GPR139

Functionⁱ

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

GO - Molecular functionⁱ

neuropeptide receptor activity Source: Ensembl
protein dimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 15845401
phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable G-protein coupled receptor 139 Alternative name(s): G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3
Gene namesⁱ	Name:GPR139 Synonyms:GPRG1, PGR3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180269.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19995 GPR139
neXtProtⁱ	NX_Q6DWJ6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 29	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	30 – 50	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	51 – 65	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	66 – 86	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	87 – 102	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	103 – 123	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	124 – 148	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	149 – 169	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	170 – 181	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	182 – 202	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	203 – 228	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	229 – 249	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	250 – 268	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	269 – 289	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	290 – 353	CytoplasmicSequence analysisAdd BLAST	64

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180269
PharmGKBⁱ	PA134970866

Chemistry databases

ChEMBLⁱ	CHEMBL3632455
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	130

Polymorphism and mutation databases

BioMutaⁱ	GPR139
DMDMⁱ	74762300

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069615	1 – 353	Probable G-protein coupled receptor 139Add BLAST		353

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q6DWJ6
PaxDbⁱ	Q6DWJ6
PRIDEⁱ	Q6DWJ6
ProteomicsDBⁱ	66257

PTM databases

iPTMnetⁱ	Q6DWJ6
PhosphoSitePlusⁱ	Q6DWJ6

Expressionⁱ

Tissue specificityⁱ

Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000180269 Expressed in 7 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_GPR139
ExpressionAtlasⁱ	Q6DWJ6 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046596

HPAⁱ

HPA046596

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000458791

STRINGⁱ

9606.ENSP00000458791

Chemistry databases

BindingDBⁱ

Q6DWJ6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6DWJ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006613
HOGENOMⁱ	HOG000231257
HOVERGENⁱ	HBG081564
InParanoidⁱ	Q6DWJ6
KEGG Orthology (KO) More...KOⁱ	K08428
OMAⁱ	SPIHNSW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HIF
PhylomeDBⁱ	Q6DWJ6
TreeFamⁱ	TF334275

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15919 7tmA_GPR139, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR037486 GPR139
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6DWJ6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII 
        60         70         80         90        100
LSQLVARRQK SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP 
       110        120        130        140        150
DKIIEVLEFS SIHTSIWITV PLTIDRYIAV CHPLKYHTVS YPARTRKVIV 
       160        170        180        190        200
SVYITCFLTS IPYYWWPNIW TEDYISTSVH HVLIWIHCFT VYLVPCSIFF 
       210        220        230        240        250
ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL WAPRIIMILY 
       260        270        280        290        300
HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL 
       310        320        330        340        350
KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK 

VSP

Length:353

Mass (Da):40,679

Last modified:August 16, 2004 - v1

Checksum:ⁱCF1088FCE5C84F85

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3KPI8	J3KPI8_HUMAN		Probable G-protein-coupled receptor... Probable G-protein-coupled receptor 139	GPR139	50	Annotation score:

Sequence cautionⁱ

The sequence BAB89307 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY635179 mRNA Translation: AAT65818.1 AB196529 mRNA Translation: BAD97440.1 AB083594 Genomic DNA Translation: BAB89307.1 Sequence problems. AK291384 mRNA Translation: BAF84073.1 CH471186 Genomic DNA Translation: EAW50306.1 BC137237 mRNA Translation: AAI37238.1 BC137238 mRNA Translation: AAI37239.1 AY255545 mRNA Translation: AAO85057.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32398.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001002911.1, NM_001002911.3 NP_001305412.1, NM_001318483.1
UniGeneⁱ	Hs.446875

Genome annotation databases

Ensemblⁱ	ENST00000570682; ENSP00000458791; ENSG00000180269
GeneIDⁱ	124274
KEGGⁱ	hsa:124274
UCSC genome browser More...UCSCⁱ	uc002dgu.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6DWJ6	G-protein coupled receptor 139		HUMAN		353	UniRef100_Q6DWJ6
G protein-coupled receptor 139		PANTR		353
G-protein coupled receptor 139		MACMU		353
Uncharacterized protein		COLAP		353
GPR139 isoform 1		PONAB		353
+11

Protein	Similar proteins		Species	Score	Length	Source
Q6DWJ6	G-protein coupled receptor 139		HUMAN		353	UniRef90_Q6DWJ6
G protein-coupled receptor 139		PANTR		353
G-protein coupled receptor 139		MACMU		353
Uncharacterized protein		COLAP		353
GPR139 isoform 1		PONAB		353
+74

Protein	Similar proteins		Species	Score	Length	Source
Q6DWJ6	Probable G-protein coupled receptor 139		MOUSE		345	UniRef50_Q80UC8
Probable G-protein coupled receptor 139		RAT		345
Putative G-protein coupled receptor 139		TUPCH		364
Putative G-protein coupled receptor 139		FUKDA		353
probable G-protein coupled receptor 139		Yangtze finless porpoise		352
+290

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY635179 mRNA Translation: AAT65818.1 AB196529 mRNA Translation: BAD97440.1 AB083594 Genomic DNA Translation: BAB89307.1 Sequence problems. AK291384 mRNA Translation: BAF84073.1 CH471186 Genomic DNA Translation: EAW50306.1 BC137237 mRNA Translation: AAI37238.1 BC137238 mRNA Translation: AAI37239.1 AY255545 mRNA Translation: AAO85057.1
CCDSⁱ	CCDS32398.1
RefSeqⁱ	NP_001002911.1, NM_001002911.3 NP_001305412.1, NM_001318483.1
UniGeneⁱ	Hs.446875

3D structure databases

ProteinModelPortalⁱ	Q6DWJ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000458791

STRINGⁱ

9606.ENSP00000458791

Chemistry databases

BindingDBⁱ	Q6DWJ6
ChEMBLⁱ	CHEMBL3632455
GuidetoPHARMACOLOGYⁱ	130

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q6DWJ6
PhosphoSitePlusⁱ	Q6DWJ6

Polymorphism and mutation databases

BioMutaⁱ	GPR139
DMDMⁱ	74762300

Proteomic databases

EPDⁱ	Q6DWJ6
PaxDbⁱ	Q6DWJ6
PRIDEⁱ	Q6DWJ6
ProteomicsDBⁱ	66257

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000570682; ENSP00000458791; ENSG00000180269
GeneIDⁱ	124274
KEGGⁱ	hsa:124274
UCSCⁱ	uc002dgu.2 human

Organism-specific databases

CTDⁱ	124274
EuPathDBⁱ	HostDB:ENSG00000180269.7
GeneCardsⁱ	GPR139
HGNCⁱ	HGNC:19995 GPR139
HPAⁱ	HPA046596
neXtProtⁱ	NX_Q6DWJ6
OpenTargetsⁱ	ENSG00000180269
PharmGKBⁱ	PA134970866
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00390000006613
HOGENOMⁱ	HOG000231257
HOVERGENⁱ	HBG081564
InParanoidⁱ	Q6DWJ6
KOⁱ	K08428
OMAⁱ	SPIHNSW
OrthoDBⁱ	EOG091G0HIF
PhylomeDBⁱ	Q6DWJ6
TreeFamⁱ	TF334275

Miscellaneous databases

GeneWikiⁱ	GPR139
GenomeRNAiⁱ	124274
Protein Ontology More...PROⁱ	PR:Q6DWJ6

Gene expression databases

Bgeeⁱ	ENSG00000180269 Expressed in 7 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_GPR139
ExpressionAtlasⁱ	Q6DWJ6 baseline and differential

Family and domain databases

CDDⁱ	cd15919 7tmA_GPR139, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR037486 GPR139
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GP139_HUMAN
Accessionⁱ	Q6DWJ6Primary (citable) accession number: Q6DWJ6 Secondary accession number(s): A8K5R9, Q86SP2, Q8TDU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	August 16, 2004
	Last modified:	November 7, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6DWJ6 (GP139_HUMAN)

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Probable G-protein coupled receptor 139

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ