UniProtKB - Q6E0U4 (DMKN_HUMAN)
Dermokine
DMKN
Functioni
May act as a soluble regulator of keratinocyte differentiation.
CuratedGO - Biological processi
- cornified envelope assembly Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q6E0U4 |
SignaLinki | Q6E0U4 |
Names & Taxonomyi
Protein namesi | Recommended name: DermokineAlternative name(s): Epidermis-specific secreted protein SK30/SK89 |
Gene namesi | Name:DMKN ORF Names:UNQ729/PRO1411 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25063, DMKN |
neXtProti | NX_Q6E0U4 |
VEuPathDBi | HostDB:ENSG00000161249 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 93099 |
OpenTargetsi | ENSG00000161249 |
PharmGKBi | PA145149020 |
Miscellaneous databases
Pharosi | Q6E0U4, Tbio |
Genetic variation databases
BioMutai | DMKN |
DMDMi | 290457677 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000330764 | 22 – 476 | DermokineAdd BLAST | 455 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q6E0U4 |
MassIVEi | Q6E0U4 |
MaxQBi | Q6E0U4 |
PaxDbi | Q6E0U4 |
PeptideAtlasi | Q6E0U4 |
PRIDEi | Q6E0U4 |
ProteomicsDBi | 66258 [Q6E0U4-1] 66259 [Q6E0U4-10] 66260 [Q6E0U4-11] 66261 [Q6E0U4-12] 66262 [Q6E0U4-13] 66263 [Q6E0U4-14] 66265 [Q6E0U4-2] 66266 [Q6E0U4-3] 66267 [Q6E0U4-4] 66268 [Q6E0U4-5] 66269 [Q6E0U4-6] 66270 [Q6E0U4-7] 66271 [Q6E0U4-8] 66272 [Q6E0U4-9] 8509 |
PTM databases
iPTMneti | Q6E0U4 |
PhosphoSitePlusi | Q6E0U4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000161249, Expressed in skin of leg and 164 other tissues |
ExpressionAtlasi | Q6E0U4, baseline and differential |
Genevisiblei | Q6E0U4, HS |
Organism-specific databases
HPAi | ENSG00000161249, Tissue enriched (skin) |
Interactioni
Subunit structurei
Homooligomer. Seems to be able to homodimerize and homotrimerize.
1 PublicationBinary interactionsi
Q6E0U4
Protein-protein interaction databases
BioGRIDi | 125000, 27 interactors |
IntActi | Q6E0U4, 13 interactors |
MINTi | Q6E0U4 |
STRINGi | 9606.ENSP00000342012 |
Miscellaneous databases
RNActi | Q6E0U4, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q6E0U4 |
SMRi | Q6E0U4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 153 – 351 | DisorderedSequence analysisAdd BLAST | 199 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 200 – 320 | Polar residuesSequence analysisAdd BLAST | 121 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502T1EG, Eukaryota |
GeneTreei | ENSGT00570000079107 |
HOGENOMi | CLU_045546_1_0_1 |
InParanoidi | Q6E0U4 |
OMAi | WQGMPGS |
OrthoDBi | 917254at2759 |
PhylomeDBi | Q6E0U4 |
TreeFami | TF338112 |
Family and domain databases
InterProi | View protein in InterPro IPR033541, Dermokine |
PANTHERi | PTHR36881, PTHR36881, 1 hit |
s (16+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 16 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 16 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKFQGPLACL LLALCLGSGE AGPLQSGEES TGTNIGEALG HGLGDALSEG
60 70 80 90 100
VGKAIGKEAG GAAGSKVSEA LGQGTREAVG TGVRQVPGFG VADALGNRVG
110 120 130 140 150
EAAHALGNTG HEIGRQAEDV IRHGADAVRG SWQGVPGHNG AWETSGGHGI
160 170 180 190 200
FGSQGGLGGQ GQGNPGGLGT PWVHGYPGNS AGSFGMNPQG APWGQGGNGG
210 220 230 240 250
PPNFGTNTQG AVAQPGYGSV RASNQNEGCT NPPPSGSGGG SSNSGGGSGS
260 270 280 290 300
QSGSSGSGSN GDNNNGSSSG GSSSGSSSGG SSGGSSGGSS GNSGGSRGDS
310 320 330 340 350
GSESSWGSST GSSSGNHGGS GGGNGHKPGC EKPGNEARGS GESGIQNSET
360 370 380 390 400
SPGMFNFDTF WKNFKSKLGF INWDAINKNQ VPPPSTRALL YFSRLWEDFK
410 420 430 440 450
QNTPFLNWKA IIEGADASSL QKRAGRDDQN YNYNQHAYPT AYGGKYSVKT
460 470
PAKGGVSPSS SASRVQPGLL QWVKFW
The sequence of this isoform differs from the canonical sequence as follows:
1-324: Missing.
325-346: GHKPGCEKPGNEARGSGESGIQ → MRGQGSSWGSGGGDAVGGVNTV
The sequence of this isoform differs from the canonical sequence as follows:
1-344: Missing.
345-346: IQ → MR
The sequence of this isoform differs from the canonical sequence as follows:
1-344: Missing.
345-346: IQ → MR
429-429: Q → QPGAGWQEVAAVTSK
The sequence of this isoform differs from the canonical sequence as follows:
1-353: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-353: Missing.
429-429: Q → QPGAGWQEVAAVTSK
The sequence of this isoform differs from the canonical sequence as follows:
1-388: Missing.
389-413: LLYFSRLWEDFKQNTPFLNWKAIIE → MNMKPATASALLLLLLGLAWTQGSHGW
The sequence of this isoform differs from the canonical sequence as follows:
247-307: Missing.
346-346: Q → QGFRGQGVSSNMREISKEGNRLLGGSGDNYRGQGSSWGSGGGDAVGGVNTV
Computationally mapped potential isoform sequencesi
There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R265 | M0R265_HUMAN | Dermokine | DMKN | 184 | Annotation score: | ||
C9IYI1 | C9IYI1_HUMAN | Dermokine | DMKN | 253 | Annotation score: | ||
E7EMS7 | E7EMS7_HUMAN | Dermokine | DMKN | 131 | Annotation score: | ||
E9PAQ7 | E9PAQ7_HUMAN | Dermokine | DMKN | 99 | Annotation score: | ||
C9J3V3 | C9J3V3_HUMAN | Dermokine | DMKN | 116 | Annotation score: | ||
H7BZ95 | H7BZ95_HUMAN | Dermokine | DMKN | 201 | Annotation score: | ||
M0R0A5 | M0R0A5_HUMAN | Dermokine | DMKN | 201 | Annotation score: | ||
C9JCN1 | C9JCN1_HUMAN | Dermokine | DMKN | 203 | Annotation score: | ||
M0R1M0 | M0R1M0_HUMAN | Dermokine | DMKN | 74 | Annotation score: | ||
C9J186 | C9J186_HUMAN | Dermokine | DMKN | 172 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 111 | H → R in ABN11271 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 111 | H → R in ABN11272 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 198 | N → D in ABN11273 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 214 – 215 | QP → PA in ABN11273 (PubMed:17380110).Curated | 2 | |
Sequence conflicti | 271 | Missing in ABN11273 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 271 | Missing in ABN11274 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 279 | G → GSSSG in AAQ88778 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 378 | K → M in ABN11272 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 419 | S → L in ABN11272 (PubMed:17380110).Curated | 1 | |
Sequence conflicti | 450 | T → S in ABN11272 (PubMed:17380110).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042720 | 13 | A → D in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_056865 | 69 | E → D. Corresponds to variant dbSNP:rs12460932Ensembl. | 1 | |
Natural variantiVAR_059652 | 91 | V → A5 PublicationsCorresponds to variant dbSNP:rs4806163Ensembl. | 1 | |
Natural variantiVAR_056866 | 139 | N → S1 PublicationCorresponds to variant dbSNP:rs7247001Ensembl. | 1 | |
Natural variantiVAR_059653 | 280 | G → S1 PublicationCorresponds to variant dbSNP:rs11667007Ensembl. | 1 | |
Natural variantiVAR_042721 | 415 | A → S. Corresponds to variant dbSNP:rs2293696Ensembl. | 1 | |
Natural variantiVAR_047337 | 427 | D → A4 PublicationsCorresponds to variant dbSNP:rs909072Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033087 | 1 – 388 | Missing in isoform 15. CuratedAdd BLAST | 388 | |
Alternative sequenceiVSP_033088 | 1 – 353 | Missing in isoform 13 and isoform 14. 2 PublicationsAdd BLAST | 353 | |
Alternative sequenceiVSP_033089 | 1 – 344 | Missing in isoform 11 and isoform 12. 1 PublicationAdd BLAST | 344 | |
Alternative sequenceiVSP_033090 | 1 – 324 | Missing in isoform 10. 1 PublicationAdd BLAST | 324 | |
Alternative sequenceiVSP_033091 | 1 – 306 | Missing in isoform 9. 1 PublicationAdd BLAST | 306 | |
Alternative sequenceiVSP_033092 | 1 – 287 | Missing in isoform 8. 1 PublicationAdd BLAST | 287 | |
Alternative sequenceiVSP_033093 | 247 – 346 | GSGSQ…ESGIQ → SSTGSSSGNHGGSGGGNGHK PGCEKPGNEARGSGESGIQG FRGPGSFPXNMREISKEGNR LLGGSGDNYRGQGSSWGSGG GDAVGGVNTV in isoform 2. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_033094 | 247 – 307 | Missing in isoform 4 and isoform 16. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_033095 | 288 – 306 | GSSGN…SESSW → MLGITSCSDQQAKEGEGLE in isoform 8. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_033096 | 307 – 346 | GSSTG…ESGIQ → MSPPDQGVVESRLWRQMLHK GQGSSWGSGGGDAVGGVNTV in isoform 9. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_033097 | 325 – 346 | GHKPG…ESGIQ → MRGQGSSWGSGGGDAVGGVN TV in isoform 10. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_033098 | 330 – 346 | Missing in isoform 7. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_033099 | 345 – 346 | IQ → MR in isoform 11 and isoform 12. 1 Publication | 2 | |
Alternative sequenceiVSP_047249 | 346 | Q → QGFRGQGVSSNMREISKEGN RLLGGSGDNYRGQGSSWGSG GGDAVGGVNTV in isoform 16. Curated | 1 | |
Alternative sequenceiVSP_033100 | 346 | Q → QGQGSSWGSGGGDAVGGVNT V in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_033101 | 346 | Q → QGFRGQGVSSNMR in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_033102 | 347 – 476 | NSETS…WVKFW → GFRGQGVSSNMREISKEGNR LLGGSGDNYRGQGSSWGSGG GDAVGGVNTVNSETSPGMFN FDTFWKNFKSKLGFINWDAI NKDQRSSRIP in isoform 6. 1 PublicationAdd BLAST | 130 | |
Alternative sequenceiVSP_033103 | 379 – 386 | NQVPPPST → DQRSSRIP in isoform 3, isoform 5 and isoform 7. 2 Publications | 8 | |
Alternative sequenceiVSP_033104 | 387 – 476 | Missing in isoform 3, isoform 5 and isoform 7. 2 PublicationsAdd BLAST | 90 | |
Alternative sequenceiVSP_033105 | 389 – 413 | LLYFS…KAIIE → MNMKPATASALLLLLLGLAW TQGSHGW in isoform 15. CuratedAdd BLAST | 25 | |
Alternative sequenceiVSP_033106 | 429 | Q → QPGAGWQEVAAVTSK in isoform 4, isoform 12 and isoform 14. 3 Publications | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4F20 | X-ray | 2.50 | Q | 251-262 | [»] | |
AlphaFoldDBi | Q6E0U4 | |||||
SMRi | Q6E0U4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125000, 27 interactors |
IntActi | Q6E0U4, 13 interactors |
MINTi | Q6E0U4 |
STRINGi | 9606.ENSP00000342012 |
PTM databases
iPTMneti | Q6E0U4 |
PhosphoSitePlusi | Q6E0U4 |
Genetic variation databases
BioMutai | DMKN |
DMDMi | 290457677 |
Proteomic databases
EPDi | Q6E0U4 |
MassIVEi | Q6E0U4 |
MaxQBi | Q6E0U4 |
PaxDbi | Q6E0U4 |
PeptideAtlasi | Q6E0U4 |
PRIDEi | Q6E0U4 |
ProteomicsDBi | 66258 [Q6E0U4-1] 66259 [Q6E0U4-10] 66260 [Q6E0U4-11] 66261 [Q6E0U4-12] 66262 [Q6E0U4-13] 66263 [Q6E0U4-14] 66265 [Q6E0U4-2] 66266 [Q6E0U4-3] 66267 [Q6E0U4-4] 66268 [Q6E0U4-5] 66269 [Q6E0U4-6] 66270 [Q6E0U4-7] 66271 [Q6E0U4-8] 66272 [Q6E0U4-9] 8509 |
Protocols and materials databases
Antibodypediai | 29370, 108 antibodies from 20 providers |
DNASUi | 93099 |
Genome annotation databases
Organism-specific databases
CTDi | 93099 |
DisGeNETi | 93099 |
GeneCardsi | DMKN |
HGNCi | HGNC:25063, DMKN |
HPAi | ENSG00000161249, Tissue enriched (skin) |
neXtProti | NX_Q6E0U4 |
OpenTargetsi | ENSG00000161249 |
PharmGKBi | PA145149020 |
VEuPathDBi | HostDB:ENSG00000161249 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T1EG, Eukaryota |
GeneTreei | ENSGT00570000079107 |
HOGENOMi | CLU_045546_1_0_1 |
InParanoidi | Q6E0U4 |
OMAi | WQGMPGS |
OrthoDBi | 917254at2759 |
PhylomeDBi | Q6E0U4 |
TreeFami | TF338112 |
Enzyme and pathway databases
PathwayCommonsi | Q6E0U4 |
SignaLinki | Q6E0U4 |
Miscellaneous databases
BioGRID-ORCSi | 93099, 29 hits in 1074 CRISPR screens |
ChiTaRSi | DMKN, human |
GenomeRNAii | 93099 |
Pharosi | Q6E0U4, Tbio |
PROi | PR:Q6E0U4 |
RNActi | Q6E0U4, protein |
Gene expression databases
Bgeei | ENSG00000161249, Expressed in skin of leg and 164 other tissues |
ExpressionAtlasi | Q6E0U4, baseline and differential |
Genevisiblei | Q6E0U4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033541, Dermokine |
PANTHERi | PTHR36881, PTHR36881, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DMKN_HUMAN | |
Accessioni | Q6E0U4Primary (citable) accession number: Q6E0U4 Secondary accession number(s): A3EZ79 Q9BSY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | March 2, 2010 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families