UniProtKB - Q6E213 (AWAT2_HUMAN)
Acyl-CoA wax alcohol acyltransferase 2
AWAT2
Functioni
Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705).
Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038).
Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687).
Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687).
5 PublicationsCatalytic activityi
- EC:2.3.1.754 PublicationsThis reaction proceeds in the forward4 Publications direction.
- EC:2.3.1.762 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Kineticsi
- KM=5.8 µM for 11-cis-retinol1 Publication
- KM=19.8 µM for 9-cis-retinol1 Publication
- KM=27.4 µM for 13-cis-retinol1 Publication
- KM=24.8 µM for all-trans-retinol1 Publication
- Vmax=980 pmol/min/mg enzyme for 11-cis-retinol1 Publication
- Vmax=1010 pmol/min/mg enzyme for 9-cis-retinol1 Publication
- Vmax=6.4 pmol/min/mg enzyme for 13-cis-retinol1 Publication
- Vmax=148 pmol/min/mg enzyme for all-trans-retinol1 Publication
GO - Molecular functioni
- 2-acylglycerol O-acyltransferase activity Source: Reactome
- arachidoyl-CoA:1-dodecanol O-acyltransferase activity Source: UniProtKB-EC
- long-chain-alcohol O-fatty-acyltransferase activity Source: Reactome
- retinol O-fatty-acyltransferase activity Source: UniProtKB
GO - Biological processi
- acylglycerol acyl-chain remodeling Source: Reactome
- lipid metabolic process Source: GO_Central
- monoacylglycerol biosynthetic process Source: UniProtKB
- retinoid metabolic process Source: Reactome
- wax biosynthetic process Source: Reactome
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.75, 2681 |
PathwayCommonsi | Q6E213 |
Reactomei | R-HSA-1482883, Acyl chain remodeling of DAG and TAG R-HSA-2187335, The retinoid cycle in cones (daylight vision) R-HSA-9640463, Wax biosynthesis |
Chemistry databases
SwissLipidsi | SLP:000000301 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA wax alcohol acyltransferase 2 (EC:2.3.1.754 Publications)Alternative name(s): 11-cis-specific retinyl-ester synthase1 Publication Short name: 11-cis-RE-synthase1 Publication Acyl-CoA retinol O-fatty-acyltransferase (EC:2.3.1.762 Publications) Short name: ARAT Short name: Retinol O-fatty-acyltransferase Diacylglycerol O-acyltransferase 2-like protein 4 Diacylglycerol O-acyltransferase candidate 4 Short name: hDC4 Long-chain-alcohol O-fatty-acyltransferase 2 Multifunctional O-acyltransferase1 Publication Wax synthase Short name: hWS |
Gene namesi | Name:AWAT2 Synonyms:DC4, DGAT2L4, MFAT1 Publication, WS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23251, AWAT2 |
MIMi | 300925, gene |
neXtProti | NX_Q6E213 |
VEuPathDBi | HostDB:ENSG00000147160 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 35 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 130 – 150 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 158835 |
OpenTargetsi | ENSG00000147160 |
PharmGKBi | PA164716410 |
Miscellaneous databases
Pharosi | Q6E213, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2375204 |
Genetic variation databases
BioMutai | AWAT2 |
DMDMi | 74748433 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249052 | 1 – 333 | Acyl-CoA wax alcohol acyltransferase 2Add BLAST | 333 |
Proteomic databases
jPOSTi | Q6E213 |
PaxDbi | Q6E213 |
PeptideAtlasi | Q6E213 |
PRIDEi | Q6E213 |
PTM databases
iPTMneti | Q6E213 |
PhosphoSitePlusi | Q6E213 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000147160, Expressed in lung and 24 other tissues |
ExpressionAtlasi | Q6E213, baseline and differential |
Organism-specific databases
HPAi | ENSG00000147160, Tissue enriched (skin) |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
BioGRIDi | 127716, 29 interactors |
STRINGi | 9606.ENSP00000421172 |
Chemistry databases
BindingDBi | Q6E213 |
Miscellaneous databases
RNActi | Q6E213, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q6E213 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01030000234582 |
HOGENOMi | CLU_023995_0_0_1 |
InParanoidi | Q6E213 |
OMAi | HYCNYFP |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q6E213 |
TreeFami | TF314707 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLLPSKKDLK TALDVFAVFQ WSFSALLITT TVIAVNLYLV VFTPYWPVTV
60 70 80 90 100
LILTWLAFDW KTPQRGGRRF TCVRHWRLWK HYSDYFPLKL LKTHDICPSR
110 120 130 140 150
NYILVCHPHG LFAHGWFGHF ATEASGFSKI FPGITPYILT LGAFFWMPFL
160 170 180 190 200
REYVMSTGAC SVSRSSIDFL LTHKGTGNMV IVVIGGLAEC RYSLPGSSTL
210 220 230 240 250
VLKNRSGFVR MALQHGVPLI PAYAFGETDL YDQHIFTPGG FVNRFQKWFQ
260 270 280 290 300
SMVHIYPCAF YGRGFTKNSW GLLPYSRPVT TIVGEPLPMP KIENPSQEIV
310 320 330
AKYHTLYIDA LRKLFDQHKT KFGISETQEL EII
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YAL0 | H0YAL0_HUMAN | Acyl-CoA wax alcohol acyltransferas... | AWAT2 | 166 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY605053 mRNA Translation: AAT68764.1 BC063698 mRNA Translation: AAH63698.1 BN000156 mRNA Translation: CAD89267.1 |
CCDSi | CCDS35320.1 |
RefSeqi | NP_001002254.1, NM_001002254.1 XP_011529178.1, XM_011530876.2 |
Genome annotation databases
Ensembli | ENST00000276101.7; ENSP00000421172.1; ENSG00000147160.9 |
GeneIDi | 158835 |
KEGGi | hsa:158835 |
MANE-Selecti | ENST00000276101.7; ENSP00000421172.1; NM_001002254.1; NP_001002254.1 |
UCSCi | uc004dxt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY605053 mRNA Translation: AAT68764.1 BC063698 mRNA Translation: AAH63698.1 BN000156 mRNA Translation: CAD89267.1 |
CCDSi | CCDS35320.1 |
RefSeqi | NP_001002254.1, NM_001002254.1 XP_011529178.1, XM_011530876.2 |
3D structure databases
AlphaFoldDBi | Q6E213 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127716, 29 interactors |
STRINGi | 9606.ENSP00000421172 |
Chemistry databases
BindingDBi | Q6E213 |
ChEMBLi | CHEMBL2375204 |
SwissLipidsi | SLP:000000301 |
PTM databases
iPTMneti | Q6E213 |
PhosphoSitePlusi | Q6E213 |
Genetic variation databases
BioMutai | AWAT2 |
DMDMi | 74748433 |
Proteomic databases
jPOSTi | Q6E213 |
PaxDbi | Q6E213 |
PeptideAtlasi | Q6E213 |
PRIDEi | Q6E213 |
Protocols and materials databases
Antibodypediai | 55918, 102 antibodies from 23 providers |
DNASUi | 158835 |
Genome annotation databases
Ensembli | ENST00000276101.7; ENSP00000421172.1; ENSG00000147160.9 |
GeneIDi | 158835 |
KEGGi | hsa:158835 |
MANE-Selecti | ENST00000276101.7; ENSP00000421172.1; NM_001002254.1; NP_001002254.1 |
UCSCi | uc004dxt.1, human |
Organism-specific databases
CTDi | 158835 |
DisGeNETi | 158835 |
GeneCardsi | AWAT2 |
HGNCi | HGNC:23251, AWAT2 |
HPAi | ENSG00000147160, Tissue enriched (skin) |
MIMi | 300925, gene |
neXtProti | NX_Q6E213 |
OpenTargetsi | ENSG00000147160 |
PharmGKBi | PA164716410 |
VEuPathDBi | HostDB:ENSG00000147160 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01030000234582 |
HOGENOMi | CLU_023995_0_0_1 |
InParanoidi | Q6E213 |
OMAi | HYCNYFP |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q6E213 |
TreeFami | TF314707 |
Enzyme and pathway databases
BRENDAi | 2.3.1.75, 2681 |
PathwayCommonsi | Q6E213 |
Reactomei | R-HSA-1482883, Acyl chain remodeling of DAG and TAG R-HSA-2187335, The retinoid cycle in cones (daylight vision) R-HSA-9640463, Wax biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 158835, 15 hits in 692 CRISPR screens |
GenomeRNAii | 158835 |
Pharosi | Q6E213, Tbio |
PROi | PR:Q6E213 |
RNActi | Q6E213, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147160, Expressed in lung and 24 other tissues |
ExpressionAtlasi | Q6E213, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AWAT2_HUMAN | |
Accessioni | Q6E213Primary (citable) accession number: Q6E213 Secondary accession number(s): Q6IEE3, Q6P437 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | August 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families