UniProtKB - Q6DIA6 (Q6DIA6_MOUSE)
Protein
Homeobox protein
Gene
Pitx2
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 92 – 151 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- brain development Source: Ensembl
- female gonad development Source: Ensembl
- male gonad development Source: Ensembl
- neuron differentiation Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- response to hormone Source: Ensembl
- response to vitamin A Source: Ensembl
Keywordsi
Molecular function | Developmental proteinUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox proteinUniRule annotation |
Gene namesi | Name:Pitx2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:109340, Pitx2 |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000028023, Expressed in pituitary gland and 313 other tissues |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 286 – 299 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationImportedARBA annotationPhylogenomic databases
OrthoDBi | 1432356at2759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR016233, Homeobox_Pitx/unc30 IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PIRSFi | PIRSF000563, Homeobox_protein_Pitx/Unc30, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6DIA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNCMKGPLPL EHRAAGTKLS AASSPFCHHP QALAMASVLA PGQPRSLDSS
60 70 80 90 100
KHRLEVHTIS DTSSPEVAEK DKGQQGKNED VGAEDPSKKK RQRRQRTHFT
110 120 130 140 150
SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR
160 170 180 190 200
ERNQQAELCK NGFGPQFNGL MQPYDDMYPG YSYNNWAAKG LTSASLSTKS
210 220 230 240 250
FPFFNSMNVN PLSSQSMFSP PNSISSMSMS SSMVPSAVTG VPGSSLNSLN
260 270 280 290 300
NLNNLSSPSL NSAVPTPACP YAPPTPPYVY RDTCNSSLAS LRLKAKQHSS
310 320
FGYASVQNPA SNLSACQYAV DRPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC075660 mRNA Translation: AAH75660.1 |
RefSeqi | NP_001035967.1, NM_001042502.2 NP_001273977.1, NM_001287048.1 |
Genome annotation databases
GeneIDi | 18741 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC075660 mRNA Translation: AAH75660.1 |
RefSeqi | NP_001035967.1, NM_001042502.2 NP_001273977.1, NM_001287048.1 |
3D structure databases
SMRi | Q6DIA6 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q6DIA6 |
Genome annotation databases
GeneIDi | 18741 |
Organism-specific databases
CTDi | 5308 |
MGIi | MGI:109340, Pitx2 |
Phylogenomic databases
OrthoDBi | 1432356at2759 |
Miscellaneous databases
BioGRID-ORCSi | 18741, 1 hit in 18 CRISPR screens |
ChiTaRSi | Pitx2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028023, Expressed in pituitary gland and 313 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR016233, Homeobox_Pitx/unc30 IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PIRSFi | PIRSF000563, Homeobox_protein_Pitx/Unc30, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6DIA6_MOUSE | |
Accessioni | Q6DIA6Primary (citable) accession number: Q6DIA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |