UniProtKB - Q6DIY3 (2ABD_XENTR)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
ppp2r2d
Functioni
GO - Molecular functioni
- protein phosphatase regulator activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- exit from mitosis Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- peptidyl-serine dephosphorylation Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAlternative name(s): PP2A subunit B isoform B55-delta PP2A subunit B isoform PR55-delta PP2A subunit B isoform R2-delta PP2A subunit B isoform delta |
Gene namesi | Name:ppp2r2d |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-940312, ppp2r2d |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Other locations
- protein phosphatase type 2A complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000408326 | 1 – 447 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAdd BLAST | 447 |
Proteomic databases
PRIDEi | Q6DIY3 |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when phosphorylated at 'Ser-67'), leading to inhibit PP2A activity (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 8364.ENSXETP00000059786 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 65 | WD 1Add BLAST | 40 | |
Repeati | 91 – 132 | WD 2Add BLAST | 42 | |
Repeati | 175 – 213 | WD 3Add BLAST | 39 | |
Repeati | 224 – 264 | WD 4Add BLAST | 41 | |
Repeati | 283 – 321 | WD 5Add BLAST | 39 | |
Repeati | 338 – 379 | WD 6Add BLAST | 42 | |
Repeati | 414 – 447 | WD 7Add BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
InParanoidi | Q6DIY3 |
OMAi | RMFDRGH |
OrthoDBi | 810409at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAGVGGGNDF QWCFSQVKGA IDEDVAEADI ISTVEFNCSG DLLATGDKGG
60 70 80 90 100
RVVIFQREQE NKSRPHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQQNAAHF LLSTNDKTIK LWKISERDKR VEGYNLKDDD GRLRDPFRIT
160 170 180 190 200
SLRVPILKPM DLMVEASPRR IFANAHTYHI NSISVNSDHE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPHHCN VFVYSSSKGT
260 270 280 290 300
IRLCDMRDSA LCDRHSKFFE EPEDPSSRSF FSEIISSISD VKFSNSGRYM
310 320 330 340 350
MTRDYLSVKV WDLNMESRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSAIMTG SYNNFFRMFD RNTRRDITLE ASRESSKPRA ILKPRKVCTG
410 420 430 440
GKRKKDEINV DSLDFNKKIL HTAWHPTDNI IAVAATNNLY IFQDKVN
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8RPK1 | A0A6I8RPK1_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 443 | Annotation score: | ||
A0A6I8PQF4 | A0A6I8PQF4_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 357 | Annotation score: | ||
A0A6I8QGF1 | A0A6I8QGF1_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 425 | Annotation score: | ||
A0A6I8QIH1 | A0A6I8QIH1_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 428 | Annotation score: | ||
A0A6I8RSH4 | A0A6I8RSH4_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 449 | Annotation score: | ||
A0A6I8SF76 | A0A6I8SF76_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 427 | Annotation score: | ||
A0A6I8SKL7 | A0A6I8SKL7_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 452 | Annotation score: | ||
A0A6I8SYZ7 | A0A6I8SYZ7_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 437 | Annotation score: | ||
A0A6I8SZ40 | A0A6I8SZ40_XENTR | Serine/threonine-protein phosphatas... | ppp2r2d | 430 | Annotation score: | ||
F7E6K8 | F7E6K8_XENTR | MORC family CW-type zinc finger 2 | ppp2r2d morc2 | 804 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC075402 mRNA Translation: AAH75402.1 |
RefSeqi | NP_001006697.1, NM_001006696.1 |
Genome annotation databases
Ensembli | ENSXETT00000011981; ENSXETP00000011981; ENSXETG00000005442 |
GeneIDi | 448324 |
KEGGi | xtr:448324 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC075402 mRNA Translation: AAH75402.1 |
RefSeqi | NP_001006697.1, NM_001006696.1 |
3D structure databases
SMRi | Q6DIY3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000059786 |
Proteomic databases
PRIDEi | Q6DIY3 |
Genome annotation databases
Ensembli | ENSXETT00000011981; ENSXETP00000011981; ENSXETG00000005442 |
GeneIDi | 448324 |
KEGGi | xtr:448324 |
Organism-specific databases
CTDi | 55844 |
Xenbasei | XB-GENE-940312, ppp2r2d |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
InParanoidi | Q6DIY3 |
OMAi | RMFDRGH |
OrthoDBi | 810409at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABD_XENTR | |
Accessioni | Q6DIY3Primary (citable) accession number: Q6DIY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 3, 2011 |
Last sequence update: | August 16, 2004 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families