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Protein

Transmembrane protein PVRIG

Gene

PVRIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.1 Publication

Miscellaneous

Was named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • signaling receptor activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein PVRIG
Alternative name(s):
CD112 receptor
Short name:
CD112R
Poliovirus receptor-related immunoglobulin domain-containing protein
Gene namesi
Name:PVRIG
Synonyms:C7orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000213413.2
HGNCiHGNC:32190 PVRIG
MIMi617012 gene
neXtProtiNX_Q6DKI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei62 – 78HelicalSequence analysisAdd BLAST17
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi233Y → F: Reduced phosphorylation. 1 Publication1
Mutagenesisi293Y → F: No effect on global phosphorylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000213413
PharmGKBiPA162400434

Polymorphism and mutation databases

BioMutaiPVRIG
DMDMi74736413

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371421 – 326Transmembrane protein PVRIGAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DKI7
PeptideAtlasiQ6DKI7
PRIDEiQ6DKI7
ProteomicsDBi66232

PTM databases

iPTMnetiQ6DKI7
PhosphoSitePlusiQ6DKI7

Expressioni

Tissue specificityi

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.1 Publication

Inductioni

In T-cells, up-regulated by activation induced by treatment with anti-CD3 and anti-CD28 antibodies.1 Publication

Gene expression databases

BgeeiENSG00000213413 Expressed in 89 organ(s), highest expression level in blood
CleanExiHS_PVRIG
GenevisibleiQ6DKI7 HS

Organism-specific databases

HPAiHPA047497

Interactioni

Subunit structurei

Interacts with NECTIN2, hence competing with CD226.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi299834, 14 interactors
IntActiQ6DKI7, 1 interactor
STRINGi9606.ENSP00000316675

Structurei

3D structure databases

ProteinModelPortaliQ6DKI7
SMRiQ6DKI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF1U Eukaryota
ENOG4111EHB LUCA
GeneTreeiENSGT00390000017799
HOGENOMiHOG000115803
InParanoidiQ6DKI7
OMAiGAMGHRT
OrthoDBiEOG091G0QZI
PhylomeDBiQ6DKI7
TreeFamiTF343319

Family and domain databases

InterProiView protein in InterPro
IPR034452 TM_PVRIG
PANTHERiPTHR39220 PTHR39220, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DKI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTEAQVPAL QPPEPGLEGA MGHRTLVLPW VLLTLCVTAG TPEVWVQVRM
60 70 80 90 100
EATELSSFTI RCGFLGSGSI SLVTVSWGGP NGAGGTTLAV LHPERGIRQW
110 120 130 140 150
APARQARWET QSSISLILEG SGASSPCANT TFCCKFASFP EGSWEACGSL
160 170 180 190 200
PPSSDPGLSA PPTPAPILRA DLAGILGVSG VLLFGCVYLL HLLRRHKHRP
210 220 230 240 250
APRLQPSRTS PQAPRARAWA PSQASQAALH VPYATINTSC RPATLDTAHP
260 270 280 290 300
HGGPSWWASL PTHAAHRPQG PAAWASTPIP ARGSFVSVEN GLYAQAGERP
310 320
PHTGPGLTLF PDPRGPRAME GPLGVR
Length:326
Mass (Da):34,344
Last modified:August 16, 2004 - v1
Checksum:i7D9DF363C523F9CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04362481N → D1 PublicationCorresponds to variant dbSNP:rs2906645Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA Translation: EAW76566.1
CH471091 Genomic DNA Translation: EAW76567.1
BC001129 mRNA Translation: AAH01129.1
BC073861 mRNA Translation: AAH73861.1
BC107873 mRNA Translation: AAI07874.1
CCDSiCCDS5690.1
RefSeqiNP_076975.2, NM_024070.3
XP_011514877.1, XM_011516575.2
UniGeneiHs.729356

Genome annotation databases

EnsembliENST00000317271; ENSP00000316675; ENSG00000213413
GeneIDi79037
KEGGihsa:79037
UCSCiuc003uuf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA Translation: EAW76566.1
CH471091 Genomic DNA Translation: EAW76567.1
BC001129 mRNA Translation: AAH01129.1
BC073861 mRNA Translation: AAH73861.1
BC107873 mRNA Translation: AAI07874.1
CCDSiCCDS5690.1
RefSeqiNP_076975.2, NM_024070.3
XP_011514877.1, XM_011516575.2
UniGeneiHs.729356

3D structure databases

ProteinModelPortaliQ6DKI7
SMRiQ6DKI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi299834, 14 interactors
IntActiQ6DKI7, 1 interactor
STRINGi9606.ENSP00000316675

PTM databases

iPTMnetiQ6DKI7
PhosphoSitePlusiQ6DKI7

Polymorphism and mutation databases

BioMutaiPVRIG
DMDMi74736413

Proteomic databases

PaxDbiQ6DKI7
PeptideAtlasiQ6DKI7
PRIDEiQ6DKI7
ProteomicsDBi66232

Protocols and materials databases

DNASUi79037
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317271; ENSP00000316675; ENSG00000213413
GeneIDi79037
KEGGihsa:79037
UCSCiuc003uuf.2 human

Organism-specific databases

CTDi79037
EuPathDBiHostDB:ENSG00000213413.2
GeneCardsiPVRIG
HGNCiHGNC:32190 PVRIG
HPAiHPA047497
MIMi617012 gene
neXtProtiNX_Q6DKI7
OpenTargetsiENSG00000213413
PharmGKBiPA162400434
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1U Eukaryota
ENOG4111EHB LUCA
GeneTreeiENSGT00390000017799
HOGENOMiHOG000115803
InParanoidiQ6DKI7
OMAiGAMGHRT
OrthoDBiEOG091G0QZI
PhylomeDBiQ6DKI7
TreeFamiTF343319

Miscellaneous databases

GenomeRNAii79037
PROiPR:Q6DKI7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213413 Expressed in 89 organ(s), highest expression level in blood
CleanExiHS_PVRIG
GenevisibleiQ6DKI7 HS

Family and domain databases

InterProiView protein in InterPro
IPR034452 TM_PVRIG
PANTHERiPTHR39220 PTHR39220, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPVRIG_HUMAN
AccessioniPrimary (citable) accession number: Q6DKI7
Secondary accession number(s): D6W5U9, Q9BVK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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