
Genevisiblei | Q6ECI4 HS |
Organism-specific databases
HPAi | HPA029000 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 94 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 216 – 219 | Nuclear localization signalSequence analysis | 4 | |
Motifi | 385 – 388 | Nuclear localization signalSequence analysis | 4 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 228 – 250 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 256 – 278 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 284 – 306 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 312 – 334 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 340 – 362 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 368 – 391 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 397 – 419 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 649 – 671 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 677 – 699 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000163087 |
HOGENOMi | HOG000234617 |
InParanoidi | Q6ECI4 |
KOi | K09228 |
OMAi | IKQVFPM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ECI4 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 17 hits PS50157 ZINC_FINGER_C2H2_2, 17 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6ECI4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKSQEEVEVA GIKLCKAMSL GSVTFTDVAI DFSQDEWEWL NLAQRSLYKK
60 70 80 90 100
VMLENYRNLV SVGLCISKPD VISLLEQEKD PWVIKGGMNR GLCPDLECVW
110 120 130 140 150
VTKSLSLNQD IYEEKLPPAI IMERLKSYDL ECSTLGKNWK CEDLFERELV
160 170 180 190 200
NQKTHFRQET ITHIDTLIEK RDHSNKSGTV FHLNTLSYIK QIFPMEERIF
210 220 230 240 250
NFHTDKKSLK THSVVKKHKQ DRGEKKLLKC NDCEKIFSKI STLTLHQRIH
260 270 280 290 300
TGEKPYECIE CGKAFSQSAH LAQHQRIHTG EKPFECTECG KAFSQNAHLV
310 320 330 340 350
QHQRVHTGEK PYQCKQCNKA FSQLAHLAQH QRVHTGEKPY ECIECGKAFS
360 370 380 390 400
DCSSLAHHRR IHTGKRPYEC IDCGKAFRQN ASLIRHRRYY HTGEKPFDCI
410 420 430 440 450
DCGKAFTDHI GLIQHKRTHT GERPYKCNVC GKAFSHGSSL TVHQRIHTGE
460 470 480 490 500
KPYECNICEK AFSHRGSLTL HQRVHTGEKP YECKECGKAF RQSTHLAHHQ
510 520 530 540 550
RIHTGEKPYE CKECSKTFSQ NAHLAQHQKI HTGEKPYECK ECGKAFSQIA
560 570 580 590 600
HLVQHQRVHT GEKPYECIEC GKAFSDGSYL VQHQRLHSGK RPYECLECGK
610 620 630 640 650
AFRQRASLIC HQRCHTGEKP YECNVCGKAF SHRKSLTLHQ RIHTGEKPYE
660 670 680 690 700
CKECSKAFSQ VAHLTLHKRI HTGERPYECK ECGKAFRQSV HLAHHQRIHT
710
GESSVILSSA LPYHQVL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R0Q6 | M0R0Q6_HUMAN | Zinc finger protein 470 | ZNF470 | 102 | Annotation score: | ||
M0R2Y9 | M0R2Y9_HUMAN | Zinc finger protein 470 | ZNF470 | 46 | Annotation score: |
Sequence cautioni
The sequence BAC85218 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 542 | C → R in AAS64219 (PubMed:15302581).Curated | 1 | |
Sequence conflicti | 584 | Q → P in AAS64219 (PubMed:15302581).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031143 | 23 | V → L1 PublicationCorresponds to variant dbSNP:rs10421285Ensembl. | 1 | |
Natural variantiVAR_031144 | 254 | K → R. Corresponds to variant dbSNP:rs3752179Ensembl. | 1 | |
Natural variantiVAR_031145 | 418 | T → I2 PublicationsCorresponds to variant dbSNP:rs4801177Ensembl. | 1 | |
Natural variantiVAR_061950 | 642 | I → T. Corresponds to variant dbSNP:rs35077804Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023660 | 63 | G → GKSIFLLLPPHDSVVFYAII RISHSFPQHRQFLYVFLHAG in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_023661 | 95 – 251 | Missing in isoform 2. CuratedAdd BLAST | 157 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY484591 mRNA Translation: AAS64219.1 AC007228 Genomic DNA Translation: AAD23607.1 BC136762 mRNA Translation: AAI36763.1 AK129686 mRNA Translation: BAC85218.1 Different initiation. |
CCDSi | CCDS33122.1 [Q6ECI4-1] |
RefSeqi | NP_001001668.3, NM_001001668.3 [Q6ECI4-1] |
Genome annotation databases
Ensembli | ENST00000330619; ENSP00000333223; ENSG00000197016 [Q6ECI4-1] ENST00000391709; ENSP00000375590; ENSG00000197016 [Q6ECI4-1] |
GeneIDi | 388566 |
KEGGi | hsa:388566 |
UCSCi | uc002qnl.5 human [Q6ECI4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY484591 mRNA Translation: AAS64219.1 AC007228 Genomic DNA Translation: AAD23607.1 BC136762 mRNA Translation: AAI36763.1 AK129686 mRNA Translation: BAC85218.1 Different initiation. |
CCDSi | CCDS33122.1 [Q6ECI4-1] |
RefSeqi | NP_001001668.3, NM_001001668.3 [Q6ECI4-1] |
3D structure databases
SMRi | Q6ECI4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000333223 |
PTM databases
iPTMneti | Q6ECI4 |
PhosphoSitePlusi | Q6ECI4 |
Polymorphism and mutation databases
BioMutai | ZNF470 |
DMDMi | 313104257 |
Proteomic databases
jPOSTi | Q6ECI4 |
MassIVEi | Q6ECI4 |
MaxQBi | Q6ECI4 |
PaxDbi | Q6ECI4 |
PeptideAtlasi | Q6ECI4 |
PRIDEi | Q6ECI4 |
ProteomicsDBi | 66276 [Q6ECI4-1] 66277 [Q6ECI4-2] |
Genome annotation databases
Ensembli | ENST00000330619; ENSP00000333223; ENSG00000197016 [Q6ECI4-1] ENST00000391709; ENSP00000375590; ENSG00000197016 [Q6ECI4-1] |
GeneIDi | 388566 |
KEGGi | hsa:388566 |
UCSCi | uc002qnl.5 human [Q6ECI4-1] |
Organism-specific databases
CTDi | 388566 |
GeneCardsi | ZNF470 |
HGNCi | HGNC:22220 ZNF470 |
HPAi | HPA029000 |
neXtProti | NX_Q6ECI4 |
OpenTargetsi | ENSG00000197016 |
PharmGKBi | PA145007252 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000163087 |
HOGENOMi | HOG000234617 |
InParanoidi | Q6ECI4 |
KOi | K09228 |
OMAi | IKQVFPM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6ECI4 |
TreeFami | TF341817 |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Miscellaneous databases
GenomeRNAii | 388566 |
Pharosi | Q6ECI4 |
PROi | PR:Q6ECI4 |
Gene expression databases
Bgeei | ENSG00000197016 Expressed in 115 organ(s), highest expression level in C1 segment of cervical spinal cord |
ExpressionAtlasi | Q6ECI4 baseline and differential |
Genevisiblei | Q6ECI4 HS |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 17 hits PS50157 ZINC_FINGER_C2H2_2, 17 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN470_HUMAN | |
Accessioni | Q6ECI4Primary (citable) accession number: Q6ECI4 Secondary accession number(s): A8MTW0 Q9Y2N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | October 16, 2019 | |
This is version 135 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations