UniProtKB - Q6DN03 (H2B2C_HUMAN)
Putative histone H2B type 2-C
H2BC20P
Functioni
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Miscellaneous
Caution
GO - Molecular functioni
- DNA binding Source: GO_Central
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- nucleosome assembly Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6DN03 |
SignaLinki | Q6DN03 |
SIGNORi | Q6DN03 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative histone H2B type 2-CAlternative name(s): H2B-clustered histone 20 pseudogeneImported Histone H2B.t Short name: H2B/t |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20516, H2BC20P |
neXtProti | NX_Q6DN03 |
Subcellular locationi
Nucleus
Other locations
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome core, NucleusPathology & Biotechi
Miscellaneous databases
Pharosi | Q6DN03, Tdark |
Genetic variation databases
BioMutai | HGNC:20516 |
DMDMi | 74709215 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000244824 | 2 – 193 | Putative histone H2B type 2-CAdd BLAST | 192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylprolineBy similarity | 1 | |
Modified residuei | 6 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-butyryllysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 6 | N6-lactoyllysine; alternateBy similarity | 1 | |
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 12 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 12 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 12 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 12 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 13 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 13 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 13 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 15 | Phosphoserine; by STK4/MST11 Publication | 1 | |
Modified residuei | 16 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 16 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 16 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 17 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 17 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 17 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 21 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-butyryllysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 21 | N6-lactoyllysine; alternateBy similarity | 1 | |
Cross-linki | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 24 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 24 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 24 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 25 | N6-(2-hydroxyisobutyryl)lysine1 Publication | 1 | |
Modified residuei | 35 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-crotonyllysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 35 | N6-succinyllysine; alternate1 Publication | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 37 | Phosphoserine; by AMPKBy similarity | 1 | |
Modified residuei | 44 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 44 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 44 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 47 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 47 | N6-glutaryllysine; alternate1 Publication | 1 | |
Modified residuei | 47 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 58 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 58 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 80 | Dimethylated arginineBy similarity | 1 | |
Modified residuei | 86 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 86 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 86 | N6-(beta-hydroxybutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 86 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 86 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 87 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 93 | Omega-N-methylarginineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6DN03 |
jPOSTi | Q6DN03 |
MassIVEi | Q6DN03 |
MaxQBi | Q6DN03 |
PeptideAtlasi | Q6DN03 |
PRIDEi | Q6DN03 |
PTM databases
iPTMneti | Q6DN03 |
MetOSitei | Q6DN03 |
PhosphoSitePlusi | Q6DN03 |
SwissPalmi | Q6DN03 |
Interactioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
IntActi | Q6DN03, 29 interactors |
MINTi | Q6DN03 |
Miscellaneous databases
RNActi | Q6DN03, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 111 – 136 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 33 | Basic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 111 – 127 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
InParanoidi | Q6DN03 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000558, Histone_H2B |
PANTHERi | PTHR23428, PTHR23428, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00621, HISTONEH2B |
SMARTi | View protein in SMART SM00427, H2B, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MPEPAKFAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKRVH
60 70 80 90 100
PDTGIWCKAM GIMNSFLNDI FERIAGEASR LAHYNKRSTI TSRRSRRPCA
110 120 130 140 150
CCCPASWPST PCPRAPRRSP STPAPSESLP GPGARSLPPS LPPRVAGCFV
160 170 180 190
SKGSFQGHLT TSVKESFLCC QSQLMFLASR LVNFRRAHNT KHR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY656810 Genomic DNA Translation: AAT72343.1 AY131977 Genomic DNA No translation available. AK299891 mRNA Translation: BAH13163.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY656810 Genomic DNA Translation: AAT72343.1 AY131977 Genomic DNA No translation available. AK299891 mRNA Translation: BAH13163.1 |
3D structure databases
AlphaFoldDBi | Q6DN03 |
SMRi | Q6DN03 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6DN03, 29 interactors |
MINTi | Q6DN03 |
PTM databases
iPTMneti | Q6DN03 |
MetOSitei | Q6DN03 |
PhosphoSitePlusi | Q6DN03 |
SwissPalmi | Q6DN03 |
Genetic variation databases
BioMutai | HGNC:20516 |
DMDMi | 74709215 |
Proteomic databases
EPDi | Q6DN03 |
jPOSTi | Q6DN03 |
MassIVEi | Q6DN03 |
MaxQBi | Q6DN03 |
PeptideAtlasi | Q6DN03 |
PRIDEi | Q6DN03 |
Organism-specific databases
GeneCardsi | H2BC20P |
HGNCi | HGNC:20516, H2BC20P |
neXtProti | NX_Q6DN03 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q6DN03 |
Enzyme and pathway databases
PathwayCommonsi | Q6DN03 |
SignaLinki | Q6DN03 |
SIGNORi | Q6DN03 |
Miscellaneous databases
Pharosi | Q6DN03, Tdark |
RNActi | Q6DN03, protein |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000558, Histone_H2B |
PANTHERi | PTHR23428, PTHR23428, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00621, HISTONEH2B |
SMARTi | View protein in SMART SM00427, H2B, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H2B2C_HUMAN | |
Accessioni | Q6DN03Primary (citable) accession number: Q6DN03 Secondary accession number(s): B7Z677 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families