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Protein

Probable G-protein coupled receptor 139

Gene

GPR139

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 139
Alternative name(s):
G(q)-coupled orphan receptor GPRg1
G-protein-coupled receptor PGR3
Gene namesi
Name:GPR139
Synonyms:GPRG1, PGR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000180269.7
HGNCiHGNC:19995 GPR139
neXtProtiNX_Q6DWJ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 65CytoplasmicSequence analysisAdd BLAST15
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 102ExtracellularSequence analysisAdd BLAST16
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 148CytoplasmicSequence analysisAdd BLAST25
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 181ExtracellularSequence analysisAdd BLAST12
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 228CytoplasmicSequence analysisAdd BLAST26
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 268ExtracellularSequence analysisAdd BLAST19
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 353CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180269
PharmGKBiPA134970866

Chemistry databases

ChEMBLiCHEMBL3632455
GuidetoPHARMACOLOGYi130

Polymorphism and mutation databases

BioMutaiGPR139
DMDMi74762300

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696151 – 353Probable G-protein coupled receptor 139Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6DWJ6
PaxDbiQ6DWJ6
PRIDEiQ6DWJ6
ProteomicsDBi66257

PTM databases

iPTMnetiQ6DWJ6
PhosphoSitePlusiQ6DWJ6

Expressioni

Tissue specificityi

Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues.1 Publication

Gene expression databases

BgeeiENSG00000180269 Expressed in 7 organ(s), highest expression level in caudate nucleus
CleanExiHS_GPR139
ExpressionAtlasiQ6DWJ6 baseline and differential

Organism-specific databases

HPAiHPA046596

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000458791

Chemistry databases

BindingDBiQ6DWJ6

Structurei

3D structure databases

ProteinModelPortaliQ6DWJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00390000006613
HOGENOMiHOG000231257
HOVERGENiHBG081564
InParanoidiQ6DWJ6
KOiK08428
OMAiSPIHNSW
OrthoDBiEOG091G0HIF
PhylomeDBiQ6DWJ6
TreeFamiTF334275

Family and domain databases

CDDicd15919 7tmA_GPR139, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR037486 GPR139
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6DWJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII
60 70 80 90 100
LSQLVARRQK SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP
110 120 130 140 150
DKIIEVLEFS SIHTSIWITV PLTIDRYIAV CHPLKYHTVS YPARTRKVIV
160 170 180 190 200
SVYITCFLTS IPYYWWPNIW TEDYISTSVH HVLIWIHCFT VYLVPCSIFF
210 220 230 240 250
ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL WAPRIIMILY
260 270 280 290 300
HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL
310 320 330 340 350
KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK

VSP
Length:353
Mass (Da):40,679
Last modified:August 16, 2004 - v1
Checksum:iCF1088FCE5C84F85
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPI8J3KPI8_HUMAN
Probable G-protein-coupled receptor...
GPR139
50Annotation score:

Sequence cautioni

The sequence BAB89307 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635179 mRNA Translation: AAT65818.1
AB196529 mRNA Translation: BAD97440.1
AB083594 Genomic DNA Translation: BAB89307.1 Sequence problems.
AK291384 mRNA Translation: BAF84073.1
CH471186 Genomic DNA Translation: EAW50306.1
BC137237 mRNA Translation: AAI37238.1
BC137238 mRNA Translation: AAI37239.1
AY255545 mRNA Translation: AAO85057.1
CCDSiCCDS32398.1
RefSeqiNP_001002911.1, NM_001002911.3
NP_001305412.1, NM_001318483.1
UniGeneiHs.446875

Genome annotation databases

EnsembliENST00000570682; ENSP00000458791; ENSG00000180269
GeneIDi124274
KEGGihsa:124274
UCSCiuc002dgu.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635179 mRNA Translation: AAT65818.1
AB196529 mRNA Translation: BAD97440.1
AB083594 Genomic DNA Translation: BAB89307.1 Sequence problems.
AK291384 mRNA Translation: BAF84073.1
CH471186 Genomic DNA Translation: EAW50306.1
BC137237 mRNA Translation: AAI37238.1
BC137238 mRNA Translation: AAI37239.1
AY255545 mRNA Translation: AAO85057.1
CCDSiCCDS32398.1
RefSeqiNP_001002911.1, NM_001002911.3
NP_001305412.1, NM_001318483.1
UniGeneiHs.446875

3D structure databases

ProteinModelPortaliQ6DWJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000458791

Chemistry databases

BindingDBiQ6DWJ6
ChEMBLiCHEMBL3632455
GuidetoPHARMACOLOGYi130

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6DWJ6
PhosphoSitePlusiQ6DWJ6

Polymorphism and mutation databases

BioMutaiGPR139
DMDMi74762300

Proteomic databases

EPDiQ6DWJ6
PaxDbiQ6DWJ6
PRIDEiQ6DWJ6
ProteomicsDBi66257

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570682; ENSP00000458791; ENSG00000180269
GeneIDi124274
KEGGihsa:124274
UCSCiuc002dgu.2 human

Organism-specific databases

CTDi124274
EuPathDBiHostDB:ENSG00000180269.7
GeneCardsiGPR139
HGNCiHGNC:19995 GPR139
HPAiHPA046596
neXtProtiNX_Q6DWJ6
OpenTargetsiENSG00000180269
PharmGKBiPA134970866
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00390000006613
HOGENOMiHOG000231257
HOVERGENiHBG081564
InParanoidiQ6DWJ6
KOiK08428
OMAiSPIHNSW
OrthoDBiEOG091G0HIF
PhylomeDBiQ6DWJ6
TreeFamiTF334275

Miscellaneous databases

GeneWikiiGPR139
GenomeRNAii124274
PROiPR:Q6DWJ6

Gene expression databases

BgeeiENSG00000180269 Expressed in 7 organ(s), highest expression level in caudate nucleus
CleanExiHS_GPR139
ExpressionAtlasiQ6DWJ6 baseline and differential

Family and domain databases

CDDicd15919 7tmA_GPR139, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR037486 GPR139
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP139_HUMAN
AccessioniPrimary (citable) accession number: Q6DWJ6
Secondary accession number(s): A8K5R9, Q86SP2, Q8TDU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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