Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 91 (29 Sep 2021)
Sequence version 2 (06 Feb 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Exocyst complex component 3-like protein 4

Gene

Exoc3l4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNARE binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 3-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Exoc3l4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921363, Exoc3l4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743811 – 721Exocyst complex component 3-like protein 4Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei515PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6DIA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DIA2

PeptideAtlas

More...
PeptideAtlasi
Q6DIA2

PRoteomics IDEntifications database

More...
PRIDEi
Q6DIA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275554

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6DIA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6DIA2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
216562, 1 interactor

Molecular INTeraction database

More...
MINTi
Q6DIA2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000072438

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6DIA2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni94 – 135DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 40Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2286, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DIA2

Database of Orthologous Groups

More...
OrthoDBi
391172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6DIA2

TreeFam database of animal gene trees

More...
TreeFami
TF314979

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.357.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010326, EXOC3/Sec6
IPR042532, EXOC3/Sec6_C

The PANTHER Classification System

More...
PANTHERi
PTHR21292, PTHR21292, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06046, Sec6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6DIA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPQTGAPG PEVKSPREPR KSQTLPVTTW KSNSMKEQSV HHGGSLRPSL
60 70 80 90 100
GMLKQTLFRT SLRTSTHKPK EDPGLFRRSS RFLFRSLRRA IDEGLTAGHP
110 120 130 140 150
QGPAVPEKPS KVTDGVSRQA ATGTEAEDLE PQAESKSVAD LITERQLVKA
160 170 180 190 200
FEQLRYLETQ LVADKTSRTF TQDPTAYARR AMDLCLHYDG MAAEIGAIVR
210 220 230 240 250
EALSSEGVDR DALAELAQVV HLEEEAHQTS QAEGDFLSTP RHWRMHWEDA
260 270 280 290 300
VRLSAQESVQ QAGAKVIPGA AEGSSDLAQL LAELGGVVRH DLQKVRLEMQ
310 320 330 340 350
PAYEATDFPV WETYLRAFHS AVAQRLQELA RDARGCEQLY VLLDWAANVY
360 370 380 390 400
GSPDFLGAPD LALPTEPLPP LLEPALWARL ESDYTSFLET KITSCFDSIL
410 420 430 440 450
QLEQNRWEAD EDREVLQGLY HAPLSIDVHM LVAEHVKAAG AISAELEATT
460 470 480 490 500
LQICARALCL FVPRFEKAFL ASKAVSEWYL GAYINACVEL RTSLLARFPG
510 520 530 540 550
TIKELEKPLV AATNSFQKHL LQIVQQDMQP LFKVLYTKSW LTQDTLRPLM
560 570 580 590 600
DKVVDFAHHL EHVTPPLAQE TLQEVHRFVV REYLGQVLRP HERFSGQDRL
610 620 630 640 650
KGSNKMNLDA QAISNTFQGL GSEAKWLDQA ILSVAEILGE TYKDDIRRHL
660 670 680 690 700
ETLIRSYPDI RRDHILAILA LRRLGRRRNQ NLLQHTQDLL RAAHETRLPS
710 720
HHVLFEEIEV PTSVDVLITC I
Length:721
Mass (Da):81,035
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00703209D717E32F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0W9A0A0R4J0W9_MOUSE
Exocyst complex component 3-like pr...
Exoc3l4
721Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJ76A0A1Y7VJ76_MOUSE
Exocyst complex component 3-like pr...
Exoc3l4
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJT1A0A1Y7VJT1_MOUSE
Exocyst complex component 3-like pr...
Exoc3l4
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VMT0A0A1Y7VMT0_MOUSE
Exocyst complex component 3-like pr...
Exoc3l4
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VMU8A0A1Y7VMU8_MOUSE
Exocyst complex component 3-like pr...
Exoc3l4
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VIP9A0A1Y7VIP9_MOUSE
Exocyst complex component 3-like pr...
Exoc3l4
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti258S → R in BAB24037 (PubMed:16141072).Curated1
Sequence conflicti680Q → H in AAH75664 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK005443 mRNA Translation: BAB24037.1
BC042799 mRNA Translation: AAH42799.1
BC075664 mRNA Translation: AAH75664.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26177.1

NCBI Reference Sequences

More...
RefSeqi
NP_001276416.1, NM_001289487.1
NP_001276417.1, NM_001289488.1
NP_001276418.1, NM_001289489.1
NP_083083.3, NM_028807.4
XP_006516352.1, XM_006516289.2
XP_006516354.1, XM_006516291.3
XP_006516355.1, XM_006516292.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74190

UCSC genome browser

More...
UCSCi
uc007pcv.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005443 mRNA Translation: BAB24037.1
BC042799 mRNA Translation: AAH42799.1
BC075664 mRNA Translation: AAH75664.1
CCDSiCCDS26177.1
RefSeqiNP_001276416.1, NM_001289487.1
NP_001276417.1, NM_001289488.1
NP_001276418.1, NM_001289489.1
NP_083083.3, NM_028807.4
XP_006516352.1, XM_006516289.2
XP_006516354.1, XM_006516291.3
XP_006516355.1, XM_006516292.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi216562, 1 interactor
MINTiQ6DIA2
STRINGi10090.ENSMUSP00000072438

PTM databases

iPTMnetiQ6DIA2
PhosphoSitePlusiQ6DIA2

Proteomic databases

MaxQBiQ6DIA2
PaxDbiQ6DIA2
PeptideAtlasiQ6DIA2
PRIDEiQ6DIA2
ProteomicsDBi275554

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
74190

Genome annotation databases

GeneIDi74190
KEGGimmu:74190
UCSCiuc007pcv.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91828
MGIiMGI:1921363, Exoc3l4

Phylogenomic databases

eggNOGiKOG2286, Eukaryota
InParanoidiQ6DIA2
OrthoDBi391172at2759
PhylomeDBiQ6DIA2
TreeFamiTF314979

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
74190, 0 hits in 63 CRISPR screens

Protein Ontology

More...
PROi
PR:Q6DIA2
RNActiQ6DIA2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.357.70, 1 hit
InterProiView protein in InterPro
IPR010326, EXOC3/Sec6
IPR042532, EXOC3/Sec6_C
PANTHERiPTHR21292, PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046, Sec6, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEX3L4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DIA2
Secondary accession number(s): Q80UY5, Q9DAX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 29, 2021
This is version 91 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again