IL31

Functionⁱ

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokine-mediated signaling pathway Source: Reactome
immune system process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkⁱ	Q6EBC2
SIGNORⁱ	Q6EBC2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-31 Short name: IL-31
Gene namesⁱ	Name:IL31
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204671.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19372 IL31
MIMⁱ	609509 gene
neXtProtⁱ	NX_Q6EBC2

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	386653
Open Targets More...OpenTargetsⁱ	ENSG00000204671
PharmGKBⁱ	PA134957950

Polymorphism and mutation databases

BioMutaⁱ	IL31
DMDMⁱ	74709232

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000274570	24 – 164	Interleukin-31Add BLAST		141

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	67	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	100	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q6EBC2
PeptideAtlas More...PeptideAtlasⁱ	Q6EBC2
PRIDEⁱ	Q6EBC2
ProteomicsDBⁱ	66275

Expressionⁱ

Tissue specificityⁱ

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.1 Publication

Inductionⁱ

Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000204671
CleanExⁱ	HS_IL31

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025657

HPAⁱ

CAB025657

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q6EBC2, 1 interactor
STRINGⁱ	9606.ENSP00000366234

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6EBC2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1CB Eukaryota ENOG4111BHC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018074
HOGENOMⁱ	HOG000113046
InParanoidⁱ	Q6EBC2
KEGG Orthology (KO) More...KOⁱ	K22631
OMAⁱ	FSECMDL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YQ7
PhylomeDBⁱ	Q6EBC2
TreeFamⁱ	TF339844

Family and domain databases

InterProⁱ	View protein in InterPro IPR027987 IL-31
PANTHERⁱ	PTHR38652 PTHR38652, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15209 IL31, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6EBC2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK 
        60         70         80         90        100
MLLKDVEEEK GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN 
       110        120        130        140        150
KSVIDEIIEH LDKLIFQDAP ETNISVPTDT HECKRFILTI SQQFSECMDL 
       160 
ALKSLTSGAQ QATT

Length:164

Mass (Da):18,205

Last modified:August 16, 2004 - v1

Checksum:ⁱ1D61824CB6049445

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY499343 mRNA Translation: AAS86448.1 BC132998 mRNA Translation: AAI32999.1 BC133000 mRNA Translation: AAI33001.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31919.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001014358.1, NM_001014336.1
UniGeneⁱ	Hs.569071

Genome annotation databases

Ensemblⁱ	ENST00000377035; ENSP00000366234; ENSG00000204671
GeneIDⁱ	386653
KEGGⁱ	hsa:386653
UCSC genome browser More...UCSCⁱ	uc001ubv.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6EBC2	IL31 isoform 1		PANTR		164
Interleukin 31		PANPA		164
IL31 isoform 1		PONAB		164
Interleukin 31		NOMLE		164
Interleukin 31		GORGO		164
+11

Protein	Similar proteins		Species	Score	Length
Q6EBC2	IL31 isoform 1		PANTR		164
Interleukin 31		PANPA		164
Interleukin 31		NOMLE		164
IL31 isoform 1		PONAB		164
Interleukin 31		GORGO		164
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY499343 mRNA Translation: AAS86448.1 BC132998 mRNA Translation: AAI32999.1 BC133000 mRNA Translation: AAI33001.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31919.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001014358.1, NM_001014336.1
UniGeneⁱ	Hs.569071

3D structure databases

ProteinModelPortalⁱ	Q6EBC2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q6EBC2, 1 interactor
STRINGⁱ	9606.ENSP00000366234

Polymorphism and mutation databases

BioMutaⁱ	IL31
DMDMⁱ	74709232

Proteomic databases

PaxDbⁱ	Q6EBC2
PeptideAtlas More...PeptideAtlasⁱ	Q6EBC2
PRIDEⁱ	Q6EBC2
ProteomicsDBⁱ	66275

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000377035; ENSP00000366234; ENSG00000204671
GeneIDⁱ	386653
KEGGⁱ	hsa:386653
UCSC genome browser More...UCSCⁱ	uc001ubv.3 human

Organism-specific databases

CTDⁱ	386653
DisGeNET More...DisGeNETⁱ	386653
EuPathDBⁱ	HostDB:ENSG00000204671.1
GeneCardsⁱ	IL31
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19372 IL31
Human Protein Atlas More...HPAⁱ	CAB025657
MIMⁱ	609509 gene
neXtProtⁱ	NX_Q6EBC2
Open Targets More...OpenTargetsⁱ	ENSG00000204671
PharmGKBⁱ	PA134957950
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1CB Eukaryota ENOG4111BHC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018074
HOGENOMⁱ	HOG000113046
InParanoidⁱ	Q6EBC2
KEGG Orthology (KO) More...KOⁱ	K22631
OMAⁱ	FSECMDL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YQ7
PhylomeDBⁱ	Q6EBC2
TreeFamⁱ	TF339844

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkⁱ	Q6EBC2
SIGNORⁱ	Q6EBC2

Miscellaneous databases

GeneWikiⁱ	Interleukin_31
GenomeRNAiⁱ	386653
Protein Ontology More...PROⁱ	PR:Q6EBC2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204671
CleanExⁱ	HS_IL31

Family and domain databases

InterProⁱ	View protein in InterPro IPR027987 IL-31
PANTHERⁱ	PTHR38652 PTHR38652, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15209 IL31, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL31_HUMAN
Accessionⁱ	Q6EBC2Primary (citable) accession number: Q6EBC2 Secondary accession number(s): A2RUQ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	August 16, 2004
	Last modified:	July 18, 2018
	This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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Supporting data

UniProtKB - Q6EBC2 (IL31_HUMAN)

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Interleukin-31

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ