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UniProtKB - Q6DKK2 (TTC19_HUMAN)

Entry version 146 (07 Apr 2021)
Sequence version 4 (03 May 2011)
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Protein

Tetratricopeptide repeat protein 19, mitochondrial

Gene

TTC19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544).2 Publications

Caution

Was reported to be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed:20208530). According to the same authors, localizes to the centrosome during all stages of the cell cycle and is recruited to the midbody during cytokinesis (PubMed:20208530). However, the midbody localization could not be confirmed by others (PubMed:21278747).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6DKK2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 19, mitochondrial
Short name:
TPR repeat protein 19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26006, TTC19

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613814, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6DKK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000011295.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex III deficiency, nuclear 2 (MC3DN2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
Related information in OMIM

Keywords - Diseasei

Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		54902

MalaCards human disease database

More...MalaCardsi		TTC19
MIMi615157, phenotype

Open Targets

More...OpenTargetsi		ENSG00000011295

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1460, Isolated complex III deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134922384

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6DKK2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TTC19

Domain mapping of disease mutations (DMDM)

More...DMDMi		332278244

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 70MitochondrionSequence analysisAdd BLAST70
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000010640771 – 380Tetratricopeptide repeat protein 19, mitochondrialAdd BLAST310

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6DKK2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6DKK2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6DKK2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6DKK2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6DKK2

PeptideAtlas

More...PeptideAtlasi		Q6DKK2

PRoteomics IDEntifications database

More...PRIDEi		Q6DKK2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66236

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6DKK2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6DKK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6DKK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011295, Expressed in epithelium of mammary gland and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6DKK2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6DKK2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011295, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the mature mitochondrial complex III dimer, after the incorporation of the Rieske protein UQCRFS1 (PubMed:28673544).

Interacts with UQCRC1 and UQCRFS1 (By similarity).

Interacts with ZFYVE26 and CHMP4B (PubMed:20208530).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q6DKK2
With#Exp.IntAct
AGXT [P21549]3EBI-948354,EBI-727098
APRT [P07741]3EBI-948354,EBI-1047565
ATXN1 [P54253]7EBI-948354,EBI-930964
C20orf85 [Q9H1P6]3EBI-948354,EBI-12155483
COA6 [Q5JTJ3]3EBI-948354,EBI-2874677
DMRT3 [Q9NQL9]3EBI-948354,EBI-9679045
EIF4ENIF1 [Q9NRA8]3EBI-948354,EBI-301024
FAM136A [Q96C01]3EBI-948354,EBI-373319
FAM217B [Q9NTX9]3EBI-948354,EBI-19153639
FH [P07954]3EBI-948354,EBI-1050358
FTO - isoform 2 [Q9C0B1-2]3EBI-948354,EBI-18138793
GORASP2 [Q9H8Y8]5EBI-948354,EBI-739467
GPANK1 [O95872]4EBI-948354,EBI-751540
HOXD12 - isoform 2 [P35452-2]3EBI-948354,EBI-17244356
HTRA2 [O43464]3EBI-948354,EBI-517086
HTT [P42858]3EBI-948354,EBI-466029
IHO1 [Q8IYA8]6EBI-948354,EBI-8638439
JPH3 [Q8WXH2]3EBI-948354,EBI-1055254
L3MBTL3 [Q96JM7]3EBI-948354,EBI-2686809
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-948354,EBI-11985629
LDB2 [O43679]3EBI-948354,EBI-2865580
MLN [P12872]3EBI-948354,EBI-18053274
MXRA8 [Q9BRK3]3EBI-948354,EBI-11721798
NAB2 [Q15742]3EBI-948354,EBI-8641936
NME4 [O00746]3EBI-948354,EBI-744871
POU6F2 [P78424]3EBI-948354,EBI-12029004
PRR35 [P0CG20]3EBI-948354,EBI-11986293
RBP1 [P09455]3EBI-948354,EBI-2623483
REL [Q04864]3EBI-948354,EBI-307352
RUSC1 [Q9BVN2]3EBI-948354,EBI-6257312
SH2D4A [Q9H788]3EBI-948354,EBI-747035
SHISA6 [Q6ZSJ9]3EBI-948354,EBI-12037847
SLC22A18AS - isoform 2 [Q8N1D0-2]5EBI-948354,EBI-12829638
SMG9 [Q9H0W8]3EBI-948354,EBI-2872322
TBX2 [Q13207]3EBI-948354,EBI-2853051
TCAP [O15273]4EBI-948354,EBI-954089
USP20 [A0A024R8A9]3EBI-948354,EBI-14096082
USP54 - isoform 6 [Q70EL1-9]3EBI-948354,EBI-11975223
ZNF688 [P0C7X2]3EBI-948354,EBI-4395732

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120248, 98 interactors

Protein interaction database and analysis system

More...IntActi		Q6DKK2, 77 interactors

Molecular INTeraction database

More...MINTi		Q6DKK2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6DKK2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6DKK2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati136 – 169TPR 1Add BLAST34
Repeati179 – 212TPR 2Add BLAST34
Repeati237 – 270TPR 3Add BLAST34
Repeati279 – 312TPR 4Add BLAST34
Repeati318 – 351TPR 5Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi73 – 76Poly-Glu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC19 family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1840, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_057135_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6DKK2

Identification of Orthologs from Complete Genome Data

More...OMAi		LCIQREQ

Database of Orthologous Groups

More...OrthoDBi		864714at2759

TreeFam database of animal gene trees

More...TreeFami		TF314010

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR040395, TTC19

The PANTHER Classification System

More...PANTHERi		PTHR13143, PTHR13143, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q6DKK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRLLSWSLG RGFLRAAGRR CRGCSARLLP GLAGGPGPEV QVPPSRVAPH 
        60         70         80         90        100
GRGPGLLPLL AALAWFSRPA AAEEEEQQGA DGAAAEDGAD EAEAEIIQLL 
       110        120        130        140        150
KRAKLSIMKD EPEEAELILH DALRLAYQTD NKKAITYTYD LMANLAFIRG 
       160        170        180        190        200
QLENAEQLFK ATMSYLLGGG MKQEDNAIIE ISLKLASIYA AQNRQEFAVA 
       210        220        230        240        250
GYEFCISTLE EKIEREKELA EDIMSVEEKA NTHLLLGMCL DACARYLLFS 
       260        270        280        290        300
KQPSQAQRMY EKALQISEEI QGERHPQTIV LMSDLATTLD AQGRFDEAYI 
       310        320        330        340        350
YMQRASDLAR QINHPELHMV LSNLAAVLMH RERYTQAKEI YQEALKQAKL 
       360        370        380
KKDEISVQHI REELAELSKK SRPLTNSVKL
Length:380
Mass (Da):42,457
Last modified:May 3, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA082C9F6F8EE429
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJA1K7EJA1_HUMAN
Tetratricopeptide repeat protein 19...
TTC19
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKH7K7EKH7_HUMAN
Tetratricopeptide repeat protein 19...
TTC19
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERR1K7ERR1_HUMAN
Tetratricopeptide repeat protein 19...
TTC19
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELX2K7ELX2_HUMAN
Tetratricopeptide repeat protein 19...
TTC19
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKS0K7EKS0_HUMAN
Tetratricopeptide repeat protein 19...
TTC19
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11698 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH73796 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAI05129 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAI12108 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA91103 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15296 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG51574 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG51820 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti282M → V in BAG51574 (PubMed:14702039).Curated1
Sequence conflicti366E → K in BAB15296 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000350 mRNA Translation: BAA91103.1 Different initiation.
AK025958 mRNA Translation: BAB15296.1 Different initiation.
AK055780 mRNA Translation: BAG51574.1 Different initiation.
AK056878 mRNA Translation: BAG51820.1 Different initiation.
AK297783 mRNA Translation: BAG60127.1
AC006251 Genomic DNA No translation available.
AC002553 Genomic DNA No translation available.
CH471222 Genomic DNA Translation: EAX04490.1
BC011698 mRNA Translation: AAH11698.2 Different initiation.
BC073796 mRNA Translation: AAH73796.1 Different initiation.
BC105128 mRNA Translation: AAI05129.1 Different initiation.
BC112107 mRNA Translation: AAI12108.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11174.2

NCBI Reference Sequences

More...RefSeqi		NP_001258349.1, NM_001271420.1
NP_060245.3, NM_017775.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261647; ENSP00000261647; ENSG00000011295

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54902

UCSC genome browser

More...UCSCi		uc002gph.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000350 mRNA Translation: BAA91103.1 Different initiation.
AK025958 mRNA Translation: BAB15296.1 Different initiation.
AK055780 mRNA Translation: BAG51574.1 Different initiation.
AK056878 mRNA Translation: BAG51820.1 Different initiation.
AK297783 mRNA Translation: BAG60127.1
AC006251 Genomic DNA No translation available.
AC002553 Genomic DNA No translation available.
CH471222 Genomic DNA Translation: EAX04490.1
BC011698 mRNA Translation: AAH11698.2 Different initiation.
BC073796 mRNA Translation: AAH73796.1 Different initiation.
BC105128 mRNA Translation: AAI05129.1 Different initiation.
BC112107 mRNA Translation: AAI12108.1 Different initiation.
CCDSiCCDS11174.2
RefSeqiNP_001258349.1, NM_001271420.1
NP_060245.3, NM_017775.3

3D structure databases

SMRiQ6DKK2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120248, 98 interactors
IntActiQ6DKK2, 77 interactors
MINTiQ6DKK2
STRINGi9606.ENSP00000261647

PTM databases

iPTMnetiQ6DKK2
MetOSiteiQ6DKK2
PhosphoSitePlusiQ6DKK2

Genetic variation databases

BioMutaiTTC19
DMDMi332278244

Proteomic databases

EPDiQ6DKK2
jPOSTiQ6DKK2
MassIVEiQ6DKK2
MaxQBiQ6DKK2
PaxDbiQ6DKK2
PeptideAtlasiQ6DKK2
PRIDEiQ6DKK2
ProteomicsDBi66236

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13179, 76 antibodies

Genome annotation databases

EnsembliENST00000261647; ENSP00000261647; ENSG00000011295
GeneIDi54902
KEGGihsa:54902
UCSCiuc002gph.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54902
DisGeNETi54902

GeneCards: human genes, protein and diseases

More...GeneCardsi		TTC19
HGNCiHGNC:26006, TTC19
HPAiENSG00000011295, Low tissue specificity
MalaCardsiTTC19
MIMi613814, gene
615157, phenotype
neXtProtiNX_Q6DKK2
OpenTargetsiENSG00000011295
Orphaneti1460, Isolated complex III deficiency
PharmGKBiPA134922384
VEuPathDBiHostDB:ENSG00000011295.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1840, Eukaryota
GeneTreeiENSGT00390000009194
HOGENOMiCLU_057135_1_0_1
InParanoidiQ6DKK2
OMAiLCIQREQ
OrthoDBi864714at2759
TreeFamiTF314010

Enzyme and pathway databases

PathwayCommonsiQ6DKK2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54902, 73 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TTC19, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54902
PharosiQ6DKK2, Tbio

Protein Ontology

More...PROi		PR:Q6DKK2
RNActiQ6DKK2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000011295, Expressed in epithelium of mammary gland and 236 other tissues
ExpressionAtlasiQ6DKK2, baseline and differential
GenevisibleiQ6DKK2, HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR040395, TTC19
PANTHERiPTHR13143, PTHR13143, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 4 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DKK2
Secondary accession number(s): A8MZ52
, B3KP62, B4DN65, Q2M248, Q7L3U8, Q9H6G3, Q9NXB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 3, 2011
Last modified: April 7, 2021
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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