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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/Viet Nam/1203/2004(H5N1))
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

Enzyme regulationi

Inhibited by the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs interfere with the release of progeny virus from infected cells and are effective against all influenza strains. Resistance to neuraminidase inhibitors is quite rare.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98SubstrateUniRule annotation1
Binding sitei126N-acetyl-D-glucosamineCombined sources1
Active sitei131Proton donor/acceptorUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei273SubstrateUniRule annotation1
Metal bindingi274Calcium; via carbonyl oxygenUniRule annotationCombined sources1
Metal bindingi278Calcium; via carbonyl oxygenUniRule annotationCombined sources1
Metal bindingi304CalciumUniRule annotationCombined sources1
Metal bindingi322Calcium; via carbonyl oxygenCombined sources1
Metal bindingi324Calcium; via carbonyl oxygenCombined sources1
Binding sitei348SubstrateUniRule annotation1
Active sitei382NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationCombined sourcesSAAS annotation, Metal-bindingUniRule annotationCombined sourcesSAAS annotation

Enzyme and pathway databases

SABIO-RKiQ6DPL2

Protein family/group databases

CAZyiGH34 Glycoside Hydrolase Family 34

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (A/Viet Nam/1203/2004(H5N1))Imported
Taxonomic identifieri284218 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Proteomesi
  • UP000102152 Componenti: Genome
  • UP000206680 Componenti: Genome
  • UP000206660 Componenti: Genome
  • UP000206700 Componenti: Genome

Subcellular locationi

  • Host apical cell membrane SAAS annotation; Single-pass type II membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 34HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 397UniRule annotationCombined sources
Disulfide bondi104 ↔ 109UniRule annotationCombined sources
Disulfide bondi164 ↔ 211UniRule annotationCombined sources
Disulfide bondi213 ↔ 218UniRule annotationCombined sources
Disulfide bondi259 ↔ 272UniRule annotationCombined sources
Disulfide bondi261 ↔ 270UniRule annotationCombined sources
Disulfide bondi298 ↔ 315UniRule annotationCombined sources
Disulfide bondi401 ↔ 426UniRule annotationCombined sources

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-59842N

Structurei

3D structure databases

SMRiQ6DPL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 33Involved in apical transport and lipid raft associationUniRule annotationAdd BLAST23
Regioni71 – 449Head of neuraminidaseUniRule annotationAdd BLAST379
Regioni257 – 258Substrate bindingUniRule annotation2

Domaini

Intact N-terminus is essential for virion morphogenesis. Possess two apical sorting signals, one in the ectodomain, which is likely to be a glycan, and the other in the transmembrane domain. The transmembrane domain also plays a role in lipid raft association.UniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd15483 Influenza_NA, 1 hit
HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DPL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPNQKIITI GSICMVTGIV SLMLQIGNMI SIWVSHSIHT GNQHQSEPIS
60 70 80 90 100
NTNFLTEKAV ASVKLAGNSS LCPINGWAVY SKDNSIRIGS KGDVFVIREP
110 120 130 140 150
FISCSHLECR TFFLTQGALL NDKHSNGTVK DRSPHRTLMS CPVGEAPSPY
160 170 180 190 200
NSRFESVAWS ASACHDGTSW LTIGISGPDN GAVAVLKYNG IITDTIKSWR
210 220 230 240 250
NNILRTQESE CACVNGSCFT VMTDGPSNGQ ASHKIFKMEK GKVVKSVELD
260 270 280 290 300
APNYHYEECS CYPNAGEITC VCRDNWHGSN RPWVSFNQNL EYQIGYICSG
310 320 330 340 350
VFGDNPRPND GTGSCGPVSS NGAYGVKGFS FKYGNGVWIG RTKSTNSRSG
360 370 380 390 400
FEMIWDPNGW TETDSSFSVK QDIVAITDWS GYSGSFVQHP ELTGLDCIRP
410 420 430 440
CFWVELIRGR PKESTIWTSG SSISFCGVNS DTVGWSWPDG AELPFTIDK
Length:449
Mass (Da):49,081
Last modified:August 16, 2004 - v1
Checksum:i5FCFA35BAC5F9902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY651447 Viral cRNA Translation: AAT73329.1
AY818141 Genomic RNA Translation: AAW80723.1
EF541467 Viral cRNA Translation: ABP52008.1
HM006761 Viral cRNA Translation: ADD97097.1

Similar proteinsi

Entry informationi

Entry nameiQ6DPL2_9INFA
AccessioniPrimary (citable) accession number: Q6DPL2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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