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Entry version 107 (07 Apr 2021)
Sequence version 2 (03 Oct 2012)
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Protein

Autophagy-related protein 9B

Gene

Atg9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1632852, Macroautophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy-related protein 9B
Alternative name(s):
APG9-like 2
Nitric oxide synthase 3-overlapping antisense gene protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atg9b
Synonyms:Apg9l2, Nos3as
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685420, Atg9b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 206CytoplasmicBy similarityAdd BLAST206
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 275LumenalBy similarityAdd BLAST48
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 437CytoplasmicBy similarityAdd BLAST141
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 523LumenalBy similarityAdd BLAST65
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 550CytoplasmicBy similarity6
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 624LumenalBy similarityAdd BLAST53
Transmembranei625 – 645HelicalSequence analysisAdd BLAST21
Topological domaini646 – 922CytoplasmicBy similarityAdd BLAST277

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148681 – 922Autophagy-related protein 9BAdd BLAST922

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6EBV9

PRoteomics IDEntifications database

More...
PRIDEi
Q6EBV9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277191

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6EBV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6EBV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, and placenta and testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038295, Expressed in lip and 145 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6EBV9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000051864

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6EBV9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6EBV9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 146Pro-richAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2173, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006200_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6EBV9

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQQWGTQ

Database of Orthologous Groups

More...
OrthoDBi
712239at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313665

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007241, Autophagy-rel_prot_9

The PANTHER Classification System

More...
PANTHERi
PTHR13038, PTHR13038, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04109, APG9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6EBV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRRTGWGGS RRQRGRWGDL GPSSVPLLPM ALPLPASPCR GTGGRRISVF
60 70 80 90 100
SLSPAPRTRS CSSSVFPPAS GSPCLVIQEA GASQTPHNVL PTPTTPSTQA
110 120 130 140 150
HPTMIHTSAS PSWGSHSTPP LASATPPPSC PRPQDHPGLR MGPLIPEQDY
160 170 180 190 200
ERLEDCDPEG SQDSPIHGED HQPLLHVPEG LRGSWHHIQN LDSFFTKIYS
210 220 230 240 250
YHQRNGFACI LLEDVFQLGQ FIFIVTFTTF LLRCVDYNVL FNNQPKNHTR
260 270 280 290 300
RGPLHSKVTL SDAILPSAQC AEKIHDSPLL VFLLVLAAGF WLFQLLRSVC
310 320 330 340 350
NLFSYWDIQV FYREALHIPP EELSSVPWAE VQSRLLELQR SGGLCVQPRP
360 370 380 390 400
LTELDVHHRI LRYTNYQVAL ANKGLLPARC PLPWGSSAAF LSRGLALNVD
410 420 430 440 450
LLLFRGPFSL FRGGWELPEA YKRSDLRGVL ANRWRRTVLL LAAVNLALSP
460 470 480 490 500
LVLAWQVLHA FYSHVELLRR EPGAFGARRW SRLARLQLRH FNELPHELRA
510 520 530 540 550
RLGRAYRPAA AFLRAAEPPA PLRALLARQL VFFSGALFAA LLVLTIYDED
560 570 580 590 600
VLAVEHVLTT MTALGVTATV ARSFIPEEQC QGRSSQLLLQ AALAHMHYLP
610 620 630 640 650
EEPGATGARA SSYWQMAQLL QYRAVSLLEE LLSPLLTPLF LLFWFRPRAL
660 670 680 690 700
EIIDFFHHFT VDVAGVGDIC SFALMDVKRH GHPQWLSEGQ TEASLSQRAE
710 720 730 740 750
DGKTELSLMR FSLAHPQWQP PGHSSKFLGH LRGRVQQDAA AWGAPSTRSP
760 770 780 790 800
PTPGVLSDCT SPLPEAFLAN LLVNPRPPQR DLSPTAPCPA AATASLLASI
810 820 830 840 850
SRMVQDPSCV SPGGTGGQKL TQLPELVSAE MSLHAIYLHQ LHQQQQQELW
860 870 880 890 900
GEASASSPSR PWSSPSQPGS PDEEKPSWSS DGSSPASSPR QQWGTQRAQN
910 920
LFPKGFQENT DTQKEPLTGP LH
Length:922
Mass (Da):101,913
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E79390541C3DB9D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS87213 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29P → H in AAS72555 (PubMed:15234981).Curated1
Sequence conflicti29P → H in AAS87214 (PubMed:15234981).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY495541 mRNA Translation: AAS72555.1
AY515312 mRNA Translation: AAS87213.1 Different initiation.
AY515313 mRNA Translation: AAS87214.1
AC113055 Genomic DNA No translation available.
BK004021 mRNA Translation: DAA05202.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39027.1

NCBI Reference Sequences

More...
RefSeqi
NP_001002897.2, NM_001002897.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000059401; ENSMUSP00000051864; ENSMUSG00000038295

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
213948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213948

UCSC genome browser

More...
UCSCi
uc033ihy.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY495541 mRNA Translation: AAS72555.1
AY515312 mRNA Translation: AAS87213.1 Different initiation.
AY515313 mRNA Translation: AAS87214.1
AC113055 Genomic DNA No translation available.
BK004021 mRNA Translation: DAA05202.1
CCDSiCCDS39027.1
RefSeqiNP_001002897.2, NM_001002897.3

3D structure databases

SMRiQ6EBV9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051864

PTM databases

iPTMnetiQ6EBV9
PhosphoSitePlusiQ6EBV9

Proteomic databases

PaxDbiQ6EBV9
PRIDEiQ6EBV9
ProteomicsDBi277191

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32933, 264 antibodies

The DNASU plasmid repository

More...
DNASUi
213948

Genome annotation databases

EnsembliENSMUST00000059401; ENSMUSP00000051864; ENSMUSG00000038295
GeneIDi213948
KEGGimmu:213948
UCSCiuc033ihy.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285973
MGIiMGI:2685420, Atg9b

Phylogenomic databases

eggNOGiKOG2173, Eukaryota
GeneTreeiENSGT00390000014839
HOGENOMiCLU_006200_2_0_1
InParanoidiQ6EBV9
OMAiRQQWGTQ
OrthoDBi712239at2759
TreeFamiTF313665

Enzyme and pathway databases

ReactomeiR-MMU-1632852, Macroautophagy

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
213948, 1 hit in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q6EBV9
RNActiQ6EBV9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038295, Expressed in lip and 145 other tissues
GenevisibleiQ6EBV9, MM

Family and domain databases

InterProiView protein in InterPro
IPR007241, Autophagy-rel_prot_9
PANTHERiPTHR13038, PTHR13038, 1 hit
PfamiView protein in Pfam
PF04109, APG9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG9B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6EBV9
Secondary accession number(s): F8VQL8, Q674R6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2012
Last modified: April 7, 2021
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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