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Entry version 130 (26 Feb 2020)
Sequence version 2 (20 Mar 2007)
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Protein

Fc receptor-like protein 6

Gene

FCRL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8+ T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fc receptor-like protein 6
Short name:
FcR-like protein 6
Short name:
FcRL6
Alternative name(s):
Fc receptor homolog 6
Short name:
FcRH6
IFGP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCRL6
Synonyms:FCRH6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:31910 FCRL6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613562 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6DN72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 307ExtracellularSequence analysisAdd BLAST288
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 434CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi356Y → F: No change of phosphorylation implicated in interaction with PTPN11. Loss of interaction with INPPD5, INPPL1 and GRB2. 2 Publications1
Mutagenesisi371Y → F: Loss of phosphorylation implicated in interaction with PTPN11. Loss of interaction with PTPN11, PTPN6 and INPPL1. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
343413

Open Targets

More...
OpenTargetsi
ENSG00000181036

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671770

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6DN72 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FCRL6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134034126

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028021320 – 434Fc receptor-like protein 6Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 83PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 180PROSITE-ProRule annotation
Disulfide bondi228 ↔ 276PROSITE-ProRule annotation
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei371Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6DN72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DN72

PeptideAtlas

More...
PeptideAtlasi
Q6DN72

PRoteomics IDEntifications database

More...
PRIDEi
Q6DN72

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66248 [Q6DN72-1]
66249 [Q6DN72-2]
66250 [Q6DN72-3]
66251 [Q6DN72-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6DN72-3 [Q6DN72-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6DN72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6DN72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells, and a subset of NKT cells (at protein level) (PubMed:17213291, PubMed:18991291, PubMed:20933011). Also expressed in gamma delta T cells and in a rare subset of effector CD4+ T-cells (at protein level) (PubMed:18991291). Expressed in spleen, skin, peripheral blood leukocytes, liver, lung, bone marrow, small intestine and placenta (PubMed:20933011). Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells (PubMed:17213291, PubMed:20933011). Expression among CD8+ T-cells and NK cells is expanded in individuals with chronic lymphocytic leukemia (CLL) but is reduced in PBMCs from patients with acute (AML), chronic myeloid leukemia (CML) and non-Hodgkin's lymphoma (PubMed:18991291, PubMed:20933011). Expression is higher in PBMCs and/or CD3+ cells of patients with autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and idiopathic thrombocytopenia purpura (ITP) (PubMed:20933011). In contrast, expression in CD3+ cells from patients with lupus anticoagulans (LA) is higher (PubMed:20933011).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated upon stimulation with mitogen phytohaemagglutinin (PHA) or concavalin A in peripheral blood mononuclear cells (PBMCs).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181036 Expressed in spleen and 84 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6DN72 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (tyrosine phosphorylated) with PTPN11 (PubMed:17213291, PubMed:20933011).

Interacts (tyrosine phosphorylated) with PTPN6, INPP5D, INPPL1 and GRB2 (PubMed:20933011).

Interacts with class II MHC HLA-DR when the alpha chain is associated with a beta-1, beta-4 or a beta-5 but not a beta-3 chain (PubMed:20519654).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6DN72 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6DN72

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 95Ig-like C2-type 1Add BLAST76
Domaini111 – 197Ig-like C2-type 2Add BLAST87
Domaini207 – 293Ig-like C2-type 3Add BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi369 – 374ITIM motif6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.1 Publication

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J025 Eukaryota
ENOG41117EG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186653

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023383_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DN72

KEGG Orthology (KO)

More...
KOi
K17273

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRSEMTT

Database of Orthologous Groups

More...
OrthoDBi
866496at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6DN72

TreeFam database of animal gene trees

More...
TreeFami
TF335097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6DN72-1) [UniParc]FASTAAdd to basket
Also known as: FCRL6v11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLWTAVLLF VPCVGKTVWL YLQAWPNPVF EGDALTLRCQ GWKNTPLSQV
60 70 80 90 100
KFYRDGKFLH FSKENQTLSM GAATVQSRGQ YSCSGQVMYI PQTFTQTSET
110 120 130 140 150
AMVQVQELFP PPVLSAIPSP EPREGSLVTL RCQTKLHPLR SALRLLFSFH
160 170 180 190 200
KDGHTLQDRG PHPELCIPGA KEGDSGLYWC EVAPEGGQVQ KQSPQLEVRV
210 220 230 240 250
QAPVSRPVLT LHHGPADPAV GDMVQLLCEA QRGSPPILYS FYLDEKIVGN
260 270 280 290 300
HSAPCGGTTS LLFPVKSEQD AGNYSCEAEN SVSRERSEPK KLSLKGSQVL
310 320 330 340 350
FTPASNWLVP WLPASLLGLM VIAAALLVYV RSWRKAGPLP SQIPPTAPGG
360 370 380 390 400
EQCPLYANVH HQKGKDEGVV YSVVHRTSKR SEARSAEFTV GRKDSSIICA
410 420 430
EVRCLQPSEV SSTEVNMRSR TLQEPLSDCE EVLC
Length:434
Mass (Da):47,748
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i469C1E503AB2CDDE
GO
Isoform 2 (identifier: Q6DN72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLPSLGPM
     394-406: DSSIICAEVRCLQ → FYHLCGGEMPAAQ
     407-434: Missing.

Show »
Length:413
Mass (Da):45,309
Checksum:i8618AE9172BAE4F1
GO
Isoform 3 (identifier: Q6DN72-3) [UniParc]FASTAAdd to basket
Also known as: FCRL6v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     383-397: ARSAEFTVGRKDSSI → GQFYHLCGGEMPAAQ
     398-434: Missing.

Show »
Length:397
Mass (Da):43,595
Checksum:i33F9DF84E0D52EE4
GO
Isoform 4 (identifier: Q6DN72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-199: Missing.
     394-406: DSSIICAEVRCLQ → FYHLCGGEMPAAQ
     407-434: Missing.

Show »
Length:311
Mass (Da):34,128
Checksum:i28F4161B10AB4FD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYB3F5GYB3_HUMAN
Fc receptor-like protein 6
FCRL6
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51 – 52KF → RL in AAP47270 (Ref. 2) Curated2
Sequence conflicti59L → P in AAP47270 (Ref. 2) Curated1
Sequence conflicti114L → P in AAP47270 (Ref. 2) Curated1
Sequence conflicti123R → Q in AAP47270 (Ref. 2) Curated1
Sequence conflicti250N → S in AAT66025 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031090427S → G. Corresponds to variant dbSNP:rs4443889Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0235651M → MLPSLGPM in isoform 2. 1 Publication1
Alternative sequenceiVSP_023566105 – 199Missing in isoform 4. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_023567383 – 397ARSAE…KDSSI → GQFYHLCGGEMPAAQ in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023568394 – 406DSSII…VRCLQ → FYHLCGGEMPAAQ in isoform 2 and isoform 4. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_023569398 – 434Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_023570407 – 434Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY513661 mRNA Translation: AAS82876.1
AY212514 mRNA Translation: AAP47270.1
AY654627 mRNA Translation: AAT66024.1
AY654628 mRNA Translation: AAT66025.1
AK131201 mRNA Translation: BAD18394.1
AL590560 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS30912.1 [Q6DN72-1]
CCDS60312.1 [Q6DN72-2]

NCBI Reference Sequences

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RefSeqi
NP_001004310.2, NM_001004310.2 [Q6DN72-1]
NP_001271146.1, NM_001284217.1 [Q6DN72-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000321935; ENSP00000320625; ENSG00000181036 [Q6DN72-2]
ENST00000339348; ENSP00000340949; ENSG00000181036 [Q6DN72-3]
ENST00000368106; ENSP00000357086; ENSG00000181036 [Q6DN72-1]
ENST00000392235; ENSP00000376068; ENSG00000181036 [Q6DN72-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
343413

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:343413

UCSC genome browser

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UCSCi
uc001fuc.4 human [Q6DN72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513661 mRNA Translation: AAS82876.1
AY212514 mRNA Translation: AAP47270.1
AY654627 mRNA Translation: AAT66024.1
AY654628 mRNA Translation: AAT66025.1
AK131201 mRNA Translation: BAD18394.1
AL590560 Genomic DNA No translation available.
CCDSiCCDS30912.1 [Q6DN72-1]
CCDS60312.1 [Q6DN72-2]
RefSeqiNP_001004310.2, NM_001004310.2 [Q6DN72-1]
NP_001271146.1, NM_001284217.1 [Q6DN72-2]

3D structure databases

SMRiQ6DN72
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357086

PTM databases

iPTMnetiQ6DN72
PhosphoSitePlusiQ6DN72

Polymorphism and mutation databases

BioMutaiFCRL6
DMDMi134034126

Proteomic databases

MassIVEiQ6DN72
PaxDbiQ6DN72
PeptideAtlasiQ6DN72
PRIDEiQ6DN72
ProteomicsDBi66248 [Q6DN72-1]
66249 [Q6DN72-2]
66250 [Q6DN72-3]
66251 [Q6DN72-4]
TopDownProteomicsiQ6DN72-3 [Q6DN72-3]

Genome annotation databases

EnsembliENST00000321935; ENSP00000320625; ENSG00000181036 [Q6DN72-2]
ENST00000339348; ENSP00000340949; ENSG00000181036 [Q6DN72-3]
ENST00000368106; ENSP00000357086; ENSG00000181036 [Q6DN72-1]
ENST00000392235; ENSP00000376068; ENSG00000181036 [Q6DN72-4]
GeneIDi343413
KEGGihsa:343413
UCSCiuc001fuc.4 human [Q6DN72-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
343413
DisGeNETi343413

GeneCards: human genes, protein and diseases

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GeneCardsi
FCRL6
HGNCiHGNC:31910 FCRL6
MIMi613562 gene
neXtProtiNX_Q6DN72
OpenTargetsiENSG00000181036
PharmGKBiPA142671770

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J025 Eukaryota
ENOG41117EG LUCA
GeneTreeiENSGT00960000186653
HOGENOMiCLU_023383_5_0_1
InParanoidiQ6DN72
KOiK17273
OMAiQRSEMTT
OrthoDBi866496at2759
PhylomeDBiQ6DN72
TreeFamiTF335097

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
343413
PharosiQ6DN72 Tdark

Protein Ontology

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PROi
PR:Q6DN72
RNActiQ6DN72 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000181036 Expressed in spleen and 84 other tissues
ExpressionAtlasiQ6DN72 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCRL6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DN72
Secondary accession number(s): A1KXW6
, A2A4D6, Q6DN73, Q6XRC3, Q6ZNI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 26, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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