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Protein

Interleukin-31

Gene

IL31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiQ6EBC2
SIGNORiQ6EBC2

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-31
Short name:
IL-31
Gene namesi
Name:IL31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000204671.1
HGNCiHGNC:19372 IL31
MIMi609509 gene
neXtProtiNX_Q6EBC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi386653
OpenTargetsiENSG00000204671
PharmGKBiPA134957950

Polymorphism and mutation databases

BioMutaiIL31
DMDMi74709232

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000027457024 – 164Interleukin-31Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6EBC2
PeptideAtlasiQ6EBC2
PRIDEiQ6EBC2
ProteomicsDBi66275

Expressioni

Tissue specificityi

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.1 Publication

Inductioni

Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).2 Publications

Gene expression databases

BgeeiENSG00000204671
CleanExiHS_IL31

Organism-specific databases

HPAiCAB025657

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6EBC2, 1 interactor
STRINGi9606.ENSP00000366234

Structurei

3D structure databases

ProteinModelPortaliQ6EBC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1CB Eukaryota
ENOG4111BHC LUCA
GeneTreeiENSGT00390000018074
HOGENOMiHOG000113046
InParanoidiQ6EBC2
KOiK22631
OMAiFSECMDL
OrthoDBiEOG091G0YQ7
PhylomeDBiQ6EBC2
TreeFamiTF339844

Family and domain databases

InterProiView protein in InterPro
IPR027987 IL-31
PANTHERiPTHR38652 PTHR38652, 1 hit
PfamiView protein in Pfam
PF15209 IL31, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6EBC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK
60 70 80 90 100
MLLKDVEEEK GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN
110 120 130 140 150
KSVIDEIIEH LDKLIFQDAP ETNISVPTDT HECKRFILTI SQQFSECMDL
160
ALKSLTSGAQ QATT
Length:164
Mass (Da):18,205
Last modified:August 16, 2004 - v1
Checksum:i1D61824CB6049445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY499343 mRNA Translation: AAS86448.1
BC132998 mRNA Translation: AAI32999.1
BC133000 mRNA Translation: AAI33001.1
CCDSiCCDS31919.1
RefSeqiNP_001014358.1, NM_001014336.1
UniGeneiHs.569071

Genome annotation databases

EnsembliENST00000377035; ENSP00000366234; ENSG00000204671
GeneIDi386653
KEGGihsa:386653
UCSCiuc001ubv.3 human

Similar proteinsi

Entry informationi

Entry nameiIL31_HUMAN
AccessioniPrimary (citable) accession number: Q6EBC2
Secondary accession number(s): A2RUQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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