Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine deaminase-like protein

Gene

ADAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Zinc; catalyticBy similarity1
Metal bindingi26Zinc; catalyticBy similarity1
Binding sitei26SubstrateBy similarity1
Binding sitei181Substrate; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi208Zinc; catalyticBy similarity1
Active sitei211Proton donorBy similarity1
Sitei232Important for catalytic activityBy similarity1
Metal bindingi293Zinc; catalyticBy similarity1
Binding sitei294SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2161541 Abacavir metabolism
R-HSA-74217 Purine salvage

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase-like protein (EC:3.5.4.-)
Gene namesi
Name:ADAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000168803.14
HGNCiHGNC:31853 ADAL
neXtProtiNX_Q6DHV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168803
PharmGKBiPA142672643

Chemistry databases

ChEMBLiCHEMBL1795150

Polymorphism and mutation databases

BioMutaiADAL
DMDMi146286026

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850901 – 355Adenosine deaminase-like proteinAdd BLAST355

Proteomic databases

EPDiQ6DHV7
MaxQBiQ6DHV7
PeptideAtlasiQ6DHV7
PRIDEiQ6DHV7
ProteomicsDBi66225
66226 [Q6DHV7-2]
66227 [Q6DHV7-3]

Expressioni

Gene expression databases

BgeeiENSG00000168803 Expressed in 165 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_ADAL
ExpressionAtlasiQ6DHV7 baseline and differential
GenevisibleiQ6DHV7 HS

Organism-specific databases

HPAiHPA046215
HPA048175

Interactioni

Protein-protein interaction databases

BioGridi127803, 3 interactors
IntActiQ6DHV7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6DHV7
SMRiQ6DHV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111081
HOGENOMiHOG000205847
HOVERGENiHBG055638
InParanoidiQ6DHV7
OMAiRGWFRFQ
OrthoDBiEOG091G0UAU
PhylomeDBiQ6DHV7
TreeFamiTF314270

Family and domain databases

InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6DHV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD
60 70 80 90 100
QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK
110 120 130 140 150
YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR
160 170 180 190 200
GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTVGQAKD FLEPLLEAKK
210 220 230 240 250
AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE GGSLDLVDFV
260 270 280 290 300
RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT
310 320 330 340 350
HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP

RVLHI
Length:355
Mass (Da):40,264
Last modified:May 1, 2007 - v2
Checksum:i02810E9BC5F56CD5
GO
Isoform 2 (identifier: Q6DHV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-355: ELCLTSNVKS...NHLKPRVLHI → GKAWSFRSSR

Show »
Length:267
Mass (Da):30,040
Checksum:iC4ED476D40B4C512
GO
Isoform 3 (identifier: Q6DHV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-211: Missing.

Show »
Length:328
Mass (Da):37,362
Checksum:iF3AE94C2AF38E5FD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUD6H3BUD6_HUMAN
Adenosine deaminase-like protein
ADAL
110Annotation score:
H3BQR9H3BQR9_HUMAN
Adenosine deaminase-like protein
ADAL
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119K → E in AK126583 (PubMed:14702039).Curated1
Sequence conflicti139I → T in AK126583 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042782185 – 211Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_024821258 – 355ELCLT…RVLHI → GKAWSFRSSR in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126583 mRNA No translation available.
AK298870 mRNA Translation: BAG60990.1
AC009852 Genomic DNA No translation available.
AC018924 Genomic DNA No translation available.
BC075857 mRNA Translation: AAH75857.1
CCDSiCCDS32214.1 [Q6DHV7-2]
CCDS53936.1 [Q6DHV7-3]
CCDS81868.1 [Q6DHV7-1]
RefSeqiNP_001012987.1, NM_001012969.3 [Q6DHV7-2]
NP_001152752.1, NM_001159280.2 [Q6DHV7-3]
NP_001311293.1, NM_001324364.1 [Q6DHV7-2]
NP_001311294.1, NM_001324365.1 [Q6DHV7-2]
NP_001311295.1, NM_001324366.1 [Q6DHV7-1]
NP_001311297.1, NM_001324368.1 [Q6DHV7-2]
XP_011519593.1, XM_011521291.2 [Q6DHV7-1]
XP_016877453.1, XM_017021964.1 [Q6DHV7-1]
XP_016877454.1, XM_017021965.1 [Q6DHV7-1]
XP_016877455.1, XM_017021966.1 [Q6DHV7-1]
UniGeneiHs.533913

Genome annotation databases

EnsembliENST00000389651; ENSP00000374302; ENSG00000168803 [Q6DHV7-2]
ENST00000422466; ENSP00000398744; ENSG00000168803 [Q6DHV7-3]
ENST00000428046; ENSP00000413074; ENSG00000168803 [Q6DHV7-3]
ENST00000562188; ENSP00000456242; ENSG00000168803 [Q6DHV7-1]
ENST00000610420; ENSP00000478575; ENSG00000168803 [Q6DHV7-2]
GeneIDi161823
KEGGihsa:161823
UCSCiuc001zrh.5 human [Q6DHV7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126583 mRNA No translation available.
AK298870 mRNA Translation: BAG60990.1
AC009852 Genomic DNA No translation available.
AC018924 Genomic DNA No translation available.
BC075857 mRNA Translation: AAH75857.1
CCDSiCCDS32214.1 [Q6DHV7-2]
CCDS53936.1 [Q6DHV7-3]
CCDS81868.1 [Q6DHV7-1]
RefSeqiNP_001012987.1, NM_001012969.3 [Q6DHV7-2]
NP_001152752.1, NM_001159280.2 [Q6DHV7-3]
NP_001311293.1, NM_001324364.1 [Q6DHV7-2]
NP_001311294.1, NM_001324365.1 [Q6DHV7-2]
NP_001311295.1, NM_001324366.1 [Q6DHV7-1]
NP_001311297.1, NM_001324368.1 [Q6DHV7-2]
XP_011519593.1, XM_011521291.2 [Q6DHV7-1]
XP_016877453.1, XM_017021964.1 [Q6DHV7-1]
XP_016877454.1, XM_017021965.1 [Q6DHV7-1]
XP_016877455.1, XM_017021966.1 [Q6DHV7-1]
UniGeneiHs.533913

3D structure databases

ProteinModelPortaliQ6DHV7
SMRiQ6DHV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127803, 3 interactors
IntActiQ6DHV7, 1 interactor

Chemistry databases

ChEMBLiCHEMBL1795150

Polymorphism and mutation databases

BioMutaiADAL
DMDMi146286026

Proteomic databases

EPDiQ6DHV7
MaxQBiQ6DHV7
PeptideAtlasiQ6DHV7
PRIDEiQ6DHV7
ProteomicsDBi66225
66226 [Q6DHV7-2]
66227 [Q6DHV7-3]

Protocols and materials databases

DNASUi161823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389651; ENSP00000374302; ENSG00000168803 [Q6DHV7-2]
ENST00000422466; ENSP00000398744; ENSG00000168803 [Q6DHV7-3]
ENST00000428046; ENSP00000413074; ENSG00000168803 [Q6DHV7-3]
ENST00000562188; ENSP00000456242; ENSG00000168803 [Q6DHV7-1]
ENST00000610420; ENSP00000478575; ENSG00000168803 [Q6DHV7-2]
GeneIDi161823
KEGGihsa:161823
UCSCiuc001zrh.5 human [Q6DHV7-1]

Organism-specific databases

CTDi161823
EuPathDBiHostDB:ENSG00000168803.14
GeneCardsiADAL
HGNCiHGNC:31853 ADAL
HPAiHPA046215
HPA048175
neXtProtiNX_Q6DHV7
OpenTargetsiENSG00000168803
PharmGKBiPA142672643
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111081
HOGENOMiHOG000205847
HOVERGENiHBG055638
InParanoidiQ6DHV7
OMAiRGWFRFQ
OrthoDBiEOG091G0UAU
PhylomeDBiQ6DHV7
TreeFamiTF314270

Enzyme and pathway databases

ReactomeiR-HSA-2161541 Abacavir metabolism
R-HSA-74217 Purine salvage

Miscellaneous databases

GenomeRNAii161823
PROiPR:Q6DHV7

Gene expression databases

BgeeiENSG00000168803 Expressed in 165 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_ADAL
ExpressionAtlasiQ6DHV7 baseline and differential
GenevisibleiQ6DHV7 HS

Family and domain databases

InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADAL_HUMAN
AccessioniPrimary (citable) accession number: Q6DHV7
Secondary accession number(s): A6NHZ3, B4DQM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 12, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again