PLAG1

Functionⁱ

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.3 Publications

Miscellaneous

Residual nuclear import after mutation of the nuclear localization signal is assigned to zinc finger domains of PLAG1.

When cultured cells transformed by PLAG1 overexpression are injected in nude mouse, rapidly growing tumors (fibrosarcomaS) are observed at the site of inoculation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	34 – 56	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	62 – 86	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	92 – 114	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	121 – 143	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	150 – 172	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	185 – 207	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	213 – 236	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 9722527
metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10646861
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10646861

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: GO_Central
gland morphogenesis Source: Ensembl
multicellular organism growth Source: Ensembl
negative regulation of gene expression Source: Ensembl
positive regulation of glial cell proliferation Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10646861
prostate gland growth Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q6DJT9
SIGNORⁱ	Q6DJT9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein PLAG1 Alternative name(s): Pleiomorphic adenoma gene 1 protein
Gene namesⁱ	Name:PLAG1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000181690.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9045 PLAG1
MIMⁱ	603026 gene
neXtProtⁱ	NX_Q6DJT9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving PLAG1 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with constitutively expressed beta-catenin/CTNNB1. Fusion occurs in the 5'-regulatory regions, leading to promoter swapping between the 2 genes and activation of PLAG1 expression in adenomas. The chimeric transcript is formed by fusion of CTNNB1 exon 1 to PLAG1 exon 3. Reciprocal fusion transcript consisting of PLAG1 exon 1 and CTNNB1 exon 2-16 is also revealed in some adenomas (PubMed:9020842, PubMed:10029085). Translocation t(3;8)(p21;q12) with transcription elongation factor SII/TCEA1. The fusion transcript is composed of 5'-non-coding sequences as well as 63 nucleotides of the coding region of TCEA1 fused to the acceptor splice site of PLAG1 exon 3. The fusion transcript encodes a truncated TCEA1-PLAG1 protein of 90 AA as well as an apparently normal PLAG1 protein. Reciprocal fusion transcript PLAG1-TCEA1 is also present in one adenoma (PubMed:10029085, PubMed:16736500). Translocation t(5;8)(p13;q12) with leukemia inhibitory factor receptor LIFR. This fusion occured in the 5'-non-coding sequences of both genes, exchanging regulatory control element while preserving the coding sequences (PubMed:9525740). Translocation t(6;8)(p21.3-22;q13) with Coiled-coil-helix-coiled-coil-helix domain-containing protein 7/CHCHD7. Fusion occurs in the 5' regulatory regions, leading to promoter swapping and up-regulation of PLAG1 expression (PubMed:16736500). Ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleiomorphic adenomas with 8q aberrations. These fusion genes are likely to be found in adenomas with normal karyotype as this subgroup of tumors also exhibit PLAG1 activation (PubMed:9020842, PubMed:10029085, PubMed:9525740, PubMed:16736500).4 Publications

A chromosomal aberration involving PLAG1 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal rearrangement with hyaluronic acid synthase 2/HAS2 results in promoter swapping and activation of PLAG1 expression. The breakpoint of HAS2 gene is in PLAG1 intron 1, whereas its coding sequence starts at exon 2 or exon 3. Translocation t(7;8)(p22;q13) with collagen 1A2/COL1A2. Fusion transcript COL1A2-PLAG1 as well as HAS2-PLAG1 encode a full-length PLAG1 protein.2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	23 – 24	RK → AA: Inhibition of KPNA2 interaction when mutation occurs in the NLS; decreased nuclear import with localization in the nucleus but also in the cytoplasm; Complete inhibition of nuclear import when associated with a lack of zinc-finger domains. 1 Publication	2
Mutagenesisⁱ	31 – 32	RK → AA: No inhibition of KPNA2 interaction and no change in nuclear import. 1 Publication	2
Mutagenesisⁱ	92	H → A: Prevents formation of functional zinc-finger 3; induces drastic decrease of DNA affinity and complete modification of DNA binding specificity. 1 Publication	1
Mutagenesisⁱ	227	H → A: Prevents formation of functional zinc-finger 7 and inhibits DNA binding; No proliferation and transformation of cultured cells. 2 Publications	1
Mutagenesisⁱ	244	K → R: Abolishes single and double sumoylation; nuclear localization conserved. Increases transcriptional activity and inhibits repression domain activity; when associated with R-263 and R-353. 2 Publications	1
Mutagenesisⁱ	263	K → R: Decreases sumoylation; Abolishes double sumoylation only; Nuclear localization conserved. Increases transcriptional activity and inhibits repression domain activity; when associated with R-244 and R-353. 2 Publications	1
Mutagenesisⁱ	339	T → A: No effect on transcription activation capacity. 1 Publication	1
Mutagenesisⁱ	340	S → A: No effect on transcription activation capacity. 1 Publication	1
Mutagenesisⁱ	353	K → R: No effect on sumoylation. Increases transcriptional activity and inhibits repression domain activity; when associated with R-244 and R-263. 2 Publications	1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5324
MalaCards human disease database More...MalaCardsⁱ	PLAG1
MIMⁱ	181030 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000181690
PharmGKBⁱ	PA33378

Polymorphism and mutation databases

BioMutaⁱ	PLAG1
DMDMⁱ	74757442

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000295107	1 – 500	Zinc finger protein PLAG1Add BLAST		500

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	244	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linkⁱ	263	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationⁱ

Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1.

Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q6DJT9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6DJT9
PaxDbⁱ	Q6DJT9
PeptideAtlas More...PeptideAtlasⁱ	Q6DJT9
PRIDEⁱ	Q6DJT9
ProteomicsDBⁱ	66229

PTM databases

iPTMnetⁱ	Q6DJT9
PhosphoSitePlusⁱ	Q6DJT9

Expressionⁱ

Tissue specificityⁱ

Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000181690 Expressed in 172 organ(s), highest expression level in intestine
CleanExⁱ	HS_PLAG1
ExpressionAtlasⁱ	Q6DJT9 baseline and differential
Genevisibleⁱ	Q6DJT9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA072290

HPAⁱ

HPA072290

Interactionⁱ

Subunit structureⁱ

Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal. Interacts with E3 SUMO-protein ligase PIAS1, PIAS2 and PIAS4.2 Publications

Protein-protein interaction databases

BioGridⁱ	111340, 6 interactors
IntActⁱ	Q6DJT9, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q6DJT9
STRINGⁱ	9606.ENSP00000325546

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6DJT9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 84	Interaction with KPNA21 PublicationAdd BLAST	83
Regionⁱ	41 – 242	Decreased nuclear import with localization in the nucleus but also in the cytoplasmAdd BLAST	202
Regionⁱ	243 – 500	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interactionAdd BLAST	258
Regionⁱ	243 – 384	Repression domain; contains 3 sumoylation motifs and massively decrease transcription activityAdd BLAST	142
Regionⁱ	385 – 500	Massively activates transcriptionAdd BLAST	116

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	22 – 25	Nuclear localization signal		4

Domainⁱ

C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA-binding site core sequence.

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	34 – 56	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	62 – 86	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	92 – 114	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	121 – 143	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	150 – 172	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	185 – 207	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	213 – 236	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013640
HOGENOMⁱ	HOG000294191
HOVERGENⁱ	HBG053608
InParanoidⁱ	Q6DJT9
KEGG Orthology (KO) More...KOⁱ	K19484
OMAⁱ	IDMDAVH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G061O
PhylomeDBⁱ	Q6DJT9
TreeFamⁱ	TF332024

Family and domain databases

InterProⁱ	View protein in InterPro IPR027765 PLAG1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44197:SF2 PTHR44197:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q6DJT9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK 
        60         70         80         90        100
VHSYSHTGER PYKCIQQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM 
       110        120        130        140        150
FHRKDHLKNH LHTHDPNKET FKCEECGKNY NTKLGFKRHL ALHAATSGDL 
       160        170        180        190        200
TCKVCLQTFE STGVLLEHLK SHAGKSSGGV KEKKHQCEHC DRRFYTRKDV 
       210        220        230        240        250
RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL LKVKTEPVDF 
       260        270        280        290        300
LDPFTCNVSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS 
       310        320        330        340        350
SGSAHQMITT LPLGMTCPID MDTVHPSHHL SFKYPFSSTS YAISIPEKEQ 
       360        370        380        390        400
PLKGEIESYL MELQGGVPSS SQDSQASSSS KLGLDPQIGS LDDGAGDLSL 
       410        420        430        440        450
SKSSISISDP LNTPALDFSQ LFNFIPLNGP PYNPLSVGSL GMSYSQEEAH 
       460        470        480        490        500
SSVSQLPPQT QDLQDPANTI GLGSLHSLSA AFTSSLSTST TLPRFHQAFQ

Length:500

Mass (Da):55,909

Last modified:August 16, 2004 - v1

Checksum:ⁱCF022A132A1BFD43

GO

Isoform 2 (identifier: Q6DJT9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.

« Hide

        10         20         30         40         50
MATHSPEKTH KCNYCEKMFH RKDHLKNHLH THDPNKETFK CEECGKNYNT 
        60         70         80         90        100
KLGFKRHLAL HAATSGDLTC KVCLQTFEST GVLLEHLKSH AGKSSGGVKE 
       110        120        130        140        150
KKHQCEHCDR RFYTRKDVRR HMVVHTGRKD FLCQYCAQRF GRKDHLTRHM 
       160        170        180        190        200
KKSHNQELLK VKTEPVDFLD PFTCNVSVPI KDELLPVMSL PSSELLSKPF 
       210        220        230        240        250
TNTLQLNLYN TPFQSMQSSG SAHQMITTLP LGMTCPIDMD TVHPSHHLSF 
       260        270        280        290        300
KYPFSSTSYA ISIPEKEQPL KGEIESYLME LQGGVPSSSQ DSQASSSSKL 
       310        320        330        340        350
GLDPQIGSLD DGAGDLSLSK SSISISDPLN TPALDFSQLF NFIPLNGPPY 
       360        370        380        390        400
NPLSVGSLGM SYSQEEAHSS VSQLPPQTQD LQDPANTIGL GSLHSLSAAF 
       410 
TSSLSTSTTL PRFHQAFQ

Note: No experimental confirmation available.

Show »

Length:418

Mass (Da):46,474

Checksum:ⁱ00BA4A605A99B39C

GO

Sequence cautionⁱ

The sequence BAD92368 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	276	E → D in BAD92368 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033212	458	P → T1 PublicationCorresponds to variant dbSNP:rs35883156Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045183	1 – 82	Missing in isoform 2. 1 PublicationAdd BLAST		82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65002 mRNA Translation: AAC50995.1 AK296933 mRNA Translation: BAG59484.1 AB209131 mRNA Translation: BAD92368.1 Different initiation. AC107952 Genomic DNA No translation available. BC075047 mRNA Translation: AAH75047.1 BC075048 mRNA Translation: AAH75048.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47860.1 [Q6DJT9-2] CCDS6165.1 [Q6DJT9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001108106.1, NM_001114634.1 [Q6DJT9-1] NP_001108107.1, NM_001114635.1 [Q6DJT9-2] NP_002646.2, NM_002655.2 [Q6DJT9-1] XP_011515846.1, XM_011517544.2 [Q6DJT9-2] XP_016869065.1, XM_017013576.1 [Q6DJT9-1] XP_016869066.1, XM_017013577.1 [Q6DJT9-2]
UniGeneⁱ	Hs.14968

Genome annotation databases

Ensemblⁱ	ENST00000316981; ENSP00000325546; ENSG00000181690 [Q6DJT9-1] ENST00000423799; ENSP00000404067; ENSG00000181690 [Q6DJT9-2] ENST00000429357; ENSP00000416537; ENSG00000181690 [Q6DJT9-1]
GeneIDⁱ	5324
KEGGⁱ	hsa:5324
UCSC genome browser More...UCSCⁱ	uc003xsr.5 human [Q6DJT9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6DJT9	Pleiomorphic adenoma gene 1, isoform CRA_a		HUMAN		500	UniRef100_Q6DJT9
PLAG1 isoform 1		PANTR		500
PLAG1 isoform 1		PONAB		500
Uncharacterized protein		PANPA		500
Uncharacterized protein		NOMLE		500
+5

Protein	Similar proteins		Species	Score	Length	Source
Q6DJT9	Zinc finger protein PLAG1		CHICK		501	UniRef90_Q6DJT9
Pleiomorphic adenoma gene 1, isoform CRA_a		HUMAN		500
PLAG1 isoform 1		PANTR		500
PLAG1 isoform 1		PONAB		500
Uncharacterized protein		PANPA		500
+242

Protein	Similar proteins		Species	Score	Length	Source
Q6DJT9	Zinc finger protein PLAG1		CHICK		501	UniRef50_Q6DJT9
Zinc finger protein PLAG1		MOUSE		499
Zinc finger protein PLAG1		RAT		499
Pleiomorphic adenoma gene 1, isoform CRA_a		HUMAN		500
PLAG1 isoform 1		PANTR		500
+375

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65002 mRNA Translation: AAC50995.1 AK296933 mRNA Translation: BAG59484.1 AB209131 mRNA Translation: BAD92368.1 Different initiation. AC107952 Genomic DNA No translation available. BC075047 mRNA Translation: AAH75047.1 BC075048 mRNA Translation: AAH75048.1
CCDSⁱ	CCDS47860.1 [Q6DJT9-2] CCDS6165.1 [Q6DJT9-1]
RefSeqⁱ	NP_001108106.1, NM_001114634.1 [Q6DJT9-1] NP_001108107.1, NM_001114635.1 [Q6DJT9-2] NP_002646.2, NM_002655.2 [Q6DJT9-1] XP_011515846.1, XM_011517544.2 [Q6DJT9-2] XP_016869065.1, XM_017013576.1 [Q6DJT9-1] XP_016869066.1, XM_017013577.1 [Q6DJT9-2]
UniGeneⁱ	Hs.14968

3D structure databases

ProteinModelPortalⁱ	Q6DJT9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111340, 6 interactors
IntActⁱ	Q6DJT9, 3 interactors
MINTⁱ	Q6DJT9
STRINGⁱ	9606.ENSP00000325546

PTM databases

iPTMnetⁱ	Q6DJT9
PhosphoSitePlusⁱ	Q6DJT9

Polymorphism and mutation databases

BioMutaⁱ	PLAG1
DMDMⁱ	74757442

Proteomic databases

EPDⁱ	Q6DJT9
MaxQBⁱ	Q6DJT9
PaxDbⁱ	Q6DJT9
PeptideAtlasⁱ	Q6DJT9
PRIDEⁱ	Q6DJT9
ProteomicsDBⁱ	66229

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5324
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316981; ENSP00000325546; ENSG00000181690 [Q6DJT9-1] ENST00000423799; ENSP00000404067; ENSG00000181690 [Q6DJT9-2] ENST00000429357; ENSP00000416537; ENSG00000181690 [Q6DJT9-1]
GeneIDⁱ	5324
KEGGⁱ	hsa:5324
UCSCⁱ	uc003xsr.5 human [Q6DJT9-1]

Organism-specific databases

CTDⁱ	5324
DisGeNETⁱ	5324
EuPathDBⁱ	HostDB:ENSG00000181690.7
GeneCardsⁱ	PLAG1
HGNCⁱ	HGNC:9045 PLAG1
HPAⁱ	HPA072290
MalaCardsⁱ	PLAG1
MIMⁱ	181030 phenotype 603026 gene
neXtProtⁱ	NX_Q6DJT9
OpenTargetsⁱ	ENSG00000181690
PharmGKBⁱ	PA33378
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00390000013640
HOGENOMⁱ	HOG000294191
HOVERGENⁱ	HBG053608
InParanoidⁱ	Q6DJT9
KOⁱ	K19484
OMAⁱ	IDMDAVH
OrthoDBⁱ	EOG091G061O
PhylomeDBⁱ	Q6DJT9
TreeFamⁱ	TF332024

Enzyme and pathway databases

SignaLinkⁱ	Q6DJT9
SIGNORⁱ	Q6DJT9

Miscellaneous databases

ChiTaRSⁱ	PLAG1 human
GeneWikiⁱ	PLAG1
GenomeRNAiⁱ	5324
Protein Ontology More...PROⁱ	PR:Q6DJT9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000181690 Expressed in 172 organ(s), highest expression level in intestine
CleanExⁱ	HS_PLAG1
ExpressionAtlasⁱ	Q6DJT9 baseline and differential
Genevisibleⁱ	Q6DJT9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027765 PLAG1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44197:SF2 PTHR44197:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLAG1_HUMAN
Accessionⁱ	Q6DJT9Primary (citable) accession number: Q6DJT9 Secondary accession number(s): B4DLC2, Q59GH8, Q9Y4L2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
	Last sequence update:	August 16, 2004
	Last modified:	October 10, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q6DJT9 (PLAG1_HUMAN)

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Zinc finger protein PLAG1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ