UniProtKB - Q6DWJ6 (GP139_HUMAN)
Protein
Probable G-protein coupled receptor 139
Gene
GPR139
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
GO - Molecular functioni
- identical protein binding Source: Ensembl
- neuropeptide receptor activity Source: Ensembl
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q6DWJ6 |
Protein family/group databases
TCDBi | 9.A.14.13.25, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 139Alternative name(s): G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 |
Gene namesi | Name:GPR139 Synonyms:GPRG1, PGR3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180269.7 |
HGNCi | HGNC:19995, GPR139 |
MIMi | 618448, gene |
neXtProti | NX_Q6DWJ6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 51 – 65 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 66 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 102 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 103 – 123 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 148 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 149 – 169 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 181 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 182 – 202 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 228 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 229 – 249 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 250 – 268 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 353 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 124274 |
OpenTargetsi | ENSG00000180269 |
PharmGKBi | PA134970866 |
Miscellaneous databases
Pharosi | Q6DWJ6, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3632455 |
DrugCentrali | Q6DWJ6 |
GuidetoPHARMACOLOGYi | 130 |
Polymorphism and mutation databases
BioMutai | GPR139 |
DMDMi | 74762300 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069615 | 1 – 353 | Probable G-protein coupled receptor 139Add BLAST | 353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q6DWJ6 |
PRIDEi | Q6DWJ6 |
ProteomicsDBi | 66257 |
PTM databases
GlyGeni | Q6DWJ6, 1 site |
iPTMneti | Q6DWJ6 |
PhosphoSitePlusi | Q6DWJ6 |
Expressioni
Tissue specificityi
Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000180269, Expressed in cortical plate and 11 other tissues |
ExpressionAtlasi | Q6DWJ6, baseline and differential |
Organism-specific databases
HPAi | ENSG00000180269, Group enriched (brain, endometrium, smooth muscle) |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9606.ENSP00000458791 |
Chemistry databases
BindingDBi | Q6DWJ6 |
Miscellaneous databases
RNActi | Q6DWJ6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159473 |
HOGENOMi | CLU_009579_24_1_1 |
InParanoidi | Q6DWJ6 |
OMAi | MQMPPVP |
OrthoDBi | 790152at2759 |
PhylomeDBi | Q6DWJ6 |
TreeFami | TF334275 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6DWJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII
60 70 80 90 100
LSQLVARRQK SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP
110 120 130 140 150
DKIIEVLEFS SIHTSIWITV PLTIDRYIAV CHPLKYHTVS YPARTRKVIV
160 170 180 190 200
SVYITCFLTS IPYYWWPNIW TEDYISTSVH HVLIWIHCFT VYLVPCSIFF
210 220 230 240 250
ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL WAPRIIMILY
260 270 280 290 300
HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL
310 320 330 340 350
KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK
VSP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3KPI8 | J3KPI8_HUMAN | Probable G-protein-coupled receptor... | GPR139 | 50 | Annotation score: |
Sequence cautioni
The sequence BAB89307 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY635179 mRNA Translation: AAT65818.1 AB196529 mRNA Translation: BAD97440.1 AB083594 Genomic DNA Translation: BAB89307.1 Sequence problems. AK291384 mRNA Translation: BAF84073.1 CH471186 Genomic DNA Translation: EAW50306.1 BC137237 mRNA Translation: AAI37238.1 BC137238 mRNA Translation: AAI37239.1 AY255545 mRNA Translation: AAO85057.1 |
CCDSi | CCDS32398.1 |
RefSeqi | NP_001002911.1, NM_001002911.3 NP_001305412.1, NM_001318483.1 |
Genome annotation databases
Ensembli | ENST00000570682; ENSP00000458791; ENSG00000180269 |
GeneIDi | 124274 |
KEGGi | hsa:124274 |
UCSCi | uc002dgu.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY635179 mRNA Translation: AAT65818.1 AB196529 mRNA Translation: BAD97440.1 AB083594 Genomic DNA Translation: BAB89307.1 Sequence problems. AK291384 mRNA Translation: BAF84073.1 CH471186 Genomic DNA Translation: EAW50306.1 BC137237 mRNA Translation: AAI37238.1 BC137238 mRNA Translation: AAI37239.1 AY255545 mRNA Translation: AAO85057.1 |
CCDSi | CCDS32398.1 |
RefSeqi | NP_001002911.1, NM_001002911.3 NP_001305412.1, NM_001318483.1 |
3D structure databases
SMRi | Q6DWJ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000458791 |
Chemistry databases
BindingDBi | Q6DWJ6 |
ChEMBLi | CHEMBL3632455 |
DrugCentrali | Q6DWJ6 |
GuidetoPHARMACOLOGYi | 130 |
Protein family/group databases
TCDBi | 9.A.14.13.25, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q6DWJ6, 1 site |
iPTMneti | Q6DWJ6 |
PhosphoSitePlusi | Q6DWJ6 |
Polymorphism and mutation databases
BioMutai | GPR139 |
DMDMi | 74762300 |
Proteomic databases
PaxDbi | Q6DWJ6 |
PRIDEi | Q6DWJ6 |
ProteomicsDBi | 66257 |
Protocols and materials databases
Antibodypediai | 12144, 141 antibodies |
Genome annotation databases
Ensembli | ENST00000570682; ENSP00000458791; ENSG00000180269 |
GeneIDi | 124274 |
KEGGi | hsa:124274 |
UCSCi | uc002dgu.2, human |
Organism-specific databases
CTDi | 124274 |
DisGeNETi | 124274 |
EuPathDBi | HostDB:ENSG00000180269.7 |
GeneCardsi | GPR139 |
HGNCi | HGNC:19995, GPR139 |
HPAi | ENSG00000180269, Group enriched (brain, endometrium, smooth muscle) |
MIMi | 618448, gene |
neXtProti | NX_Q6DWJ6 |
OpenTargetsi | ENSG00000180269 |
PharmGKBi | PA134970866 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159473 |
HOGENOMi | CLU_009579_24_1_1 |
InParanoidi | Q6DWJ6 |
OMAi | MQMPPVP |
OrthoDBi | 790152at2759 |
PhylomeDBi | Q6DWJ6 |
TreeFami | TF334275 |
Enzyme and pathway databases
PathwayCommonsi | Q6DWJ6 |
Miscellaneous databases
BioGRID-ORCSi | 124274, 3 hits in 836 CRISPR screens |
ChiTaRSi | GPR139, human |
GeneWikii | GPR139 |
GenomeRNAii | 124274 |
Pharosi | Q6DWJ6, Tchem |
PROi | PR:Q6DWJ6 |
RNActi | Q6DWJ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180269, Expressed in cortical plate and 11 other tissues |
ExpressionAtlasi | Q6DWJ6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP139_HUMAN | |
Accessioni | Q6DWJ6Primary (citable) accession number: Q6DWJ6 Secondary accession number(s): A8K5R9, Q86SP2, Q8TDU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries