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UniProtKB - Q6EBC2 (IL31_HUMAN)
Protein
Interleukin-31
Gene
IL31
Organism
Homo sapiens (Human)
Status
Functioni
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
May function in skin immunity (PubMed:15184896).
Enhances myeloid progenitor cell survival in vitro (By similarity).
Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
By similarity1 PublicationGO - Molecular functioni
- cytokine activity Source: GO_Central
- cytokine receptor binding Source: GO_Central
GO - Biological processi
- immune system process Source: UniProtKB-KW
Keywordsi
Molecular function | Cytokine |
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q6EBC2 |
Reactomei | R-HSA-6788467, IL-6-type cytokine receptor ligand interactions |
SignaLinki | Q6EBC2 |
SIGNORi | Q6EBC2 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-31Short name: IL-31 |
Gene namesi | Name:IL31 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19372, IL31 |
MIMi | 609509, gene |
neXtProti | NX_Q6EBC2 |
VEuPathDBi | HostDB:ENSG00000204671 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 386653 |
OpenTargetsi | ENSG00000204671 |
PharmGKBi | PA134957950 |
Miscellaneous databases
Pharosi | Q6EBC2, Tbio |
Genetic variation databases
BioMutai | IL31 |
DMDMi | 74709232 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000274570 | 24 – 164 | Interleukin-31Add BLAST | 141 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q6EBC2 |
PaxDbi | Q6EBC2 |
PeptideAtlasi | Q6EBC2 |
PRIDEi | Q6EBC2 |
ProteomicsDBi | 66275 |
PTM databases
GlyGeni | Q6EBC2, 2 sites |
Expressioni
Tissue specificityi
Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.1 Publication
Inductioni
Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).2 Publications
Gene expression databases
Bgeei | ENSG00000204671, Expressed in testis and 5 other tissues |
Organism-specific databases
HPAi | ENSG00000204671, Not detected |
Interactioni
Binary interactionsi
Q6EBC2
With | #Exp. | IntAct |
---|---|---|
NTAQ1 [Q96HA8] | 3 | EBI-18286692,EBI-741158 |
GO - Molecular functioni
- cytokine activity Source: GO_Central
- cytokine receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 132118, 15 interactors |
IntActi | Q6EBC2, 1 interactor |
STRINGi | 9606.ENSP00000366234 |
Miscellaneous databases
RNActi | Q6EBC2, protein |
Structurei
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TF53, Eukaryota |
GeneTreei | ENSGT00390000018074 |
HOGENOMi | CLU_1660075_0_0_1 |
InParanoidi | Q6EBC2 |
OMAi | QHEPETE |
OrthoDBi | 428855at2759 |
PhylomeDBi | Q6EBC2 |
TreeFami | TF339844 |
Family and domain databases
InterProi | View protein in InterPro IPR027987, IL-31 |
PANTHERi | PTHR38652, PTHR38652, 1 hit |
Pfami | View protein in Pfam PF15209, IL31, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6EBC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK
60 70 80 90 100
MLLKDVEEEK GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN
110 120 130 140 150
KSVIDEIIEH LDKLIFQDAP ETNISVPTDT HECKRFILTI SQQFSECMDL
160
ALKSLTSGAQ QATT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY499343 mRNA Translation: AAS86448.1 BC132998 mRNA Translation: AAI32999.1 BC133000 mRNA Translation: AAI33001.1 |
CCDSi | CCDS31919.1 |
RefSeqi | NP_001014358.1, NM_001014336.1 |
Genome annotation databases
Ensembli | ENST00000377035; ENSP00000366234; ENSG00000204671 |
GeneIDi | 386653 |
KEGGi | hsa:386653 |
MANE-Selecti | ENST00000377035.2; ENSP00000366234.1; NM_001014336.2; NP_001014358.1 |
UCSCi | uc001ubv.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY499343 mRNA Translation: AAS86448.1 BC132998 mRNA Translation: AAI32999.1 BC133000 mRNA Translation: AAI33001.1 |
CCDSi | CCDS31919.1 |
RefSeqi | NP_001014358.1, NM_001014336.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132118, 15 interactors |
IntActi | Q6EBC2, 1 interactor |
STRINGi | 9606.ENSP00000366234 |
PTM databases
GlyGeni | Q6EBC2, 2 sites |
Genetic variation databases
BioMutai | IL31 |
DMDMi | 74709232 |
Proteomic databases
MassIVEi | Q6EBC2 |
PaxDbi | Q6EBC2 |
PeptideAtlasi | Q6EBC2 |
PRIDEi | Q6EBC2 |
ProteomicsDBi | 66275 |
Protocols and materials databases
Antibodypediai | 19131, 451 antibodies from 37 providers |
DNASUi | 386653 |
Genome annotation databases
Ensembli | ENST00000377035; ENSP00000366234; ENSG00000204671 |
GeneIDi | 386653 |
KEGGi | hsa:386653 |
MANE-Selecti | ENST00000377035.2; ENSP00000366234.1; NM_001014336.2; NP_001014358.1 |
UCSCi | uc001ubv.3, human |
Organism-specific databases
CTDi | 386653 |
DisGeNETi | 386653 |
GeneCardsi | IL31 |
HGNCi | HGNC:19372, IL31 |
HPAi | ENSG00000204671, Not detected |
MIMi | 609509, gene |
neXtProti | NX_Q6EBC2 |
OpenTargetsi | ENSG00000204671 |
PharmGKBi | PA134957950 |
VEuPathDBi | HostDB:ENSG00000204671 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TF53, Eukaryota |
GeneTreei | ENSGT00390000018074 |
HOGENOMi | CLU_1660075_0_0_1 |
InParanoidi | Q6EBC2 |
OMAi | QHEPETE |
OrthoDBi | 428855at2759 |
PhylomeDBi | Q6EBC2 |
TreeFami | TF339844 |
Enzyme and pathway databases
PathwayCommonsi | Q6EBC2 |
Reactomei | R-HSA-6788467, IL-6-type cytokine receptor ligand interactions |
SignaLinki | Q6EBC2 |
SIGNORi | Q6EBC2 |
Miscellaneous databases
BioGRID-ORCSi | 386653, 6 hits in 1025 CRISPR screens |
GeneWikii | Interleukin_31 |
GenomeRNAii | 386653 |
Pharosi | Q6EBC2, Tbio |
PROi | PR:Q6EBC2 |
RNActi | Q6EBC2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204671, Expressed in testis and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027987, IL-31 |
PANTHERi | PTHR38652, PTHR38652, 1 hit |
Pfami | View protein in Pfam PF15209, IL31, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL31_HUMAN | |
Accessioni | Q6EBC2Primary (citable) accession number: Q6EBC2 Secondary accession number(s): A2RUQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot