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UniProtKB - Q6DKI2 (LEG9C_HUMAN)
Protein
Galectin-9C
Gene
LGALS9C
Organism
Homo sapiens (Human)
Status
Functioni
Binds galactosides.
By similarityMiscellaneous
The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.
GO - Molecular functioni
- carbohydrate binding Source: GO_Central
- galactoside binding Source: GO_Central
GO - Biological processi
- negative regulation of CD4-positive, alpha-beta T cell proliferation Source: GO_Central
- negative regulation of interferon-gamma production Source: GO_Central
- positive regulation of gene expression Source: GO_Central
Keywordsi
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q6DKI2 |
SignaLinki | Q6DKI2 |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-9CShort name: Gal-9C Alternative name(s): Galectin-9-like protein B |
Gene namesi | Name:LGALS9C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33874, LGALS9C |
neXtProti | NX_Q6DKI2 |
VEuPathDBi | HostDB:ENSG00000171916 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 654346 |
OpenTargetsi | ENSG00000171916 |
PharmGKBi | PA162393930 |
Miscellaneous databases
Pharosi | Q6DKI2, Tdark |
Genetic variation databases
BioMutai | LGALS9C |
DMDMi | 296434563 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332131 | 1 – 356 | Galectin-9CAdd BLAST | 356 |
Proteomic databases
jPOSTi | Q6DKI2 |
MassIVEi | Q6DKI2 |
MaxQBi | Q6DKI2 |
PaxDbi | Q6DKI2 |
PeptideAtlasi | Q6DKI2 |
PRIDEi | Q6DKI2 |
ProteomicsDBi | 66231 |
PTM databases
iPTMneti | Q6DKI2 |
PhosphoSitePlusi | Q6DKI2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171916, Expressed in muscle tissue and 98 other tissues |
ExpressionAtlasi | Q6DKI2, baseline and differential |
Organism-specific databases
HPAi | ENSG00000171916, Tissue enhanced (esophagus, intestine, stomach) |
Interactioni
Binary interactionsi
Q6DKI2
Protein-protein interaction databases
BioGRIDi | 576335, 35 interactors |
IntActi | Q6DKI2, 51 interactors |
STRINGi | 9606.ENSP00000329932 |
Miscellaneous databases
RNActi | Q6DKI2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 148 | Galectin 1PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 228 – 356 | Galectin 2PROSITE-ProRule annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 88 | Beta-galactoside binding 1By similarity | 7 | |
Regioni | 170 – 190 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 288 – 294 | Beta-galactoside binding 2By similarity | 7 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000162701 |
InParanoidi | Q6DKI2 |
OMAi | FLCFNND |
OrthoDBi | 829777at2759 |
PhylomeDBi | Q6DKI2 |
TreeFami | TF315551 |
Family and domain databases
CDDi | cd00070, GLECT, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 2 hits |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 2 hits SM00276, GLECT, 2 hits |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q6DKI2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFSGCQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSC SGTRFAVDFQ
60 70 80 90 100
TGFSGNDIAF HFNPRFEDGG YVVCNTRQKG TWGPEERKMH MPFQKGMPFD
110 120 130 140 150
LCFLVQSSDF KVMVNGSLFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP
160 170 180 190 200
RAVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPSVRPANPA PITQTVIHTV
210 220 230 240 250
QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK SIILSGTVLP
260 270 280 290 300
SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP
310 320 330 340 350
FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ
LTHVQT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KSY2 | J3KSY2_HUMAN | Galectin | LGALS9C | 323 | Annotation score: | ||
J3KT17 | J3KT17_HUMAN | Galectin | LGALS9C | 234 | Annotation score: | ||
J3QSH0 | J3QSH0_HUMAN | Galectin | LGALS9C | 175 | Annotation score: | ||
J3QR96 | J3QR96_HUMAN | Galectin | LGALS9C | 246 | Annotation score: | ||
J3KSV0 | J3KSV0_HUMAN | Galectin-9C | LGALS9C | 53 | Annotation score: | ||
J3KRF0 | J3KRF0_HUMAN | Galectin-9C | LGALS9C | 75 | Annotation score: | ||
J3QKS2 | J3QKS2_HUMAN | Galectin-9C | LGALS9C | 35 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 81 | T → R in BAF98709 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 153 | V → A in BAF98709 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 183 | S → I in AAH73889 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 306 | S → C in BAF98709 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056004 | 126 | V → M1 PublicationCorresponds to variant dbSNP:rs3907319Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315818 mRNA Translation: BAF98709.1 AC107983 Genomic DNA No translation available. AL353997 Genomic DNA No translation available. BC073889 mRNA Translation: AAH73889.1 |
CCDSi | CCDS32587.1 |
RefSeqi | NP_001035167.2, NM_001040078.2 |
Genome annotation databases
Ensembli | ENST00000328114.11; ENSP00000329932.6; ENSG00000171916.17 ENST00000639265.2; ENSP00000491587.1; ENSG00000284021.2 |
GeneIDi | 654346 |
KEGGi | hsa:654346 |
MANE-Selecti | ENST00000328114.11; ENSP00000329932.6; NM_001040078.3; NP_001035167.2 |
UCSCi | uc002gtw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315818 mRNA Translation: BAF98709.1 AC107983 Genomic DNA No translation available. AL353997 Genomic DNA No translation available. BC073889 mRNA Translation: AAH73889.1 |
CCDSi | CCDS32587.1 |
RefSeqi | NP_001035167.2, NM_001040078.2 |
3D structure databases
AlphaFoldDBi | Q6DKI2 |
SMRi | Q6DKI2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 576335, 35 interactors |
IntActi | Q6DKI2, 51 interactors |
STRINGi | 9606.ENSP00000329932 |
PTM databases
iPTMneti | Q6DKI2 |
PhosphoSitePlusi | Q6DKI2 |
Genetic variation databases
BioMutai | LGALS9C |
DMDMi | 296434563 |
Proteomic databases
jPOSTi | Q6DKI2 |
MassIVEi | Q6DKI2 |
MaxQBi | Q6DKI2 |
PaxDbi | Q6DKI2 |
PeptideAtlasi | Q6DKI2 |
PRIDEi | Q6DKI2 |
ProteomicsDBi | 66231 |
Protocols and materials databases
Antibodypediai | 67999, 81 antibodies from 14 providers |
DNASUi | 654346 |
Genome annotation databases
Ensembli | ENST00000328114.11; ENSP00000329932.6; ENSG00000171916.17 ENST00000639265.2; ENSP00000491587.1; ENSG00000284021.2 |
GeneIDi | 654346 |
KEGGi | hsa:654346 |
MANE-Selecti | ENST00000328114.11; ENSP00000329932.6; NM_001040078.3; NP_001035167.2 |
UCSCi | uc002gtw.4, human |
Organism-specific databases
CTDi | 654346 |
DisGeNETi | 654346 |
GeneCardsi | LGALS9C |
HGNCi | HGNC:33874, LGALS9C |
HPAi | ENSG00000171916, Tissue enhanced (esophagus, intestine, stomach) |
neXtProti | NX_Q6DKI2 |
OpenTargetsi | ENSG00000171916 |
PharmGKBi | PA162393930 |
VEuPathDBi | HostDB:ENSG00000171916 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000162701 |
InParanoidi | Q6DKI2 |
OMAi | FLCFNND |
OrthoDBi | 829777at2759 |
PhylomeDBi | Q6DKI2 |
TreeFami | TF315551 |
Enzyme and pathway databases
PathwayCommonsi | Q6DKI2 |
SignaLinki | Q6DKI2 |
Miscellaneous databases
BioGRID-ORCSi | 654346, 114 hits in 987 CRISPR screens |
GenomeRNAii | 654346 |
Pharosi | Q6DKI2, Tdark |
PROi | PR:Q6DKI2 |
RNActi | Q6DKI2, protein |
Gene expression databases
Bgeei | ENSG00000171916, Expressed in muscle tissue and 98 other tissues |
ExpressionAtlasi | Q6DKI2, baseline and differential |
Family and domain databases
CDDi | cd00070, GLECT, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 2 hits |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 2 hits SM00276, GLECT, 2 hits |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LEG9C_HUMAN | |
Accessioni | Q6DKI2Primary (citable) accession number: Q6DKI2 Secondary accession number(s): B0AZM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports