Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (02 Jun 2021)
Sequence version 1 (16 Aug 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Proteasome subunit beta

Gene

psmb1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-1169091, Activation of NF-kappaB in B cells
R-DRE-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DRE-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-DRE-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154, APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DRE-195253, Degradation of beta-catenin by the destruction complex
R-DRE-2467813, Separation of Sister Chromatids
R-DRE-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-DRE-350562, Regulation of ornithine decarboxylase (ODC)
R-DRE-382556, ABC-family proteins mediated transport
R-DRE-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DRE-4608870, Asymmetric localization of PCP proteins
R-DRE-4641257, Degradation of AXIN
R-DRE-4641258, Degradation of DVL
R-DRE-5358346, Hedgehog ligand biogenesis
R-DRE-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DRE-5610780, Degradation of GLI1 by the proteasome
R-DRE-5610785, GLI3 is processed to GLI3R by the proteasome
R-DRE-5632684, Hedgehog 'on' state
R-DRE-5658442, Regulation of RAS by GAPs
R-DRE-5668541, TNFR2 non-canonical NF-kB pathway
R-DRE-5676590, NIK-->noncanonical NF-kB signaling
R-DRE-5687128, MAPK6/MAPK4 signaling
R-DRE-5689603, UCH proteinases
R-DRE-5689880, Ub-specific processing proteases
R-DRE-6798695, Neutrophil degranulation
R-DRE-68827, CDT1 association with the CDC6:ORC:origin complex
R-DRE-68949, Orc1 removal from chromatin
R-DRE-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DRE-69481, G2/M Checkpoints
R-DRE-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DRE-75815, Ubiquitin-dependent degradation of Cyclin D
R-DRE-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-DRE-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DRE-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DRE-8939902, Regulation of RUNX2 expression and activity
R-DRE-8941858, Regulation of RUNX3 expression and activity
R-DRE-8948751, Regulation of PTEN stability and activity
R-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
T01.990

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:psmb1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040618-2, psmb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation, ProteasomeUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6DRF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000009640, Expressed in retina and 31 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the proteasome complex.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000011778

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0179, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035750_1_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHYTGPV

Database of Orthologous Groups

More...
OrthoDBi
1092660at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR035202, Proteasome_beta1
IPR016050, Proteasome_bsu_CS
IPR001353, Proteasome_sua/b
IPR023333, Proteasome_suB-type

The PANTHER Classification System

More...
PANTHERi
PTHR11599:SF59, PTHR11599:SF59, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00227, Proteasome, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00854, PROTEASOME_BETA_1, 1 hit
PS51476, PROTEASOME_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6DRF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISAQAYGEN GKMKEYHYTG PVEHKFSPYA FNGGTVLAVA GEDFAIVASD
60 70 80 90 100
TRLSEGYSIH SRDSPKCYKL TDTTVLGCSG FHGDCLTLTK IIEARLKMYK
110 120 130 140 150
HSNNKSMTSG AIAAMLSTIL YGRRFFPYYV YNIIGGLDEE GRGAVYSFDP
160 170 180 190 200
VGSYQRDTYK AGGSASAMLQ PLLDNQIGFK NMENVEHVPL TQEKAVQLVK
210 220 230
DVFISAAERD VYTGDALKVC IVSKEGIKEE IVPLRKD
Length:237
Mass (Da):26,101
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5FCB5C17E976263
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX323887 Genomic DNA No translation available.
BC085580 mRNA Translation: AAH85580.1
BC165077 mRNA Translation: AAI65077.1
AY648806 mRNA Translation: AAT68124.1

NCBI Reference Sequences

More...
RefSeqi
NP_001003889.1, NM_001003889.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000007231; ENSDARP00000011778; ENSDARG00000009640

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
445413

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:445413

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323887 Genomic DNA No translation available.
BC085580 mRNA Translation: AAH85580.1
BC165077 mRNA Translation: AAI65077.1
AY648806 mRNA Translation: AAT68124.1
RefSeqiNP_001003889.1, NM_001003889.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011778

Protein family/group databases

MEROPSiT01.990

Proteomic databases

PRIDEiQ6DRF3

Genome annotation databases

EnsembliENSDART00000007231; ENSDARP00000011778; ENSDARG00000009640
GeneIDi445413
KEGGidre:445413

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5689
ZFINiZDB-GENE-040618-2, psmb1

Phylogenomic databases

eggNOGiKOG0179, Eukaryota
GeneTreeiENSGT00550000075035
HOGENOMiCLU_035750_1_1_1
OMAiYHYTGPV
OrthoDBi1092660at2759
TreeFamiTF106218

Enzyme and pathway databases

ReactomeiR-DRE-1169091, Activation of NF-kappaB in B cells
R-DRE-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DRE-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-DRE-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154, APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DRE-195253, Degradation of beta-catenin by the destruction complex
R-DRE-2467813, Separation of Sister Chromatids
R-DRE-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-DRE-350562, Regulation of ornithine decarboxylase (ODC)
R-DRE-382556, ABC-family proteins mediated transport
R-DRE-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DRE-4608870, Asymmetric localization of PCP proteins
R-DRE-4641257, Degradation of AXIN
R-DRE-4641258, Degradation of DVL
R-DRE-5358346, Hedgehog ligand biogenesis
R-DRE-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DRE-5610780, Degradation of GLI1 by the proteasome
R-DRE-5610785, GLI3 is processed to GLI3R by the proteasome
R-DRE-5632684, Hedgehog 'on' state
R-DRE-5658442, Regulation of RAS by GAPs
R-DRE-5668541, TNFR2 non-canonical NF-kB pathway
R-DRE-5676590, NIK-->noncanonical NF-kB signaling
R-DRE-5687128, MAPK6/MAPK4 signaling
R-DRE-5689603, UCH proteinases
R-DRE-5689880, Ub-specific processing proteases
R-DRE-6798695, Neutrophil degranulation
R-DRE-68827, CDT1 association with the CDC6:ORC:origin complex
R-DRE-68949, Orc1 removal from chromatin
R-DRE-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DRE-69481, G2/M Checkpoints
R-DRE-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DRE-75815, Ubiquitin-dependent degradation of Cyclin D
R-DRE-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-DRE-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DRE-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DRE-8939902, Regulation of RUNX2 expression and activity
R-DRE-8941858, Regulation of RUNX3 expression and activity
R-DRE-8948751, Regulation of PTEN stability and activity
R-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSDARG00000009640, Expressed in retina and 31 other tissues

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR035202, Proteasome_beta1
IPR016050, Proteasome_bsu_CS
IPR001353, Proteasome_sua/b
IPR023333, Proteasome_suB-type
PANTHERiPTHR11599:SF59, PTHR11599:SF59, 1 hit
PfamiView protein in Pfam
PF00227, Proteasome, 1 hit
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854, PROTEASOME_BETA_1, 1 hit
PS51476, PROTEASOME_BETA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6DRF3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DRF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 2, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again