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Entry version 113 (12 Aug 2020)
Sequence version 1 (16 Aug 2004)
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Protein

Soluble guanylate cyclase gcy-37

Gene

gcy-37

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons.By similarity

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 1 or 2 heme groups per heterodimer.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi105Iron (heme proximal ligand)By similarity1
Metal bindingi439MagnesiumBy similarity1
Metal bindingi483MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Heme, Iron, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Soluble guanylate cyclase gcy-37 (EC:4.6.1.2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gcy-37
ORF Names:C54E4.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C54E4.3 ; CE37494 ; WBGene00001557 ; gcy-37

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000741281 – 708Soluble guanylate cyclase gcy-37Add BLAST708

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DNF3

PRoteomics IDEntifications database

More...
PRIDEi
Q6DNF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001557, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; with other soluble guanylate cyclases.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C54E4.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6DNF3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini434 – 562Guanylate cyclasePROSITE-ProRule annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili368 – 409Sequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1573, Eukaryota
KOG4171, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011614_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DNF3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKSEMKG

Database of Orthologous Groups

More...
OrthoDBi
531253at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6DNF3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.450.260, 1 hit
3.30.70.1230, 1 hit
3.90.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR038158, H-NOX_domain_sf
IPR011644, Heme_NO-bd
IPR011645, HNOB_dom_associated
IPR042463, HNOB_dom_associated_sf
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR029787, Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF07700, HNOB, 1 hit
PF07701, HNOBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111126, SSF111126, 1 hit
SSF55073, SSF55073, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6DNF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGWTHVCVS ALILRKYGPE VLEEILRKAG YQEDIKFDIQ CYYDDTETMR
60 70 80 90 100
IFRVAATVLG LSVDDMWEMY GEFLITHACE TGWQKMLFCM ANNLQEFLDN
110 120 130 140 150
LNSMHYFIDQ IAFKSEMKGP TFQCEPFGES GLKLHYFSFR QGLFPIVKGL
160 170 180 190 200
VRKTARTLFE MDVKVCMLER NQERRKSGMV EHVIFSVEPD DNHRKGKRLF
210 220 230 240 250
HKFRNTKTTE NAPSFTLSST ILVGLRDFKN IFPYHVCFNK QMIIEHIGIY
260 270 280 290 300
LLREYGLENK KTLKVSDLMQ LVQPSDIQLT YKNVLSYLNT LFIFQLKHHS
310 320 330 340 350
KRNEVQEGSS EAFQQPLVLK GEMMPINDGN SIIFICSPHV TTVRDILNLK
360 370 380 390 400
LYISDMPMHD ATRDLVMLNQ SRICQMELNK KLEETMKKMK KMTEELEVKK
410 420 430 440 450
SQTDRLLFEF VPPVIAEALR AAKTVPAQEF SDCSVIFTDI PDFFTISVNC
460 470 480 490 500
SPTEIITVVT DLFHRFDRII EKHKGYKVLS LMDSYLIVGG VPNANQYHCE
510 520 530 540 550
DSLNLALGLL FEAKQVVVPK LERSVRLRIG VHCGPVVAGI VSQQKPRFCV
560 570 580 590 600
LGNTVNVTKS ICSHSSPGKV LVSNAVRTMV TKHLKSIFVF NANGYLELQS
610 620 630 640 650
GKVLTHFLEK NEKCSVWDIV DRDKATNDSI DGYRELHSDN GTEEWQEATV
660 670 680 690 700
AAYRVISVVD ALENKQSRTR KALTRLRSVK RKFRTIQSND SGVSVSEPNV

ESAVCSIM
Length:708
Mass (Da):81,104
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34CBFD592F48B715
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY652946 mRNA Translation: AAT73713.1
FO080949 Genomic DNA Translation: CCD68037.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F88642

NCBI Reference Sequences

More...
RefSeqi
NP_500171.2, NM_067770.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C54E4.3.1; C54E4.3.1; WBGene00001557

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
191658

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C54E4.3

UCSC genome browser

More...
UCSCi
C54E4.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY652946 mRNA Translation: AAT73713.1
FO080949 Genomic DNA Translation: CCD68037.1
PIRiF88642
RefSeqiNP_500171.2, NM_067770.3

3D structure databases

SMRiQ6DNF3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C54E4.3

Proteomic databases

PaxDbiQ6DNF3
PRIDEiQ6DNF3

Genome annotation databases

EnsemblMetazoaiC54E4.3.1; C54E4.3.1; WBGene00001557
GeneIDi191658
KEGGicel:CELE_C54E4.3
UCSCiC54E4.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
191658
WormBaseiC54E4.3 ; CE37494 ; WBGene00001557 ; gcy-37

Phylogenomic databases

eggNOGiKOG1573, Eukaryota
KOG4171, Eukaryota
HOGENOMiCLU_011614_4_0_1
InParanoidiQ6DNF3
OMAiFKSEMKG
OrthoDBi531253at2759
PhylomeDBiQ6DNF3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6DNF3

Gene expression databases

BgeeiWBGene00001557, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

Gene3Di3.30.450.260, 1 hit
3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR038158, H-NOX_domain_sf
IPR011644, Heme_NO-bd
IPR011645, HNOB_dom_associated
IPR042463, HNOB_dom_associated_sf
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR029787, Nucleotide_cyclase
PfamiView protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF07700, HNOB, 1 hit
PF07701, HNOBA, 1 hit
SMARTiView protein in SMART
SM00044, CYCc, 1 hit
SUPFAMiSSF111126, SSF111126, 1 hit
SSF55073, SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCY37_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DNF3
Secondary accession number(s): O44468, Q65CM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: August 12, 2020
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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