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Entry version 144 (29 Sep 2021)
Sequence version 1 (16 Aug 2004)
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Protein

Multiple epidermal growth factor-like domains protein 10

Gene

Megf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117).

Cooperates with ABCA1 within the process of engulfment (By similarity).

Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568).

Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117).

Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977,Ref. 10).

May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:22407321).

By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Myogenesis, Phagocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 10Imported
Short name:
Multiple EGF-like domains protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Megf10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685177, Megf10

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000024593

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 857ExtracellularSequence analysisAdd BLAST832
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei858 – 878HelicalSequence analysisAdd BLAST21
Topological domaini879 – 1147CytoplasmicSequence analysisAdd BLAST269

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants show at postnatal day 7 an increased amount of apoptotic cells in the developing cerebellum. However, adult brains do not show higher numbers of apoptotic cells in the cerebellum compared to wild-type. Astrocytes from knockout mice as well as heterozygous mice have a significant impairment in engulfment of apoptotic cells (PubMed:27170117). Reduced proliferation of primary myoblasts (Ref. 10). Mutants have normal mobility and their skeletal muscles show mildly increased endomysial connective tissue. They display reduced motor activity after exercise and show slower muscle regeneration (PubMed:28498977). MEGF10 and DMD double knockout animals have pronounced fiber size variability and intracellular inclusions in the quadriceps femoris with extensive endomysial connective tissue infiltration. Mice develop muscle weakness, kyphosis and a waddling gait. At 2 months of age, they have reduced contractile force compared to wild-type mice. They display reduced motor activity after exercise and they walk shorter distances than wild-type. They have a delayed regeneration after muscle injury and an aberrant muscle fber typing and cross-sectional areas (PubMed:28498977).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030973326 – 1147Multiple epidermal growth factor-like domains protein 10Add BLAST1122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 95Sequence analysis
Disulfide bondi60 ↔ 69Sequence analysis
Disulfide bondi94 ↔ 105Sequence analysis
Disulfide bondi109 ↔ 124By similarity
Disulfide bondi126 ↔ 135By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 160By similarity
Disulfide bondi154 ↔ 167By similarity
Disulfide bondi169 ↔ 178By similarity
Disulfide bondi191 ↔ 203By similarity
Disulfide bondi197 ↔ 210By similarity
Disulfide bondi212 ↔ 221By similarity
Disulfide bondi234 ↔ 246By similarity
Disulfide bondi240 ↔ 253By similarity
Disulfide bondi255 ↔ 264By similarity
Disulfide bondi281 ↔ 289By similarity
Disulfide bondi283 ↔ 296By similarity
Disulfide bondi298 ↔ 307By similarity
Disulfide bondi320 ↔ 332By similarity
Disulfide bondi326 ↔ 339By similarity
Disulfide bondi341 ↔ 350By similarity
Disulfide bondi409 ↔ 421By similarity
Disulfide bondi415 ↔ 428By similarity
Disulfide bondi430 ↔ 439By similarity
Disulfide bondi456 ↔ 464By similarity
Disulfide bondi458 ↔ 471By similarity
Disulfide bondi473 ↔ 482By similarity
Disulfide bondi495 ↔ 507By similarity
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi501 ↔ 514By similarity
Disulfide bondi516 ↔ 525By similarity
Disulfide bondi542 ↔ 550By similarity
Disulfide bondi544 ↔ 557By similarity
Disulfide bondi559 ↔ 568By similarity
Disulfide bondi581 ↔ 593By similarity
Disulfide bondi587 ↔ 600By similarity
Disulfide bondi602 ↔ 611By similarity
Disulfide bondi669 ↔ 681By similarity
Disulfide bondi675 ↔ 688By similarity
Disulfide bondi690 ↔ 699By similarity
Disulfide bondi716 ↔ 724By similarity
Disulfide bondi718 ↔ 731By similarity
Disulfide bondi733 ↔ 742By similarity
Disulfide bondi755 ↔ 767By similarity
Disulfide bondi761 ↔ 774By similarity
Disulfide bondi776 ↔ 785By similarity
Disulfide bondi802 ↔ 810By similarity
Disulfide bondi804 ↔ 817By similarity
Disulfide bondi819 ↔ 828By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1030PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mono- and polyubiquitinated forms are detected.By similarity
Phosphorylated on tyrosine residues. Phosphorylation at Tyr-1030 may be important for muscle cell proliferation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6DIB5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DIB5

PeptideAtlas

More...
PeptideAtlasi
Q6DIB5

PRoteomics IDEntifications database

More...
PRIDEi
Q6DIB5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
292292

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6DIB5, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6DIB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6DIB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cerebellum (at protein level). Expressed in kidney, stellate cells of the cerebellum and macrophage cell lines.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo at 15 dpc (at protein level). Expressed in embryo at 8, 10, 11, 13, 14 and 15 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024593, Expressed in utricle of membranous labyrinth and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6DIB5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6DIB5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomer (Probable).

Interacts with GULP1 and ABCA1.

Interacts with AP2M1. Does not interact with MEGF11 (By similarity). Binds with high affinity to complement C1q (By similarity).

Interacts (via the cytoplasmic domain) with NOTCH1 (via NICD domain) (PubMed:28498977).

By similarityCurated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214036, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000075174

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6DIB5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6DIB5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 107EMIPROSITE-ProRule annotationAdd BLAST78
Domaini101 – 136EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini187 – 222EGF-like 3PROSITE-ProRule annotationAdd BLAST36
Domaini230 – 265EGF-like 4PROSITE-ProRule annotationAdd BLAST36
Domaini278 – 308EGF-like 5PROSITE-ProRule annotationAdd BLAST31
Domaini316 – 351EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini405 – 440EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini453 – 483EGF-like 8PROSITE-ProRule annotationAdd BLAST31
Domaini491 – 526EGF-like 9PROSITE-ProRule annotationAdd BLAST36
Domaini539 – 569EGF-like 10PROSITE-ProRule annotationAdd BLAST31
Domaini577 – 612EGF-like 11PROSITE-ProRule annotationAdd BLAST36
Domaini665 – 700EGF-like 12PROSITE-ProRule annotationAdd BLAST36
Domaini713 – 743EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini751 – 786EGF-like 14PROSITE-ProRule annotationAdd BLAST36
Domaini799 – 829EGF-like 15PROSITE-ProRule annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 857Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion patternBy similarityAdd BLAST857
Regioni945 – 1147Necessary for formation of large intracellular vacuolesBy similarityAdd BLAST203
Regioni1093 – 1147DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1125 – 1147Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EMI and EGF-like domains work in concert to promote self-assembly.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEGF family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157703

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008281_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DIB5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNINCSP

Database of Orthologous Groups

More...
OrthoDBi
561378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6DIB5

TreeFam database of animal gene trees

More...
TreeFami
TF332598

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR011489, EMI_domain
IPR002049, Laminin_EGF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12661, hEGF, 7 hits
PF00053, Laminin_EGF, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 17 hits
SM00180, EGF_Lam, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 17 hits
PS01186, EGF_2, 17 hits
PS50026, EGF_3, 15 hits
PS51041, EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6DIB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISSSSCLG LICSLLCHWV GTASSLNLED PNVCSHWESY SVTVQESYPH
60 70 80 90 100
PFDQIYYTSC TDILNWFKCT RHRISYRTAY RHGEKTMYRR KSQCCPGFYE
110 120 130 140 150
SRDMCVPHCA DKCVHGRCIA PNTCQCEPGW GGTNCSSACD GDHWGPHCSS
160 170 180 190 200
RCQCKNRALC NPITGACHCA AGYRGWRCED RCEQGTYGND CHQRCQCQNG
210 220 230 240 250
ATCDHITGEC RCSPGYTGAF CEDLCPPGKH GPHCEQRCPC QNGGVCHHVT
260 270 280 290 300
GECSCPSGWM GTVCGQPCPE GRFGKNCSQE CQCHNGGTCD AATGQCHCSP
310 320 330 340 350
GYTGERCQDE CPVGSYGVRC AEACRCVNGG KCYHVSGTCL CEAGFSGELC
360 370 380 390 400
EARLCPEGLY GIKCDKRCPC HLDNTHSCHP MSGECGCKPG WSGLYCNETC
410 420 430 440 450
SPGFYGEACQ QICSCQNGAD CDSVTGRCAC APGFKGTDCS TPCPLGRYGI
460 470 480 490 500
NCSSRCGCKN DAVCSPVDGS CICKAGWHGV DCSIRCPSGT WGFGCNLTCQ
510 520 530 540 550
CLNGGACNTL DGTCTCAPGW RGAKCEFPCQ DGTYGLNCAE RCDCSHADGC
560 570 580 590 600
HPTTGHCRCL PGWSGVHCDS VCAEGRWGPN CSLPCYCKNG ASCSPDDGIC
610 620 630 640 650
ECAPGFRGTT CQRICSPGFY GHRCSQTCPQ CVHSSGPCHH ITGLCDCLPG
660 670 680 690 700
FTGALCNEVC PSGRFGKNCA GVCTCTNNGT CNPIDRSCQC YPGWIGSDCS
710 720 730 740 750
QPCPPAHWGP NCIHTCNCHN GAFCSAYDGE CKCTPGWTGL YCTQRCPLGF
760 770 780 790 800
YGKDCALICQ CQNGADCDHI SGQCTCRTGF MGRHCEQKCP AGTYGYGCRQ
810 820 830 840 850
ICDCLNNSTC DHITGTCYCS PGWKGARCDQ AGVIIVGNLN SLSRTSTALP
860 870 880 890 900
ADSYQIGAIA GIVVLVLVVL FLLALFIIYR HKQKRKESSM PAVTYTPAMR
910 920 930 940 950
VINADYTIAE TLPHSNGGNA NSHYFTNPSY HTLSQCATSP HVNNRDRMTI
960 970 980 990 1000
AKSKNNQLFV NLKNVNPGKR GTLVDCTGTL PADWKQGGYL NELGAFGLDR
1010 1020 1030 1040 1050
SYMGKSLKDL GKNSEYNSST CSLSSSENPY ATIKDPPALL PKSSECGYVE
1060 1070 1080 1090 1100
MKSPARRDSP YAEINNSTPA NRNVYEVEPT VSVVQGVFSN SGHVTQDPYD
1110 1120 1130 1140
LPKNSHIPCH YDLLPVRDSS SSPKREDGGG SNSTSSNSTS SSSSSSE
Length:1,147
Mass (Da):122,972
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBC50896096181CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8S0A0A140T8S0_MOUSE
Multiple epidermal growth factor-li...
Megf10
1,061Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti323A → T in BAE38699 (PubMed:16141072).Curated1
Sequence conflicti1092G → S in BAE38699 (PubMed:16141072).Curated1
Sequence conflicti1137N → S in BAE38699 (PubMed:16141072).Curated1
Sequence conflicti1140S → T in BAE38699 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK147238 mRNA Translation: BAE27788.1
AK148084 mRNA Translation: BAE28336.1
AK166316 mRNA Translation: BAE38699.1
BC075647 mRNA Translation: AAH75647.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS29264.1

NCBI Reference Sequences

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RefSeqi
NP_001001979.1, NM_001001979.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000075770; ENSMUSP00000075174; ENSMUSG00000024593

Database of genes from NCBI RefSeq genomes

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GeneIDi
70417

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:70417

UCSC genome browser

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UCSCi
uc008eyz.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147238 mRNA Translation: BAE27788.1
AK148084 mRNA Translation: BAE28336.1
AK166316 mRNA Translation: BAE38699.1
BC075647 mRNA Translation: AAH75647.1
CCDSiCCDS29264.1
RefSeqiNP_001001979.1, NM_001001979.2

3D structure databases

SMRiQ6DIB5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi214036, 2 interactors
STRINGi10090.ENSMUSP00000075174

PTM databases

GlyGeniQ6DIB5, 2 sites
iPTMnetiQ6DIB5
PhosphoSitePlusiQ6DIB5

Proteomic databases

MaxQBiQ6DIB5
PaxDbiQ6DIB5
PeptideAtlasiQ6DIB5
PRIDEiQ6DIB5
ProteomicsDBi292292

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14004, 91 antibodies

The DNASU plasmid repository

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DNASUi
70417

Genome annotation databases

EnsembliENSMUST00000075770; ENSMUSP00000075174; ENSMUSG00000024593
GeneIDi70417
KEGGimmu:70417
UCSCiuc008eyz.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84466
MGIiMGI:2685177, Megf10
VEuPathDBiHostDB:ENSMUSG00000024593

Phylogenomic databases

eggNOGiKOG1218, Eukaryota
GeneTreeiENSGT00940000157703
HOGENOMiCLU_008281_1_0_1
InParanoidiQ6DIB5
OMAiCNINCSP
OrthoDBi561378at2759
PhylomeDBiQ6DIB5
TreeFamiTF332598

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
70417, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Megf10, mouse

Protein Ontology

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PROi
PR:Q6DIB5
RNActiQ6DIB5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024593, Expressed in utricle of membranous labyrinth and 191 other tissues
ExpressionAtlasiQ6DIB5, baseline and differential
GenevisibleiQ6DIB5, MM

Family and domain databases

InterProiView protein in InterPro
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR011489, EMI_domain
IPR002049, Laminin_EGF
PfamiView protein in Pfam
PF12661, hEGF, 7 hits
PF00053, Laminin_EGF, 5 hits
SMARTiView protein in SMART
SM00181, EGF, 17 hits
SM00180, EGF_Lam, 14 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 17 hits
PS01186, EGF_2, 17 hits
PS50026, EGF_3, 15 hits
PS51041, EMI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEG10_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DIB5
Secondary accession number(s): Q3TLU3, Q3UG73
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 16, 2004
Last modified: September 29, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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