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Protein

UDP-glucose 6-dehydrogenase

Gene

ugdh.2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.UniRule annotation

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei41NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Active sitei276NucleophileUniRule annotation1
Binding sitei346NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi89 – 93NADUniRule annotation5
Nucleotide bindingi130 – 131NADUniRule annotation2
Nucleotide bindingi276 – 279NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

  • glycosaminoglycan biosynthetic process Source: GO_Central

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
Gene namesi
Name:ugdh.2Imported
Synonyms:LOC541453Imported
ORF Names:TGas086a22.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5783367 ugdh.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSXETG00000016526 Expressed in 6 organ(s), highest expression level in gastrula

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000036025

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 449UDPG_MGDP_dh_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
KOiK00012
OMAiANVCFIF
OrthoDBiEOG091G05RK
TreeFamiTF105671

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DIG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQVKNICCI GAGYVGGPTC TVIAQMCPEV TVTVVDINEE RIRAWNSDQL
60 70 80 90 100
PIYEPGLQDV VDFCRGKNLF FSTNINEAIK KADIIFISVN TPTKTFGMGK
110 120 130 140 150
GRAADLKYVE ACARQIADVA DGYKIVVEKS TVPVRAAEII RRIFKTSTKP
160 170 180 190 200
NLSFQVLSNP EFLAEGTAIE NLKNPDRILI GGDETPAGQN AIAALSEVYE
210 220 230 240 250
HWVPKSKIIT TNTWSSELSK LAANAFLAQR ISSINSISAL CEVTGADVGE
260 270 280 290 300
VAHAIGTDQR IGRPFLQASI GFGGSCFQKD ILNLIYICET LSLHEVALYW
310 320 330 340 350
QQVLDINEYQ RRRFASRIVN CLFNTVADKK IALLGFAFKK DTGDTRESSS
360 370 380 390 400
IYVCKYLMDE GAHLAVYDPK VKKEQIIRDL SHPAISGDNP ERVSELVTIT
410 420 430 440 450
SEPYAACENT HALVICTEWD LFKDLDYERI YGKMLKPAFI FDGRRVLDNL
460 470 480 490
HKRLQQIGFQ VETIGKKVNP VSSLVYRAAS KPACQEQDPT PAKKVKI
Length:497
Mass (Da):55,100
Last modified:August 16, 2004 - v1
Checksum:iBAAD29FCE0516FA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01100028 Genomic DNA No translation available.
AAMC01100029 Genomic DNA No translation available.
BC075574 mRNA Translation: AAH75574.1
CR855655 mRNA Translation: CAJ83398.1
RefSeqiNP_001013630.1, NM_001013612.1
UniGeneiStr.20247

Genome annotation databases

EnsembliENSXETT00000036025; ENSXETP00000036025; ENSXETG00000016526
GeneIDi541453
KEGGixtr:541453

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01100028 Genomic DNA No translation available.
AAMC01100029 Genomic DNA No translation available.
BC075574 mRNA Translation: AAH75574.1
CR855655 mRNA Translation: CAJ83398.1
RefSeqiNP_001013630.1, NM_001013612.1
UniGeneiStr.20247

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000036025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000036025; ENSXETP00000036025; ENSXETG00000016526
GeneIDi541453
KEGGixtr:541453

Organism-specific databases

CTDi541453
XenbaseiXB-GENE-5783367 ugdh.2

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
KOiK00012
OMAiANVCFIF
OrthoDBiEOG091G05RK
TreeFamiTF105671

Gene expression databases

BgeeiENSXETG00000016526 Expressed in 6 organ(s), highest expression level in gastrula

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6DIG8_XENTR
AccessioniPrimary (citable) accession number: Q6DIG8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 10, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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