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Entry version 132 (02 Jun 2021)
Sequence version 1 (16 Aug 2004)
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Protein

LEM domain-containing protein 2

Gene

Lemd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nuclear structure organization (PubMed:16339967).

Required for maintaining the integrity of the nuclear envelope (By similarity).

By similarity1 Publication

Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465).

Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin DNA binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2980766, Nuclear Envelope Breakdown
R-MMU-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-MMU-4419969, Depolymerisation of the Nuclear Lamina
R-MMU-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LEM domain-containing protein 2
Alternative name(s):
Nuclear envelope transmembrane protein 25
Short name:
NET25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lemd2
Synonyms:Lem2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385045, Lemd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal by 11.5 dpc. At 10.5 dpc most tissues are substantially reduced in size, specifically neural and heart structures are developmentally less advanced and/or abnormal. At 10.5 dpc hyperactive MAPK and AKT signaling has been observed.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002852502 – 511LEM domain-containing protein 2Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei505PhosphoserineBy similarity1
Modified residuei507PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6DVA0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6DVA0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6DVA0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DVA0

PeptideAtlas

More...
PeptideAtlasi
Q6DVA0

PRoteomics IDEntifications database

More...
PRIDEi
Q6DVA0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
265059

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6DVA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6DVA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at detectable levels throughout later stages of mouse development such as 12 dpc, 14 dpc, 16 dpc and 18 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044857, Expressed in spleen and 269 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6DVA0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6DVA0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the lamin tail, in vitro.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230294, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058221

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6DVA0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6DVA0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 42LEMPROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 110DisorderedSequence analysisAdd BLAST93
Regioni80 – 112Interaction with lamin A/C complexesBy similarityAdd BLAST33
Regioni128 – 206DisorderedSequence analysisAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 80Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi145 – 167Basic and acidic residuesSequence analysisAdd BLAST23

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRKK, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160955

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_045257_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DVA0

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDNSTSW

Database of Orthologous Groups

More...
OrthoDBi
873705at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6DVA0

TreeFam database of animal gene trees

More...
TreeFami
TF315385

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1180, 1 hit
1.10.720.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011015, LEM/LEM-like_dom_sf
IPR003887, LEM_dom
IPR034994, LEMD2
IPR041885, MAN1_winged_helix_dom
IPR018996, MSC

The PANTHER Classification System

More...
PANTHERi
PTHR13428:SF8, PTHR13428:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03020, LEM, 1 hit
PF09402, MSC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00540, LEM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63451, SSF63451, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50954, LEM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6DVA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLSDLELR RELQALGFQP GPITDTTRNV YRNKLRRLRG EARLRDDERL
60 70 80 90 100
REDAGPREDA GPRGPERQRE EARLREEAPL RARPAASVLR SEPWPLSPSP
110 120 130 140 150
PAPSAASDAS GPYGNFGASA SPWAASRGLS YPPHAGPGPL RRRASVRGSS
160 170 180 190 200
EDDEDTRTPD RHAPGRGRHW WAPPSASARP HSALLGADAR PGLKGSRTGS
210 220 230 240 250
AGAGRTRPEV GRWLERCLSR LLLWASLGLL LGFLAILWVK MGKPSAPQEA
260 270 280 290 300
EDNMKLLPVD CERKTDEFCQ AKQKAALLEL LHELYNFLAI QAGNFECGNP
310 320 330 340 350
EKLKSKCIPV LEAQEYIANV TSSPSSRFKA ALTWILSSNK DVGIWLKGED
360 370 380 390 400
PSELATTVDK VVCLESARPR MGIGCRLSRA LLTAVTHVLI FFWCLAFLWG
410 420 430 440 450
LLILLKYRWR KLEEEEQAMY EMVKKIIDVV QDHYVDWEQD MERYPYVGIL
460 470 480 490 500
HVRDSLIPPQ SRRRMKRVWD RAVEFLASNE SRIQTESHRV AGEDMLVWRW
510
TKPSSFSDSE R
Length:511
Mass (Da):57,507
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i190BEA7724BF7EDB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BBB1A0A494BBB1_MOUSE
LEM domain-containing protein 2
Lemd2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38419 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357T → A in BAC38419 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY640307 mRNA Translation: AAT71319.1
AK082131 mRNA Translation: BAC38419.1 Sequence problems.
AK143224 mRNA Translation: BAE25316.1
BC026588 mRNA Translation: AAH26588.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50043.1

NCBI Reference Sequences

More...
RefSeqi
NP_666187.2, NM_146075.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000055117; ENSMUSP00000058221; ENSMUSG00000044857

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
224640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:224640

UCSC genome browser

More...
UCSCi
uc008bfm.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY640307 mRNA Translation: AAT71319.1
AK082131 mRNA Translation: BAC38419.1 Sequence problems.
AK143224 mRNA Translation: BAE25316.1
BC026588 mRNA Translation: AAH26588.1 Different initiation.
CCDSiCCDS50043.1
RefSeqiNP_666187.2, NM_146075.2

3D structure databases

SMRiQ6DVA0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230294, 1 interactor
STRINGi10090.ENSMUSP00000058221

PTM databases

iPTMnetiQ6DVA0
PhosphoSitePlusiQ6DVA0

Proteomic databases

EPDiQ6DVA0
jPOSTiQ6DVA0
MaxQBiQ6DVA0
PaxDbiQ6DVA0
PeptideAtlasiQ6DVA0
PRIDEiQ6DVA0
ProteomicsDBi265059

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1891, 137 antibodies

The DNASU plasmid repository

More...
DNASUi
224640

Genome annotation databases

EnsembliENSMUST00000055117; ENSMUSP00000058221; ENSMUSG00000044857
GeneIDi224640
KEGGimmu:224640
UCSCiuc008bfm.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221496
MGIiMGI:2385045, Lemd2

Phylogenomic databases

eggNOGiENOG502QRKK, Eukaryota
GeneTreeiENSGT00940000160955
HOGENOMiCLU_045257_0_0_1
InParanoidiQ6DVA0
OMAiEDNSTSW
OrthoDBi873705at2759
PhylomeDBiQ6DVA0
TreeFamiTF315385

Enzyme and pathway databases

ReactomeiR-MMU-2980766, Nuclear Envelope Breakdown
R-MMU-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-MMU-4419969, Depolymerisation of the Nuclear Lamina
R-MMU-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
224640, 11 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lemd2, mouse

Protein Ontology

More...
PROi
PR:Q6DVA0
RNActiQ6DVA0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044857, Expressed in spleen and 269 other tissues
ExpressionAtlasiQ6DVA0, baseline and differential
GenevisibleiQ6DVA0, MM

Family and domain databases

Gene3Di1.10.10.1180, 1 hit
1.10.720.40, 1 hit
InterProiView protein in InterPro
IPR011015, LEM/LEM-like_dom_sf
IPR003887, LEM_dom
IPR034994, LEMD2
IPR041885, MAN1_winged_helix_dom
IPR018996, MSC
PANTHERiPTHR13428:SF8, PTHR13428:SF8, 1 hit
PfamiView protein in Pfam
PF03020, LEM, 1 hit
PF09402, MSC, 1 hit
SMARTiView protein in SMART
SM00540, LEM, 1 hit
SUPFAMiSSF63451, SSF63451, 1 hit
PROSITEiView protein in PROSITE
PS50954, LEM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEMD2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DVA0
Secondary accession number(s): Q8C4H8, Q8R0N2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: August 16, 2004
Last modified: June 2, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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