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Protein

Nucleoredoxin

Gene

NXN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Oxidoreductase
Biological processDifferentiation, Wnt signaling pathway
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoredoxin (EC:1.8.1.8)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NXN
Synonyms:NRX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000167693.16

Human Gene Nomenclature Database

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HGNCi
HGNC:18008 NXN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612895 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6DKJ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64359

MalaCards human disease database

More...
MalaCardsi
NXN

Open Targets

More...
OpenTargetsi
ENSG00000167693

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1507 Autosomal recessive Robinow syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31863

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NXN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187471109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003329332 – 435NucleoredoxinAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6DKJ4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6DKJ4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6DKJ4

PeptideAtlas

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PeptideAtlasi
Q6DKJ4

PRoteomics IDEntifications database

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PRIDEi
Q6DKJ4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66233
66234 [Q6DKJ4-2]
66235 [Q6DKJ4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6DKJ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6DKJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167693 Expressed in 228 organ(s), highest expression level in skeletal muscle tissue

CleanEx database of gene expression profiles

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CleanExi
HS_NXN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6DKJ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6DKJ4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023566

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122144, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q6DKJ4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6DKJ4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337443

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6DKJ4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6DKJ4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 321ThioredoxinPROSITE-ProRule annotationAdd BLAST155

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoredoxin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2501 Eukaryota
ENOG410ZIWC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007309

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053461

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6DKJ4

KEGG Orthology (KO)

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KOi
K17609

Identification of Orthologs from Complete Genome Data

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OMAi
NAVQLHE

Database of Orthologous Groups

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OrthoDBi
EOG091G079A

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6DKJ4

TreeFam database of animal gene trees

More...
TreeFami
TF331873

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13905 Thioredoxin_8, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52833 SSF52833, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6DKJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS
60 70 80 90 100
ASLAAFYGRL RGDAAAGPGP GAGAGAAAEP EPRRRLEIVF VSSDQDQRQW
110 120 130 140 150
QDFVRDMPWL ALPYKEKHRK LKLWNKYRIS NIPSLIFLDA TTGKVVCRNG
160 170 180 190 200
LLVIRDDPEG LEFPWGPKPF REVIAGPLLR NNGQSLESSS LEGSHVGVYF
210 220 230 240 250
SAHWCPPCRS LTRVLVESYR KIKEAGQNFE IIFVSADRSE ESFKQYFSEM
260 270 280 290 300
PWLAVPYTDE ARRSRLNRLY GIQGIPTLIM LDPQGEVITR QGRVEVLNDE
310 320 330 340 350
DCREFPWHPK PVLELSDSNA AQLNEGPCLV LFVDSEDDGE SEAAKQLIQP
360 370 380 390 400
IAEKIIAKYK AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM
410 420 430
SARAKYVMDV EEITPAIVEA FVNDFLAEKL KPEPI
Length:435
Mass (Da):48,392
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB67927F001BE4E5B
GO
Isoform 2 (identifier: Q6DKJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.
     114-120: YKEKHRK → MQELRNS
     275-290: IPTLIMLDPQGEVITR → RRSRPRLRVAPGNLLT
     291-435: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,328
Checksum:iD36156E815E83ACF
GO
Isoform 3 (identifier: Q6DKJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     109-120: WLALPYKEKHRK → MADVSLHRNPAT

Show »
Length:327
Mass (Da):36,871
Checksum:iA9343547616F7A95
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4V6I3L4V6_HUMAN
Nucleoredoxin
NXN
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGI2A0A0C4DGI2_HUMAN
Nucleoredoxin
NXN
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQK5A0A0G2JQK5_HUMAN
Nucleoredoxin
NXN
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14171 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55122 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124W → K in BAB55122 (PubMed:14702039).Curated1
Sequence conflicti165W → K in BAB14171 (PubMed:14702039).Curated1
Sequence conflicti372V → I in AAH73845 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0333921 – 113Missing in isoform 2. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0427921 – 108Missing in isoform 3. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_042793109 – 120WLALP…EKHRK → MADVSLHRNPAT in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033393114 – 120YKEKHRK → MQELRNS in isoform 2. 1 Publication7
Alternative sequenceiVSP_033394275 – 290IPTLI…EVITR → RRSRPRLRVAPGNLLT in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_033395291 – 435Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022676 mRNA Translation: BAB14171.1 Different initiation.
AK027451 mRNA Translation: BAB55122.1 Different initiation.
AK302073 mRNA Translation: BAG63462.1
AC015884 Genomic DNA No translation available.
AC036164 Genomic DNA No translation available.
AC087392 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90640.1
CH471108 Genomic DNA Translation: EAW90641.1
BC009327 mRNA Translation: AAH09327.2
BC063828 mRNA Translation: AAH63828.1
BC073845 mRNA Translation: AAH73845.1
BC104634 mRNA Translation: AAI04635.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10998.1 [Q6DKJ4-1]
CCDS56013.1 [Q6DKJ4-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001192248.1, NM_001205319.1 [Q6DKJ4-3]
NP_071908.2, NM_022463.4 [Q6DKJ4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.527989

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336868; ENSP00000337443; ENSG00000167693 [Q6DKJ4-1]
ENST00000575801; ENSP00000461038; ENSG00000167693 [Q6DKJ4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64359

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64359

UCSC genome browser

More...
UCSCi
uc002fsa.4 human [Q6DKJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022676 mRNA Translation: BAB14171.1 Different initiation.
AK027451 mRNA Translation: BAB55122.1 Different initiation.
AK302073 mRNA Translation: BAG63462.1
AC015884 Genomic DNA No translation available.
AC036164 Genomic DNA No translation available.
AC087392 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90640.1
CH471108 Genomic DNA Translation: EAW90641.1
BC009327 mRNA Translation: AAH09327.2
BC063828 mRNA Translation: AAH63828.1
BC073845 mRNA Translation: AAH73845.1
BC104634 mRNA Translation: AAI04635.1
CCDSiCCDS10998.1 [Q6DKJ4-1]
CCDS56013.1 [Q6DKJ4-3]
RefSeqiNP_001192248.1, NM_001205319.1 [Q6DKJ4-3]
NP_071908.2, NM_022463.4 [Q6DKJ4-1]
UniGeneiHs.527989

3D structure databases

ProteinModelPortaliQ6DKJ4
SMRiQ6DKJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122144, 19 interactors
IntActiQ6DKJ4, 3 interactors
MINTiQ6DKJ4
STRINGi9606.ENSP00000337443

PTM databases

iPTMnetiQ6DKJ4
PhosphoSitePlusiQ6DKJ4

Polymorphism and mutation databases

BioMutaiNXN
DMDMi187471109

Proteomic databases

EPDiQ6DKJ4
MaxQBiQ6DKJ4
PaxDbiQ6DKJ4
PeptideAtlasiQ6DKJ4
PRIDEiQ6DKJ4
ProteomicsDBi66233
66234 [Q6DKJ4-2]
66235 [Q6DKJ4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64359
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336868; ENSP00000337443; ENSG00000167693 [Q6DKJ4-1]
ENST00000575801; ENSP00000461038; ENSG00000167693 [Q6DKJ4-3]
GeneIDi64359
KEGGihsa:64359
UCSCiuc002fsa.4 human [Q6DKJ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64359
DisGeNETi64359
EuPathDBiHostDB:ENSG00000167693.16

GeneCards: human genes, protein and diseases

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GeneCardsi
NXN

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013394
HGNCiHGNC:18008 NXN
HPAiHPA023566
MalaCardsiNXN
MIMi612895 gene
neXtProtiNX_Q6DKJ4
OpenTargetsiENSG00000167693
Orphaneti1507 Autosomal recessive Robinow syndrome
PharmGKBiPA31863

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2501 Eukaryota
ENOG410ZIWC LUCA
GeneTreeiENSGT00940000161894
HOGENOMiHOG000007309
HOVERGENiHBG053461
InParanoidiQ6DKJ4
KOiK17609
OMAiNAVQLHE
OrthoDBiEOG091G079A
PhylomeDBiQ6DKJ4
TreeFamiTF331873

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NXN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64359

Protein Ontology

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PROi
PR:Q6DKJ4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167693 Expressed in 228 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_NXN
ExpressionAtlasiQ6DKJ4 baseline and differential
GenevisibleiQ6DKJ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF13905 Thioredoxin_8, 2 hits
SUPFAMiSSF52833 SSF52833, 3 hits
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DKJ4
Secondary accession number(s): B4DXQ0
, D3DTH2, Q3SWW6, Q6P3U6, Q7L4C6, Q9H9Q1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 5, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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