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UniProtKB - Q6DN67 (L_CPSVP)

Entry version 57 (07 Oct 2020)
Sequence version 1 (16 Aug 2004)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Citrus psorosis virus (isolate Spain/P-121) (CPsV) (Citrus ringspot virus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N7-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 3 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56)
mRNA guanylyltransferase (EC:2.7.7.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCitrus psorosis virus (isolate Spain/P-121) (CPsV) (Citrus ringspot virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri652963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Milneviricetes › Serpentovirales › Aspiviridae › Ophiovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCitrus aurantiifolia (Key lime) (Limonia aurantifolia) [TaxID: 159033]
Citrus limon (Lemon) (Citrus medica var. limon) [TaxID: 2708]
Citrus paradisi (Grapefruit) [TaxID: 37656]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009269 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003914791 – 2416RNA-directed RNA polymerase LAdd BLAST2416

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q6DN67

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini698 – 864RdRp catalyticPROSITE-ProRule annotationAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili27 – 59Sequence analysisAdd BLAST33
Coiled coili1082 – 1115Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2404 – 2408Poly-Asp5

Keywords - Domaini

Coiled coil

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014023, Mononeg_RNA_pol_cat

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6DN67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWSDEKASS KITLEDEIEI ITSDIVASED TIIELAKKEE EAKKALEARK 
        60         70         80         90        100
GYAEEYIKLI EEMKNYPSAY SILSGKKEEY IMLRTAQDHE KSLEPKKEKI 
       110        120        130        140        150
KYTSMIKYWI KWDHLAYIGT YVDRPALISR LDSPYKTITN ETIEDFLYRE 
       160        170        180        190        200
DYPEKFGVRA KIDLFRLREF VGQEKWSSKI KQGNQKETEI WVSYLKETKN 
       210        220        230        240        250
KSKKLETLLE YGKNMADEEL LSNREKITGK MQKTYKEAWK IEPSEDTQTS 
       260        270        280        290        300
LWFINLLEII IFKIKMTYSQ LLNRIESVSE SMEREGRKII TKVNLDGSST 
       310        320        330        340        350
TTLVVNNAQT NEKIKTEIFI SNTFHAIKYN GVILIGDNTL LKFVLSTEEN 
       360        370        380        390        400
ELNMNIVKDY NFMKGEKSDN FFIDFMMRLK KVPQPLRTLI AATYETVCLM 
       410        420        430        440        450
MADHKCSSST LPIIDAVIEL MKLDKKIGEE LLSICMTSDG VXCIKASTLA 
       460        470        480        490        500
KMNTYAEVNE LEGLRKYIQR TNRNHDVSKE SIERLRCMMR MKIITNYIKK 
       510        520        530        540        550
FGVVPQMTCN SGLLEQELNL MASGGSYNNH IIRNTSHYKD VKLGKMLQPG 
       560        570        580        590        600
NEVNISSRVI DKACTKDEYD FSGNSVKELV YYITKNDLVD LIDEIEIGKV 
       610        620        630        640        650
YEENKNQDRE TKCFFRKDKE LARMQKYKIC RLIEKEKELK TEGRFYGVAS 
       660        670        680        690        700
FKLKIYISII MEMIKRAMKL IPGQMMTMTE DERRTVMHRM SVMLEEKDAY 
       710        720        730        740        750
TLFLDYSGHN TSQRPENNLF ILEEIADMYG FEENSIERKR LTQVVYLFNE 
       760        770        780        790        800
LEILYEHLFS DMVVWSRRQK GAIEGWFGPL WGIQSQLMLD DMMVSMGIEK 
       810        820        830        840        850
YIGTTYSDDS CGVFIKKNLD QEELNRMIEY IQSYSLKMGL LVKLSQTQIT 
       860        870        880        890        900
NGRCSMLKNH YYFDKPIDTS YKRIMSISPN SDILWGNDSE RVSVIDSAYT 
       910        920        930        940        950
SSVLRADDNY IQTVIRNFRI MIEIEKDVIR WALFYDLELD PRFINLRGSL 
       960        970        980        990       1000
STLGKIYRKI VDEASELREL KEIENSMPNE DEIVTQFFLF HIKNRKLLKL 
      1010       1020       1030       1040       1050
TLALMYLPST CYGHALTSMV DSFISGYSYS NVKRLSYVES LFNDKKDKVF 
      1060       1070       1080       1090       1100
IYSLVRLSEN AISYVGEPFP MTGGRYDTKT ILKDELKQLL KHKVQNNELK 
      1110       1120       1130       1140       1150
EMLNSFSEDK EHLFKAVLVH TFEKCFSHRI ASKFYECSIF NYINELYAKI 
      1160       1170       1180       1190       1200
NNSTTMSYLV GKKKMNKLWN KAWKVNHKIE YKFQGNIINE IKSDPSYFGL 
      1210       1220       1230       1240       1250
IMGRNKVDKR IVQNNEMKYF RMNFLNIEEL PIIGKMSADN LTGQLRCIIK 
      1260       1270       1280       1290       1300
PMRVYSKIKG LRLPGPVRTA INITKFDRDL EIEGMFQNKL IFMAYELVRY 
      1310       1320       1330       1340       1350
VKWMIFDMEK YNKQDNTQAI KSLRKLTDIT IGTFSNAKIN DIEEAVVCPK 
      1360       1370       1380       1390       1400
GGRYFHRALS GGFNPKTGDL SSNMLSSRVE VTGLDRLTNE TGGVDNNINL 
      1410       1420       1430       1440       1450
QLVITALKVQ LALIGYTNNE TISIGLDSDV KYFARDVTFM LDQIKSEKEL 
      1460       1470       1480       1490       1500
ECDLGLSHRF DSMTLDKLNE KRTLYHNFSH FVSVNEDIAG KFIDHKTILP 
      1510       1520       1530       1540       1550
SSKIEEISSF QSLNKYMQDM EILVPTQIPE NIMKELVPNL NSYGSIDRYL 
      1560       1570       1580       1590       1600
EEFYKFYKGL NIIGNESFTK AVVRSIINKE LFDRKNIEGK DWLKEIELTG 
      1610       1620       1630       1640       1650
FSYGYRKSLL KIFIVSCCMV FRVEEPTGNT LKITIFEDKT KINCLNNIKR 
      1660       1670       1680       1690       1700
IKNSEAHLHI NDKRISDLIN MAFPLVGYQL KDVFVAVREI MEEHNGKIID 
      1710       1720       1730       1740       1750
GTKVIQYFNV ENTSYASQLE EENCGRISYS NIVLKPSDLS DEKQFIASIK 
      1760       1770       1780       1790       1800
AFEMIATLNC KPQHVSSPTK SDVYPSAKAL LDYLINSNVV SVDDKIADIF 
      1810       1820       1830       1840       1850
AGRGDFHLIM DNMGITHTSI SRNDGYNLIN RIPGMKEIKA NIDMTYSENY 
      1860       1870       1880       1890       1900
GQYLDHDVFI LDISHFTGDP NNIIRMIDDI LAVGKKVIIR WNSIAPMCTK 
      1910       1920       1930       1940       1950
LLYNFVIKRH HKIDILMPTI ESPGYIYLLF NGGFYEPKEI LEGENSKKEK 
      1960       1970       1980       1990       2000
KTYNENIITS NMVLELNRIR KTSILNCSGI KVSDHTQELI SDDKLISILE 
      2010       2020       2030       2040       2050
ENESKSYISN DIEMRIEEGE KLEELLMVLN PSDKLLGLEN IIRQEIRVEE 
      2060       2070       2080       2090       2100
AERGAKSLKY FKRLIAETKP ISGMKKIKLD KNFLKWMIRE NKMKLENDKL 
      2110       2120       2130       2140       2150
IIVEGVKNGH CKEIKKTIDL IINDKNTSKM NQEAWTCVKA GINQFISVEG 
      2160       2170       2180       2190       2200
EETECDMKVI LMMIQGSTEY KSRFFSYDRI LRLAHMASDA IKTGTMAESI 
      2210       2220       2230       2240       2250
LILSGLRSGV LSSLKKNKGK ALRYDCLNIK LIMNRMLVLS EERNIIIQSS 
      2260       2270       2280       2290       2300
NLRLSEIVKD ILLFRKIGQG DKRVKKSIRG KFKRGEKNNK HIISWFDEDE 
      2310       2320       2330       2340       2350
ELELKCTELL EQREIEEEIL KLREFDRLED YLESQGINEL FSAITDELSK 
      2360       2370       2380       2390       2400
EGVRMEMTEE HLAQGIDEQA NILSEGFKSF LGVQDEEVEK NRNMTVEEMR 
      2410 
KLVDDDDDCE YLSDEE
Length:2,416
Mass (Da):280,374
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF740508DB16D85D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY654892 Genomic DNA Translation: AAT72907.1

NCBI Reference Sequences

More...RefSeqi		YP_089661.1, NC_006314.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3077255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:3077255

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY654892 Genomic DNA Translation: AAT72907.1
RefSeqiYP_089661.1, NC_006314.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Proteomic databases

PRIDEiQ6DN67

Genome annotation databases

GeneIDi3077255
KEGGivg:3077255

Family and domain databases

InterProiView protein in InterPro
IPR014023, Mononeg_RNA_pol_cat
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_CPSVP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DN67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: August 16, 2004
Last modified: October 7, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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